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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:icosa-5,8,10,14-tetraenoic acid
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Accession:CHEBI:36039 term browser browse the term
Definition:Any icosatetraenoic acid with the double bonds at positions 5, 8, 10 and 14.
Synonyms:related_synonym: 5,8,10,14-18:4;   5,8,10,14-eicosatetraenoic acid;   5,8,10,14-eicosatetraenoic acids;   5,8,10,14-icosatetraenoic acid;   5,8,10,14-icosatetraenoic acids;   C18:4, n-6,10,12,15;   Formula=C20H32O2;   InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,10-13,15-16H,2-5,8-9,14,17-19H2,1H3,(H,21,22);   InChIKey=ZRVOHYJWSYEIDY-UHFFFAOYSA-N;   SMILES=[H]C(CCC=C([H])C=C([H])CC=C([H])CCCC(O)=O)=CCCCCC;   eicosa-5,8,10,14-tetraenoic acid;   eicosa-5,8,10,14-tetraenoic acids;   icosa-5,8,10,14-tetraenoic acids


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12(S)-HPETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 protein results in increased susceptibility to 12-HPETE CTD PMID:11115402 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases chemical synthesis ISO GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      atom 19919
        nonmetal atom 19848
          carbon atom 19801
            organic molecular entity 19801
              olefinic compound 16991
                olefinic fatty acid 800
                  icosatetraenoic acid 364
                    icosa-5,8,10,14-tetraenoic acid 3
                      12(R)-HPETE + 0
                      12(S)-HPETE + 3
                      12-HETE + 0
                      12-oxo-ETE 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      monocarboxylic acid 18028
                                        fatty acid 16848
                                          unsaturated fatty acid 1672
                                            polyunsaturated fatty acid 841
                                              fatty acid 20:4 364
                                                icosatetraenoic acid 364
                                                  icosa-5,8,10,14-tetraenoic acid 3
                                                    12(R)-HPETE + 0
                                                    12(S)-HPETE + 3
                                                    12-HETE + 0
                                                    12-oxo-ETE 0
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