Por (cytochrome p450 oxidoreductase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Por (cytochrome p450 oxidoreductase) Rattus norvegicus
Analyze
Symbol: Por
Name: cytochrome p450 oxidoreductase
RGD ID: 68335
Description: Enables several functions, including iron-cytochrome-c reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; nitric oxide catabolic process; and oxoacid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CPR; CYPOR; cytochrome P450 reductase; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,587,674 - 26,655,612 (-)NCBIGRCr8
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Celera1222,713,689 - 22,732,174 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatcongenital adrenal hyperplasia  ISOPOR (Homo sapiens)4889128DNA:missense mutations:cds:p.A287P and p.H628P (human)RGD 
PorRatHypotension  IEP 1625563mRNA:increased expression:kidney (rat)RGD 
PorRatMusculoskeletal Abnormalities  ISOPOR (Homo sapiens)1599697Antley-Bixler syndrome more ...RGD 
PorRatneural tube defect  ISOPor (Mus musculus)4889811 RGD 
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRat46, XY Disorders of Sex Development  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: 46 and XY disorder of sex developmentClinVar 
PorRatAntley-Bixler syndrome  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: POR DeficiencyClinVarPMID:12116245 more ...
PorRatAntley-Bixler syndrome with disordered steroidogenesis  ISOPOR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12116245 more ...
PorRatChromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: DISTAL CHROMOSOME 7q11.23 DELETION SYNDROMEClinVar 
PorRatcongenital adrenal hyperplasia  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital adrenal hyperplasiaClinVarPMID:14758361 more ...
PorRatCongenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiencyClinVarPMID:21070833 more ...
PorRatcytochrome P450 oxidoreductase deficiency  ISOPOR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12116245 more ...
PorRatdisorder of sexual development  ISOPOR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
PorRatFine-Lubinsky Syndrome  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Fine-Lubinsky syndromeClinVarPMID:22162478 and PMID:25741868
PorRatgenetic disease  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
PorRatHirschsprung's disease  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Aganglionic megacolonClinVar 
PorRatpleomorphic xanthoastrocytoma  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
PorRatprimary ovarian insufficiency  ISOPOR (Homo sapiens)8554872ClinVar Annotator: match by term: Premature ovarian failureClinVarPMID:25741868
1 to 13 of 13 rows
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatamenorrhea  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14758361
PorRatAntley-Bixler syndrome  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14758361 more ...
PorRatcongenital adrenal hyperplasia  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18559916
PorRatcongestive heart failure  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
PorRatgliosarcoma  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9766669
PorRatlearning disability  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21987461
PorRatLung Injury  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:33033841
PorRatNeoplastic Cell Transformation  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15089088
PorRaturinary bladder cancer  ISOPOR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8631603
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatAntley-Bixler syndrome with disordered steroidogenesis  ISOPOR (Homo sapiens)7240710 OMIM 
PorRatcytochrome P450 oxidoreductase deficiency  ISOPOR (Homo sapiens)7240710 OMIM 

1 to 20 of 513 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRat(-)-epigallocatechin 3-gallate increases activityISOPOR (Homo sapiens)6480464epigallocatechin gallate results in increased activity of POR proteinCTDPMID:15998352
PorRat(1->4)-beta-D-glucan multiple interactionsISOPor (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of POR mRNACTDPMID:36331819
PorRat(2,4,5-trichlorophenoxy)acetic acid decreases expressionISOPor (Mus musculus)64804642 more ...CTDPMID:18579281
PorRat(R)-lipoic acid multiple interactionsISOPor (Mus musculus)6480464[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] more ...CTDPMID:21932800
PorRat(R)-lipoic acid multiple interactionsISOPOR (Homo sapiens)6480464Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]CTDPMID:24120545
PorRat(R)-lipoic acid decreases activityISOPOR (Homo sapiens)6480464Thioctic Acid results in decreased activity of POR proteinCTDPMID:16391466
PorRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of POR mRNACTDPMID:17984292
PorRat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of POR proteinCTDPMID:17337753
PorRat1,2-dimethylhydrazine increases activityEXP 64804641 and 2-Dimethylhydrazine results in increased activity of POR proteinCTDPMID:19497424 and PMID:29108773
PorRat1,2-dimethylhydrazine multiple interactionsISOPor (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of POR mRNACTDPMID:22206623
PorRat1,2-dimethylhydrazine decreases expressionISOPor (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of POR mRNACTDPMID:22206623
PorRat1,2-dimethylhydrazine multiple interactionsEXP 6480464asiatic acid inhibits the reaction [1 more ...CTDPMID:19497424 and PMID:29108773
PorRat1,3-Dinitropyrene multiple interactionsISOPOR (Homo sapiens)6480464[CYP1A1 protein co-treated with POR protein] results in decreased metabolism of 1 more ...CTDPMID:11113705
PorRat1,8-Dinitropyrene multiple interactionsISOPOR (Homo sapiens)6480464[CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1 more ...CTDPMID:11113705
PorRat17alpha-ethynylestradiol multiple interactionsISOPor (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POR mRNACTDPMID:17942748
PorRat17alpha-ethynylestradiol increases expressionISOPor (Mus musculus)6480464Ethinyl Estradiol results in increased expression of POR mRNACTDPMID:17942748
PorRat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of POR mRNACTDPMID:32145629
PorRat17beta-estradiol 3-benzoate decreases expressionEXP 6480464estradiol 3-benzoate results in decreased expression of POR proteinCTDPMID:24752506
PorRat2,2',3,3',6,6'-hexachlorobiphenyl affects metabolic processingISOPor (Mus musculus)6480464POR protein affects the metabolism of 2 more ...CTDPMID:30729780
PorRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOPor (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925

