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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bipyridines
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Accession:CHEBI:50511 term browser browse the term
Definition:Compounds containing a bipyridine group.
Synonyms:related_synonym: bipyridyls


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2,2'-bipyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl4 angiopoietin-like 4 increases expression ISO 2,2'-Dipyridyl results in increased expression of ANGPTL4 mRNA CTD PMID:19924283 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Copper binds to phthalic acid binds to 2,2'-Dipyridyl] which results in increased expression of H2AX protein modified form CTD PMID:22659117 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO 2,2'-Dipyridyl results in decreased expression of HAMP mRNA CTD PMID:19924283 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
ISO 2,2'-Dipyridyl results in increased expression of HIF1A protein
resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased expression of HIF1A protein]
CTD PMID:18674879 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; 2,2'-Dipyridyl inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; 2,2'-Dipyridyl inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]] CTD PMID:20934533 PMID:26945724 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO 2,2'-Dipyridyl results in increased expression of IGFBP1 mRNA CTD PMID:19924283 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 2,2'-Dipyridyl inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA] CTD PMID:24570342 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2,2'-Dipyridyl inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA] CTD PMID:24570342 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2,2'-Dipyridyl inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:24570342 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions
increases expression
ISO 2,2'-Dipyridyl results in increased activity of MMP9 protein
resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased activity of MMP9 protein]
2,2'-Dipyridyl results in increased expression of MMP9 mRNA
CTD PMID:18674879 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2,2'-Dipyridyl inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA] CTD PMID:24570342 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases activity
multiple interactions
increases expression
ISO 2,2'-Dipyridyl results in increased activity of VEGFA protein
resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased activity of VEGFA protein]
2,2'-Dipyridyl results in increased expression of VEGFA mRNA
CTD PMID:15075239 PMID:18674879 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
amrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Amrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:9004165 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Amrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:9004165 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Anabaseine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP anabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
Benzyl viologen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Benzyl Viologen results in increased expression of NQO1 mRNA CTD PMID:22846377 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Benzyl Viologen results in increased expression of POR mRNA CTD PMID:22846377 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Benzyl Viologen results in increased expression of UGT1A6 mRNA CTD PMID:22846377 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO Diquat results in increased expression of ADM mRNA CTD PMID:21172416 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diquat results in increased expression of ADORA2B mRNA CTD PMID:21172416 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Diquat results in increased expression of AKR1B10 mRNA CTD PMID:21172416 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Diquat results in increased expression of AKR1C2 mRNA CTD PMID:21172416 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein] CTD PMID:20826540 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Diquat results in increased expression of ANKRD1 mRNA CTD PMID:21172416 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Diquat results in increased expression of ATF3 mRNA CTD PMID:21172416 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA] CTD PMID:26785375 PMID:27057282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Diquat affects the expression of BCL2 mRNA
Diquat results in decreased expression of BCL2 protein
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]
CTD PMID:26785375 PMID:27057282 PMID:29484840 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Diquat results in increased expression of BCL2L11 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]
CTD PMID:26785375 PMID:27057282 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
ISO
EXP
GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; SN50 peptide inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
Diquat results in increased expression of CASP3 mRNA
Diquat results in increased expression of CASP3 mRNA; Diquat results in increased expression of CASP3 protein modified form
Diquat results in increased cleavage of and results in increased activity of CASP3 protein; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:15496407 PMID:18164269 PMID:19815060 PMID:26785375 PMID:27057282 PMID:29484840 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO
EXP
Diquat results in increased cleavage of and results in increased activity of CASP9 protein; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]
CTD PMID:18164269 PMID:20826540 PMID:29484840 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]
Diquat results in decreased activity of CAT protein
CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
CTD PMID:21215309 PMID:26785375 PMID:27057282 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Diquat results in increased expression of CLIP4 mRNA CTD PMID:21172416 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Diquat results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Diquat results in increased expression of CYP4A1 mRNA CTD PMID:7676460 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Diquat results in increased expression of DDIT3 mRNA; Diquat results in increased expression of DDIT3 protein
PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]
CTD PMID:20826540 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO Diquat results in increased expression of DKK1 mRNA CTD PMID:21172416 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Diquat results in increased expression of DUSP1 mRNA CTD PMID:21172416 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA] CTD PMID:20826540 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Diquat results in increased expression of ELL2 mRNA CTD PMID:21172416 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Diquat results in increased expression of FOS mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]
CTD PMID:20826540 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
ISO Diquat results in increased expression of FOXO1 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]
CTD PMID:27057282 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Diquat results in increased expression of FTH1 mRNA CTD PMID:21698372 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Diquat results in increased expression of FTL1 mRNA CTD PMID:16962985 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
increases activity
EXP
ISO
Diquat results in increased expression of G6PD mRNA; Diquat results in increased expression of G6PD protein
Diquat results in increased activity of G6PD protein
CTD PMID:8934631 PMID:28108222 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Diquat results in increased expression of GADD45A mRNA CTD PMID:21172416 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
decreases activity
decreases expression
ISO
EXP
Diquat results in increased expression of GCLC mRNA
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA
Diquat results in decreased activity of GCLC protein
Diquat results in decreased expression of GCLC mRNA
CTD PMID:7676460 PMID:16962985 PMID:22762311 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Diquat results in increased expression of GCLM mRNA CTD PMID:16962985 PMID:20826540 PMID:21172416 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glrx glutaredoxin increases response to substance ISO GLRX gene mutant form results in increased susceptibility to Diquat CTD PMID:17893043 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein] CTD PMID:15496407 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
decreases response to substance
affects response to substance
multiple interactions
increases response to substance
ISO Diquat results in decreased expression of GPX1 protein
GPX1 protein results in decreased susceptibility to Diquat
GPX1 protein affects the susceptibility to Diquat
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]; GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]
GPX1 gene mutant form results in increased susceptibility to Diquat; GPX1 protein results in increased susceptibility to Diquat
CTD PMID:10490281 PMID:11568445 PMID:11672444 PMID:15182862 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance
increases expression
multiple interactions
ISO GPX4 protein alternative form results in decreased susceptibility to Diquat
Diquat results in increased expression of GPX4 mRNA
GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]; GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
CTD PMID:15496407 PMID:16962985 PMID:19744930 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Diquat results in increased expression of GSR mRNA CTD PMID:16962985 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Diquat results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Diquat results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Diquat results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Diquat results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Diquat results in decreased expression of GSTM2 mRNA CTD PMID:7676460 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Diquat results in increased expression of HAMP mRNA CTD PMID:21698372 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
multiple interactions
ISO Diquat results in increased expression of HMOX1 mRNA; Diquat results in increased expression of HMOX1 protein
Diquat results in increased activity of HMOX1 protein
PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]
CTD PMID:20826540 PMID:21172416 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Diquat results in increased expression of HSPA1A mRNA CTD PMID:21172416 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diquat results in increased expression of HSPA1B mRNA CTD PMID:21172416 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ifng interferon gamma multiple interactions ISO Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide] CTD PMID:11498278 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases response to substance ISO IGF1R protein results in increased susceptibility to Diquat CTD PMID:22132081 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il6 interleukin 6 increases expression EXP Diquat results in increased expression of IL6 protein CTD PMID:21698372 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diquat results in increased expression of JUN mRNA CTD PMID:21172416 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat] CTD PMID:22762311 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kynu kynureninase increases expression ISO Diquat results in increased expression of KYNU mRNA CTD PMID:21172416 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Diquat results in increased expression of MAP2 mRNA CTD PMID:21172416 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK1 protein CTD PMID:20826540 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK3 protein CTD PMID:20826540 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein] CTD PMID:20826540 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Diquat results in increased expression of ME1 mRNA CTD PMID:16962985 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Capsaicin inhibits the reaction [Diquat results in increased activity of MPO protein] CTD PMID:15046732 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA] CTD PMID:20826540 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A decreases expression
multiple interactions
ISO Diquat results in decreased expression of MT2 mRNA
PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]
CTD PMID:20826540 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nefh neurofilament heavy affects expression EXP Diquat affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases response to substance
decreases response to substance
increases activity
multiple interactions
ISO Diquat results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Diquat
NFE2L2 results in decreased susceptibility to Diquat
Diquat results in increased activity of NFE2L2 protein
KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]
CTD PMID:16962985 PMID:20143881 PMID:20826540 PMID:21172416 PMID:22762311 PMID:23056183 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity
ISO Diquat results in increased expression of NQO1 mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]
Diquat results in increased expression of NQO1 mRNA; Diquat results in increased expression of NQO1 protein
Diquat results in increased activity of NQO1 protein
CTD PMID:20826540 PMID:21172416 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Diquat results in increased cleavage of PARP1 protein CTD PMID:25693864 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Diquat results in increased expression of PGD mRNA CTD PMID:16962985 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing
ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; NADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; POR protein results in increased metabolism of Diquat
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; [POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen; POR protein results in increased metabolism of Diquat
CTD PMID:21215309 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO Diquat results in increased expression of PPIF mRNA CTD PMID:21172416 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Diquat results in increased expression of PPP1R15A mRNA CTD PMID:21172416 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Diquat results in increased expression of PRDX1 mRNA CTD PMID:16962985 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Diquat results in increased expression of PRDX3 mRNA CTD PMID:16962985 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance
affects response to substance
multiple interactions
ISO PROP1 gene mutant form results in decreased susceptibility to Diquat
PROP1 protein affects the susceptibility to Diquat
PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein]
CTD PMID:19414510 PMID:20826540 NCBI chr10:36,449,920...36,452,381
Ensembl chr10:36,449,920...36,452,378
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Diquat results in increased expression of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of PTGS2 protein]
CTD PMID:29484840 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasgef1b RasGEF domain family, member 1B increases expression ISO Diquat results in increased expression of RASGEF1B mRNA CTD PMID:21172416 NCBI chr14:11,499,692...12,028,513
Ensembl chr14:11,988,671...12,027,381
JBrowse link
G Rgs20 regulator of G-protein signaling 20 increases expression ISO Diquat results in increased expression of RGS20 mRNA CTD PMID:21172416 NCBI chr 5:14,367,498...14,494,048
Ensembl chr 5:14,415,606...14,494,756
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Diquat results in increased expression of RGS4 mRNA CTD PMID:21172416 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Diquat results in increased expression of RND3 mRNA CTD PMID:21172416 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Diquat results in increased expression of SAT1 mRNA CTD PMID:21172416 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Diquat results in increased expression of SERPINB8 mRNA CTD PMID:21172416 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Diquat results in increased expression of SERPINE1 mRNA CTD PMID:21172416 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression EXP Diquat results in decreased expression of SLC40A1 mRNA CTD PMID:21698372 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Diquat results in increased expression of SLC7A11 mRNA CTD PMID:21172416 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
Diquat results in decreased expression of SOD1 mRNA
CTD PMID:7676460 PMID:11672444 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
Diquat results in increased expression of SOD2 protein
