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P(1),P(4)-bis(5'-adenosyl) tetraphosphate - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:P(1),P(4)-bis(5'-adenosyl) tetraphosphate
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Accession:CHEBI:17422 term browser browse the term
Definition:A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions.
Synonyms:related_synonym: (ppA)2;   A(5')p4(5')A;   Adenosine-(5')-tetraphospho-(5')-adenosine;   AppppA;   Formula=C20H28N10O19P4;   InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1;   InChIKey=YOAHKNVSNCMZGQ-XPWFQUROSA-N;   P1,P4-Bis(5'-adenosyl) tetraphosphate;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O;   bis(5'-adenylyl) diphosphate
 alt_id: CHEBI:12726;   CHEBI:12729;   CHEBI:21998;   CHEBI:7875
 xref: KEGG:C01260
 xref_mesh: MESH:C020733
 xref: PDBeChem:B4P
 cyclic_relationship: is_conjugate_acid_of CHEBI:58141


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P(1),P(4)-bis(5'-adenosyl) tetraphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] CTD PMID:19442829 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Nudt2 nudix hydrolase 2 increases hydrolysis ISO NUDT2 protein results in increased hydrolysis of diadenosine tetraphosphate CTD PMID:20533549 NCBI chr 4:41,465,085...41,480,926
Ensembl chr 4:41,465,151...41,480,926
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19442829 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link

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  CHEBI ontology 22289
    role 22274
      biological role 22273
        pharmacological role 19862
          analgesic 14944
            adenosine 409
              diadenosyl tetraphosphate 3
                P(1),P(4)-bis(5'-adenosyl) tetraphosphate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 22289
    subatomic particle 22284
      composite particle 22284
        hadron 22284
          baryon 22284
            nucleon 22284
              atomic nucleus 22284
                atom 22284
                  main group element atom 22164
                    p-block element atom 22164
                      carbon group element atom 21966
                        carbon atom 21906
                          organic molecular entity 21906
                            heteroorganic entity 21548
                              organochalcogen compound 21035
                                organooxygen compound 20883
                                  carbohydrates and carbohydrate derivatives 16045
                                    carbohydrate 16045
                                      carbohydrate derivative 14802
                                        glycosyl compound 13185
                                          N-glycosyl compound 5943
                                            nucleoside 5801
                                              ribonucleoside 1172
                                                purine ribonucleoside 821
                                                  purines D-ribonucleoside 421
                                                    adenosine 409
                                                      diadenosyl tetraphosphate 3
                                                        P(1),P(4)-bis(5'-adenosyl) tetraphosphate 3
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