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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:arsine oxides
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Accession:CHEBI:35843 term browser browse the term
Definition:H3As=O and its hydrocarbyl derivatives.



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phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein] CTD PMID:26763395 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases phosphorylation
multiple interactions
ISO oxophenylarsine results in increased phosphorylation of BCAR1 protein
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]
CTD PMID:10537051 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases activity ISO oxophenylarsine results in decreased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Casp3 caspase 3 increases activity ISO oxophenylarsine results in increased activity of CASP3 protein CTD PMID:10515888 PMID:19465042 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Cd79a CD79a molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79A protein CTD PMID:8559152 NCBI chr 1:80,493,520...80,497,936
Ensembl chr 1:80,493,581...80,497,935
JBrowse link
G Cd79b CD79b molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79B protein CTD PMID:8559152 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein] CTD PMID:17141199 PMID:20512473 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Egf epidermal growth factor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]; oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein CTD PMID:9685416 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects localization ISO oxophenylarsine affects the localization of FYN protein CTD PMID:9546377 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
CTD PMID:12471042 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein] CTD PMID:9281317 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO oxophenylarsine results in increased expression of GSTA1 mRNA CTD PMID:7568053 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
oxophenylarsine results in increased expression of HMOX1 mRNA
Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]
CTD PMID:8612205 PMID:15368090 PMID:19786557 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects binding ISO oxophenylarsine binds to ID3 protein CTD PMID:23523789 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Igf1 insulin-like growth factor 1 decreases localization
multiple interactions
EXP oxophenylarsine results in decreased localization of IGF1 protein
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 PMID:9145794 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 decreases localization EXP oxophenylarsine results in decreased localization of IGF2 protein CTD PMID:9145794 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:20512473 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxophenylarsine results in decreased expression of and results in decreased activity of IL1B protein CTD PMID:9266823 PMID:10515888 PMID:10802230 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il3 interleukin 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il6 interleukin 6 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]
CTD PMID:17141199 PMID:26763395 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein] CTD PMID:8048502 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor multiple interactions ISO oxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein] CTD PMID:2458350 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases activity ISO oxophenylarsine results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 PMID:19808700 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]
CTD PMID:11880281 PMID:12927602 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]
CTD PMID:11880281 PMID:12927602 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation
ISO
EXP
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases activity
multiple interactions
ISO oxophenylarsine results in increased activity of MARK1 protein
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]
CTD PMID:10737602 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] CTD PMID:10569804 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] CTD PMID:10569804 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects binding ISO oxophenylarsine binds to MTF1 protein CTD PMID:19276070 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein] CTD PMID:16183647 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] CTD PMID:12471042 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
ISO oxophenylarsine results in increased activity of NFE2L2 protein
oxophenylarsine binds to and results in increased activity of NFE2L2 protein
CTD PMID:19786557 PMID:19808700 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
multiple interactions
ISO oxophenylarsine affects the localization of NFKB1 protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of NFKB1 protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of NFKB1 protein]
CTD PMID:25417048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO oxophenylarsine results in decreased phosphorylation of NFKBIA protein
oxophenylarsine promotes the reaction [Viper Venoms results in decreased phosphorylation of NFKBIA protein]; Viper Venoms promotes the reaction [oxophenylarsine results in decreased phosphorylation of NFKBIA protein]
CTD PMID:25417048 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos3 nitric oxide synthase 3 affects localization ISO oxophenylarsine affects the localization of NOS3 protein CTD PMID:9546377 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO oxophenylarsine results in increased expression of NQO1 mRNA CTD PMID:19786557 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO oxophenylarsine results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO oxophenylarsine results in increased cleavage of PARP1 protein CTD PMID:10515888 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