CTD PMID:11672444 PMID:29484840 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Diquat results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Diquat results in increased expression of SPINK1 mRNA CTD PMID:21172416 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Diquat results in increased expression of SRXN1 mRNA CTD PMID:21172416 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Diquat results in increased expression of STC2 mRNA CTD PMID:21172416 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tfrc transferrin receptor increases expression EXP Diquat results in increased expression of TFRC mRNA CTD PMID:21698372 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diquat results in increased expression of and affects the localization of TP53 protein; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein] CTD PMID:29484840 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO Diquat results in increased expression of TRIM16 mRNA CTD PMID:21172416 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Txn2 thioredoxin 2 increases expression
decreases response to substance
multiple interactions
ISO Diquat results in increased expression of TXN2 mRNA
TXN2 protein results in decreased susceptibility to Diquat
TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
CTD PMID:16962985 PMID:18164269 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Diquat results in increased expression of TXNRD1 mRNA CTD PMID:20826540 PMID:21172416 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Diquat results in increased expression of UPP1 mRNA CTD PMID:21172416 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Diquat results in increased expression of ZFAND2A mRNA CTD PMID:21172416 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link
etoricoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO etoricoxib results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO etoricoxib results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO etoricoxib results in decreased expression of ICAM1 mRNA; etoricoxib results in decreased expression of ICAM1 protein CTD PMID:17931847 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
EXP
ISO
etoricoxib inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
etoricoxib results in decreased activity of PTGS2 protein; etoricoxib results in decreased activity of PTGS2 protein mutant form
CTD PMID:17164136 PMID:17638016 PMID:22245433 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
LGK974 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased expression of BAK1 protein] CTD PMID:30205152 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Casp3 caspase 3 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein] CTD PMID:30205152 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in decreased expression of CCND1 protein] CTD PMID:30205152 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein]; LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein] CTD PMID:30205152 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of DIABLO protein] CTD PMID:30205152 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of HTRA2 protein] CTD PMID:30205152 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:30205152 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
milrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Milrinone results in increased expression of ADH1 mRNA CTD PMID:22936366 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression EXP Milrinone results in increased expression of AKIP1 mRNA CTD PMID:22936366 NCBI chr 1:174,330,628...174,339,494
Ensembl chr 1:174,330,695...174,339,494
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Milrinone results in decreased expression of ANGPTL4 mRNA CTD PMID:22936366 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Aqp7 aquaporin 7 decreases expression EXP Milrinone results in decreased expression of AQP7 mRNA CTD PMID:22936366 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Milrinone results in decreased expression of ARNTL mRNA CTD PMID:22936366 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Aspn asporin increases expression EXP Milrinone results in increased expression of ASPN mRNA CTD PMID:22936366 NCBI chr17:14,655,958...14,681,355
Ensembl chr17:14,656,009...14,679,409
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides]
Milrinone results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 increases expression EXP Milrinone results in increased expression of CHTF8 mRNA CTD PMID:22936366 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Milrinone results in increased expression of CREM mRNA CTD PMID:22936366 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crp C-reactive protein decreases expression ISO Milrinone results in decreased expression of CRP protein CTD PMID:11772795 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Milrinone results in increased expression of CSRP2 mRNA CTD PMID:22936366 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression EXP Milrinone results in increased expression of CTHRC1 mRNA CTD PMID:22936366 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP Milrinone results in increased expression of DBP mRNA CTD PMID:22936366 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression EXP Milrinone results in decreased expression of EIF4EBP2 mRNA CTD PMID:22936366 NCBI chr20:31,055,292...31,072,469
Ensembl chr20:31,055,789...31,072,469
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 decreases expression EXP Milrinone results in decreased expression of FAM171A1 mRNA CTD PMID:22936366 NCBI chr17:79,030,150...79,149,480
Ensembl chr17:79,031,423...79,085,076
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Milrinone results in increased expression of FHL1 mRNA CTD PMID:22936366 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Milrinone results in increased expression of GADD45G mRNA CTD PMID:22936366 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Milrinone results in increased expression of GPNMB mRNA CTD PMID:22936366 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression EXP Milrinone results in increased expression of HADH mRNA CTD PMID:22936366 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Milrinone results in decreased expression of IGKC mRNA CTD PMID:22936366
G Il6 interleukin 6 multiple interactions ISO Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lyz2 lysozyme 2 increases expression EXP Milrinone results in increased expression of LYZ2 mRNA CTD PMID:22936366 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Msi2 musashi RNA-binding protein 2 increases expression EXP Milrinone results in increased expression of MSI2 mRNA CTD PMID:22936366 NCBI chr10:75,673,840...76,040,106
Ensembl chr10:75,681,393...76,039,964
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Milrinone results in increased expression of MYH7 mRNA CTD PMID:22936366 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Milrinone results in increased expression of MYL1 mRNA CTD PMID:22936366 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Noct nocturnin increases expression EXP Milrinone results in increased expression of NOCT mRNA CTD PMID:22936366 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Milrinone results in increased expression of NPPA mRNA CTD PMID:22936366 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Milrinone results in increased expression of NR4A3 mRNA CTD PMID:22936366 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Per2 period circadian regulator 2 increases expression EXP Milrinone results in increased expression of PER2 mRNA CTD PMID:22936366 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Postn periostin increases expression EXP Milrinone results in increased expression of POSTN mRNA CTD PMID:22936366 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Milrinone results in increased expression of REG3B mRNA CTD PMID:22936366 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Ren renin multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Milrinone results in increased expression of S100A4 mRNA CTD PMID:22936366 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Thbs4 thrombospondin 4 increases expression EXP Milrinone results in increased expression of THBS4 mRNA CTD PMID:22936366 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Milrinone results in increased expression of TIMP1 mRNA CTD PMID:22936366 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8937731 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
N'-Nitrosoanatabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of N'-nitrosoanatabine CTD PMID:18238858 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
paraquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin affects response to substance ISO AAAS protein affects the susceptibility to Paraquat CTD PMID:23315990 NCBI chr 7:143,937,198...143,956,668
Ensembl chr 7:143,937,199...143,956,668
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression
decreases expression
multiple interactions
ISO Paraquat results in increased expression of ABCA1 mRNA
Paraquat results in decreased expression of ABCA1 protein
TO-901317 inhibits the reaction [Paraquat results in decreased expression of ABCA1 protein]
CTD PMID:27788593 PMID:28480221 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects expression
ISO
EXP
[Doxorubicin results in increased expression of ABCB1 protein] which results in decreased susceptibility to Paraquat; ABCB1 protein affects the reaction [Doxorubicin results in decreased susceptibility to Paraquat]; ABCB1 protein results in increased export of and results in decreased susceptibility to Paraquat; valspodar inhibits the reaction [ABCB1 protein results in increased export of Paraquat]
Paraquat affects the expression of ABCB1A mRNA
[ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of HAVCR1 mRNA; [ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of LCN2 mRNA; [ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of NQO1 mRNA; ABCB1A protein results in increased export of and results in decreased susceptibility to Paraquat
CTD PMID:16854511 PMID:23220037 PMID:25015657 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression
multiple interactions
EXP
ISO
Paraquat results in increased expression of ABCB1B mRNA
[ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of HAVCR1 mRNA; [ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of LCN2 mRNA; [ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of NQO1 mRNA; ABCB1B protein results in increased export of and results in decreased susceptibility to Paraquat
CTD PMID:11557130 PMID:15177642 PMID:25015657 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases expression
ISO ABCC1 protein promotes the reaction [cycloartenyl ferulate results in increased transport of and results in decreased abundance of Paraquat]; cycloartenyl ferulate inhibits the reaction [Paraquat results in decreased expression of ABCC1 protein] CTD PMID:26358524 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression EXP Paraquat affects the expression of ABCC4 mRNA CTD PMID:16854511 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 affects expression EXP Paraquat affects the expression of ABCC9 mRNA CTD PMID:16854511 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Paraquat results in increased expression of ABCG2 mRNA CTD PMID:12595580 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd17b abhydrolase domain containing 17B, depalmitoylase increases expression ISO Paraquat results in increased expression of ABHD17B mRNA CTD PMID:21371552 NCBI chr 1:239,266,140...239,301,133
Ensembl chr 1:239,266,921...239,301,176
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO Paraquat results in increased expression of ABL1 mRNA CTD PMID:18836921 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
EXP
ISO
Paraquat results in increased phosphorylation of ACACA protein
PRKAA1 protein affects the reaction [Paraquat results in increased phosphorylation of ACACA protein]
CTD PMID:27324791 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain affects expression EXP Paraquat affects the expression of ACADL mRNA CTD PMID:18198484 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acan aggrecan decreases expression ISO Paraquat results in decreased expression of ACAN mRNA CTD PMID:26108578 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
decreases activity
affects expression
ISO
EXP
pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]
Paraquat results in decreased expression of ACE mRNA
Paraquat affects the expression of ACE protein
Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]; Unithiol inhibits the reaction [Paraquat results in decreased expression of ACE mRNA]
CTD PMID:10666014 PMID:12161173 PMID:16182431 PMID:20465954 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
decreases expression
EXP Unithiol inhibits the reaction [Paraquat results in decreased expression of ACE2 mRNA] CTD PMID:20465954 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
increases expression
ISO
EXP
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA
Paraquat results in decreased activity of ACHE protein
Paraquat results in increased expression of ACHE mRNA
CTD PMID:23017109 PMID:28916328 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aco1 aconitase 1 increases activity
decreases expression
decreases activity
ISO
EXP
Paraquat results in increased activity of ACO1 protein
Paraquat results in decreased expression of ACO1 protein
Paraquat results in decreased activity of ACO1 protein
CTD PMID:11520895 PMID:15664434 PMID:17324120 PMID:28542246 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 decreases activity
multiple interactions
affects response to substance
ISO
EXP
Paraquat results in decreased activity of ACO2 protein
[GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased activity of ACO2 protein; [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA
ACO2 protein affects the susceptibility to Paraquat
ACO2 protein affects the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]; ACO2 protein affects the reaction [Paraquat results in increased abundance of Iron]
SNCA protein inhibits the reaction [Paraquat results in decreased activity of ACO2 protein]
CTD PMID:11520895 PMID:15234109 PMID:18386188 PMID:21517855 PMID:23704229 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acot7 acyl-CoA thioesterase 7 affects expression EXP Paraquat affects the expression of BACH mRNA CTD PMID:15206577 NCBI chr 5:169,357,582...169,450,215
Ensembl chr 5:169,357,517...169,450,219
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 affects expression
decreases expression
EXP Paraquat affects the expression of ACSL1 mRNA
Paraquat results in decreased expression of ACSL1 mRNA
CTD PMID:15206577 PMID:18198484 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
CMA1 protein promotes the reaction [Paraquat results in increased expression of ACTA2 protein]; HIF1A protein affects the reaction [Paraquat results in increased expression of ACTA2 protein]
Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]; HIF1A protein affects the reaction [Paraquat results in increased expression of ACTA2 protein]; TRAM 34 inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]
Paraquat results in increased expression of ACTA2 mRNA; Paraquat results in increased expression of ACTA2 protein
ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]; pirfenidone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]
CTD PMID:17215068 PMID:19969051 PMID:24893116 PMID:25304964 PMID:25873302 PMID:25945502 PMID:26099602 PMID:26758514 PMID:26781174 PMID:26824344 PMID:27375216 PMID:29273418 PMID:30036685 PMID:30317802 PMID:30403199 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta increases expression ISO Paraquat results in increased expression of ACTB mRNA CTD PMID:20883675 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Acvr1 activin A receptor type 1 affects expression
decreases expression
EXP Paraquat affects the expression of ACVR1 mRNA
Paraquat results in decreased expression of ACVR1 mRNA
CTD PMID:15206577 PMID:18198484 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr2a activin A receptor type 2A decreases expression
affects expression
EXP Paraquat results in decreased expression of ACVR2A mRNA
Paraquat affects the expression of ACVR2A mRNA
CTD PMID:16854511 PMID:18198484 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 increases expression ISO Paraquat results in increased expression of ADAM17 mRNA; Paraquat results in increased expression of ADAM17 protein CTD PMID:29495171 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA
Paraquat results in increased expression of ADAM22 mRNA
CTD PMID:22563483 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645
JBrowse link
G Adcy5 adenylate cyclase 5 increases expression EXP Paraquat results in increased expression of ADCY5 mRNA CTD PMID:17077588 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 increases expression EXP Paraquat results in increased expression of ADCY6 mRNA CTD PMID:18198484 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 decreases response to substance ISO ADCYAP1 protein results in decreased susceptibility to Paraquat CTD PMID:23500093 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA CTD PMID:23017109 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA CTD PMID:18386188 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 affects expression EXP Paraquat affects the expression of ADGRL1 mRNA CTD PMID:15493455 NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]; ADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 mRNA]; ADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 protein]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]]
ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of MMP9 protein]; ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of TIMP1 protein]
CTD PMID:25945502 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor1 adiponectin receptor 1 multiple interactions
increases expression
ISO ADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 mRNA]; ADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 protein]; ADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 mRNA]; ADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 protein]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]]
Paraquat results in increased expression of ADIPOR1 mRNA; Paraquat results in increased expression of ADIPOR1 protein
CTD PMID:25945502 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression
ISO ADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 mRNA]; ADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 protein]
Paraquat results in increased expression of ADIPOR2 mRNA; Paraquat results in increased expression of ADIPOR2 protein
CTD PMID:25945502 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA CTD PMID:23017109 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor affects expression
increases expression
EXP Paraquat affects the expression of ADORA2A mRNA
Paraquat results in increased expression of ADORA2A mRNA
CTD PMID:16854511 PMID:17077588 PMID:18198484 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adprh ADP-ribosylarginine hydrolase increases expression ISO Paraquat results in increased expression of ADPRH mRNA CTD PMID:21371552 NCBI chr11:64,861,772...64,868,112
Ensembl chr11:64,861,768...64,868,108
JBrowse link
G Adra1a adrenoceptor alpha 1A decreases expression EXP Paraquat results in decreased expression of ADRA1A mRNA CTD PMID:17077588 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1d adrenoceptor alpha 1D decreases expression EXP Paraquat results in decreased expression of ADRA1D mRNA CTD PMID:17077588 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Ago3 argonaute RISC catalytic component 3 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA
Paraquat results in increased expression of AGO3 mRNA
CTD PMID:22563483 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
increases secretion
ISO AGT protein modified form promotes the reaction [Paraquat results in increased expression of TGFB1 protein]; CMA1 protein promotes the reaction [Paraquat results in increased expression of AGT protein modified form]
Paraquat results in increased expression of AGT mRNA; Paraquat results in increased expression of AGT protein modified form
Paraquat results in increased secretion of AGT protein
CTD PMID:19969051 PMID:20035857 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO Paraquat results in increased expression of AGTR1 mRNA; Paraquat results in increased expression of AGTR1 protein CTD PMID:20035857 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO Paraquat results in decreased expression of AGTR2 mRNA CTD PMID:20035857 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ahnak AHNAK nucleoprotein increases expression ISO Paraquat results in increased expression of AHNAK mRNA CTD PMID:22563483 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO Paraquat results in decreased expression of AHR protein CTD PMID:26196221 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [MTHFR gene polymorphism affects the susceptibility to Paraquat] which results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:30726997 PMID:32375810 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [Paraquat results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Ak1 adenylate kinase 1 increases expression ISO Paraquat results in increased expression of AK1 mRNA CTD PMID:21371552 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of AKR1C3 mRNA CTD PMID:28012437 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
affects phosphorylation
multiple interactions
ISO Paraquat results in decreased expression of AKT1 mRNA
Paraquat affects the phosphorylation of AKT1 protein
ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]
[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; AKT1 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]; AKT1 protein affects the reaction [Paraquat results in increased activity of CASP3 protein]; AKT1 protein affects the reaction [Paraquat results in increased expression of BAX protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Paraquat results in increased expression of and results in increased phosphorylation of AKT1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]
CTD PMID:16797015 PMID:23898955 PMID:23963992 PMID:28115273 PMID:28428137 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
increases response to substance
ISO AKT2 protein affects the reaction [Paraquat results in decreased expression of PPARGC1A protein]; AKT2 protein affects the reaction [Paraquat results in increased expression of NFE2L2 protein]
AKT2 protein results in increased susceptibility to Paraquat
CTD PMID:28115273 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP Paraquat results in decreased activity of ALAD protein CTD PMID:12180188 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases activity
EXP alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein] CTD PMID:12180188 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin decreases expression EXP Paraquat results in decreased expression of ALB protein CTD PMID:17481832 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Paraquat results in increased expression of ALDH1A1 mRNA CTD PMID:12595580 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 affects expression EXP Paraquat affects the expression of ALDH1A2 mRNA CTD PMID:15206577 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression EXP Paraquat results in decreased expression of ALDH2 mRNA CTD PMID:18198484 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA] CTD PMID:23963992 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA CTD PMID:18386188 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alkbh8 alkB homolog 8, tRNA methyltransferase increases expression ISO Paraquat results in increased expression of ALKBH8 mRNA CTD PMID:21371552 NCBI chr 6:18,877,885...18,952,773
Ensembl chr 6:18,877,907...18,949,393
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression ISO Paraquat results in increased expression of ALOX12B mRNA CTD PMID:28012437 NCBI chr10:55,744,646...55,756,524
Ensembl chr10:55,744,588...55,756,566
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
decreases expression
ISO APOD protein affects the reaction [Paraquat results in decreased expression of ALOX15 mRNA]; Paraquat affects the reaction [APOD protein affects the expression of ALOX15 mRNA] CTD PMID:21688324 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B increases expression ISO Paraquat results in increased expression of ALOX8 mRNA CTD PMID:28012437 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO Paraquat results in increased expression of ALOX5 mRNA CTD PMID:28012437 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Amn amnion associated transmembrane protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:135,724,455...135,731,896
Ensembl chr 6:135,724,455...135,731,896
JBrowse link
G Amph amphiphysin decreases expression EXP Paraquat results in decreased expression of AMPH mRNA CTD PMID:18198484 NCBI chr17:48,304,324...48,562,838
Ensembl chr17:48,304,322...48,562,905
JBrowse link
G Anxa1 annexin A1 increases expression EXP Paraquat results in increased expression of ANXA1 protein CTD PMID:24521700 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 increases expression EXP Paraquat results in increased expression of ANXA2 protein CTD PMID:24521700 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa5 annexin A5 increases expression ISO Paraquat results in increased expression of ANXA5 mRNA CTD PMID:20883675 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Ap3b2 adaptor related protein complex 3 subunit beta 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA CTD PMID:18386188 NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633
JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA CTD PMID:18386188 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
affects splicing
increases expression
ISO Paraquat results in decreased expression of APAF1 mRNA
Paraquat affects the splicing of APAF1 exon
Paraquat affects the splicing of APAF1 mRNA
Paraquat results in increased expression of APAF1 mRNA alternative form
CTD PMID:17064354 PMID:23613995 PMID:27111068 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA CTD PMID:23017109 NCBI chr 1:170,387,625...170,411,263
Ensembl chr 1:170,387,609...170,404,056
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases response to substance ISO APEH protein results in decreased susceptibility to Paraquat CTD PMID:12727222 NCBI chr 8:116,862,664...116,871,776
Ensembl chr 8:116,862,625...116,872,215
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
affects response to substance
ISO APEX1 gene mutant form results in increased susceptibility to Paraquat
APEX1 gene SNP affects the susceptibility to Paraquat
CTD PMID:11454706 PMID:28460087 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Paraquat affects the expression of and results in increased degradation of APOA1 mRNA CTD PMID:9169468 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apod apolipoprotein D multiple interactions
increases expression
decreases response to substance
affects response to substance
ISO Paraquat results in increased uptake of and affects the localization of APOD protein; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein]
APOD protein results in decreased susceptibility to Paraquat
APOD protein affects the susceptibility to Paraquat
[Paraquat co-treated with APOD gene mutant form] results in increased expression of NOS2 mRNA; APOD protein affects the reaction [Paraquat results in decreased expression of ALOX15 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of AQR mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of EPX mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of GAB1 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of GPX2 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of IDH1 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of LPO mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of NOS2 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of NOX4 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of NOXO1 mRNA]; APOD protein affects the reaction [Paraquat results in decreased expression of PTGS1 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of DUOX1 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of GDNF mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of GFAP protein]; APOD protein affects the reaction [Paraquat results in increased expression of GPX3 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of IL19 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of MPP4 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of PTGS2 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of SOD2 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of SOD3 mRNA]; APOD protein affects the reaction [Paraquat results in increased expression of SRXN1 mRNA]; APOD protein inhibits the reaction [Paraquat results in decreased activity of CTSB protein]; Paraquat affects the reaction [APOD protein affects the expression of ALOX15 mRNA]; Paraquat affects the reaction [APOD protein affects the expression of HMOX1 protein]; Paraquat affects the reaction [APOD protein affects the expression of SOD2 protein]
Paraquat results in increased expression of APOD mRNA; Paraquat results in increased expression of APOD protein
CTD PMID:18419796 PMID:18458334 PMID:21688324 PMID:28182653 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein increases response to substance
multiple interactions
increases expression
ISO
EXP
APP protein results in increased susceptibility to Paraquat
Estradiol inhibits the reaction [Paraquat results in increased expression of APP protein alternative form]; Estradiol inhibits the reaction [Paraquat results in increased expression of APP protein]
Paraquat results in increased expression of APP protein; Paraquat results in increased expression of APP protein alternative form
Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Paraquat results in increased expression of APP mRNA; Paraquat results in increased expression of APP protein
CTD PMID:23827522 PMID:27793699 PMID:31715309 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aprt adenine phosphoribosyl transferase decreases expression ISO Paraquat results in decreased expression of APRT mRNA CTD PMID:21371552 NCBI chr19:55,387,288...55,389,256
Ensembl chr19:55,387,288...55,389,256
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Paraquat results in increased expression of AQP1 mRNA CTD PMID:12595580 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor multiple interactions
decreases expression
ISO APOD protein affects the reaction [Paraquat results in decreased expression of AQR mRNA] CTD PMID:21688324 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Arf1 ADP-ribosylation factor 1 affects expression EXP Paraquat affects the expression of ARF1 mRNA CTD PMID:15206577 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arf3 ADP-ribosylation factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA CTD PMID:18386188 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arf5 ADP-ribosylation factor 5 increases expression EXP Paraquat results in increased expression of ARF5 mRNA CTD PMID:17077588 NCBI chr 4:55,715,744...55,718,670
Ensembl chr 4:55,715,744...55,718,670
JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions
decreases expression
EXP
ISO
Paraquat results in increased expression of ARG1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA
Paraquat results in decreased expression of ARG1 protein
Paraquat results in decreased expression of ARG1 mRNA
CTD PMID:20388547 PMID:24521700 PMID:28467894 PMID:29568078 PMID:31299241 PMID:32375810 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arg2 arginase 2 increases expression EXP Paraquat results in increased expression of ARG2 mRNA CTD PMID:16854511 PMID:20388547 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arl2 ADP-ribosylation factor like GTPase 2 decreases expression ISO Paraquat results in decreased expression of ARL2 protein CTD PMID:23807224 NCBI chr 1:221,504,150...221,516,191
Ensembl chr 1:221,504,170...221,516,110
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 affects response to substance
increases expression
multiple interactions
ISO ARL6IP5 protein affects the susceptibility to Paraquat
Paraquat results in increased expression of ARL6IP5
Paraquat results in increased expression of ARL6IP5 protein
ARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the expression of TH protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK1 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK3 protein]
ARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK1 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK3 protein]
CTD PMID:28428137 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA CTD PMID:23017109 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Art3 ADP-ribosyltransferase 3 increases expression ISO Paraquat results in increased expression of ART3 mRNA CTD PMID:12595580 NCBI chr14:17,143,037...17,225,389
Ensembl chr14:17,143,040...17,225,389
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA CTD PMID:23017109 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Asic1 acid sensing ion channel subunit 1 affects expression
increases expression
EXP Paraquat affects the expression of ASIC1 mRNA
Paraquat results in increased expression of ASIC1 mRNA
CTD PMID:15206577 PMID:17077588 PMID:18198484 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic3 acid sensing ion channel subunit 3 increases expression EXP Paraquat results in increased expression of ACCN3 mRNA CTD PMID:18198484 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Paraquat results in increased expression of ATF3 mRNA CTD PMID:12595580 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Paraquat results in increased expression of ATF4 mRNA CTD PMID:21371552 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression
increases cleavage
multiple interactions
EXP
ISO
Paraquat results in increased expression of ATF6 protein
Paraquat results in increased cleavage of ATF6 protein
Paraquat results in increased expression of ATF6 protein modified form
Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein]
CTD PMID:22245251 PMID:28986289 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions
ISO Paraquat results in increased expression of ATG12 protein
Paraquat results in increased expression of ATG12 mRNA
ATG5 protein affects the reaction [Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]]; Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]
Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein]; Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]
CTD PMID:22292029 PMID:22982048 PMID:27220436 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase increases expression ISO Paraquat results in increased expression of ATG4B mRNA CTD PMID:21371552 NCBI chr 9:100,888,457...100,920,123
