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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:doxapram
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Accession:CHEBI:681848 term browser browse the term
Definition:A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Synonyms:exact_synonym: 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
 related_synonym: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone;   Formula=C24H30N2O2;   InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3;   InChIKey=XFDJYSQDBULQSI-UHFFFAOYSA-N;   SMILES=CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
 xref: CAS:309-29-5;   DrugBank:DB00561;   Drug_Central:953;   KEGG:D07873;   LINCS:LSM-5058
 xref_mesh: MESH:D004315
 xref: PMID:19663568;   PMID:20140700;   PMID:25819170;   PMID:26896538;   PMID:4122029;   PMID:4126096;   PMID:527638;   Patent:BE613734;   Patent:US3192206;   Reaxys:628691;   VSDB:1819;   Wikipedia:Doxapram


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doxapram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone increases expression EXP Doxapram results in increased expression of CRH mRNA; Doxapram results in increased expression of CRH protein CTD PMID:16269353 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Prl prolactin increases expression ISO Doxapram results in increased expression of PRL protein CTD PMID:15741000 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      application 19693
        pharmaceutical 19529
          drug 19529
            central nervous system drug 16782
              central nervous system stimulant 8526
                doxapram 2
                  (R)-doxapram 0
                  (S)-doxapram 0
                  doxapram hydrochloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      carbon group element atom 19756
                        carbon atom 19753
                          organic molecular entity 19753
                            heteroorganic entity 19521
                              organochalcogen compound 19281
                                organooxygen compound 19199
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17706
                                        univalent carboacyl group 17706
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              lactam 8391
                                                gamma-lactam 6657
                                                  pyrrolidin-2-ones 169
                                                    doxapram 2
                                                      (R)-doxapram 0
                                                      (S)-doxapram 0
                                                      doxapram hydrochloride (anhydrous) + 0
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