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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylarsine oxide
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Accession:CHEBI:75253 term browser browse the term
Definition:An arsine oxide derived from phenylarsine.
Synonyms:exact_synonym: oxo(phenyl)arsine
 related_synonym: Arsenosobenzene;   Formula=C6H5AsO;   InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H;   InChIKey=BQVCCPGCDUSGOE-UHFFFAOYSA-N;   Oxophenylarsine;   PhAsO;   Phenyl arsine oxide;   Phenylarsenoxide;   SMILES=O=[As]c1ccccc1
 xref: CAS:637-03-6
 xref_mesh: MESH:C029341
 xref: PDBeChem:PA0;   PMID:22048238;   PMID:22617457;   PMID:23044393;   PMID:23201556;   Reaxys:2935227


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phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOX2 dual oxidase 2 affects folding EXP oxophenylarsine affects the folding of DUOX2 protein CTD PMID:10601291 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP oxophenylarsine results in increased expression of HIF1A protein CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G INS insulin multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid] CTD PMID:1928324 PMID:8048502 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G NOS3 nitric oxide synthase 3 decreases phosphorylation
affects localization		 EXP oxophenylarsine results in decreased phosphorylation of NOS3 protein
oxophenylarsine affects the localization of NOS3 protein		 CTD PMID:9546377 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5163
    role 5130
      biological role 5130
        biochemical role 5053
          apoptosis inducer 109
            phenylarsine oxide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 5163
    subatomic particle 5154
      composite particle 5154
        hadron 5154
          baryon 5154
            nucleon 5154
              atomic nucleus 5154
                atom 5154
                  main group element atom 5126
                    p-block element atom 5123
                      p-block molecular entity 5123
                        pnictogen molecular entity 542
                          arsenic molecular entity 24
                            arsine oxides 4
                              phenylarsine oxide 4
paths to the root