CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: P(1),P(4)-bis(5'-adenosyl) tetraphosphate
Accession: CHEBI:17422
browse the term
Definition: A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions.
Synonyms: related_synonym: (ppA)2; A(5')p4(5')A; Adenosine-(5')-tetraphospho-(5')-adenosine; AppppA; Formula=C20H28N10O19P4; InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1; InChIKey=YOAHKNVSNCMZGQ-XPWFQUROSA-N; P1,P4-Bis(5'-adenosyl) tetraphosphate; SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O; bis(5'-adenylyl) diphosphate
alt_id: CHEBI:12726; CHEBI:12729; CHEBI:21998; CHEBI:7875
xref: KEGG:C01260
xref_mesh: MESH:C020733
xref: PDBeChem:B4P
cyclic_relationship: is_conjugate_acid_of CHEBI:58141
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Casp3
caspase 3
multiple interactions
ISO
diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
CTD
PMID:19442829
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Nudt2
nudix hydrolase 2
increases hydrolysis
ISO
NUDT2 protein results in increased hydrolysis of diadenosine tetraphosphate
CTD
PMID:20533549
NCBI chr 4:41,465,085...41,480,926
Ensembl chr 4:41,465,151...41,480,926
G
Th
tyrosine hydroxylase
multiple interactions
ISO
diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
CTD
PMID:19442829
NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
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