Actn1 (actinin, alpha 1) - Rat Genome Database

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Gene: Actn1 (actinin, alpha 1) Mus musculus
Analyze
Symbol: Actn1
Name: actinin, alpha 1
RGD ID: 736412
MGI Page MGI
Description: Enables cytoskeletal protein binding activity; integrin binding activity; and protein homodimerization activity. Involved in actin filament bundle assembly. Located in several cellular components, including Z disc; fascia adherens; and ruffle. Colocalizes with stress fiber. Is expressed in brain; heart; heart ventricle; and testis. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3110023F10Rik; Actn1a; alpha actinin 1a; alpha-actinin cytoskeletal isoform; alpha-actinin-1; F-actin cross-linking protein; non-muscle alpha-actinin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,214,316 - 80,307,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)EnsemblGRCm39 Ensembl
GRCm381280,167,542 - 80,260,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,268,529 - 81,361,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,086,387 - 81,179,156 (-)NCBIMGSCv36mm8
Celera1281,632,311 - 81,725,181 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-nitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (ISO)
buspirone  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosic acid  (EXP)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP)
fenamidone  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (ISO)
metformin  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (ISO)
N-nitrosodimethylamine  (ISO)
ochratoxin A  (ISO)
oxycodone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prostaglandin A1  (EXP)
pyrethrins  (ISO)
quercitrin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
starch  (ISO)
sulindac sulfide  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Koh TJ and Escobedo J, Am J Physiol Cell Physiol 2004 Mar;286(3):C713-22. Epub 2003 Nov 19.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Pashmforoush M, etal., Nat Med 2001 May;7(5):591-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10833443   PMID:10922068   PMID:10926853   PMID:11042159   PMID:11076861   PMID:11114196   PMID:11223950   PMID:11440986   PMID:11732910   PMID:12223541  
PMID:12477932   PMID:12520002   PMID:12782671   PMID:12837758   PMID:14610273   PMID:15465019   PMID:15489334   PMID:15608679   PMID:15665106   PMID:15721864   PMID:15782199   PMID:15841212  
PMID:16043482   PMID:16141072   PMID:16141073   PMID:16196101   PMID:16407299   PMID:16501493   PMID:16751418   PMID:16973135   PMID:17194709   PMID:17258700   PMID:17298598   PMID:17311919  
PMID:17967808   PMID:18292603   PMID:18332105   PMID:18425115   PMID:18799693   PMID:19091974   PMID:19411759   PMID:19793892   PMID:20215401   PMID:20368620   PMID:20697350   PMID:20886612  
PMID:21266579   PMID:21565611   PMID:21653829   PMID:21677750   PMID:21784188   PMID:21873635   PMID:22114352   PMID:22398722   PMID:22659138   PMID:22693585   PMID:22794259   PMID:22802532  
PMID:22927399   PMID:22940199   PMID:22956146   PMID:23047121   PMID:23145029   PMID:23515331   PMID:23557398   PMID:23575307   PMID:23664615   PMID:23890175   PMID:24355925   PMID:24364879  
PMID:24457600   PMID:24614889   PMID:24840128   PMID:24938781   PMID:25262166   PMID:26391954   PMID:26403541   PMID:26465331   PMID:26568308   PMID:27487483   PMID:28190767   PMID:28378742  
PMID:28634551   PMID:28682694   PMID:28706196   PMID:29107716   PMID:29467473   PMID:29518331   PMID:30061013   PMID:30244178   PMID:30401699   PMID:30409884   PMID:30562941   PMID:31162944  
PMID:31573406   PMID:32272490   PMID:32325033   PMID:32581705   PMID:35472321   PMID:36899856  


Genomics

Comparative Map Data
Actn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,214,316 - 80,307,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)EnsemblGRCm39 Ensembl
GRCm381280,167,542 - 80,260,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,268,529 - 81,361,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,086,387 - 81,179,156 (-)NCBIMGSCv36mm8
Celera1281,632,311 - 81,725,181 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.49NCBI
ACTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,874,128 - 68,979,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,874,128 - 68,979,440 (-)EnsemblGRCh38hg38GRCh38
GRCh371469,340,845 - 69,446,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,410,793 - 68,515,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 341468,410,792 - 68,515,709NCBI
Celera1449,401,716 - 49,506,993 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,510,917 - 49,616,121 (-)NCBIHuRef
CHM1_11469,279,215 - 69,384,488 (-)NCBICHM1_1
T2T-CHM13v2.01463,083,135 - 63,188,360 (-)NCBIT2T-CHM13v2.0
Actn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,192,048 - 103,286,329NCBI
Celera697,355,796 - 97,450,012 (-)NCBICelera
Cytogenetic Map6q24NCBI
Actn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,388,507 - 1,480,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,388,507 - 1,480,990 (+)NCBIChiLan1.0ChiLan1.0
ACTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,460,390 - 49,565,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,335,694 - 68,440,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)Ensemblpanpan1.1panPan2
ACTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,714,806 - 42,808,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,712,142 - 42,808,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,404,474 - 42,497,710 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,945,028 - 43,038,491 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,945,037 - 43,038,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,559,338 - 42,652,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,634,268 - 42,727,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,993,500 - 43,086,762 (-)NCBIUU_Cfam_GSD_1.0
Actn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,974,520 - 62,067,210 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,124,443 - 12,217,242 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,124,489 - 12,217,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,550,007 - 92,644,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,550,132 - 92,644,842 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,863,871 - 98,874,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,089,989 - 46,196,897 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,085,751 - 46,196,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,323,625 - 34,430,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,097,671 - 32,192,729 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473432,097,364 - 32,190,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actn1
3057 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:530
Count of miRNA genes:337
Interacting mature miRNAs:374
Transcripts:ENSMUST00000021554, ENSMUST00000167327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301868Fbgl1_mfasting blood glucose 1 (mouse)Not determined127904016483162211Mouse

