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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amino dicarboxylic acid
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Accession:CHEBI:36164 term browser browse the term
Synonyms:related_synonym: amino dicarboxylic acids



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aminomalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmr1 FMRP translational regulator 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of aminomalonic acid CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
leukotriene E4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4
CTD PMID:8621850 PMID:10764316 PMID:12794006 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 affects binding
multiple interactions
ISO Leukotriene E4 binds to CYSLTR1 protein
[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:8384568 PMID:9620942 PMID:10462554 PMID:11705452 PMID:12853847 NCBI chr  X:71,661,415...71,690,158
Ensembl chr  X:71,663,821...71,690,121
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity
ISO [Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239 PMID:11093801 NCBI chr15:48,190,251...48,229,906
Ensembl chr15:48,189,073...48,304,136
JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Leukotriene E4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:23,576,212...23,583,177
Ensembl chr18:23,577,242...23,582,966
JBrowse link
G Il13 interleukin 13 increases abundance EXP IL13 protein results in increased abundance of Leukotriene E4 CTD PMID:12654629 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene E4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression EXP Leukotriene E4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4] CTD PMID:25432964 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase affects abundance ISO DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CTD PMID:22639866 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
CTD PMID:22639866 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nefl neurofilament light chain multiple interactions
decreases expression
EXP 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        refrigerant 17695
          ammonia 17279
            organic amino compound 17279
              amino acid 14885
                amino dicarboxylic acid 16
                  (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                  (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                  (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                  (2R*,6S*)-2,6-diamino-3xi-hydroxyheptanedioic acid 0
                  (2S)-2-[(R)-1-carboxyethylamino]pentanoic acid 0
                  (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                  (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                  (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                  2,2'-iminodipropanoic acid + 0
                  2,3,4,5-tetrahydrodipicolinic acid + 0
                  2,6-diaminopimelic acid + 0
                  2-S-cysteinyl-DOPA 0
                  2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                  2-amino-3-oxoadipic acid 0
                  2-aminoadipic acid + 0
                  2-aminopimelic acid + 0
                  20-hydroxy-leukotriene E4 0
                  20-oxoleukotriene E4 0
                  3-aminoadipic acid + 0
                  3-hydroxy-L-glutamic acid + 0
                  3-hydroxyaspartic acid + 0
                  3-methylthioaspartic acid + 0
                  3-thio-L-aspartic acid + 0
                  4-(L-gamma-glutamylamino)butanoic acid 0
                  4-hydroxy-4-methylglutamate 0
                  4-hydroxy-4-methylglutamic acid 0
                  4-hydroxy-L-glutamic acid + 0
                  4-methyl-L-glutamic acid 0
                  5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                  5-adenylyl-2-aminoadipic acid 0
                  D-octopine 0
                  N(2)-(2-carboxyethyl)-L-arginine 0
                  N-(2-hydroxyethyl)iminodiacetic acid 0
                  N-(carboxymethyl)-L-alanine 0
                  N-(phosphonomethyl)iminodiacetic acid 0
                  N-acetyl-LL-2,6-diaminopimelic acid 0
                  N-methyl-D-aspartic acid 7
                  N-oxalylglycine + 0
                  O-succinyl-L-serine 0
                  aminomalonic acid 1
                  beta-alanopine + 0
                  dinoflagellate luciferin 0
                  ethylenediaminediacetic acid 0
                  iminodiacetic acid + 0
                  leukotriene E3 + 0
                  leukotriene E4 + 8
                  oxidized dinoflagellate luciferin 0
                  succinyladenosine 0
                  threo-3-methyl-L-aspartic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        amino acid 14885
                                          amino dicarboxylic acid 16
                                            (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                                            (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                                            (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                                            (2R*,6S*)-2,6-diamino-3xi-hydroxyheptanedioic acid 0
                                            (2S)-2-[(R)-1-carboxyethylamino]pentanoic acid 0
                                            (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                                            (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                                            (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                                            2,2'-iminodipropanoic acid + 0
                                            2,3,4,5-tetrahydrodipicolinic acid + 0
                                            2,6-diaminopimelic acid + 0
                                            2-S-cysteinyl-DOPA 0
                                            2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                                            2-amino-3-oxoadipic acid 0
                                            2-aminoadipic acid + 0
                                            2-aminopimelic acid + 0
                                            20-hydroxy-leukotriene E4 0
                                            20-oxoleukotriene E4 0
                                            3-aminoadipic acid + 0
                                            3-hydroxy-L-glutamic acid + 0
                                            3-hydroxyaspartic acid + 0
                                            3-methylthioaspartic acid + 0
                                            3-thio-L-aspartic acid + 0
                                            4-(L-gamma-glutamylamino)butanoic acid 0
                                            4-hydroxy-4-methylglutamate 0
                                            4-hydroxy-4-methylglutamic acid 0
                                            4-hydroxy-L-glutamic acid + 0
                                            4-methyl-L-glutamic acid 0
                                            5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                                            5-adenylyl-2-aminoadipic acid 0
                                            D-octopine 0
                                            N(2)-(2-carboxyethyl)-L-arginine 0
                                            N-(2-hydroxyethyl)iminodiacetic acid 0
                                            N-(carboxymethyl)-L-alanine 0
                                            N-(phosphonomethyl)iminodiacetic acid 0
                                            N-acetyl-LL-2,6-diaminopimelic acid 0
                                            N-methyl-D-aspartic acid 7
                                            N-oxalylglycine + 0
                                            O-succinyl-L-serine 0
                                            aminomalonic acid 1
                                            beta-alanopine + 0
                                            dinoflagellate luciferin 0
                                            ethylenediaminediacetic acid 0
                                            iminodiacetic acid + 0
                                            leukotriene E3 + 0
                                            leukotriene E4 + 8
                                            oxidized dinoflagellate luciferin 0
                                            succinyladenosine 0
                                            threo-3-methyl-L-aspartic acid 0
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