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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,5-diethylbarbituric acid
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Accession:CHEBI:31252 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Synonyms:related_synonym: 2,4,6(1H,3H,5H)-pyrimidinetrione;   5,5-Diethyl-pyrimidine-2,4,6-trione;   5,5-diethylpyrimidine-2,4,6(1H,3H,5H)-trione;   Barbital;   Barbitone;   DEBA;   Formula=C8H12N2O3;   InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13);   InChIKey=FTOAOBMCPZCFFF-UHFFFAOYSA-N;   SMILES=CCC1(CC)C(=O)NC(=O)NC1=O;   Veronal;   diethylmalonyl urea
 alt_id: CHEBI:102256
 xref: CAS:57-44-3;   DrugBank:DB01483;   Drug_Central:289;   Gmelin:4113;   KEGG:D01740
 xref_mesh: MESH:D001462
 xref: PMID:10866370;   PMID:15857133;   PMID:17827020;   PMID:20681553;   PMID:22467201;   PMID:3654008;   PMID:6864729;   Reaxys:163999;   Wikipedia:Barbital


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5,5-diethylbarbituric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression		 ISO Barbital results in increased activity of ALAD protein
Barbital results in increased expression of ALAD mRNA		 CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Barbital results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Barbital results in increased activity of CYP2B1 protein CTD PMID:7697745 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Barbital results in increased expression of HMOX1 mRNA CTD PMID:16309571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19901
    role 19871
      application 19716
        pharmaceutical 19552
          drug 19552
            drug allergen 11869
              5,5-diethylbarbituric acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19901
    subatomic particle 19899
      composite particle 19899
        hadron 19899
          baryon 19899
            nucleon 19899
              atomic nucleus 19899
                atom 19899
                  main group element atom 19838
                    p-block element atom 19838
                      carbon group element atom 19778
                        carbon atom 19775
                          organic molecular entity 19775
                            organic molecule 19728
                              organic cyclic compound 19519
                                organic heterocyclic compound 18898
                                  organic heteromonocyclic compound 17824
                                    diazines 13239
                                      pyrimidines 13109
                                        pyrimidone 10533
                                          barbiturates 4640
                                            5,5-diethylbarbituric acid 4
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