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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vindesine
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Accession:CHEBI:36373 term browser browse the term
Definition:A vinca alkaloid that has formula C43H55N5O7.
Synonyms:exact_synonym: 3-carbamoyl-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine;   methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate
 related_synonym: 3-(aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine;   3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine;   Formula=C43H55N5O7;   InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1;   InChIKey=HHJUWIANJFBDHT-KOTLKJBCSA-N;   SMILES=[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C)[C@@]1([H])[C@](O)([C@H](O)[C@]2(CC)C=CC3)C(N)=O)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC;   desacetylvinblastine amide
 xref: Beilstein:7162300;   CAS:53643-48-4;   DrugBank:DB00309
 xref_mesh: MESH:D014751


show annotations for term's descendants           Sort by:
vindesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 ISO Tamoxifen promotes the reaction [Vindesine results in decreased expression of BAX mRNA] CTD PMID:19757172 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO Tamoxifen promotes the reaction [Vindesine results in increased expression of BCL2 mRNA] CTD PMID:19757172 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Ngf nerve growth factor decreases response to substance EXP Vindesine results in decreased susceptibility to NGF protein CTD PMID:9524088 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        fuel 11364
          methanol 3967
            methyl ester 3913
              vindesine 3
                vindesine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      carboacyl group 17724
                                        univalent carboacyl group 17724
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              primary carboxamide 6007
                                                vindesine 3
                                                  vindesine sulfate 0
paths to the root