Actn1 (actinin, alpha 1) - Rat Genome Database

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Gene: Actn1 (actinin, alpha 1) Rattus norvegicus
Analyze
Symbol: Actn1
Name: actinin, alpha 1
RGD ID: 70907
Description: Enables cytoskeletal regulatory protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; focal adhesion assembly; and platelet formation. Located in several cellular components, including cytoskeleton; dendritic spine; and plasma membrane. Colocalizes with cortical actin cytoskeleton and stress fiber. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1); PARTICIPATES IN E-cadherin signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (R)-adrenaline; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-actinin cytoskeletal isoform; alpha-actinin-1; F-actin cross-linking protein; non-muscle alpha-actinin 1; non-muscle alpha-actinin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Actn1_v3   Actn1_v2   Actn1_v1  
Candidate Gene For: Uae22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,192,048 - 103,286,329NCBI
Celera697,355,796 - 97,450,012 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromochloroacetic acid  (EXP)
buspirone  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
isoflavones  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (EXP)
N-nitrosodimethylamine  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
prostaglandin A1  (ISO)
pyrethrins  (EXP)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
starch  (EXP)
sulindac sulfide  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
2. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA. Kremerskothen J, etal., Biochem Biophys Res Commun 2002 Jul 19;295(3):678-81.
6. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. Kremerskothen J, etal., J Neurochem. 2006 Mar;96(6):1659-66. doi: 10.1111/j.1471-4159.2006.03679.x. Epub 2006 Feb 8.
7. Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
8. Alpha-actinin associates with polycystin-2 and regulates its channel activity. Li Q, etal., Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. CLP36 and RIL recruit a-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts. Miyazaki K, etal., Exp Cell Res. 2012 Aug 15;318(14):1716-25. doi: 10.1016/j.yexcr.2012.05.006. Epub 2012 May 30.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. Nuriya M, etal., J Neurochem. 2005 Oct;95(2):544-52. doi: 10.1111/j.1471-4159.2005.03410.x.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. Ooshio T, etal., J Biol Chem 2004 Jul 23;279(30):31365-73. Epub 2004 May 12.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy. Ridinger H, etal., Exp Mol Pathol. 2009 Feb;86(1):23-31. Epub 2008 Nov 27.
21. [Organization of the activities of the medical-sanitary battalion] Sherniakov MA Voen Med Zh 1978 Nov;(11):20-2.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
24. The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin. Vallenius T, etal., Exp Cell Res 2004 Feb 1;293(1):117-28.
25. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:7750553   PMID:7983147   PMID:11223950   PMID:11274145   PMID:11732910   PMID:12493766   PMID:12837758   PMID:15465019   PMID:15665106   PMID:15988023   PMID:16025302   PMID:16043482  
PMID:16170337   PMID:16502470   PMID:16807302   PMID:16820411   PMID:17298598   PMID:17311919   PMID:17854826   PMID:17944866   PMID:18332105   PMID:18519573   PMID:19056867   PMID:19160484  
PMID:19199708   PMID:19943616   PMID:20124353   PMID:20215401   PMID:20368620   PMID:21266579   PMID:21362503   PMID:21423176   PMID:21784188   PMID:22114352   PMID:22351778   PMID:22772996  
PMID:22871113   PMID:23434115   PMID:23533145   PMID:23890175   PMID:24069336   PMID:24364879   PMID:24625528   PMID:24780915   PMID:25931508   PMID:26316108   PMID:29429936   PMID:29476059  
PMID:30039887   PMID:35352799  


Genomics

Comparative Map Data
Actn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,192,048 - 103,286,329NCBI
Celera697,355,796 - 97,450,012 (-)NCBICelera
Cytogenetic Map6q24NCBI
ACTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,874,128 - 68,979,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,874,128 - 68,979,440 (-)EnsemblGRCh38hg38GRCh38
GRCh371469,340,845 - 69,446,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,410,793 - 68,515,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 341468,410,792 - 68,515,709NCBI
Celera1449,401,716 - 49,506,993 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,510,917 - 49,616,121 (-)NCBIHuRef
CHM1_11469,279,215 - 69,384,488 (-)NCBICHM1_1
T2T-CHM13v2.01463,083,135 - 63,188,360 (-)NCBIT2T-CHM13v2.0
