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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amrinone
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Accession:CHEBI:2686 term browser browse the term
Definition:A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Synonyms:exact_synonym: 5-amino[3,4'-bipyridin]-6(1H)-one
 related_synonym: 3-amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone;   3-amino-5-(4-pyridinyl)-2(1H)-pyridinone;   3-amino-5-pyridin-4-yl-1H-pyridin-2-one;   5-amino-1,6-dihydro-6-oxo-[3,4'-bipyridine];   Formula=C10H9N3O;   InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14);   InChIKey=RNLQIBCLLYYYFJ-UHFFFAOYSA-N;   SMILES=C1=CN=CC=C1C2=CNC(=O)C(=C2)N;   WIN 40680;   amrinona;   amrinonum;   inamrinone
 alt_id: CHEBI:95269
 xref: CAS:60719-84-8;   DrugBank:DB01427;   Drug_Central:201;   HMDB:HMDB0015496;   KEGG:D00231;   LINCS:LSM-6600
 xref_mesh: MESH:D000676
 xref: PMID:10513074;   PMID:10835763;   PMID:10919416;   PMID:10969688;   PMID:10972600;   PMID:12076859;   PMID:12111179;   PMID:12354747;   PMID:14754535;   PMID:15064331;   PMID:15892406;   PMID:15972057;   PMID:16154150;   PMID:16236146;   PMID:17582263;   PMID:18468627;   PMID:23112975;   PMID:23184630;   PMID:23908328;   PMID:28166217;   PMID:29764757;   PMID:31194440;   PMID:3764113;   PMID:3916118;   PMID:39684;   PMID:7379253;   Wikipedia:Amrinone


show annotations for term's descendants           Sort by:
amrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Amrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:9004165 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Amrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:9004165 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19729
        pharmaceutical 19563
          drug 19563
            cardiovascular drug 8644
              amrinone 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18900
                                  organonitrogen heterocyclic compound 18179
                                    bipyridines 4317
                                      amrinone 2
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