Ensembl chr 9:100,888,501...100,918,637
JBrowse link
G Atg5 autophagy related 5 affects response to substance
increases expression
multiple interactions
ISO
EXP
ATG5 protein affects the susceptibility to Paraquat
Paraquat results in increased expression of ATG5 mRNA
[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin; ATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]; Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]; TLR4 protein affects the reaction [Paraquat results in increased expression of ATG5 protein]
Paraquat results in increased expression of ATG5 mRNA; Paraquat results in increased expression of ATG5 protein
[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin; ATG5 protein affects the reaction [Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]]; ATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]; ATG5 protein affects the reaction [Paraquat results in increased expression of MAP1LC3A protein]; ATG5 protein promotes the reaction [Paraquat results in increased cleavage of and results in increased activity of CASP3 protein]; Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]; WNT1 protein inhibits the reaction [Paraquat results in increased expression of ATG5 mRNA]
CTD PMID:22982048 PMID:23997112 PMID:27220436 PMID:27246695 PMID:27324791 PMID:30171970 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression
affects response to substance
multiple interactions
ISO Paraquat results in increased expression of ATG7 protein
ATG7 protein affects the susceptibility to Paraquat
Paraquat results in increased expression of ATG7 mRNA
[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of AKR1C3 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of ATM mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BACH1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BARD1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BLM mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BRCA1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BUB1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BUB1B mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNA2 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNB1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNB2 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNE1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNE2 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDC20 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDC25C mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDK1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDK2 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDKN1A mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CHEK1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCA mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCB mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCD2 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of KIF11 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of KIF14 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of KIF23 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of NBN mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of PLK1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of PLK4 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of PRC1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of SMC1A mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of STAT1 mRNA; [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of TRP53 protein; ATG7 protein affects the reaction [Paraquat results in decreased expression of LMNB1 protein]; ATG7 protein affects the reaction [Paraquat results in increased expression of CDKN1A protein]; ATG7 protein affects the reaction [Paraquat results in increased expression of H2AX protein]; ATG7 protein affects the reaction [Paraquat results in increased expression of TRP53 mRNA]; Paraquat affects the reaction [ATG7 protein affects the expression of CDK1 mRNA]; Paraquat affects the reaction [ATG7 protein affects the expression of CDK1 protein]; Paraquat affects the reaction [ATG7 protein affects the expression of LMNB1 mRNA]; TLR4 protein affects the reaction [Paraquat results in increased expression of ATG7 protein]
CTD PMID:27220436 PMID:27246695 PMID:28012437 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase increases expression
multiple interactions
ISO Paraquat results in increased expression of ATM mRNA
[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of ATM mRNA
CTD PMID:20883675 PMID:28012437 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 multiple interactions
increases response to substance
ISO [ATP13A2 protein results in increased susceptibility to Paraquat] which results in increased abundance of Reactive Oxygen Species CTD PMID:22265822 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Paraquat results in increased expression of ATP1A1 mRNA CTD PMID:16854511 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 affects expression
increases expression
decreases expression
EXP
ISO
Paraquat affects the expression of ATP1A2 mRNA
Paraquat results in increased expression of ATP1A2 mRNA
Paraquat results in decreased expression of ATP1A2 mRNA
CTD PMID:16854511 PMID:17077588 PMID:18198484 PMID:21371552 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 affects expression
increases expression
EXP Paraquat affects the expression of ATP1B1 mRNA
Paraquat results in increased expression of ATP1B1 mRNA
CTD PMID:16555045 PMID:16854511 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
affects expression
increases expression
ISO
EXP
IGF1 gene mutant form inhibits the reaction [Paraquat results in increased expression of ATP2A2 protein]
Paraquat affects the expression of ATP2A2 mRNA
CTD PMID:16854511 PMID:17979500 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Paraquat results in decreased expression of ATP2B2 mRNA CTD PMID:18198484 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA CTD PMID:18386188 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 multiple interactions ISO ATP6V0A1 protein affects the reaction [Paraquat results in increased expression of MAP1LC3A protein] CTD PMID:22982048 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA CTD PMID:18386188 NCBI chr 5:136,718,352...136,719,868
Ensembl chr 5:136,718,352...136,721,379
JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA CTD PMID:18386188 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 increases expression ISO Paraquat results in increased expression of ATP6V0E2 mRNA CTD PMID:21371552 NCBI chr 4:78,168,117...78,171,265
Ensembl chr 4:78,168,117...78,171,265
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 7:77,678,853...77,716,658
Ensembl chr 7:77,678,968...77,716,408
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
increases response to substance
ISO ATP7A protein promotes the reaction [Paraquat results in increased chemical synthesis of Hydrogen Peroxide]
ATP7A protein results in increased susceptibility to Paraquat
CTD PMID:29058724 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA
Paraquat results in increased expression of ATP8A2 mRNA
CTD PMID:22563483 NCBI chr15:39,955,689...40,488,737
Ensembl chr15:40,000,322...40,428,800
JBrowse link
G Atxn1 ataxin 1 affects expression EXP Paraquat affects the expression of ATXN1 mRNA CTD PMID:15206577 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Atxn2 ataxin 2 affects splicing ISO Paraquat affects the splicing of ATXN2 exon CTD PMID:27111068 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612
JBrowse link
G Aurka aurora kinase A affects expression ISO Paraquat affects the expression of AURKA mRNA CTD PMID:26345256 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Avpr1b arginine vasopressin receptor 1B decreases expression EXP Paraquat results in decreased expression of AVPR1B mRNA CTD PMID:17077588 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Avpr2 arginine vasopressin receptor 2 decreases expression EXP Paraquat results in decreased expression of AVPR2 mRNA CTD PMID:18198484 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213
JBrowse link
G Axin1 axin 1 decreases expression
multiple interactions
ISO Paraquat results in decreased expression of AXIN1 mRNA; Paraquat results in decreased expression of AXIN1 protein
WNT1 protein inhibits the reaction [Paraquat results in decreased expression of AXIN1 mRNA]
CTD PMID:30171970
G Axin2 axin 2 decreases expression ISO Paraquat results in decreased expression of AXIN2 mRNA CTD PMID:27788593 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BACH1 mRNA CTD PMID:28012437 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
decreases expression
ISO
EXP
[Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein
TLR4 gene mutant form inhibits the reaction [Paraquat results in increased expression of BAD protein]
Paraquat results in decreased expression of BAD mRNA
Paraquat results in increased expression of BAD mRNA
CTD PMID:15824117 PMID:17935786 PMID:18836921 PMID:27442881 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag1 BAG cochaperone 1 increases expression ISO Paraquat results in increased expression of BAG1 mRNA CTD PMID:18836921 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bag4 BAG cochaperone 4 increases expression ISO Paraquat results in increased expression of BAG4 mRNA CTD PMID:18836921 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
affects response to substance
decreases expression
ISO
EXP
Paraquat results in increased expression of BAK1 mRNA; Paraquat results in increased expression of BAK1 protein
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; LGK974 inhibits the reaction [Paraquat results in increased expression of BAK1 protein]; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
Paraquat results in decreased expression of BAK1 mRNA
NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of BAK1 mRNA]; Paraquat promotes the reaction [BAX protein binds to BAK1 protein]
CTD PMID:18056701 PMID:18266926 PMID:18836921 PMID:22230393 PMID:22678742 PMID:23963992 PMID:25947082 PMID:30205152 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bard1 BRCA1 associated RING domain 1 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BARD1 mRNA CTD PMID:28012437 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; AKT1 protein affects the reaction [Paraquat results in increased expression of BAX protein]; GPX1 protein affects the reaction [Paraquat affects the expression of BAX mRNA]; Lithium Chloride inhibits the reaction [Paraquat results in increased expression of BAX protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [Paraquat results in increased expression of BAX protein]; TO-901317 inhibits the reaction [Paraquat results in increased expression of BAX protein]
Paraquat results in increased expression of BAX mRNA; Paraquat results in increased expression of BAX protein
[Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; WNT1 protein inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; WNT1 protein inhibits the reaction [Paraquat results in increased expression of BAX protein]
Paraquat results in decreased expression of BAX mRNA
[Paraquat co-treated with Decitabine] results in increased expression of BAX protein; Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX protein]; Docosahexaenoic Acids inhibits the reaction [Paraquat results in increased expression of BAX protein]; fasudil inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Paraquat promotes the reaction [BAX protein binds to BAK1 protein]; Paraquat results in increased expression of and affects the localization of BAX protein
CTD PMID:12654481 PMID:12714668 PMID:15206577 PMID:15824117 PMID:18253895 PMID:18266926 PMID:18836921 PMID:20964710 PMID:22678742 PMID:22796470 PMID:23963992 PMID:25947082 PMID:26468117 PMID:26686574 PMID:26887261 PMID:27220436 PMID:27442881 PMID:27793699 PMID:28115273 PMID:28480221 PMID:29054699 PMID:30088170 PMID:30171970 PMID:30185695 PMID:30403199 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Paraquat results in increased expression of BBC3 protein CTD PMID:18266926 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Paraquat results in decreased activity of BCHE protein CTD PMID:17364237 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta increases expression ISO Paraquat results in increased expression of BCKDHB mRNA CTD PMID:21371552 NCBI chr 8:91,464,229...91,656,134
Ensembl chr 8:91,464,229...91,656,134
JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression ISO Paraquat results in decreased expression of BCL10 mRNA CTD PMID:18836921 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
decreases response to substance
increases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; AKT1 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]; GPX1 protein affects the reaction [Paraquat affects the expression of BCL2 mRNA]; Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; TO-901317 inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]
Paraquat results in decreased expression of BCL2 mRNA; Paraquat results in decreased expression of BCL2 protein
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Paraquat
Paraquat results in increased expression of BCL2 mRNA
[Paraquat co-treated with Decitabine] results in decreased expression of BCL2 protein; Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Docosahexaenoic Acids inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; fasudil inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]
CTD PMID:12654481 PMID:12714668 PMID:15475374 PMID:18836921 PMID:22230393 PMID:22678742 PMID:22796470 PMID:23963992 PMID:26468117 PMID:26686574 PMID:26887261 PMID:27220436 PMID:28115273 PMID:28480221 PMID:29054699 PMID:30088170 PMID:30171970 PMID:30185695 PMID:30403199 PMID:30698896 PMID:31400064 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression
multiple interactions
increases expression
ISO Paraquat results in decreased expression of BCL2A1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein
Paraquat results in increased expression of BCL2A1 mRNA; Paraquat results in increased expression of BCL2A1 protein
CTD PMID:18056701 PMID:18266926 PMID:18836921 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
decreases expression
affects expression
decreases response to substance
ISO
EXP
[Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Paraquat results in increased expression of BCL2L1 mRNA; Paraquat results in increased expression of BCL2L1 protein
Paraquat results in decreased expression of BCL2L1 mRNA
Paraquat affects the expression of BCL2L1 mRNA
BCL2L1 gene mutant form results in decreased susceptibility to Paraquat
GPX1 protein affects the reaction [Paraquat results in increased expression of BCL2L1 protein]
CTD PMID:10970895 PMID:12595580 PMID:12654481 PMID:15824117 PMID:16797015 PMID:16854511 PMID:18056701 PMID:18836921 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression ISO Paraquat results in decreased expression of BCL2L10 mRNA CTD PMID:18836921 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression
multiple interactions
increases expression
ISO Paraquat results in decreased expression of BCL2L11 mRNA
[Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein
Paraquat results in increased expression of BCL2L11 protein
Paraquat results in increased expression of BCL2L11 mRNA
FOXO3 mutant form inhibits the reaction [Paraquat results in increased expression of BCL2L11 mRNA]
CTD PMID:18266926 PMID:18836921 PMID:23620592 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l2 Bcl2-like 2 multiple interactions ISO GPX1 protein affects the reaction [Paraquat affects the expression of BCL2L2 mRNA] CTD PMID:12654481 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Paraquat results in decreased expression of BCLAF1 mRNA CTD PMID:18836921 NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
Paraquat results in increased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein
CTD PMID:23017109 PMID:27460631 PMID:29454966 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression
increases expression
ISO [Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of BECN1 protein]; WNT1 protein inhibits the reaction [Paraquat results in increased expression of BECN1 mRNA]
Paraquat results in increased expression of BECN1 mRNA; Paraquat results in increased expression of BECN1 protein
CTD PMID:20929985 PMID:22292029 PMID:25092649 PMID:27220436 PMID:30171970 PMID:32306690 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bfar bifunctional apoptosis regulator increases expression ISO Paraquat results in increased expression of BFAR mRNA CTD PMID:18836921 NCBI chr10:1,464,658...1,471,152
NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Bicd1 BICD cargo adaptor 1 increases expression
multiple interactions
ISO Paraquat results in increased expression of BICD1 mRNA
[Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA
CTD PMID:22563483 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
multiple interactions
increases expression
increases cleavage
ISO Paraquat results in decreased expression of BID mRNA
[Maneb co-treated with Paraquat] results in increased expression of BID protein
Paraquat results in increased expression of BID mRNA; Paraquat results in increased expression of BID protein