Actn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,214,316 - 80,307,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)EnsemblGRCm39 Ensembl
GRCm381280,167,542 - 80,260,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,268,529 - 81,361,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,086,387 - 81,179,156 (-)NCBIMGSCv36mm8
Celera1281,632,311 - 81,725,181 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.49NCBI
Actn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,388,507 - 1,480,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,388,507 - 1,480,990 (+)NCBIChiLan1.0ChiLan1.0
ACTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,460,390 - 49,565,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,335,694 - 68,440,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)Ensemblpanpan1.1panPan2
ACTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,714,806 - 42,808,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,712,142 - 42,808,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,404,474 - 42,497,710 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,945,028 - 43,038,491 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,945,037 - 43,038,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,559,338 - 42,652,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,634,268 - 42,727,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,993,500 - 43,086,762 (-)NCBIUU_Cfam_GSD_1.0
Actn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,974,520 - 62,067,210 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,124,443 - 12,217,242 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,124,489 - 12,217,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,550,007 - 92,644,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,550,132 - 92,644,842 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,863,871 - 98,874,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,089,989 - 46,196,897 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,085,751 - 46,196,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,323,625 - 34,430,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,097,671 - 32,192,729 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473432,097,364 - 32,190,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actn1
517 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000068522
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

Markers in Region
C77473  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,998,858 - 98,998,992 (+)MAPPERmRatBN7.2
Rnor_6.06103,376,175 - 103,376,308NCBIRnor6.0
Rnor_5.06116,055,867 - 116,055,999UniSTSRnor5.0
RGSC_v3.46103,188,211 - 103,188,344UniSTSRGSC3.4
Celera697,355,417 - 97,355,550UniSTS
Cytogenetic Map6q24UniSTS
RH142024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,000,729 - 99,000,918 (+)MAPPERmRatBN7.2
Rnor_6.06103,378,046 - 103,378,234NCBIRnor6.0
Rnor_5.06116,057,737 - 116,057,925UniSTSRnor5.0
RGSC_v3.46103,190,082 - 103,190,270UniSTSRGSC3.4
Celera697,357,285 - 97,357,473UniSTS
RH 3.4 Map6692.1UniSTS
Cytogenetic Map6q24UniSTS
BE119221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,091,243 - 99,091,419 (+)MAPPERmRatBN7.2
Rnor_6.06103,468,554 - 103,468,729NCBIRnor6.0
Rnor_5.06116,147,528 - 116,147,703UniSTSRnor5.0
RGSC_v3.46103,280,930 - 103,281,105UniSTSRGSC3.4
Celera697,448,069 - 97,448,244UniSTS
RH 3.4 Map6690.0UniSTS
Cytogenetic Map6q24UniSTS
BE098731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,094,236 - 99,094,390 (+)MAPPERmRatBN7.2
Rnor_6.06103,471,547 - 103,471,700NCBIRnor6.0
Rnor_5.06116,150,521 - 116,150,674UniSTSRnor5.0
RGSC_v3.46103,283,923 - 103,284,076UniSTSRGSC3.4
Celera697,451,062 - 97,451,215UniSTS
RH 3.4 Map6711.3UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 45 30 19 30 74 33 33 11
Low 11 12 11 11 8 11 2 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079824   ⟹   ENSRNOP00000074946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,998,559 - 99,093,245 (-)Ensembl
Rnor_6.0 Ensembl6103,375,873 - 103,470,555 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088795   ⟹   ENSRNOP00000069598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,998,751 - 99,093,251 (-)Ensembl
Rnor_6.0 Ensembl6103,376,557 - 103,470,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091560   ⟹   ENSRNOP00000068851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,998,556 - 99,093,031 (-)Ensembl