1 to 20 of 513 rows

Biological Process
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatcarnitine metabolic process  IEP 4889829 RGD 
PorRatcellular response to follicle-stimulating hormone stimulus  IEP 2316787 RGD 
PorRatcellular response to gonadotropin stimulus  IEP 2316787 RGD 
PorRatcellular response to peptide hormone stimulus  IEP 2316787 RGD 
PorRatdemethylation  IDA 4889812positive regulation of N-demethylation by cytochrome P450 2B4RGD 
PorRatelectron transport chain involved_inIEAUniProtKB:P16435 and ensembl:ENSP000004199701600115GO_REF:0000107EnsemblGO_REF:0000107
PorRatelectron transport chain involved_inISOPOR (Homo sapiens)1624291 PMID:10048323 and PMID:2513880RGDPMID:10048323 and PMID:2513880
PorRatfatty acid oxidation  IDA 4889827 RGD 
PorRatflavonoid metabolic process  IEP 4889813anthocyaninRGD 
PorRatinternal peptidyl-lysine acetylation  IDA 4889819negative regulation of heme oxygenase-1 acetylationRGD 
PorRatnegative regulation of apoptotic process  IMP 2316785chondrocytesRGD 
PorRatnegative regulation of lipase activity  IDA 4889814phospholipase DRGD 
PorRatnitrate catabolic process  IDA 4889831 RGD 
PorRatnitric oxide biosynthetic process involved_inIBAFB:FBgn0011676 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PorRatnitric oxide catabolic process  IDA 2316786 RGD 
PorRatnitric oxide catabolic process  IMP 2316786 RGD 
PorRatorganofluorine metabolic process involved_inIEAUniProtKB:P16435 and ensembl:ENSP000004199701600115GO_REF:0000107EnsemblGO_REF:0000107
PorRatorganofluorine metabolic process involved_inISOPOR (Homo sapiens)1624291 PMID:19448135RGDPMID:19448135
PorRatpositive regulation of chondrocyte differentiation  IMP 2316785 RGD 
PorRatpositive regulation of growth plate cartilage chondrocyte proliferation  IMP 2316785positive regulationRGD 
1 to 20 of 27 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatcytosol is_active_inIBAPANTHER:PTN000453956 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PorRatendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
PorRatintracellular membrane-bounded organelle located_inISOPOR (Homo sapiens)1624291 PMID:9618440RGDPMID:9618440

Molecular Function
1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatcytochrome-b5 reductase activity, acting on NAD(P)H  IDA 4889840 RGD 
PorRatelectron transfer activity  IDA 4889812 RGD 
PorRatenzyme binding  IPICYP2C9 (Homo sapiens)4889826 RGD 
PorRatenzyme binding  IPICyp1a1 (Rattus norvegicus)2306635 RGD 
PorRatenzyme binding enablesIPIUniProtKB:P051818553304PMID:15680923BHF-UCL 
PorRatenzyme binding enablesIPIUniProtKB:P332618553304PMID:15680923BHF-UCL 
PorRatenzyme binding enablesIPIUniProtKB:P115098553304PMID:15680923BHF-UCL 
PorRatenzyme binding enablesIPIUniProtKB:P051778553304PMID:15680923BHF-UCL 
PorRatenzyme binding enablesIPIUniProtKB:P067628554849PMID:15516695BHF-UCL 
PorRatenzyme binding  IMP 1599694 RGD 
PorRatenzyme binding  IDA 1599688 RGD 
PorRatflavin adenine dinucleotide binding  IMP 1599694 RGD 
PorRatflavin adenine dinucleotide binding enablesIBAMGI:97361 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PorRatflavin adenine dinucleotide binding enablesIEAUniRule:UR0002394761600115GO_REF:0000104UniProtGO_REF:0000104
PorRatFMN binding  IMP 1599694 RGD 
PorRatFMN binding enablesIBAMGI:97361 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PorRatFMN binding enablesIEAUniRule:UR0002394761600115GO_REF:0000104UniProtGO_REF:0000104
PorRathydrolase activity  IDA 48898382-phenylpropionaldehyde deformylase activityRGD 
PorRatiron-cytochrome-c reductase activity  IDA 4889615 RGD 
PorRatNADP binding  IMP 1599694 RGD 
1 to 20 of 31 rows

