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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:LY 379268
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Accession:CHEBI:192545 term browser browse the term
Definition:An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.
Synonyms:exact_synonym: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
 related_synonym: Formula=C7H9NO5;   InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1;   InChIKey=YASVRZWVUGJELU-MDASVERJSA-N;   LY-379,268;   LY379268;   SMILES=[H][C@@]12OC[C@@](N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O
 xref: CAS:191471-52-0
 xref_mesh: MESH:C118218
 xref: PMID:10090786;   PMID:21139059;   PMID:21477044;   PMID:22659409;   PMID:22820300;   PMID:23593498;   PMID:23624743;   PMID:23769742;   PMID:23827202;   PMID:23948211;   PMID:23953655;   PMID:24631484;   PMID:24859609;   PMID:25063582;   PMID:25158962;   PMID:26044619;   PMID:26149611;   PMID:26241341;   PMID:26317098;   PMID:26861891;   PMID:26955838;   PMID:27394931;   PMID:29462112;   PMID:29562588;   PMID:29858599;   PMID:30909243;   PMID:31306647;   PMID:31536785;   PMID:31580222;   PMID:31705165;   PMID:33763176;   PMID:34330748;   PMID:34416343;   PMID:35772967;   Wikipedia:LY-379\,268


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LY 379268 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP LY 379268 inhibits the reaction [bisphenol A results in decreased expression of NR3C1 mRNA] CTD PMID:25812946 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        pharmacological role 19064
          agonist 18607
            metabotropic glutamate receptor agonist 3
              LY 379268 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        amino acid 15954
                                          amino dicarboxylic acid 51
                                            LY 379268 1
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