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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:asenapine
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Accession:CHEBI:71253 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Synonyms:exact_synonym: rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
 related_synonym: (3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole;   asenapina;   asenapinum;   trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
 xref: CAS:65576-45-6
 xref_mesh: MESH:C522667
 xref: PMID:21474903;   PMID:21557265;   PMID:21628604;   PMID:21755540;   PMID:21875607;   PMID:22156709;   PMID:22182459;   PMID:22198448;   PMID:22198451;   PMID:22332980;   PMID:22344545;   PMID:22362425;   PMID:22454251;   PMID:22494521;   PMID:22700206;   PMID:22726414;   PMID:22745558;   PMID:22849428;   PMID:22868059;   PMID:22877962;   PMID:22896826;   PMID:22900950;   PMID:22936407;   PMID:23095277;   PMID:23121334;   Patent:US2005119248;   Patent:US2006084692;   Patent:US2006229352;   Patent:WO2012038975;   Patent:WO2012040845;   Patent:WO2012123325;   Reaxys:3654823;   Wikipedia:Asenapine
 cyclic_relationship: is_conjugate_base_of CHEBI:71249


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asenapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression
ISO Asenapine results in decreased activity of CYP1A2 protein
Asenapine results in decreased expression of CYP1A2 mRNA
CTD PMID:32941854 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    chemical entity 19786
      chemical substance 12245
        mixture 11208
          racemate 10085
            asenapine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19443
                        hydrogen molecular entity 19439
                          hydrides 18763
                            inorganic hydride 17484
                              pnictogen hydride 17461
                                nitrogen hydride 17315
                                  azane 17021
                                    ammonia 17020
                                      organic amino compound 17019
                                        tertiary amino compound 8677
                                          5-chloro-2-methyl-2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 1
                                            (S,S)-asenapine 1
                                              asenapine 1
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