Markers in Region
C77473  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381280,167,843 - 80,167,976UniSTSGRCm38
MGSCv371281,268,830 - 81,268,963UniSTSGRCm37
Celera1281,632,612 - 81,632,745UniSTS
Cytogenetic Map12C3UniSTS
cM Map1235.0UniSTS
Whitehead/MRC_RH12741.87UniSTS
RH125310  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381280,238,725 - 80,238,841UniSTSGRCm38
MGSCv371281,339,712 - 81,339,828UniSTSGRCm37
Celera1281,703,530 - 81,703,646UniSTS
Cytogenetic Map12C3UniSTS
cM Map1235.0UniSTS
UniSTS:236891  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381280,183,243 - 80,183,338UniSTSGRCm38
MGSCv371281,284,230 - 81,284,325UniSTSGRCm37
Celera1281,648,061 - 81,648,156UniSTS
Cytogenetic Map12C3UniSTS
cM Map1235.0UniSTS
Actn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C3UniSTS
cM Map1235.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001346669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ288940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021554   ⟹   ENSMUSP00000021554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)Ensembl
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167327   ⟹   ENSMUSP00000127176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,215,096 - 80,306,865 (-)Ensembl
GRCm38.p6 Ensembl1280,168,322 - 80,260,091 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,229,991 - 80,231,622 (-)Ensembl
GRCm38.p6 Ensembl1280,183,217 - 80,184,848 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,230,240 - 80,306,664 (-)Ensembl
GRCm38.p6 Ensembl1280,183,466 - 80,259,890 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,215,139 - 80,216,925 (-)Ensembl
GRCm38.p6 Ensembl1280,168,365 - 80,170,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219634
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,214,877 - 80,218,918 (-)Ensembl
GRCm38.p6 Ensembl1280,168,103 - 80,172,144 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1280,243,723 - 80,305,558 (-)Ensembl
GRCm38.p6 Ensembl1280,196,949 - 80,258,784 (-)Ensembl
RefSeq Acc Id: NM_001346669   ⟹   NP_001333598
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,137 (-)NCBI
GRCm381280,167,542 - 80,260,363 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001379075   ⟹   NP_001366004
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,137 (-)NCBI
GRCm381280,167,542 - 80,260,363 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001379076   ⟹   NP_001366005
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,137 (-)NCBI
GRCm381280,167,542 - 80,260,363 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134156   ⟹   NP_598917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,137 (-)NCBI
GRCm381280,167,542 - 80,260,363 (-)NCBI
MGSCv371281,268,529 - 81,361,358 (-)RGD
Celera1281,632,311 - 81,725,181 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515389   ⟹   XP_006515452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,305,549 (-)NCBI
GRCm381280,167,542 - 80,258,744 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246514   ⟹   XP_030102374
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,165 (-)NCBI
GRCm381280,167,542 - 80,260,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157160   ⟹   XP_036013053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,306,659 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157161   ⟹   XP_036013054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391280,214,316 - 80,307,141 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598917   ⟸   NM_134156
- Peptide Label: isoform 1
- UniProtKB: Q7TPR4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006515452   ⟸   XM_006515389
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030102374   ⟸   XM_030246514
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001333598   ⟸   NM_001346669
- Peptide Label: isoform 2
- UniProtKB: A1BN54 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001366004   ⟸   NM_001379075
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001366005   ⟸   NM_001379076
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000127176   ⟸   ENSMUST00000167327
RefSeq Acc Id: ENSMUSP00000021554   ⟸   ENSMUST00000021554
RefSeq Acc Id: XP_036013054   ⟸   XM_036157161
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036013053   ⟸   XM_036157160
- Peptide Label: isoform X1
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPR4-F1-model_v2 AlphaFold Q7TPR4 1-892 view protein structure

Promoters
RGD ID:8678654
Promoter ID:EPDNEW_M17358
Type:initiation region
Name:Actn1_2
Description:Mus musculus actinin, alpha 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17359  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381280,260,157 - 80,260,217EPDNEW
RGD ID:8678656
Promoter ID:EPDNEW_M17359
Type:initiation region
Name:Actn1_1
Description:Mus musculus actinin, alpha 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17358  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381280,260,363 - 80,260,423EPDNEW
RGD ID:6846949
Promoter ID:MM_ACW:11249
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Lung
Transcripts:ACTN1.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361281,270,126 - 81,272,032 (-)MPROMDB
RGD ID:6822655
Promoter ID:MM_KWN:12052
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC007OAO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361281,272,856 - 81,274,122 (-)MPROMDB
RGD ID:6846974
Promoter ID:MM_ACW:11254
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:ACTN1.HSEP07,   MOYPOY.ASEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361281,359,656 - 81,360,742 (-)MPROMDB
RGD ID:6822657
Promoter ID:MM_KWN:12054
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_134156,   UC007OAQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361281,360,911 - 81,361,732 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2137706 AgrOrtholog
Ensembl Genes ENSMUSG00000015143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021554 ENTREZGENE
  ENSMUST00000021554.16 UniProtKB/Swiss-Prot
  ENSMUST00000167327 ENTREZGENE
  ENSMUST00000167327.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:109711 UniProtKB/Swiss-Prot
MGD MGI:2137706 ENTREZGENE
NCBI Gene 109711 ENTREZGENE
PANTHER ALPHA-ACTININ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_6 UniProtKB/Swiss-Prot
  EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actn1 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1BN54 ENTREZGENE, UniProtKB/TrEMBL
  ACTN1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99LJ3_MOUSE UniProtKB/TrEMBL