Paraquat results in increased cleavage of BID protein
CTD PMID:18056701 PMID:18266926 PMID:18836921 PMID:28414160 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer increases expression
multiple interactions
ISO Paraquat results in increased expression of BIK mRNA
[Paraquat co-treated with Maneb] results in increased expression of BIK protein
CTD PMID:18266926 PMID:18836921 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Bin1 bridging integrator 1 affects splicing ISO Paraquat affects the splicing of BIN1 mRNA CTD PMID:23613995 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Paraquat results in decreased expression of BIRC2 mRNA CTD PMID:18836921 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Paraquat results in decreased expression of BIRC3 mRNA CTD PMID:18836921 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
ISO
EXP
Paraquat results in increased expression of BIRC5 mRNA
Paraquat results in decreased expression of BIRC5 mRNA
CTD PMID:26345256 PMID:26887261 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Blm BLM RecQ like helicase multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BLM mRNA CTD PMID:28012437 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA CTD PMID:23017109 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions
decreases expression
ISO
EXP
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA
Paraquat results in decreased expression of BMP4 mRNA
CTD PMID:18198484 PMID:23017109 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bnip1 BCL2 interacting protein 1 decreases expression ISO Paraquat results in decreased expression of BNIP1 mRNA CTD PMID:18836921 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression
affects response to substance
increases expression
ISO Paraquat results in decreased expression of BNIP3 mRNA
BNIP3 protein affects the susceptibility to Paraquat
Paraquat results in increased expression of BNIP3 protein
Paraquat results in increased expression of BNIP3 mRNA; Paraquat results in increased expression of BNIP3 protein
CTD PMID:18056701 PMID:18266926 PMID:18836921 PMID:23315990 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Paraquat results in increased expression of BNIP3L mRNA CTD PMID:18836921 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor increases expression ISO Paraquat results in increased expression of BOP1 mRNA CTD PMID:21371552 NCBI chr 7:117,514,529...117,538,342
Ensembl chr 7:117,514,533...117,538,342
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases response to substance
multiple interactions
ISO BRCA1 protein results in decreased susceptibility to Paraquat
[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BRCA1 mRNA
CTD PMID:15520196 PMID:28012437 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO Paraquat results in decreased expression of BRCA2 mRNA CTD PMID:28012437 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA CTD PMID:18386188 NCBI chr 6:137,762,230...137,808,573
Ensembl chr 6:137,765,122...137,808,303
JBrowse link
G Bsg basigin (Ok blood group) increases expression ISO Paraquat results in increased expression of BSG protein CTD PMID:29287252 NCBI chr 7:12,875,536...12,882,753
Ensembl chr 7:12,875,537...12,882,753
JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases expression EXP Paraquat results in increased expression of BST1 mRNA CTD PMID:18198484 NCBI chr14:71,798,218...71,814,540
Ensembl chr14:71,798,651...71,814,523
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Paraquat results in increased expression of BTG2 mRNA CTD PMID:12595580 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BUB1 mRNA CTD PMID:28012437 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BUB1B mRNA CTD PMID:28012437 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Ca3 carbonic anhydrase 3 affects expression EXP Paraquat affects the expression of CAR3 mRNA CTD PMID:15206577 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression EXP Paraquat results in increased expression of CACNA1C mRNA CTD PMID:18198484 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA
Paraquat results in increased expression of CACNA1E mRNA
CTD PMID:22563483 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression EXP Paraquat results in increased expression of CACNB3 mRNA CTD PMID:18198484 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cacybp calcyclin binding protein multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA
Paraquat results in increased expression of CACYBP mRNA
CTD PMID:18386188 PMID:28619522 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Calcr calcitonin receptor decreases expression EXP Paraquat results in decreased expression of CALCR mRNA CTD PMID:17077588 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Calm1 calmodulin 1 multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]
Paraquat results in increased expression of CALM1 mRNA
CTD PMID:23963992 PMID:31368498 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO
EXP
[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA
CTD PMID:22563483 PMID:27460631 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn1 calpain 1 multiple interactions
increases activity
EXP
ISO
Paraquat results in increased expression of and results in increased activity of CAPN1 protein
calpeptin inhibits the reaction [Paraquat results in increased activity of CAPN1 protein]
CTD PMID:22678742 PMID:24509835 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn11 calpain 11 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:17,728,845...17,750,357
Ensembl chr 9:17,728,816...17,750,363
JBrowse link
G Capn2 calpain 2 multiple interactions EXP Paraquat results in increased expression of and results in increased activity of CAPN2 protein CTD PMID:22678742 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Capn6 calpain 6 increases expression ISO Paraquat results in increased expression of CAPN6 mRNA CTD PMID:26345256 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Paraquat results in increased expression of CAR2 protein CTD PMID:24521700 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Card6 caspase recruitment domain family, member 6 decreases expression ISO Paraquat results in decreased expression of CARD6 mRNA CTD PMID:18836921 NCBI chr 2:54,810,676...54,824,050
Ensembl chr 2:54,810,110...54,824,033
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
decreases activity
EXP
ISO
Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of CASP1 protein]; Sodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein]
Paraquat results in increased expression of CASP1 protein; Paraquat results in increased expression of CASP1 protein modified form
Paraquat results in increased expression of CASP1 mRNA; Paraquat results in increased expression of CASP1 protein
[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [Paraquat results in increased expression of CASP1 protein modified form]; Silymarin inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
CTD PMID:17561093 PMID:18836921 PMID:23963992 PMID:25338942 PMID:29054699 PMID:30025709 PMID:32375810 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions
increases activity
increases expression
increases degradation
EXP Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of CASP12 mRNA]
Paraquat results in increased activity of CASP12 protein
Paraquat results in increased expression of CASP12 mRNA; Paraquat results in increased expression of CASP12 protein
Paraquat results in increased degradation of CASP12 protein
CTD PMID:22245251 PMID:22678742 PMID:24912633 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp2 caspase 2 decreases expression ISO Paraquat results in decreased expression of CASP2 mRNA CTD PMID:18836921 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
decreases expression
increases cleavage
ISO
EXP
AKT1 protein affects the reaction [Paraquat results in increased activity of CASP3 protein]; GPX1 protein affects the reaction [Paraquat results in increased activity of CASP3 protein]; GPX1 protein affects the reaction [Paraquat results in increased expression of CASP3 protein]; PARK7 protein affects the reaction [Paraquat results in increased cleavage of CASP3 protein]; Silymarin inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]
Paraquat results in increased expression of CASP3 mRNA; Paraquat results in increased expression of CASP3 protein modified form
Paraquat results in decreased expression of CASP3 mRNA
Paraquat results in increased expression of CASP3 mRNA; Paraquat results in increased expression of CASP3 protein; Paraquat results in increased expression of CASP3 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; 3-methyladenine promotes the reaction [Paraquat results in increased activity of CASP3 protein]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]; [PTGDS protein results in decreased susceptibility to Paraquat] which results in decreased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; ATG5 protein promotes the reaction [Paraquat results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; GHRL protein inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; LGK974 inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; Paraquat promotes the reaction [Trientine results in increased activity of CASP3 protein]; Paraquat results in increased cleavage of and results in increased activity of CASP3 protein; PRKN protein inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; PTGDS mutant form promotes the reaction [Paraquat results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]; salubrinal inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; TLR9 protein promotes the reaction [Paraquat results in increased expression of CASP3 protein modified form]
Acetylcysteine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; calpeptin inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Dibucaine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Edaravone inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; U 74389F inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]
CTD PMID:11369509 PMID:12654481 PMID:16310883 PMID:17018646 PMID:17215068 PMID:17324951 PMID:17341480 PMID:17561093 PMID:17936647 PMID:18056701 PMID:18253895 PMID:18836921 PMID:19735704 PMID:20929985 PMID:21300143 PMID:21777615 PMID:22043816 PMID:22245251 PMID:22678742 PMID:22736252 PMID:22987761 PMID:23807224 PMID:23997112 PMID:24060684 PMID:24130211 PMID:24866057 PMID:24912633 PMID:25947082 PMID:26468117 PMID:26686574 PMID:27442881 PMID:28115273 PMID:28363843 PMID:28414160 PMID:28428137 PMID:28474156 PMID:28986289 PMID:29054699 PMID:30088170 PMID:30144575 PMID:30185695 PMID:30205152 PMID:30698896 PMID:30967525 PMID:31381934 PMID:31400064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
increases expression
EXP
ISO
Paraquat results in increased activity of CASP7 protein
CAT protein inhibits the reaction [Paraquat results in increased activity of CASP7 protein]
Paraquat results in increased expression of CASP7 mRNA
NFE2L2 mutant form inhibits the reaction [Paraquat results in increased activity of CASP7 protein]
CTD PMID:17324951 PMID:18836921 PMID:22678742 PMID:24866057 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases expression
increases cleavage
multiple interactions
decreases expression
increases activity
ISO
EXP
Paraquat results in increased expression of CASP8 mRNA; Paraquat results in increased expression of CASP8 mRNA alternative form
Paraquat results in increased cleavage of CASP8 protein
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form]; Paraquat promotes the reaction [TNFRSF10B protein binds to CASP8 protein]
Paraquat results in decreased expression of CASP8 mRNA
Paraquat results in increased activity of CASP8 protein
Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]
CTD PMID:17064354 PMID:17561093 PMID:20883675 PMID:24912633 PMID:26468117 PMID:28414160 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases activity
decreases expression
increases cleavage
ISO
EXP
Paraquat results in increased expression of CASP9 mRNA; Paraquat results in increased expression of CASP9 mRNA alternative form; Paraquat results in increased expression of CASP9 protein
Paraquat results in increased expression of CASP9 protein modified form
[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CASP9 mRNA]; [PTGDS protein results in decreased susceptibility to Paraquat] which results in decreased cleavage of CASP9 protein; PRKN protein inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; PTGDS mutant form promotes the reaction [Paraquat results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]
Paraquat results in decreased expression of CASP9 mRNA
[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
CTD PMID:17064354 PMID:18253895 PMID:18836921 PMID:20964710 PMID:22043816 PMID:22736252 PMID:23963992 PMID:24912633 PMID:26649146 PMID:26686574 PMID:27442881 PMID:30144575 PMID:30698896 PMID:31400064 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase affects response to substance
decreases expression
affects activity
decreases activity
increases expression
increases activity
multiple interactions
decreases response to substance
increases response to substance
ISO
EXP
CAT protein affects the susceptibility to Paraquat
Paraquat results in decreased expression of CAT protein
Paraquat affects the activity of CAT protein
Paraquat results in decreased activity of CAT protein
Paraquat results in increased expression of CAT mRNA; Paraquat results in increased expression of CAT protein
Paraquat results in increased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA; [Mifepristone co-treated with Paraquat] results in decreased activity of CAT protein; [Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of CAT mRNA; [Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; betanin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in decreased activity of CAT protein]; Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Paraquat results in increased activity of CAT protein]; Unithiol promotes the reaction [Paraquat results in increased activity of CAT protein]; Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of CAT protein]
Paraquat results in decreased expression of CAT mRNA; Paraquat results in decreased expression of CAT protein
CAT protein results in decreased susceptibility to Paraquat
Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Hydroxylamine inhibits the reaction [CAT protein results in decreased susceptibility to Paraquat]; NFKB1 protein mutant form inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; NFKBIA protein mutant form inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased activity of CAT protein]; Resveratrol inhibits the reaction [Paraquat results in decreased activity of CAT protein]; SIRT1 protein affects the reaction [Paraquat affects the activity of CAT protein]; TO-901317 inhibits the reaction [Paraquat results in decreased activity of CAT protein]
[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; [NR1I2 protein results in decreased activity of CAT protein] which results in increased susceptibility to Paraquat; [Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA; [Plant Extracts co-treated with Paraquat] results in increased expression of CAT mRNA; [SOD1 protein co-treated with CAT protein] results in decreased susceptibility to Paraquat; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]; CAT protein inhibits the reaction [Paraquat results in decreased expression of GCLC protein]; CAT protein inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; CAT protein inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [Paraquat results in increased activity of CASP7 protein]; CAT protein inhibits the reaction [Paraquat results in increased activity of ODC1 protein]; CAT protein inhibits the reaction [Paraquat results in increased expression of JUN mRNA]; CAT protein inhibits the reaction [Paraquat results in increased expression of MIR153 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; IL1A protein promotes the reaction [Paraquat results in increased expression of CAT protein]; IL1B protein promotes the reaction [Paraquat results in increased expression of CAT protein]; Plant Extracts promotes the reaction [Paraquat results in increased expression of CAT mRNA]; TNF protein promotes the reaction [Paraquat results in increased expression of CAT protein]
CAT protein modified form results in increased susceptibility to Paraquat; CAT protein results in increased susceptibility to Paraquat
CTD PMID:7662713 PMID:8317554 PMID:9169468 PMID:10699569 PMID:10751631 PMID:10754530 PMID:10959798 PMID:11178967 PMID:11325355 PMID:11728812 PMID:12180188 PMID:12826488 PMID:14759608 PMID:15177642 PMID:15190189 PMID:15754033 PMID:16195250 PMID:16677106 PMID:17107770 PMID:17215068 PMID:17935786 PMID:18620719 PMID:19486935 PMID:20095329 PMID:20553223 PMID:20883675 PMID:21215309 PMID:22736252 PMID:23649336 PMID:24141985 PMID:24376630 PMID:24799198 PMID:24812154 PMID:24866057 PMID:25169090 PMID:25461551 PMID:26468117 PMID:26598004 PMID:26649146 PMID:26708779 PMID:26935021 PMID:27993944 PMID:28480221 PMID:28696894 PMID:28921394 PMID:29273418 PMID:29859004 PMID:30243747 PMID:32020686 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 increases expression EXP Paraquat results in increased expression of CAV1 mRNA; Paraquat results in increased expression of CAV1 protein CTD PMID:26813466 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cbl Cbl proto-oncogene multiple interactions