decreases phosphorylation
affects localization
EXP
ISO
[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]
oxophenylarsine affects the localization of PLCG1 protein
CTD PMID:1325458 PMID:9281317 PMID:9546377 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein; oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein mutant form CTD PMID:28125064 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Pomc proopiomelanocortin decreases activity
multiple interactions
ISO
EXP
oxophenylarsine results in decreased activity of POMC protein
oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]
[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone
CTD PMID:10518784 PMID:12530643 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
CTD PMID:9266823 PMID:9576062 PMID:9580637 PMID:18267125 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO [oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]
oxophenylarsine results in increased phosphorylation of PTK2 protein
CTD PMID:10537051 PMID:10569804 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Pxn paxillin multiple interactions
increases phosphorylation
affects localization
ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]
oxophenylarsine affects the localization of PXN protein
CTD PMID:9546377 PMID:10537051 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RCAN1 protein] CTD PMID:12927602 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO oxophenylarsine affects the localization of RELA protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of RELA protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of RELA protein]
CTD PMID:25417048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions
affects binding
EXP Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]; carboxyatractyloside inhibits the reaction [oxophenylarsine binds to SLC25A4 protein] CTD PMID:18667415 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
affects activity
ISO oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]; oxophenylarsine inhibits the reaction [Glucose deficiency results in increased activity of SLC2A1 protein]; oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]
oxophenylarsine affects the activity of SLC2A1 protein
CTD PMID:19686715 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
affects binding
ISO
EXP
oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]
oxophenylarsine binds to SLC2A4 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]
CTD PMID:1536656 PMID:1629198 PMID:8048502 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects localization ISO oxophenylarsine affects the localization of SRC protein CTD PMID:9546377 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO oxophenylarsine results in decreased expression of STAR protein CTD PMID:12530643 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] CTD PMID:11882386 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
affects localization
ISO Hydrogen Peroxide promotes the reaction [oxophenylarsine affects the localization of STAT3 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]; oxophenylarsine promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]
CTD PMID:10364193 PMID:11882386 PMID:12093727 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tf transferrin decreases uptake ISO oxophenylarsine results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor affects localization ISO oxophenylarsine affects the localization of TFRC protein CTD PMID:2643384 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity
ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
oxophenylarsine results in decreased activity of TGFB1 protein
CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oxophenylarsine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
CTD PMID:9576062 PMID:9580637 PMID:10802230 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 multiple interactions
increases expression
ISO oxophenylarsine promotes the reaction [Viper Venoms results in increased expression of TNFRSF25 protein]; Viper Venoms promotes the reaction [oxophenylarsine results in increased expression of TNFRSF25 protein] CTD PMID:25417048 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions EXP [oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein] CTD PMID:16023995 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
trimethylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP trimethylarsine oxide results in increased expression of ABCB1A mRNA; trimethylarsine oxide results in increased expression of ABCB1A protein CTD PMID:16436460 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP trimethylarsine oxide results in increased expression of ABCC1 mRNA; trimethylarsine oxide results in increased expression of ABCC1 protein CTD PMID:16436460 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP trimethylarsine oxide results in increased expression of ABCC2 mRNA; trimethylarsine oxide results in increased expression of ABCC2 protein CTD PMID:16436460 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP trimethylarsine oxide results in increased expression of ABCC3 mRNA; trimethylarsine oxide results in increased expression of ABCC3 protein CTD PMID:16436460 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO trimethylarsine oxide affects the localization of and results in increased activity of AHR protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in decreased expression of and affects the localization of AHR protein
CTD PMID:24161444 PMID:26144063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP trimethylarsine oxide results in increased expression of ALDH1A1 mRNA CTD PMID:17481689 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G As3mt arsenite methyltransferase increases chemical synthesis
multiple interactions
EXP AS3MT protein results in increased chemical synthesis of trimethylarsine oxide
Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]
