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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mepivacaine
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Accession:CHEBI:6759 term browser browse the term
Definition:A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Synonyms:related_synonym: 1-methyl-2',6'-pipecoloxylidide;   Carbocaine;   DL-Mepivacaine;   Formula=C15H22N2O;   InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);   InChIKey=INWLQCZOYSRPNW-UHFFFAOYSA-N;   N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide;   N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide;   SMILES=CN1CCCCC1C(=O)Nc1c(C)cccc1C;   mepivacaina;   mepivacainum
 alt_id: CHEBI:247981
 xref: Beilstein:211230;   CAS:96-88-8;   DrugBank:DB00961;   Drug_Central:1700;   HMDB:HMDB0015096;   KEGG:C07528;   KEGG:D08181;   LINCS:LSM-4306
 xref_mesh: MESH:D008619
 xref: PMID:13760073;   PMID:13859098;   PMID:25369391;   PMID:25827158;   PMID:26169676;   PMID:26780408;   PMID:9013953;   PMID:9425972;   PMID:9989796;   Patent:US2799679;   Reaxys:211230;   Wikipedia:Mepivacaine


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mepivacaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 multiple interactions ISO Mepivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16931984 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases activity
multiple interactions		 ISO Mepivacaine results in decreased activity of KCNQ1 protein
Mepivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]		 CTD PMID:16931984 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Slc25a29 solute carrier family 25 member 29 decreases activity EXP Mepivacaine results in decreased activity of SLC25A29 protein CTD PMID:35135371 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Mepivacaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      application 19668
        pharmaceutical 19508
          drug 19508
            drug allergen 11758
              mepivacaine 4
                mepivacaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17697
                                        univalent carboacyl group 17697
                                          carbamoyl group 17547
                                            carboxamide 17547
                                              monocarboxylic acid amide 15682
                                                piperidinecarboxamide 71
                                                  mepivacaine 4
                                                    mepivacaine hydrochloride 0
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