increases phosphorylation
EXP CBL protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]
Paraquat results in increased phosphorylation of CBL protein
CTD PMID:17298174 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccdc88a coiled coil domain containing 88A multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA
Paraquat results in increased expression of CCDC88A mRNA
CTD PMID:22563483 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263
JBrowse link
G Cckbr cholecystokinin B receptor decreases expression EXP Paraquat results in decreased expression of CCKBR mRNA CTD PMID:17077588 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA
Paraquat results in increased expression of CCL19 mRNA
CTD PMID:22563483 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
affects expression
increases expression
EXP
ISO
[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein; Ambroxol affects the reaction [Paraquat results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein]
Paraquat affects the expression of CCL2 mRNA
CTD PMID:16324872 PMID:21921364 PMID:24376630 PMID:26345256 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
multiple interactions
ISO Paraquat results in increased expression of CCL20 protein
PTPN6 protein inhibits the reaction [Paraquat results in increased expression of CCL20 protein]
CTD PMID:18441283 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA
Paraquat results in increased expression of CCL21 mRNA; Paraquat results in increased expression of CCL21A mRNA
CTD PMID:22563483 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA]; Dapsone inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA] CTD PMID:16324872 PMID:21765237 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Paraquat results in increased expression of CCN1 mRNA CTD PMID:12595580 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression
ISO
EXP
[CCN2 protein co-treated with Paraquat] affects the expression of MMP2 mRNA; [CCN2 protein co-treated with Paraquat] affects the expression of MMP9 mRNA; [CCN2 protein co-treated with Paraquat] affects the expression of TIMP1 mRNA; [Paraquat co-treated with TGFB1 protein] results in increased expression of CCN2 mRNA; Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 protein]; TGFB1 protein promotes the reaction [Paraquat results in increased expression of CCN2 protein]; Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA]
ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of CCN2 protein]
Paraquat results in increased expression of CCN2 mRNA; Paraquat results in increased expression of CCN2 protein
prolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; prolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of CCN2 protein]
CTD PMID:12595580 PMID:15728566 PMID:16767377 PMID:20035857 PMID:23433149 PMID:25815693 PMID:25945502 PMID:26129822 PMID:26758514 PMID:27682480 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNA2 mRNA CTD PMID:28012437 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNB1 mRNA CTD PMID:28012437 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNB2 mRNA CTD PMID:28012437 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnc cyclin C increases expression ISO Paraquat results in increased expression of CCNC mRNA CTD PMID:20883675 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 affects expression
multiple interactions
decreases expression
EXP
ISO
Paraquat affects the expression of CCND1 mRNA
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA
LGK974 inhibits the reaction [Paraquat results in decreased expression of CCND1 protein]; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CCND1 mRNA]
CTD PMID:16854511 PMID:26887261 PMID:29859004 PMID:30171970 PMID:30205152 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression
multiple interactions
EXP
ISO
Paraquat results in decreased expression of CCND2 mRNA
[Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA
CTD PMID:17935786 PMID:28619522 PMID:29859004 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Paraquat results in decreased expression of CCND3 mRNA CTD PMID:17935786 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNE1 mRNA CTD PMID:28012437 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CCNE2 mRNA CTD PMID:28012437 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Paraquat results in increased expression of CCNG1 mRNA CTD PMID:17935786 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases response to substance ISO CCS gene mutant form results in increased susceptibility to Paraquat CTD PMID:10694572 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cd14 CD14 molecule increases expression ISO Paraquat results in increased expression of CD14 mRNA CTD PMID:28012437 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd27 CD27 molecule decreases expression ISO Paraquat results in decreased expression of CD27 mRNA CTD PMID:18836921 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd38 CD38 molecule decreases expression EXP Paraquat results in decreased expression of CD38 mRNA CTD PMID:18198484 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd40 CD40 molecule increases expression ISO Paraquat results in increased expression of CD40 mRNA CTD PMID:18836921 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression EXP Paraquat results in decreased expression of CD44 mRNA CTD PMID:18198484 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd47 Cd47 molecule increases expression
multiple interactions
ISO Paraquat results in increased expression of CD47 protein
Paraquat results in increased expression of CD47 mRNA; Paraquat results in increased expression of CD47 protein
THBS1 protein affects the reaction [Paraquat results in increased expression of CD47 protein]
CTD PMID:29287252 PMID:30419666 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd68 Cd68 molecule decreases expression
multiple interactions
ISO Paraquat results in decreased expression of CD68 mRNA
[MTHFR gene polymorphism affects the susceptibility to Paraquat] which results in increased expression of CD68 protein; [Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA]
CTD PMID:21371552 PMID:30726997 PMID:32169474 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cd70 Cd70 molecule decreases expression ISO Paraquat results in decreased expression of CD70 mRNA CTD PMID:18836921 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cd80 Cd80 molecule increases expression EXP Paraquat results in increased expression of CD80 mRNA CTD PMID:18198484 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression
decreases expression
EXP
ISO
Paraquat results in increased expression of CD86 mRNA
Paraquat results in increased expression of CD86 protein
Paraquat results in decreased expression of CD86 mRNA
CTD PMID:24521700 PMID:28467894 PMID:31299241 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd8b CD8b molecule decreases expression ISO Paraquat results in decreased expression of CD8B mRNA CTD PMID:21371552 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cdc20 cell division cycle 20 decreases expression
multiple interactions
increases expression
EXP
ISO
Paraquat results in decreased expression of CDC20 mRNA
[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDC20 mRNA
Paraquat results in increased expression of CDC20 mRNA
CTD PMID:18198484 PMID:26345256 PMID:28012437 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A affects expression EXP Paraquat affects the expression of CDC25A mRNA CTD PMID:16854511 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Paraquat results in decreased expression of CDC25B mRNA CTD PMID:28012437 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDC25C mRNA CTD PMID:28012437 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc40 cell division cycle 40 increases expression ISO Paraquat results in increased expression of CDC40 mRNA CTD PMID:21371552 NCBI chr20:48,503,973...48,574,546
Ensembl chr20:48,503,973...48,574,546
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
EXP Paraquat results in decreased expression of CDH1 mRNA; Paraquat results in decreased expression of CDH1 protein
Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; sulforafan inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]
CTD PMID:25873302 PMID:28624451 PMID:30317802 PMID:30403199 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdhr4 cadherin-related family member 4 decreases expression
multiple interactions
ISO Paraquat results in decreased expression of CDHR4 mRNA
[Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA
CTD PMID:22563483 NCBI chr 8:116,771,377...116,779,242 JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA CTD PMID:18386188 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDK1 mRNA; Paraquat affects the reaction [ATG7 protein affects the expression of CDK1 mRNA]; Paraquat affects the reaction [ATG7 protein affects the expression of CDK1 protein]
Paraquat results in decreased expression of CDK1 mRNA; Paraquat results in decreased expression of CDK1 protein
CTD PMID:28012437 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDK2 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 PMID:28012437 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA CTD PMID:23017109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA CTD PMID:23017109 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 5:86,387,238...86,554,108
Ensembl chr 5:86,387,078...86,554,102
JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO Paraquat results in decreased expression of CDK8 mRNA CTD PMID:21371552 NCBI chr12:10,496,273...10,561,335 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression
ISO Paraquat results in increased expression of CDKN1A mRNA; Paraquat results in increased expression of CDKN1A protein
[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDKN1A mRNA; [Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; ATG7 protein affects the reaction [Paraquat results in increased expression of CDKN1A protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA]
Paraquat results in decreased expression of CDKN1A mRNA
CTD PMID:12595580 PMID:20883675 PMID:21371552 PMID:23963992 PMID:24060684 PMID:28012437 PMID:31368498 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Paraquat results in decreased expression of CDKN1C mRNA CTD PMID:21371552 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression
multiple interactions
EXP Paraquat results in increased expression of CDKN2A mRNA
[Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
CTD PMID:29859004 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression ISO Paraquat results in increased expression of CDKN2C mRNA CTD PMID:28012437 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP Paraquat affects the expression of CDO1 mRNA CTD PMID:16854511 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Paraquat results in increased expression of CEBPB mRNA CTD PMID:12595580 PMID:23613995 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression
multiple interactions
ISO Paraquat results in decreased expression of CEBPD mRNA
[Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA
CTD PMID:22563483 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cep290 centrosomal protein 290 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA
Paraquat results in increased expression of CEP290 mRNA
CTD PMID:22563483 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Cfl1 cofilin 1 increases expression EXP Paraquat results in increased expression of CFL1 mRNA CTD PMID:17077588 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Cftr CF transmembrane conductance regulator affects expression
affects splicing
EXP
ISO
Paraquat affects the expression of CFTR mRNA
Paraquat affects the splicing of CFTR exon
CTD PMID:15206577 PMID:27111068 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chat choline O-acetyltransferase decreases activity
decreases expression
EXP Paraquat results in decreased activity of CHAT protein
Paraquat results in decreased expression of CHAT mRNA
CTD PMID:24521700 PMID:28916328 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CHEK1 mRNA CTD PMID:28012437 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA CTD PMID:23017109 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit affects expression EXP Paraquat affects the expression of CHRNA5 mRNA CTD PMID:18198484 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit multiple interactions
affects expression
ISO
EXP
Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]
Paraquat affects the expression of CHRNA6 mRNA
CTD PMID:17227438 PMID:18198484 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases expression EXP Paraquat results in increased expression of CHRNA7 mRNA CTD PMID:18198484 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit increases expression EXP Paraquat results in increased expression of CHRNB1 mRNA CTD PMID:17077588 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein] CTD PMID:17227438 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit increases expression EXP Paraquat results in increased expression of CHRNE mRNA CTD PMID:17077588 NCBI chr10:57,238,960...57,246,750
Ensembl chr10:57,238,946...57,243,435
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit affects expression EXP Paraquat affects the expression of CHRNG mRNA CTD PMID:18198484 NCBI chr 9:94,302,218...94,308,591 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein] CTD PMID:29568078 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO Paraquat results in increased expression of CIDEA mRNA CTD PMID:18836921 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO Paraquat results in increased expression of CIDEB mRNA CTD PMID:18836921 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cirbp cold inducible RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA CTD PMID:18386188 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA] CTD PMID:23963992 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Paraquat results in decreased expression of CLDN1 protein CTD PMID:30698896 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Clk3 CDC-like kinase 3 increases expression EXP Paraquat results in increased expression of CLK3 mRNA CTD PMID:16328009 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Paraquat results in increased expression of CLPX mRNA CTD PMID:21371552 NCBI chr 8:70,789,137...70,843,133
Ensembl chr 8:70,789,256...70,843,123
JBrowse link
G Clspn claspin decreases expression ISO Paraquat results in decreased expression of CLSPN mRNA CTD PMID:23613995 NCBI chr 5:144,577,670...144,617,507
Ensembl chr 5:144,581,427...144,616,335
JBrowse link
G Clu clusterin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA CTD PMID:18386188 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cma1 chymase 1 multiple interactions
increases expression
ISO
EXP
CMA1 protein promotes the reaction [Paraquat results in increased expression of ACTA2 protein]; CMA1 protein promotes the reaction [Paraquat results in increased expression of AGT protein modified form]; CMA1 protein promotes the reaction [Paraquat results in increased expression of TGFB1 protein]
Paraquat results in increased expression of CMA1 mRNA
Paraquat results in increased expression of CMA1 mRNA; Paraquat results in increased expression of CMA1 protein
CTD PMID:18198484 PMID:19969051 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 increases expression EXP Paraquat results in increased expression of CMKLR1 mRNA CTD PMID:17077588 NCBI chr12:48,743,556...48,796,582
Ensembl chr12:48,789,261...48,793,553
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression ISO Paraquat results in increased expression of CMPK2 mRNA CTD PMID:21371552 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Cnr2 cannabinoid receptor 2 decreases expression
multiple interactions
EXP Paraquat results in decreased expression of CNR2 protein
1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Paraquat results in decreased expression of CNR2 protein]
CTD PMID:24963491 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP
ISO
[Paraquat co-treated with Oxygen] results in increased expression of COL1A1 mRNA; Ambroxol affects the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein]
Paraquat results in increased expression of COL1A1 mRNA; Paraquat results in increased expression of COL1A1 protein
enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
Saralasin inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
CTD PMID:12882763 PMID:17215068 PMID:19969051 PMID:20035857 PMID:21921364 PMID:24893116 PMID:25304964 PMID:25873302 PMID:26099602 PMID:26221080 PMID:26345256 PMID:27375216 PMID:29273418 PMID:30403199 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO Paraquat results in decreased expression of COL2A1 mRNA CTD PMID:26108578 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
increases expression
ISO
EXP
ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]]; Saralasin inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]
enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]
Paraquat results in increased expression of COL3A1 mRNA; Paraquat results in increased expression of COL3A1 protein
Ambroxol affects the reaction [Paraquat results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]
