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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetylsalicylic acid
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Accession:CHEBI:15365 term browser browse the term
Definition:A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Synonyms:related_synonym: 2-(ACETYLOXY)BENZOIC ACID;   2-Acetoxybenzenecarboxylic acid;   2-acetoxybenzoic acid;   ASA;   Acetylsalicylate;   Acetylsalicylsaeure;   Aspirin;   Azetylsalizylsaeure;   Easprin;   Formula=C9H8O4;   InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12);   InChIKey=BSYNRYMUTXBXSQ-UHFFFAOYSA-N;   O-acetylsalicylic acid;   SMILES=CC(=O)Oc1ccccc1C(O)=O;   acide 2-(acetyloxy)benzoique;   acide acetylsalicylique;   acido acetilsalicilico;   acidum acetylsalicylicum;   o-acetoxybenzoic acid;   o-carboxyphenyl acetate;   salicylic acid acetate
 alt_id: CHEBI:22188;   CHEBI:22203;   CHEBI:2890;   CHEBI:40705;   CHEBI:71414
 xref: Beilstein:779271;   CAS:50-78-2;   DrugBank:DB00945;   Drug_Central:74;   Gmelin:218864;   HMDB:HMDB0001879;   KEGG:C01405;   KEGG:D00109;   LINCS:LSM-5288
 xref_mesh: MESH:D001241
 xref: MetaCyc:CPD-524;   PDBeChem:AIN;   PMID:11203441;   PMID:11402787;   PMID:11597554;   PMID:11733186;   PMID:12852484;   PMID:14753751;   PMID:15542410;   PMID:15590729;   PMID:1650428;   PMID:18226435;   PMID:18335236;   PMID:18631321;   PMID:19010312;   PMID:19386367;   PMID:19706045;   PMID:21699808;   PMID:22866967;   PMID:445303;   Reaxys:779271;   Wikipedia:Aspirin
 cyclic_relationship: is_conjugate_acid_of CHEBI:13719


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acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 495
    role 495
      biological role 495
        aetiopathogenetic role 393
          teratogenic agent 52
            acetylsalicylic acid 1
              2-acetyloxy-4-pentadecylbenzoic acid 0
              Yosprala 0
              aspirin-based probe AP 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 495
    subatomic particle 495
      composite particle 495
        hadron 495
          baryon 495
            nucleon 495
              atomic nucleus 495
                atom 495
                  main group element atom 488
                    p-block element atom 488
                      carbon group element atom 477
                        carbon atom 476
                          organic molecular entity 476
                            heteroorganic entity 472
                              organochalcogen compound 426
                                organooxygen compound 424
                                  carbon oxoacid 365
                                    carboxylic acid 365
                                      aromatic carboxylic acid 19
                                        benzoic acids 16
                                          benzoic acid 2
                                            hydroxybenzoic acid 2
                                              monohydroxybenzoic acid 2
                                                salicylic acid 2
                                                  acetylsalicylic acid 1
                                                    2-acetyloxy-4-pentadecylbenzoic acid 0
                                                    Yosprala 0
                                                    aspirin-based probe AP 0
paths to the root