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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sertaconazole
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Accession:CHEBI:82866 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-sertaconazole. A broad spectrum antifungal with added antipruritic and anti-inflammatory activity used (as its nitrate salt) for treatment of various skin infections.
Synonyms:exact_synonym: rac-1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
 related_synonym: (+-)-1-(2,4-Dichloro-beta-((7-chlorobenzo(b)thien-3-yl)methoxy)phenethyl)imidazole;   (RS)-sertaconazole;   1-(2-((7-Chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole;   7-Chloro-3-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl)benzo(b)thiophene;   Formula=C20H15Cl3N2OS;   rac-sertaconazole;   racemic sertaconazole;   sertaconazol;   sertaconazolum
 xref: CAS:99592-32-2;   DrugBank:DB01153;   HMDB:HMDB0015284;   KEGG:D06883
 xref_mesh: MESH:C061131
 xref: PMID:19925567;   PMID:20349685;   PMID:21746955;   PMID:21818511;   PMID:21968663;   PMID:23210976;   PMID:23296325;   PMID:23372210;   PMID:23441833;   PMID:23470235;   PMID:23546772;   PMID:23566144;   PMID:23715821;   PMID:23829055;   PMID:24171300;   PMID:24249897;   PMID:24249898;   PMID:24511475;   PMID:24791343;   PMID:24845480;   PMID:24881281;   PMID:24909149;   PMID:24953450;   Reaxys:5385663


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sertaconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO sertaconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      chemical substance 14415
        mixture 13709
          racemate 12111
            sertaconazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            organic molecule 19714
                              organic cyclic compound 19485
                                organic heterocyclic compound 18881
                                  heteroarene 17148
                                    monocyclic heteroarene 14977
                                      azole 14500
                                        diazole 10769
                                          imidazoles 10219
                                            imidazole antifungal agent 1997
                                              imidazole antifungal drug 1583
                                                arasertaconazole 1
                                                  sertaconazole 1
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