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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oncrasin-1
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Accession:CHEBI:178196 term browser browse the term
Definition:A member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations.
Synonyms:exact_synonym: 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde
 related_synonym: 1-(p-chlorobenzyl)-1H-indole-3-carbaldehyde;   1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde;   Formula=C16H12ClNO;   InChI=1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2;   InChIKey=ZDRQMXCSSAPUMM-UHFFFAOYSA-N;   ONC-1;   SMILES=[H]C(=O)C1=CN(CC2=CC=C(Cl)C=C2)C2=CC=CC=C12
 xref: CAS:75629-57-1;   Chemspider:761753
 xref_mesh: MESH:C532252
 xref: PMID:18794128;   PMID:19208825;   PMID:21443218;   PMID:22174819;   PMID:25874341;   PMID:32019870;   PMID:32727562;   PMID:33169204;   Patent:US2009286847


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oncrasin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein mutant form results in increased susceptibility to oncrasin-1 CTD PMID:21443218 NCBI chr 4:178,185,418...178,218,484 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          apoptosis inducer 13624
            oncrasin-1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          formyl group 8999
                                            aldehyde 8999
                                              arenecarbaldehyde 139
                                                oncrasin-1 1
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