Rnor_6.0 Ensembl6103,375,799 - 103,470,427 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110416   ⟹   ENSRNOP00000097894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,998,556 - 99,092,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111498   ⟹   ENSRNOP00000087449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl699,000,287 - 99,092,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112260   ⟹   ENSRNOP00000085943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,998,556 - 99,036,899 (-)Ensembl
RefSeq Acc Id: NM_031005   ⟹   NP_112267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,485 - 104,826,172 (-)NCBI
mRatBN7.2698,998,553 - 99,093,245 (-)NCBI
Rnor_6.06103,376,557 - 103,470,497 (-)NCBI
Rnor_5.06116,056,248 - 116,149,471 (-)NCBI
RGSC_v3.46103,188,593 - 103,282,873 (-)RGD
Celera697,355,796 - 97,450,012 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112992   ⟹   XP_038968920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,826,222 (-)NCBI
mRatBN7.2698,998,556 - 99,093,334 (-)NCBI
RefSeq Acc Id: XM_039112993   ⟹   XP_038968921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,826,312 (-)NCBI
mRatBN7.2698,998,556 - 99,093,332 (-)NCBI
RefSeq Acc Id: XM_063262548   ⟹   XP_063118618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,825,744 (-)NCBI
RefSeq Acc Id: XM_063262549   ⟹   XP_063118619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,825,754 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112267   ⟸   NM_031005
- UniProtKB: Q9Z1P2 (UniProtKB/Swiss-Prot),   A0A8I6AV34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074946   ⟸   ENSRNOT00000079824
RefSeq Acc Id: ENSRNOP00000068851   ⟸   ENSRNOT00000091560
RefSeq Acc Id: ENSRNOP00000069598   ⟸   ENSRNOT00000088795
RefSeq Acc Id: XP_038968920   ⟸   XM_039112992
- Peptide Label: isoform X1
- UniProtKB: Q6T487 (UniProtKB/TrEMBL),   A0A8I6AV34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968921   ⟸   XM_039112993
- Peptide Label: isoform X2
- UniProtKB: Q6GMN8 (UniProtKB/TrEMBL),   A0A8I6AV34 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085943   ⟸   ENSRNOT00000112260
RefSeq Acc Id: ENSRNOP00000087449   ⟸   ENSRNOT00000111498
RefSeq Acc Id: ENSRNOP00000097894   ⟸   ENSRNOT00000110416
RefSeq Acc Id: XP_063118619   ⟸   XM_063262549
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063118618   ⟸   XM_063262548
- Peptide Label: isoform X3
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1P2-F1-model_v2 AlphaFold Q9Z1P2 1-892 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694699
Promoter ID:EPDNEW_R5221
Type:initiation region
Name:Actn1_1
Description:actinin, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06103,470,564 - 103,470,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70907 AgrOrtholog
BioCyc Gene G2FUF-36940 BioCyc
Ensembl Genes ENSRNOG00000056756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019526 UniProtKB/Swiss-Prot
  ENSRNOG00060022661 UniProtKB/Swiss-Prot
  ENSRNOG00065018793 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079824.2 UniProtKB/TrEMBL
  ENSRNOT00000088795.2 UniProtKB/TrEMBL
  ENSRNOT00000091560 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000091560.2 UniProtKB/Swiss-Prot
  ENSRNOT00000110416.1 UniProtKB/TrEMBL
  ENSRNOT00000111498.1 UniProtKB/TrEMBL
  ENSRNOT00000112260.1 UniProtKB/TrEMBL
  ENSRNOT00055033944 UniProtKB/Swiss-Prot
  ENSRNOT00060043134 UniProtKB/Swiss-Prot
  ENSRNOT00065032631 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099133 IMAGE-MGC_LOAD
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81634 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91658 IMAGE-MGC_LOAD
NCBI Gene 81634 ENTREZGENE
PANTHER ALPHA-ACTININ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actn1 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056756 RatGTEx
  ENSRNOG00055019526 RatGTEx
  ENSRNOG00060022661 RatGTEx
  ENSRNOG00065018793 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A472_RAT UniProtKB/TrEMBL
  A0A8I6AV34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GDI3_RAT UniProtKB/TrEMBL
  ACTN1_RAT UniProtKB/Swiss-Prot
  Q6GMN8 ENTREZGENE, UniProtKB/TrEMBL
  Q6T487 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1P2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Actn1  actinin, alpha 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has an N-terminal region containing two actin-binding motifs, a central four spectrin-like domain with the dimer forming sequence and a C-terminal domain with two EF hand motifs 625419
gene_expression expressed in the adult brain, with highest in neurons of the hippocampus, cortex, and caudate putamen while the cerebellum and other subcortical structures showed low expression 625419
gene_expression expressed in the adult rat brain 625419