CTD PMID:20035857 PMID:21921364 PMID:24893116 PMID:25233898 PMID:25304964 PMID:25873302 PMID:25945502 PMID:26099602 PMID:26758514 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
increases expression
ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA] CTD PMID:27375216 PMID:29273418 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO Paraquat results in increased expression of COL6A1 mRNA CTD PMID:26345256 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Paraquat results in increased expression of COMT mRNA CTD PMID:17935786 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cope COPI coat complex subunit epsilon multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA CTD PMID:18386188 NCBI chr16:20,863,141...20,873,516
Ensembl chr16:20,863,141...20,873,521
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 affects expression
increases expression
decreases expression
EXP Paraquat affects the expression of COX4I1 mRNA
Paraquat results in increased expression of COX4I1 protein
Paraquat results in decreased expression of COX4I1 mRNA
CTD PMID:15206577 PMID:18198484 PMID:24521700 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression
multiple interactions
EXP
ISO
Paraquat results in increased expression of COX5A protein
[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]
CTD PMID:23562983 PMID:24521700 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B decreases expression
increases expression
EXP Paraquat results in decreased expression of COX5B mRNA
Paraquat results in increased expression of COX5B protein
CTD PMID:17077588 PMID:24521700 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA CTD PMID:18386188 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression EXP Paraquat results in increased expression of COX6C protein CTD PMID:24521700 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression
multiple interactions
EXP
ISO
Paraquat results in decreased expression of COX7A2 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA
CTD PMID:17077588 PMID:18386188 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA CTD PMID:18386188 NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783
JBrowse link
G Cplx1 complexin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein CTD PMID:17532186 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Paraquat results in increased expression of CPT1A mRNA CTD PMID:18198484 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression ISO Paraquat results in increased expression of CRADD mRNA CTD PMID:18836921 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO
EXP
Paraquat results in increased phosphorylation of CREB1 protein
[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form
[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
CTD PMID:16797015 PMID:23963992 PMID:27460631 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Paraquat results in increased expression of CREB3 mRNA CTD PMID:21371552 NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188
JBrowse link
G Crebbp CREB binding protein increases expression
decreases expression
EXP
ISO
Paraquat results in increased expression of CREBBP protein
Paraquat results in decreased expression of CREBBP mRNA
CTD PMID:20478973 PMID:28619522 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crip2 cysteine-rich protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA CTD PMID:18386188 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 affects expression EXP Paraquat affects the expression of CRISPLD2 mRNA CTD PMID:16854511 NCBI chr19:52,647,038...52,705,118
Ensembl chr19:52,647,070...52,705,131
JBrowse link
G Crlf2 cytokine receptor-like factor 2 decreases expression
multiple interactions
ISO Paraquat results in decreased expression of CRLF2 mRNA
[Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA
CTD PMID:22563483 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543
JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA CTD PMID:18386188 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases expression
multiple interactions
ISO Paraquat results in decreased expression of CRTC2 mRNA
WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CRTC2 mRNA]
CTD PMID:30171970 NCBI chr 2:189,615,928...189,625,646
Ensembl chr 2:189,615,948...189,626,051
JBrowse link
G Csf1r colony stimulating factor 1 receptor affects expression
multiple interactions
increases expression
EXP
ISO
Paraquat affects the expression of CSF1R mRNA
[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA]
Paraquat results in increased expression of CSF1R mRNA
CTD PMID:15206577 PMID:17077588 PMID:18198484 PMID:21371552 PMID:32169474 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Paraquat results in increased expression of CSF2 mRNA CTD PMID:22938100 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264
JBrowse link
G Csf3 colony stimulating factor 3 increases expression ISO Paraquat results in increased expression of CSF3 protein CTD PMID:26988026 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csnk1g2 casein kinase 1, gamma 2 decreases expression ISO Paraquat results in decreased expression of CSNK1G2 mRNA CTD PMID:21371552 NCBI chr 7:11,944,957...11,963,268
Ensembl chr 7:11,944,958...11,963,268
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 increases expression ISO Paraquat results in increased expression of CSNK2A2 protein CTD PMID:26649146 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 affects expression EXP Paraquat affects the expression of CSPG4 mRNA CTD PMID:16854511 NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects localization
decreases expression
decreases response to substance
ISO
EXP
CTNNB1 protein inhibits the reaction [Paraquat results in increased abundance of Reactive Oxygen Species]; Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]; Paraquat inhibits the reaction [CTNNB1 protein binds to MPZ promoter]; Paraquat inhibits the reaction [CTNNB1 protein binds to PMP22 promoter]
LGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein]; LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]
Paraquat results in decreased expression of CTNNB1 mRNA; Paraquat results in decreased expression of CTNNB1 protein
CTNNB1 protein results in decreased susceptibility to Paraquat
CTD PMID:23620592 PMID:26887261 PMID:27788593 PMID:30171970 PMID:30205152 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 increases expression ISO Paraquat results in increased expression of CTNNBIP1 mRNA CTD PMID:28619522 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions
decreases expression
ISO mangiferin inhibits the reaction [Paraquat results in decreased expression of and affects the localization of CTNND1 protein]; mangiferin inhibits the reaction [Paraquat results in decreased expression of CTNND1 mRNA alternative form]; Paraquat results in decreased expression of and affects the localization of CTNND1 protein CTD PMID:24912632 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
JBrowse link
G Ctnnd2 catenin delta 2 decreases expression ISO Paraquat results in decreased expression of CTNND2 mRNA CTD PMID:21371552 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315
JBrowse link
G Ctrb1 chymotrypsinogen B1 increases expression EXP Paraquat results in increased expression of CTRB mRNA CTD PMID:18198484 NCBI chr19:43,906,344...43,911,020
Ensembl chr19:43,906,292...43,911,057
JBrowse link
G Ctsb cathepsin B decreases expression
multiple interactions
decreases activity
ISO Paraquat results in decreased expression of CTSB mRNA
APOD protein inhibits the reaction [Paraquat results in decreased activity of CTSB protein]
CTD PMID:16797015 PMID:28182653 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsc cathepsin C decreases expression ISO Paraquat results in decreased expression of CTSC mRNA CTD PMID:16797015 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Ctsd cathepsin D decreases expression ISO Paraquat results in decreased expression of CTSD mRNA CTD PMID:16797015 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsh cathepsin H decreases expression ISO Paraquat results in decreased expression of CTSH mRNA CTD PMID:16797015 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287
JBrowse link
G Ctsk cathepsin K increases expression ISO Paraquat results in increased expression of CTSK mRNA CTD PMID:26345256 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA] CTD PMID:23963992 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cul1 cullin 1 increases expression ISO Paraquat results in increased expression of CUL1 mRNA CTD PMID:21371552 PMID:28619522 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases response to substance ISO CX3CR1 protein results in decreased susceptibility to Paraquat CTD PMID:23299473 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Paraquat results in increased expression of CXCL10 mRNA CTD PMID:22230393 PMID:26345256 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Paraquat results in increased expression of CXCL11 mRNA CTD PMID:22230393 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
EXP
ISO
Paraquat results in increased expression of CXCL2 protein
Paraquat results in increased expression of CXCL2 mRNA; Paraquat results in increased expression of CXCL2 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]; Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein]]; SB 203580 inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]
[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CXCL2 protein; SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CXCL2 protein]
CTD PMID:12504350 PMID:16324872 PMID:16919916 PMID:24376630 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
increases expression
EXP
ISO
Paraquat results in decreased expression of CXCL3 mRNA
Paraquat results in increased expression of CXCL1 protein
CTD PMID:18198484 PMID:26988026 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression EXP Paraquat results in decreased expression of CXCR4 mRNA CTD PMID:18198484 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyb5a cytochrome b5 type A increases expression ISO Paraquat results in increased expression of CYB5A mRNA CTD PMID:21371552 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]
CTD PMID:29568078 PMID:30797899 PMID:32375810 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA CTD PMID:18386188 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
affects localization
ISO [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CYCS mRNA]; salubrinal inhibits the reaction [Paraquat affects the localization of CYCS protein]
Paraquat results in increased expression of CYCS mRNA; Paraquat results in increased expression of CYCS protein
CTD PMID:20929985 PMID:22736252 PMID:26649146 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cygb cytoglobin increases expression EXP Paraquat results in increased expression of CYGB mRNA CTD PMID:20388547 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
decreases expression
EXP Paraquat results in increased expression of CYP11A1 mRNA
Paraquat results in decreased expression of CYP11A1 mRNA; Paraquat results in decreased expression of CYP11A1 protein
CTD PMID:18198484 PMID:31610511 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Paraquat results in decreased expression of CYP17A1 protein CTD PMID:31610511 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP Paraquat results in decreased activity of CYP1A1 protein CTD PMID:17481832 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions
EXP Paraquat results in increased activity of CYP1A2 protein
Paraquat results in increased expression of CYP1A2 mRNA; Paraquat results in increased expression of CYP1A2 protein
[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP1A2 mRNA]; Paraquat results in increased expression of and results in increased activity of CYP1A2 protein; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [Paraquat results in increased expression of CYP1A2 mRNA]
CTD PMID:20888808 PMID:23159886 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression ISO Paraquat results in increased expression of CYP26B1 mRNA CTD PMID:21371552 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression EXP Paraquat results in decreased expression of CYP2C6V1 mRNA CTD PMID:16328009 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases expression
ISO Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
Paraquat results in increased expression of CYP2E1 mRNA; Paraquat results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]; Paraquat promotes the reaction [Zinc Sulfate results in increased expression of CYP2E1 mRNA]; Paraquat results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]; Zinc Sulfate promotes the reaction [Paraquat results in increased expression of CYP2E1 mRNA]
Paraquat results in increased activity of CYP2E1 protein
CTD PMID:16510128 PMID:20553223 PMID:20888808 PMID:20964710 PMID:23159886 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression EXP Paraquat results in increased expression of CYP2F4 mRNA CTD PMID:16328009 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Paraquat results in increased expression of CYP2J9 mRNA CTD PMID:21371552 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP betanin inhibits the reaction [Paraquat results in increased expression of CYP3A2 mRNA] CTD PMID:24799198 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases expression ISO Paraquat results in increased expression of CYP46A1 mRNA CTD PMID:27788593 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Paraquat results in decreased expression of CYP4A3 mRNA CTD PMID:17077588 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyth3 cytohesin 3 increases expression ISO Paraquat results in increased expression of CYTH3 mRNA CTD PMID:12595580 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192
JBrowse link
G Daam2 dishevelled associated activator of morphogenesis 2 decreases expression ISO Paraquat results in decreased expression of DAAM2 mRNA CTD PMID:28619522 NCBI chr 9:13,444,883...13,493,154
Ensembl chr 9:13,446,896...13,490,669
JBrowse link
G Dap3 death associated protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Paraquat results in increased expression of DAPK1 mRNA CTD PMID:18836921 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA CTD PMID:18386188 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Paraquat results in increased expression of DBP mRNA CTD PMID:26345256 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP Paraquat results in increased expression of DDAH1 mRNA CTD PMID:20388547 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 increases expression EXP Paraquat results in increased expression of DDAH2 mRNA CTD PMID:20388547 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Paraquat results in increased expression of DDB2 mRNA CTD PMID:23613995 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Paraquat results in decreased expression of DDC mRNA CTD PMID:21371552 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Paraquat results in increased expression of DDIT3 mRNA; Paraquat results in increased expression of DDIT3 protein
Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of DDIT3 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]
CTD PMID:19735704 PMID:20883675 PMID:22245251 PMID:22678742 PMID:23613995 PMID:27442881 PMID:28986289 PMID:30185695 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Paraquat results in increased expression of DDIT4 mRNA CTD PMID:23613995 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions
decreases expression
ISO 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of DDX3X protein modified form]; Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein] CTD PMID:28414160 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA CTD PMID:18386188 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression ISO Paraquat results in increased expression of DFFA mRNA CTD PMID:18836921 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dgkb diacylglycerol kinase, beta decreases expression ISO Paraquat results in decreased expression of DGKB mRNA CTD PMID:21371552 NCBI chr 6:57,516,351...58,277,385
Ensembl chr 6:57,516,713...58,277,279
JBrowse link
G Dgkh diacylglycerol kinase, eta increases expression ISO Paraquat results in increased expression of DGKH mRNA CTD PMID:22563483 NCBI chr15:60,791,574...60,967,236
Ensembl chr15:60,803,098...60,959,769
JBrowse link
G Dgki diacylglycerol kinase, iota increases expression
multiple interactions
ISO Paraquat results in increased expression of DGKI mRNA
[Paraquat co-treated with Maneb] affects the expression of DGKI mRNA
CTD PMID:22563483 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Paraquat results in decreased expression of DHCR24 mRNA CTD PMID:23315990 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Paraquat results in decreased expression of DHCR7 mRNA CTD PMID:16328009 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions
increases transport
affects localization
increases expression
EXP
ISO
Cyclosporine inhibits the reaction [Paraquat affects the localization of DIABLO protein]; Dibucaine inhibits the reaction [Paraquat affects the localization of DIABLO protein]; diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of DIABLO protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of DIABLO protein]
Paraquat results in increased transport of DIABLO protein
