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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:spiramide
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Accession:CHEBI:64207 term browser browse the term
Definition:An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Synonyms:exact_synonym: 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
 related_synonym: AMI-193;   Formula=C22H26FN3O2;   InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27);   InChIKey=FJUKDAZEABGEIH-UHFFFAOYSA-N;   SMILES=Fc1ccc(OCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1;   espiramida;   spiramidum
 xref: CAS:510-74-7;   LINCS:LSM-4124;   PMID:11124389;   PMID:17965538;   PMID:19875674;   PMID:4474849;   PMID:4776656;   Patent:US3238216;   Reaxys:631679;   Wikipedia:Spiramide


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Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        pharmacological role 19064
          antagonist 17248
            dopaminergic antagonist 1636
              spiramide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        tertiary amino compound 10141
                                          spiramide 0
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