RGD Manual Annotations


  

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PorRatdoxorubicin pharmacokinetics pathway   ISOPOR (Homo sapiens)10402751 SMPDBSMP:00650

1 to 20 of 41 rows
#
Reference Title
Reference Citation
1. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Aguilar A, etal., Endocrinology. 2009 Jun;150(6):2732-9. Epub 2009 Mar 5.
2. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. Anandatheerthavarada HK, etal., EMBO J. 2001 May 15;20(10):2394-403.
3. Engineering of proteolytically stable NADPH-cytochrome P450 reductase. Bonina TA, etal., Biochemistry (Mosc). 2005 Mar;70(3):357-65.
4. Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Cherala G, etal., Drug Metab Dispos. 2007 Jul;35(7):1057-63. Epub 2007 Mar 28.
5. Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. Cho EY, etal., Biochem Biophys Res Commun. 2008 Nov 21;376(3):584-9. Epub 2008 Sep 16.
6. Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Dhir V, etal., Mol Endocrinol. 2007 Aug;21(8):1958-68. Epub 2007 May 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase. Guengerich FP Arch Biochem Biophys. 2005 Aug 15;440(2):204-11.
11. Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain. Hall CN, etal., Biochem J. 2009 Apr 15;419(2):411-8.
12. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. Hamdane D, etal., J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26.
13. Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase. Higashimoto Y, etal., Biochem Biophys Res Commun. 2008 Mar 21;367(4):852-8. Epub 2008 Jan 14.
14. Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. Higashimoto Y, etal., J Biol Chem. 2005 Jan 7;280(1):729-37. Epub 2004 Oct 31.
15. The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN. Higashimoto Y, etal., J Biol Chem. 2006 Oct 20;281(42):31659-67. Epub 2006 Aug 22.
16. Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Huang N, etal., Am J Hum Genet. 2005 May;76(5):729-49. Epub 2005 Mar 25.
17. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
18. Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production. Inaoka Y, etal., Reprod Biol Endocrinol. 2008 Dec 16;6:62.
19. Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Kim D, etal., Arch Biochem Biophys. 2007 Aug 15;464(2):213-20. Epub 2007 Mar 16.
20. Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates. Li H, etal., J Biol Chem. 2006 May 5;281(18):12546-54. Epub 2006 Mar 9.
1 to 20 of 41 rows
PMID:9237990   PMID:9618440   PMID:11371558   PMID:15031143   PMID:16249336   PMID:17693640   PMID:19023562   PMID:19448135   PMID:19908820   PMID:19946888   PMID:20624491   PMID:21345800  
PMID:21462923   PMID:22871113   PMID:24853741   PMID:25450017   PMID:25512382   PMID:27189945   PMID:28684414   PMID:29308883   PMID:34196520  



Por
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,587,674 - 26,655,612 (-)NCBIGRCr8
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Celera1222,713,689 - 22,732,174 (-)NCBICelera
Cytogenetic Map12q12NCBI
POR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,915,155 - 75,986,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,899,200 - 75,986,855 (+)EnsemblGRCh38hg38GRCh38
GRCh37775,544,473 - 75,616,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,382,356 - 75,454,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 34775,227,957 - 75,260,823NCBI
Celera770,412,991 - 70,484,717 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,631,215 - 70,702,985 (+)NCBIHuRef
CHM1_1775,474,511 - 75,546,243 (+)NCBICHM1_1
T2T-CHM13v2.0777,202,773 - 77,274,511 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,877,484 - 74,949,237 (+)NCBI
Por
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,698,894 - 135,764,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,698,887 - 135,764,180 (+)EnsemblGRCm39 Ensembl
GRCm385135,670,040 - 135,735,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,670,033 - 135,735,326 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,165,084 - 136,211,195 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,973,841 - 136,019,952 (+)NCBIMGSCv36mm8
Celera5132,696,393 - 132,742,504 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.34NCBI
Por
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,698,589 - 14,748,520 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,698,589 - 14,748,520 (+)NCBIChiLan1.0ChiLan1.0
LOC100990437
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,968,924 - 94,040,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,233,562 - 142,304,506 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0768,035,021 - 68,105,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,364,311 - 82,437,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,364,418 - 82,437,530 (+)Ensemblpanpan1.1panPan2
POR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,247,780 - 7,316,282 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,263,574 - 7,316,297 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,984,488 - 9,012,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,068,561 - 7,137,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,074,449 - 7,192,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,077,907 - 7,106,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,041,376 - 7,069,585 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,204,608 - 7,232,825 (+)NCBIUU_Cfam_GSD_1.0
LOC101965545
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,708,573 - 131,760,586 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,274,059 - 2,328,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,275,981 - 2,327,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,212,735 - 10,281,823 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,212,734 - 10,272,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103246654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,145,070 - 10,230,836 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,197,503 - 10,230,468 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,191,559 - 6,265,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101712555
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,733,427 - 14,791,065 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,739,458 - 14,790,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Por
649 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000001961
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

