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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:asenapine
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Accession:CHEBI:71253 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Synonyms:exact_synonym: rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
 related_synonym: (3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole;   asenapina;   asenapinum;   trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
 xref: CAS:65576-45-6
 xref_mesh: MESH:C522667
 xref: PMID:21474903;   PMID:21557265;   PMID:21628604;   PMID:21755540;   PMID:21875607;   PMID:22156709;   PMID:22182459;   PMID:22198448;   PMID:22198451;   PMID:22332980;   PMID:22344545;   PMID:22362425;   PMID:22454251;   PMID:22494521;   PMID:22700206;   PMID:22726414;   PMID:22745558;   PMID:22849428;   PMID:22868059;   PMID:22877962;   PMID:22896826;   PMID:22900950;   PMID:22936407;   PMID:23095277;   PMID:23121334;   Patent:US2005119248;   Patent:US2006084692;   Patent:US2006229352;   Patent:WO2012038975;   Patent:WO2012040845;   Patent:WO2012123325;   Reaxys:3654823;   Wikipedia:Asenapine
 cyclic_relationship: is_conjugate_base_of CHEBI:71249


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asenapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression		 ISO Asenapine results in decreased activity of CYP1A2 protein
Asenapine results in decreased expression of CYP1A2 mRNA		 CTD PMID:32941854 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    chemical entity 19846
      chemical substance 14404
        mixture 13722
          racemate 12101
            asenapine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        tertiary amino compound 10141
                                          5-chloro-2-methyl-2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 1
                                            (S,S)-asenapine 1
                                              asenapine 1
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