CTD PMID:15606138 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
JBrowse link
G Casp3 caspase 3 increases expression EXP trimethylarsine oxide results in increased expression of CASP3 mRNA CTD PMID:17481689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trimethylarsine oxide results in increased expression of CCND1 mRNA CTD PMID:17481689 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression EXP trimethylarsine oxide results in increased expression of CCNE1 mRNA CTD PMID:17481689 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdh1 cadherin 1 increases expression EXP trimethylarsine oxide results in increased expression of CDH1 mRNA CTD PMID:17481689 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 increases expression EXP trimethylarsine oxide results in increased expression of CDH2 mRNA CTD PMID:17481689 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression
increases expression
multiple interactions
EXP
ISO
trimethylarsine oxide affects the expression of CYP1A1 mRNA
trimethylarsine oxide results in increased expression of CYP1A1 mRNA; trimethylarsine oxide results in increased expression of CYP1A1 protein
trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:17481689 PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP
ISO
trimethylarsine oxide results in increased expression of CYP1A2 mRNA
trimethylarsine oxide results in increased expression of CYP1A2 mRNA; trimethylarsine oxide results in increased expression of CYP1A2 protein
CTD PMID:17481689 PMID:26144063 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1B1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1B1 protein
trimethylarsine oxide results in increased expression of CYP1B1 mRNA
CTD PMID:26042454 PMID:26144063 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 mRNA; [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 protein
trimethylarsine oxide results in increased expression of CYP2B1 mRNA
CTD PMID:12115560 PMID:17481689 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:12115560 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP trimethylarsine oxide results in increased expression of CYP2C11 mRNA CTD PMID:17481689 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression EXP trimethylarsine oxide results in decreased expression of DNMT1 mRNA CTD PMID:17481689 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Faslg Fas ligand increases expression EXP trimethylarsine oxide results in increased expression of FASLG mRNA CTD PMID:17481689 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression EXP trimethylarsine oxide results in increased expression of GJB1 mRNA CTD PMID:17481689 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression
increases expression
EXP trimethylarsine oxide results in decreased expression of GSTA2 mRNA; trimethylarsine oxide results in decreased expression of GSTA2 protein
trimethylarsine oxide results in increased expression of GSTA2 mRNA
CTD PMID:16436460 PMID:17481689 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO trimethylarsine oxide results in increased expression of GSTA1 mRNA CTD PMID:26144063 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTM1 mRNA; trimethylarsine oxide results in increased expression of GSTM1 protein CTD PMID:16436460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTP1 mRNA CTD PMID:17481689 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO trimethylarsine oxide results in increased expression of HMOX1 mRNA; trimethylarsine oxide results in increased expression of HMOX1 protein CTD PMID:26144063 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression EXP trimethylarsine oxide results in increased expression of ITIH3 mRNA CTD PMID:17481689 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Krt18 keratin 18 decreases expression EXP trimethylarsine oxide results in decreased expression of KRT18 mRNA CTD PMID:17481689 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP trimethylarsine oxide results in increased expression of MAPK14 mRNA CTD PMID:17481689 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP trimethylarsine oxide results in decreased expression of MAPK8 mRNA CTD PMID:17481689 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:24161444 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of NQO1 protein
trimethylarsine oxide results in increased expression of NQO1 mRNA; trimethylarsine oxide results in increased expression of NQO1 protein
CTD PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP trimethylarsine oxide results in increased expression of OGG1 mRNA CTD PMID:17481689 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP trimethylarsine oxide results in increased expression of PCNA mRNA CTD PMID:17481689 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Prkca protein kinase C, alpha increases expression EXP trimethylarsine oxide results in increased expression of PRKCA mRNA CTD PMID:17481689 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP trimethylarsine oxide results in increased expression of PRKCG mRNA CTD PMID:17481689 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO trimethylarsine oxide results in decreased secretion of TNF protein CTD PMID:9548797 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    chemical entity 19658
      atom 19658
        metalloid atom 13579
          arsenic atom 12307
            arsenic molecular entity 12316
              arsine oxides 104
                arsine oxide + 0
                phenylarsine oxide 73
                trimethylarsine oxide 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      p-block molecular entity 19649
                        pnictogen molecular entity 18841
                          arsenic molecular entity 12316
                            arsine oxides 104
                              arsine oxide + 0
                              phenylarsine oxide 73
                              trimethylarsine oxide 36
paths to the root