1 to 10 of 55 rows
PMC180925P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,956,036 - 20,956,789 (+)MAPPERmRatBN7.2
Rnor_6.01224,003,392 - 24,004,144NCBIRnor6.0
Rnor_5.01226,000,644 - 26,001,396UniSTSRnor5.0
RGSC_v3.41222,083,610 - 22,084,362UniSTSRGSC3.4
Celera1222,718,658 - 22,719,410UniSTS
Cytogenetic Map12q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001961   ⟹   ENSRNOP00000001961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,971,860 (-)Ensembl
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100114   ⟹   ENSRNOP00000081146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,962,132 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101964   ⟹   ENSRNOP00000078537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)Ensembl
RefSeq Acc Id: NM_031576   ⟹   NP_113764
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,635,809 (-)NCBI
mRatBN7.21220,951,058 - 20,999,198 (-)NCBI
Rnor_6.01223,998,411 - 24,017,063 (-)NCBI
Rnor_5.01225,995,663 - 26,014,366 (-)NCBI
RGSC_v3.41222,078,629 - 22,097,301 (-)RGD
Celera1222,713,689 - 22,732,174 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271229   ⟹   XP_063127299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,655,612 (-)NCBI
RefSeq Acc Id: XM_063271230   ⟹   XP_063127300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,624,001 (-)NCBI
1 to 12 of 12 rows
Protein RefSeqs NP_113764 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127299 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127300 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41064 (Get FASTA)   NCBI Sequence Viewer  
  AAA41067 (Get FASTA)   NCBI Sequence Viewer  
  AAA41683 (Get FASTA)   NCBI Sequence Viewer  
  EDM13360 (Get FASTA)   NCBI Sequence Viewer  
  EDM13361 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001961.3
  ENSRNOP00000078537.1
  ENSRNOP00000081146.1
GenBank Protein P00388 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_113764   ⟸   NM_031576
- UniProtKB: P00388 (UniProtKB/Swiss-Prot),   A6J0C1 (UniProtKB/TrEMBL),   A0A8L2Q089 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001961   ⟸   ENSRNOT00000001961
Ensembl Acc Id: ENSRNOP00000081146   ⟸   ENSRNOT00000100114
Ensembl Acc Id: ENSRNOP00000078537   ⟸   ENSRNOT00000101964
RefSeq Acc Id: XP_063127299   ⟸   XM_063271229
- Peptide Label: isoform X1
- UniProtKB: P00388 (UniProtKB/Swiss-Prot),   A6J0C1 (UniProtKB/TrEMBL),   A0A8L2Q089 (UniProtKB/TrEMBL)
FAD-binding FR-type   Flavodoxin-like

Name Modeler Protein Id AA Range Protein Structure
AF-P00388-F1-model_v2 AlphaFold P00388 1-678 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19628 BioCyc
Ensembl Genes ENSRNOG00000001442 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001961.4 UniProtKB/TrEMBL
  ENSRNOT00000100114.1 UniProtKB/TrEMBL
  ENSRNOT00000101964.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH-cytochrome p450 Reductase, Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29441 ENTREZGENE
PANTHER NADPH--CYTOCHROME P450 REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB POR RGD
PhenoGen Por PhenoGen
PIRSF P450R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001442 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZS87_RAT UniProtKB/TrEMBL
  A0A8L2Q089 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Por  cytochrome p450 oxidoreductase  Por  P450 (cytochrome) oxidoreductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Por  P450 (cytochrome) oxidoreductase       Name updated 70584 APPROVED

Note Type Note Reference