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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pizotifen
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Accession:CHEBI:50212 term browser browse the term
Definition:A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.
Synonyms:exact_synonym: 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
 related_synonym: Formula=C19H21NS;   InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3;   InChIKey=FIADGNVRKBPQEU-UHFFFAOYSA-N;   Pizotyline;   SMILES=CN1CCC(CC1)=C1c2ccccc2CCc2sccc12;   pizotifene;   pizotifeno;   pizotifenum
 xref: Beilstein:753534;   CAS:15574-96-6;   Drug_Central:2220;   KEGG:D05523;   LINCS:LSM-3695
 xref_mesh: MESH:D010918
 xref: Patent:BE636717;   Patent:US3272826;   Reaxys:753534;   Wikipedia:Pizotifen
 cyclic_relationship: is_conjugate_base_of CHEBI:50318


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pizotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19816
      chemical role 19453
        base 17832
          piperidine 105
            pizotifen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19788
                    main group molecular entity 19788
                      s-block molecular entity 19621
                        hydrogen molecular entity 19608
                          hydrides 19112
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18018
                                  azane 17824
                                    ammonia 17823
                                      organic amino compound 17823
                                        secondary amino compound 6838
                                          secondary amine 1845
                                            piperidine 105
                                              pizotifen 1
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