Git1 (GIT ArfGAP 1) - Rat Genome Database

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Gene: Git1 (GIT ArfGAP 1) Rattus norvegicus
Analyze
Symbol: Git1
Name: GIT ArfGAP 1
RGD ID: 69331
Description: Enables several functions, including GTPase activator activity; enzyme binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including excitatory synapse; growth cone; and inhibitory synapse. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GRK-interactor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,840,165 - 62,854,508 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1062,840,394 - 62,854,508 (+)EnsemblGRCr8
mRatBN7.21062,342,082 - 62,356,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1066,992,057 - 67,006,179 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,497,543 - 66,511,665 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,970,798 - 61,984,917 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,656,000 - 62,664,467 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)Ensemblrn6Rnor6.0
Rnor_5.01062,352,883 - 62,362,201 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41066,610,282 - 66,618,919 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1061,351,008 - 61,359,475 (+)NCBICelera
RGSC_v3.11066,623,904 - 66,632,546 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
calyx of Held  (IEA,ISO)
centrosome  (IEA,ISO,ISS)
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO,TAS)
dendrite  (IDA)
distal axon  (IEA)
endosome  (IDA)
excitatory synapse  (IDA)
focal adhesion  (IEA,ISO,TAS)
GABA-ergic synapse  (IDA,IMP)
glutamatergic synapse  (IDA)
growth cone  (IDA)
inhibitory synapse  (IDA)
lamellipodium  (IEA)
mitotic spindle pole  (IEA,ISO,ISS)
neuron projection  (IBA)
postsynapse  (IBA,IDA,IEA,ISO,ISS)
postsynaptic density  (IDA,IEA)
presynapse  (IEA,ISO)
presynaptic active zone  (IDA)
protein-containing complex  (IDA)
spindle pole  (IEA)
synapse  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. Cavet ME, etal., FASEB J. 2008 Oct;22(10):3607-16. doi: 10.1096/fj.07-094086. Epub 2008 Jun 3.
2. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Goehler H, etal., Mol Cell 2004 Sep 24;15(6):853-65.
6. N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Hua KT, etal., Cancer Cell. 2011 Feb 15;19(2):218-31. doi: 10.1016/j.ccr.2010.11.010. Epub 2011 Feb 3.
7. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
8. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
9. Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. Meyer MZ, etal., J Biol Chem. 2006 Mar 24;281(12):7919-26. Epub 2006 Jan 26.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Premont RT, etal., Cell Signal 2004 Sep;16(9):1001-11.
15. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Premont RT, etal., Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14082-7.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, etal., Nat Neurosci. 2007 Mar;10(3):301-10. Epub 2007 Feb 18.
19. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Smith KR, etal., Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Won H, etal., Nat Med. 2011 May;17(5):566-72. doi: 10.1038/nm.2330. Epub 2011 Apr 17.