LGK974 inhibits the reaction [Paraquat results in increased transport of DIABLO protein]
CTD PMID:17936647 PMID:22245251 PMID:25947082 PMID:30205152 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dip2b disco-interacting protein 2 homolog B multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA
Paraquat results in increased expression of DIP2B mRNA
CTD PMID:22563483 NCBI chr 7:141,702,034...141,878,945
Ensembl chr 7:141,702,038...141,879,951
JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression ISO Paraquat results in decreased expression of DLD mRNA CTD PMID:21371552 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions
decreases expression
EXP Estradiol inhibits the reaction [Paraquat results in decreased expression of DLG4 protein] CTD PMID:31715309 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA CTD PMID:23017109 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dmd dystrophin increases response to substance ISO DMD gene mutant form results in increased susceptibility to Paraquat CTD PMID:10797403 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dmrta2 DMRT-like family A2 decreases expression
multiple interactions
ISO Paraquat results in decreased expression of DMRTA2 mRNA
[Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA
CTD PMID:22563483 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases response to substance ISO DNAJB1 protein results in decreased susceptibility to Paraquat CTD PMID:11359866 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA CTD PMID:18386188 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 decreases expression ISO Paraquat results in decreased expression of DNAJC3 mRNA CTD PMID:16797015 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Paraquat results in increased expression of DNM1L protein CTD PMID:28215578 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Dok4 docking protein 4 increases expression ISO Paraquat results in increased expression of DOK4 mRNA CTD PMID:21371552 NCBI chr19:10,563,423...10,574,094
Ensembl chr19:10,563,423...10,574,093
JBrowse link
G Drd2 dopamine receptor D2 affects expression
increases expression
multiple interactions
EXP
ISO
Paraquat affects the expression of DRD2 mRNA
Paraquat results in increased expression of DRD2 mRNA
[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA
CTD PMID:15206577 PMID:18198484 PMID:23017109 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd4 dopamine receptor D4 affects expression
multiple interactions
EXP
ISO
Paraquat affects the expression of DRD4 mRNA
[Paraquat co-treated with Maneb] results in increased expression of DRD4 protein
CTD PMID:15206577 PMID:22563483 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA CTD PMID:23017109 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 affects expression ISO Paraquat affects the expression of DTX1 mRNA CTD PMID:24053911 NCBI chr12:41,383,885...41,415,783
Ensembl chr12:41,385,241...41,414,754
JBrowse link
G Duox1 dual oxidase 1 multiple interactions
increases expression
ISO APOD protein affects the reaction [Paraquat results in increased expression of DUOX1 mRNA]
kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA]
CTD PMID:21688324 PMID:25177032 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Duox2 dual oxidase 2 multiple interactions ISO [Quercetin co-treated with Paraquat] results in increased expression of DUOX2 mRNA CTD PMID:22996356 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Paraquat results in increased expression of DUSP1 mRNA CTD PMID:12595580 PMID:23315990 PMID:28012437 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions
EXP
ISO
Paraquat results in decreased expression of DVL2 mRNA
Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of DVL2 protein]
WNT1 protein inhibits the reaction [Paraquat results in decreased expression of DVL2 mRNA]; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of DVL2 protein]
Paraquat results in decreased expression of DVL2 mRNA; Paraquat results in decreased expression of DVL2 protein
CTD PMID:26887261 PMID:27788593 PMID:30171970 NCBI chr10:56,609,810...56,619,269
Ensembl chr10:56,610,051...56,619,269
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression
increases expression
ISO
EXP
Paraquat results in decreased expression of DYNLL1 mRNA
Paraquat results in increased expression of DYNLL1 mRNA
CTD PMID:12595580 PMID:16328009 PMID:20388547 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A increases expression ISO Paraquat results in increased expression of DYRK1A mRNA CTD PMID:21371552 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions
increases expression
ISO salubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein] CTD PMID:19735704 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
EXP
ISO
green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]
Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]
Paraquat results in increased expression of EDN1 mRNA; Paraquat results in increased expression of EDN1 protein
CTD PMID:17235729 PMID:21765237 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A affects expression EXP Paraquat affects the expression of EDNRA mRNA CTD PMID:16854511 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA CTD PMID:18386188 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO Paraquat results in decreased expression of EEF1A2 mRNA CTD PMID:21371552 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Paraquat results in decreased expression of EEF2K mRNA CTD PMID:28012437 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Efnb1 ephrin B1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Paraquat results in decreased expression of EGFR protein CTD PMID:17298174 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO Paraquat results in decreased expression of EGLN2 mRNA CTD PMID:21371552 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egr1 early growth response 1 increases expression ISO Paraquat results in increased expression of EGR1 mRNA CTD PMID:20883675 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr4 early growth response 4 multiple interactions
decreases expression
ISO [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA
Paraquat results in decreased expression of EGR4 mRNA
CTD PMID:22563483 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Paraquat results in increased phosphorylation of EIF2A protein CTD PMID:20929985 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
increases expression
EXP
ISO
Paraquat results in increased phosphorylation of EIF2AK3 protein
Paraquat results in increased expression of EIF2AK3 protein modified form
CTD PMID:22245251 PMID:27442881 PMID:28986289 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
increases expression
EXP
ISO
Paraquat results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]
CTD PMID:22245251 PMID:27442881 PMID:28986289 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO Paraquat results in increased expression of EIF4EBP1 mRNA CTD PMID:12595580 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 1:175,883,362...175,895,510
Ensembl chr 1:175,883,363...175,895,510
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 affects localization ISO Paraquat affects the localization of ELAVL1 protein CTD PMID:22879928 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eln elastin increases expression ISO Paraquat results in increased expression of ELN mRNA CTD PMID:17215068 PMID:26345256 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 increases expression ISO Paraquat results in increased expression of ELP1 mRNA CTD PMID:21371552 NCBI chr 5:73,503,406...73,552,798
Ensembl chr 5:73,503,407...73,552,798
JBrowse link
G Eno1 enolase 1 multiple interactions
decreases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]
Paraquat results in decreased expression of ENO1 mRNA; Paraquat results in decreased expression of ENO1 protein
CTD PMID:17532186 PMID:18386188 PMID:23562983 PMID:27111068 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eno2 enolase 2 increases expression
multiple interactions
decreases expression
ISO
EXP
Paraquat results in increased expression of ENO2 mRNA alternative form
[Maneb co-treated with Paraquat] results in increased expression of ENO2 protein
Paraquat results in decreased expression of ENO2 protein
CTD PMID:17064354 PMID:18198484 PMID:23562983 PMID:24521700 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Epn2 epsin 2 increases expression ISO Paraquat results in increased expression of EPN2 mRNA CTD PMID:21371552 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [SOD2 gene mutant form results in increased susceptibility to Paraquat] CTD PMID:16288465 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 decreases expression ISO Paraquat results in decreased expression of EPS8 mRNA CTD PMID:21371552 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Epx eosinophil peroxidase multiple interactions
decreases expression
ISO APOD protein affects the reaction [Paraquat results in decreased expression of EPX mRNA] CTD PMID:21688324 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases response to substance
ISO NFE2L2 protein affects the reaction [ERBB2 protein results in decreased susceptibility to Paraquat] CTD PMID:25467193 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Paraquat results in decreased expression of ERBB3 mRNA CTD PMID:16797015 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Paraquat results in increased expression of ERBB4 mRNA CTD PMID:22563483 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit affects splicing ISO Paraquat affects the splicing of ERCC1 mRNA CTD PMID:23613995 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases response to substance ISO ERCC6 gene mutant form results in increased susceptibility to Paraquat CTD PMID:12509265 PMID:15340056 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Ergic2 ERGIC and golgi 2 decreases expression
increases expression
ISO Paraquat results in decreased expression of ERGIC2 mRNA
Paraquat results in increased expression of ERGIC2 mRNA
CTD PMID:21371552 NCBI chr 4:182,569,086...182,600,258
Ensembl chr 4:182,569,089...182,600,258
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 increases expression ISO Paraquat results in increased expression of ERMP1 mRNA CTD PMID:21371552 NCBI chr 1:247,784,830...247,821,771
Ensembl chr 1:247,787,582...247,821,728
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
increases phosphorylation
ISO
EXP
Paraquat promotes the reaction [MAP3K5 protein results in increased phosphorylation of ERN1 protein]
Paraquat results in increased expression of ERN1 protein modified form
Paraquat results in increased phosphorylation of ERN1 protein
CTD PMID:20929985 PMID:22245251 PMID:28986289 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP Paraquat results in decreased activity of ESR1 protein CTD PMID:31715309 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Paraquat results in decreased expression of ESRRA mRNA CTD PMID:12595580 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Etl4 enhancer trap locus 4 increases expression
multiple interactions
ISO Paraquat results in increased expression of ETL4 mRNA
[Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA
CTD PMID:22563483 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression EXP Paraquat results in decreased expression of ETS1 mRNA CTD PMID:18198484 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G F2 coagulation factor II increases expression EXP Paraquat results in increased expression of F2 mRNA CTD PMID:18198484 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Faah fatty acid amide hydrolase increases expression EXP Paraquat results in increased expression of FAAH mRNA CTD PMID:18198484 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Paraquat results in increased expression of FABP5 mRNA CTD PMID:21371552 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fadd Fas associated via death domain decreases expression ISO Paraquat results in decreased expression of FADD mRNA CTD PMID:18836921 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Paraquat results in decreased expression of FADS2 mRNA CTD PMID:21371552 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fanca FA complementation group A multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCA mRNA CTD PMID:28012437 NCBI chr19:56,067,548...56,126,075
Ensembl chr19:56,067,548...56,126,063
JBrowse link
G Fancb FA complementation group B multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCB mRNA CTD PMID:28012437 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of FANCD2 mRNA CTD PMID:28012437 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO Paraquat results in increased expression of FAS mRNA
[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]
CTD PMID:18836921 PMID:23963992 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO Paraquat results in increased expression of FASL mRNA
Paraquat results in increased expression of FASLG mRNA
CTD PMID:9657385 PMID:17215068 PMID:18836921 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fat3 FAT atypical cadherin 3 increases expression ISO Paraquat results in increased expression of FAT3 mRNA CTD PMID:22563483 NCBI chr 8:14,417,039...15,011,596
Ensembl chr 8:14,417,584...14,880,644
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA CTD PMID:23017109 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Paraquat results in increased expression of FGF1 mRNA CTD PMID:16324872 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression
decreases secretion
multiple interactions
EXP
ISO
Paraquat results in increased expression of FGF2 mRNA
Paraquat results in decreased secretion of FGF2 protein
Oxygen inhibits the reaction [Paraquat results in increased expression of FGF2 mRNA]
CTD PMID:18198484 PMID:26722498 PMID:30698896 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA] CTD PMID:23963992 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 multiple interactions
affects response to substance
ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA
FKBP4 protein affects the susceptibility to Paraquat
CTD PMID:18386188 PMID:20713718 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression
multiple interactions
affects expression
ISO
EXP
Paraquat results in increased expression of FKBP5 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA
Paraquat affects the expression of FKBP5 mRNA
CTD PMID:12595580 PMID:16854511 PMID:18386188 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Paraquat results in decreased expression of FN1 mRNA
THBS1 protein affects the reaction [Paraquat results in increased expression of FN1 protein]
Paraquat results in increased expression of FN1 mRNA; Paraquat results in increased expression of FN1 protein
prolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of FN1 mRNA]
CTD PMID:16797015 PMID:17215068 PMID:23803522 PMID:25873302 PMID:26345256 PMID:29495171 PMID:30317802 PMID:30419666 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Paraquat promotes the reaction [JUN protein binds to FOS protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
Paraquat results in increased expression of FOS mRNA
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein
[Paraquat co-treated with SOD2 protein] results in increased expression of FOS mRNA
CTD PMID:10464329 PMID:11728812 PMID:17048122 PMID:23963992 PMID:27460631 PMID:29441825 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO Paraquat results in decreased expression of FOXM1 mRNA CTD PMID:23315990 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects expression
increases response to substance
ISO FOXO3 mutant form inhibits the reaction [Paraquat results in increased expression of BCL2L11 mRNA]
Paraquat affects the expression of FOXO3 mRNA
FOXO3 protein results in increased susceptibility to Paraquat
CTD PMID:23620592 PMID:29287252 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions
increases expression
ISO plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 protein]
Paraquat results in increased expression of FSTL1 mRNA; Paraquat results in increased expression of FSTL1 protein
CTD PMID:26758514 NCBI chr11:65,791,196...65,845,721
Ensembl chr11:65,782,567...65,845,418
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]
Paraquat results in increased expression of FTL1 mRNA; Paraquat results in increased expression of FTL1 protein
CTD PMID:12644586 PMID:28542246 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Ftmt ferritin mitochondrial multiple interactions ISO Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]] CTD PMID:12644586 NCBI chr18:47,294,292...47,295,541
Ensembl chr18:47,294,292...47,295,541
JBrowse link
G Fut2 fucosyltransferase 2 increases expression EXP Paraquat results in increased expression of FUT2 mRNA CTD PMID:17077588 NCBI chr 1:101,631,633...101,651,668
Ensembl chr 1:101,631,635...101,651,668
JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA CTD PMID:18386188 NCBI chr 8:49,676,520...49,703,419
Ensembl chr 8:49,676,540...49,703,419
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions
affects expression
increases activity
EXP FYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]
Paraquat affects the expression of FYN mRNA
Paraquat results in increased activity of FYN protein
CTD PMID:15206577 PMID:17298174 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression
multiple interactions