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7-methyl-GTP - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7-methyl-GTP
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Accession:CHEBI:50210 term browser browse the term
Definition:A guanosine 5'-phosphate that has formula C11H18N5O14P3.
Synonyms:exact_synonym: 7-methylguanosine 5'-(trihydrogen triphosphate)
 related_synonym: 7-methylguanosine 5'-triphosphate;   7-methylguanosine triphosphate;   Formula=C11H18N5O14P3;   InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1;   InChIKey=DKVRNHPCAOHRSI-KQYNXXCUSA-N;   SMILES=C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12;   m(7)GTP
 xref: Beilstein:4083086;   CAS:26554-26-7
 xref_mesh: MESH:C017516
 cyclic_relationship: is_conjugate_acid_of CHEBI:87133;   is_conjugate_base_of CHEBI:50226

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7-methyl-GTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO 7-methylguanosine triphosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; 7-methylguanosine triphosphate inhibits the reaction [RNA Caps binds to EIF4E protein] CTD PMID:27592390 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
affects binding 		ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]; Sirolimus promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate] CTD PMID:25940091 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 multiple interactions
affects binding 		ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]; Sirolimus inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate] CTD PMID:25940091 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        inhibitor 18945
          uncoupling protein inhibitor 137
            GTP 57
              7-methyl-GTP 3
                7-methyl-guanosine-5'-triphosphate-5'-guanosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            hydroxides 19361
                              oxoacid 18797
                                pnictogen oxoacid 15018
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13927
                                      phosphoric acid 13927
                                        phosphoric acid derivative 13839
                                          phosphate 13838
                                            organic phosphate 13838
                                              carbohydrate phosphate 1969
                                                phospho sugar 1814
                                                  aldose phosphate 1811
                                                    aldopentose phosphate 1803
                                                      ribose phosphate 1798
                                                        ribonucleotide 1758
                                                          purine ribonucleotide 1715
                                                            guanyl ribonucleotide 149
                                                              guanosine phosphate 81
                                                                guanosine 5'-phosphate 81
                                                                  GTP 57
                                                                    7-methyl-GTP 3
                                                                      7-methyl-guanosine-5'-triphosphate-5'-guanosine 0
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