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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphorothioate oligonucleotide
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Accession:CHEBI:76674 term browser browse the term
Definition:An oligonucleotide in which one of the non-bridging oxygens in each phosphodiester linkage has been replaced by sulfur. The main application of phosphorothioate linkages in an oligonucleotide is to protect the oligonucleotide from nuclease degradation.
Synonyms:related_synonym: OPS;   PS-DNA;   S-oligo;   S-oligos;   oligo(nucleoside phosphorothioate);   oligo(nucleoside phosphorothioate)s;   oligonucleotide phosphorothioates;   phosphorothioate DNA;   phosphorothioate oligonucleotides
 xref: PMID:9746230;   Wikipedia:Oligonucleotide_synthesis#Oligonucleotide_phosphorothioates_and_their_synthesis


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phosphorothioate oligonucleotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression EXP phosphorothioate oligonucleotide decreased mRNA and activity of ALDH2 in rat liver RGD PMID:11535626 RGD:15036815 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      atom 19842
        nonmetal atom 19780
          nitrogen atom 18958
            nitrogen molecular entity 18958
              nucleobase-containing molecular entity 5670
                oligonucleotide 1
                  phosphorothioate oligonucleotide 1
                    5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3' 0
                    5'-CsGsGsCsTsCsCsAsTsGsTsAsCsAsGsCsAsTsGsCsG-3' 0
                    5'-GsCsAsGsTsCsTsAsTsTsAsCsTsGsTsGsCsGsAsGsA-3' 0
                    5'-GsCsCsGsAsGsGsTsCsCsAsTsGsTsCsGsTsAsCsGsC-3' 0
                    5'-GsCsGsTsAsCsGsAsCsAsTsGsGsAsCsCsTsCsGsGsC-3' 0
                    5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3' 0
                    d(Gs)19dG 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic heterocyclic compound 18870
                                  organonitrogen heterocyclic compound 18149
                                    nucleobase 12549
                                      nucleobase-containing molecular entity 5670
                                        oligonucleotide 1
                                          phosphorothioate oligonucleotide 1
                                            5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3' 0
                                            5'-CsGsGsCsTsCsCsAsTsGsTsAsCsAsGsCsAsTsGsCsG-3' 0
                                            5'-GsCsAsGsTsCsTsAsTsTsAsCsTsGsTsGsCsGsAsGsA-3' 0
                                            5'-GsCsCsGsAsGsGsTsCsCsAsTsGsTsCsGsTsAsCsGsC-3' 0
                                            5'-GsCsGsTsAsCsGsAsCsAsTsGsGsAsCsCsTsCsGsGsC-3' 0
                                            5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3' 0
                                            d(Gs)19dG 0
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