Additional References at PubMed
PMID:10938112   PMID:12153727   PMID:12695502   PMID:14523024   PMID:18292392   PMID:19136011   PMID:19912111   PMID:19946888   PMID:20689073   PMID:21423176   PMID:22294688   PMID:22797318  
PMID:23108400   PMID:23352984   PMID:24764294   PMID:25017023   PMID:25175053   PMID:25715677   PMID:26637799   PMID:28131823   PMID:29191942   PMID:30053369   PMID:32223487   PMID:34002676  
PMID:34154701   PMID:36044673  


Genomics

Comparative Map Data
Git1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,840,165 - 62,854,508 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1062,840,394 - 62,854,508 (+)EnsemblGRCr8
mRatBN7.21062,342,082 - 62,356,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1066,992,057 - 67,006,179 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,497,543 - 66,511,665 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,970,798 - 61,984,917 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,656,000 - 62,664,467 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)Ensemblrn6Rnor6.0
Rnor_5.01062,352,883 - 62,362,201 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41066,610,282 - 66,618,919 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1061,351,008 - 61,359,475 (+)NCBICelera
RGSC_v3.11066,623,904 - 66,632,546 (-)NCBI
Cytogenetic Map10q24NCBI
GIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381729,573,475 - 29,589,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1729,573,475 - 29,594,054 (-)Ensemblhg38GRCh38
GRCh371727,900,493 - 27,916,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,924,613 - 24,940,736 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341724,924,619 - 24,940,735NCBI
Celera1724,761,352 - 24,777,476 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1724,109,826 - 24,125,786 (-)NCBIHuRef
CHM1_11727,963,149 - 27,983,295 (-)NCBICHM1_1
T2T-CHM13v2.01730,516,351 - 30,532,526 (-)NCBIT2T-CHM13v2.0
Git1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,384,114 - 77,398,600 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,384,388 - 77,398,612 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381177,493,288 - 77,507,774 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,493,562 - 77,507,786 (+)Ensemblmm10GRCm38
MGSCv371177,306,914 - 77,321,276 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361177,309,607 - 77,323,969 (+)NCBIMGSCv36mm8
Celera1184,991,973 - 85,006,335 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.61NCBI
Git1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554813,670,111 - 3,685,051 (+)Ensembl
ChiLan1.0NW_0049554813,671,728 - 3,681,279 (+)NCBIChiLan1.0ChiLan1.0
GIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21934,866,807 - 34,882,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11736,748,981 - 36,765,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01727,185,025 - 27,201,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11727,707,452 - 27,717,857 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1727,706,776 - 27,717,857 (+)EnsemblpanPan2panpan1.1
GIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,676,707 - 43,686,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,677,899 - 43,693,177 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha942,829,811 - 42,846,296 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0944,492,902 - 44,509,385 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl944,492,901 - 44,508,582 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1943,277,271 - 43,293,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0943,567,974 - 43,584,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0943,648,051 - 43,664,538 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Git1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,806,717 - 42,827,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365385,684,644 - 5,695,043 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365385,684,660 - 5,694,779 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,768,176 - 45,783,658 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11245,768,172 - 45,783,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,719,221 - 47,730,533 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11623,313,629 - 23,329,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1623,315,439 - 23,329,469 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660756,742,731 - 6,758,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Git1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247862,071,382 - 2,086,910 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247862,071,376 - 2,086,929 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Git1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1996,161,073 - 96,178,792 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Git1
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:155
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000056112
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106174653268282731Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106184363367241334Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,356,158 - 62,356,348 (-)MAPPERmRatBN7.2
Rnor_6.01062,655,702 - 62,655,891NCBIRnor6.0
Rnor_5.01062,352,585 - 62,352,774UniSTSRnor5.0
RGSC_v3.41066,609,984 - 66,610,173UniSTSRGSC3.4
Celera1061,359,584 - 61,359,773UniSTS
Cytogenetic Map10q26UniSTS
GIT1_9564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,355,753 - 62,356,330 (-)MAPPERmRatBN7.2
Rnor_6.01062,655,720 - 62,656,296NCBIRnor6.0
Rnor_5.01062,352,603 - 62,353,179UniSTSRnor5.0
RGSC_v3.41066,610,002 - 66,610,578UniSTSRGSC3.4
Celera1061,359,179 - 61,359,755UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078730   ⟹   ENSRNOP00000073267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,840,394 - 62,854,508 (+)Ensembl
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)Ensembl
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101598   ⟹   ENSRNOP00000090288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,840,394 - 62,854,508 (+)Ensembl
mRatBN7.2 Ensembl1062,345,194 - 62,356,050 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114941   ⟹   ENSRNOP00000091910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,345,194 - 62,356,050 (+)Ensembl
RefSeq Acc Id: NM_031814   ⟹   NP_114002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,840,394 - 62,854,508 (+)NCBI
mRatBN7.21062,342,265 - 62,356,379 (+)NCBI
Rnor_6.01062,656,000 - 62,664,467 (-)NCBI
Rnor_5.01062,352,883 - 62,362,201 (-)NCBI
RGSC_v3.41066,610,282 - 66,618,919 (-)RGD
Celera1061,351,008 - 61,359,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086946   ⟹   XP_038942874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,840,165 - 62,854,462 (+)NCBI
mRatBN7.21062,342,082 - 62,356,379 (+)NCBI
RefSeq Acc Id: XM_039086947   ⟹   XP_038942875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,840,165 - 62,854,462 (+)NCBI
mRatBN7.21062,342,083 - 62,356,379 (+)NCBI
RefSeq Acc Id: XM_063269971   ⟹   XP_063126041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,840,165 - 62,854,462 (+)NCBI
RefSeq Acc Id: NP_114002   ⟸   NM_031814
- UniProtKB: Q9Z272 (UniProtKB/Swiss-Prot),   A0A8I6AGH2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073267   ⟸   ENSRNOT00000078730
RefSeq Acc Id: XP_038942874   ⟸   XM_039086946
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942875   ⟸   XM_039086947
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGH2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090288   ⟸   ENSRNOT00000101598
Ensembl Acc Id: ENSRNOP00000091910   ⟸   ENSRNOT00000114941
RefSeq Acc Id: XP_063126041   ⟸   XM_063269971
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGH2 (UniProtKB/TrEMBL)
Protein Domains
Arf-GAP   GIT Spa2 homology (SHD)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z272-F1-model_v2 AlphaFold Q9Z272 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697428
Promoter ID:EPDNEW_R7952
Type:single initiation site
Name:Git1_1
Description:GIT ArfGAP 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01062,664,455 - 62,664,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69331 AgrOrtholog
BioCyc Gene G2FUF-24125 BioCyc
Ensembl Genes ENSRNOG00000061270 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078730 ENTREZGENE
  ENSRNOT00000101598 ENTREZGENE
Gene3D-CATH 1.10.220.150 UniProtKB/Swiss-Prot
  1.20.5.170 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
  Nucleotidyltransferases domain 2 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  ARFGAP/RecO UniProtKB/Swiss-Prot
  ArfGAP_dom UniProtKB/Swiss-Prot
  ArfGAP_dom_sf UniProtKB/Swiss-Prot
  GIT-like UniProtKB/Swiss-Prot
  GIT1/2_CC UniProtKB/Swiss-Prot
  GIT1_C UniProtKB/Swiss-Prot
  GIT_SHD UniProtKB/Swiss-Prot
KEGG Report rno:83709 UniProtKB/Swiss-Prot
NCBI Gene 83709 ENTREZGENE
PANTHER ARF GTPASE-ACTIVATING PROTEIN GIT1 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  ArfGap UniProtKB/Swiss-Prot
  GIT1_C UniProtKB/Swiss-Prot
  GIT_CC UniProtKB/Swiss-Prot
  GIT_SHD UniProtKB/Swiss-Prot
PhenoGen Git1 PhenoGen
PRINTS REVINTRACTNG UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  ARFGAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061270 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  ArfGap UniProtKB/Swiss-Prot
  GIT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF57863 UniProtKB/Swiss-Prot
TIGR TC204831
UniProt A0A0G2K527_RAT UniProtKB/TrEMBL
  A0A8I6AGH2 ENTREZGENE
  A0A8I6GI27_RAT UniProtKB/TrEMBL
  A6HGY0_RAT UniProtKB/TrEMBL
  A6HGY1_RAT UniProtKB/TrEMBL
  A6HGY2_RAT UniProtKB/TrEMBL
  GIT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Git1  GIT ArfGAP 1  Git1  G protein-coupled receptor kinase interacting ArfGAP 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Git1  G protein-coupled receptor kinase interacting ArfGAP 1  Git1  G protein-coupled receptor kinase interactor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Git1  G protein-coupled receptor kinase interactor 1    G protein-coupled receptor kinase-interactor 1  Name updated 1299863 APPROVED
2002-06-10 Git1  G protein-coupled receptor kinase-interactor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process GTPase-activating protein (GAP) for the ADP ribosylation factor (ARF) family of small GTP-binding proteins 68782
gene_product member of G protein-coupled receptor kinase-interacting protein 68782