Por (cytochrome p450 oxidoreductase) - Rat Genome Database

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Gene: Por (cytochrome p450 oxidoreductase) Rattus norvegicus
Analyze
Symbol: Por
Name: cytochrome p450 oxidoreductase
RGD ID: 68335
Description: Enables several functions, including iron-cytochrome-c reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; nitric oxide catabolic process; and oxoacid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CPR; CYPOR; cytochrome P450 reductase; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,587,674 - 26,655,612 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,587,674 - 26,635,809 (-)EnsemblGRCr8
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1222,713,689 - 22,732,174 (-)NCBICelera
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,8-Dinitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichlorobenzonitrile  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-Dichlorobenzidine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-acetylaminofluorene  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-Hydroxyflavone  (ISO)
6',7'-Dihydroxybergamottin  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-hydroxy-2'-deoxyguanosine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-hydroxyellipticine  (ISO)
acetic acid  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ametryn  (ISO)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anastrozole  (ISO)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
anthocyanin  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
asiatic acid  (EXP)
astaxanthin  (EXP)
atrazine  (ISO)
azoxystrobin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
Benzyl viologen  (EXP)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bosentan  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
citral  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
ferricyanide  (EXP)
ferroheme b  (ISO)
fipronil  (ISO)
fluconazole  (EXP,ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (EXP)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycolithocholic acid  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heme b  (ISO)
hemin  (ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyl  (ISO)
hyperforin  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
imipramine  (EXP)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
masoprocol  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (EXP,ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
misonidazole  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nemorubicin  (ISO)
nevirapine  (EXP,ISO)
nimesulide  (EXP)
nitrofurantoin  (EXP,ISO)
nitrofurazone  (EXP)
Nutlin-3  (ISO)
Oxadiazon  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenolphthalein  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
propiconazole  (EXP,ISO)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
sanguinarine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
styrene  (ISO)
styrene oxide  (ISO)
Sudan I  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
terbutryn  (ISO)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiabendazole  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
tirapazamine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tranylcypromine  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
warfarin  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (EXP)
zinc atom  (EXP)
zinc pyrithione  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
endoplasmic reticulum membrane  (IEA)
nucleoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Aguilar A, etal., Endocrinology. 2009 Jun;150(6):2732-9. Epub 2009 Mar 5.
2. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. Anandatheerthavarada HK, etal., EMBO J. 2001 May 15;20(10):2394-403.
3. Engineering of proteolytically stable NADPH-cytochrome P450 reductase. Bonina TA, etal., Biochemistry (Mosc). 2005 Mar;70(3):357-65.
4. Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Cherala G, etal., Drug Metab Dispos. 2007 Jul;35(7):1057-63. Epub 2007 Mar 28.
5. Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. Cho EY, etal., Biochem Biophys Res Commun. 2008 Nov 21;376(3):584-9. Epub 2008 Sep 16.
6. Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Dhir V, etal., Mol Endocrinol. 2007 Aug;21(8):1958-68. Epub 2007 May 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase. Guengerich FP Arch Biochem Biophys. 2005 Aug 15;440(2):204-11.
11. Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain. Hall CN, etal., Biochem J. 2009 Apr 15;419(2):411-8.
12. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. Hamdane D, etal., J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26.
13. Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase. Higashimoto Y, etal., Biochem Biophys Res Commun. 2008 Mar 21;367(4):852-8. Epub 2008 Jan 14.
14. Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. Higashimoto Y, etal., J Biol Chem. 2005 Jan 7;280(1):729-37. Epub 2004 Oct 31.
15. The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN. Higashimoto Y, etal., J Biol Chem. 2006 Oct 20;281(42):31659-67. Epub 2006 Aug 22.
16. Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Huang N, etal., Am J Hum Genet. 2005 May;76(5):729-49. Epub 2005 Mar 25.
17. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
18. Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production. Inaoka Y, etal., Reprod Biol Endocrinol. 2008 Dec 16;6:62.
19. Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Kim D, etal., Arch Biochem Biophys. 2007 Aug 15;464(2):213-20. Epub 2007 Mar 16.
20. Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates. Li H, etal., J Biol Chem. 2006 May 5;281(18):12546-54. Epub 2006 Mar 9.
21. CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. Locuson CW, etal., Drug Metab Dispos. 2007 Jul;35(7):1174-81. Epub 2007 Apr 19.
22. Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate. McGuire JJ, etal., Biochem Pharmacol. 1998 Oct 1;56(7):881-93.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
25. Expression of rat NADPH-cytochrome P-450 reductase cDNA in Saccharomyces cerevisiae. Murakami H, etal., DNA 1986 Feb;5(1):1-10.
26. Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia. Nakazato K, etal., Biomed Res. 2009 Feb;30(1):17-24.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Effect of L-carnitine supplementation on xenobiotic-metabolizing hepatic enzymes exposed to methanol. Olszowy Z, etal., Exp Toxicol Pathol. 2006 Jul;57(5-6):427-35. Epub 2006 Apr 17.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains. Porter TD and Kasper CB, Proc Natl Acad Sci U S A 1985 Feb;82(4):973-7.
32. NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein. Porter TD, etal., Biochemistry 1990 Oct 23;29(42):9814-8.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. Shen AL, etal., J Biol Chem. 2002 Feb 22;277(8):6536-41. Epub 2001 Dec 12.
37. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Shimada T, etal., Arch Biochem Biophys. 2005 Mar 1;435(1):207-16.
38. Oxidative aldehyde deformylation catalyzed by NADPH-cytochrome P450 reductase and the flavoprotein domain of neuronal nitric oxide synthase. Vatsis KP and Coon MJ, Biochem Biophys Res Commun. 2005 Dec 2;337(4):1107-11. Epub 2005 Oct 5.
39. Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase. Waxman DJ, etal., Mol Pharmacol. 1989 Apr;35(4):519-25.
40. A physiogenomic approach to study the regulation of blood pressure. Westhoff TH, etal., Physiol Genomics. 2005 Sep 21;23(1):46-53. Epub 2005 Jun 7.
41. Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay. Yokohira M, etal., J Food Sci. 2008 Sep;73(7):C561-8. Epub 2008 Jul 24.
Additional References at PubMed
PMID:9237990   PMID:9618440   PMID:11371558   PMID:15031143   PMID:16249336   PMID:17693640   PMID:19023562   PMID:19448135   PMID:19908820   PMID:19946888   PMID:20624491   PMID:21345800  
PMID:21462923   PMID:22871113   PMID:24853741   PMID:25450017   PMID:25512382   PMID:27189945   PMID:28684414   PMID:29308883   PMID:34196520  


Genomics

Comparative Map Data
Por
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,587,674 - 26,655,612 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,587,674 - 26,635,809 (-)EnsemblGRCr8
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1222,713,689 - 22,732,174 (-)NCBICelera
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Cytogenetic Map12q12NCBI
POR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,915,155 - 75,986,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,899,200 - 75,986,855 (+)Ensemblhg38GRCh38
GRCh37775,544,473 - 75,616,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,382,356 - 75,454,109 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34775,227,957 - 75,260,823NCBI
Celera770,412,991 - 70,484,717 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,631,215 - 70,702,985 (+)NCBIHuRef
CHM1_1775,474,511 - 75,546,243 (+)NCBICHM1_1
T2T-CHM13v2.0777,202,773 - 77,274,511 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,877,484 - 74,949,237 (+)NCBI
Por
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,698,894 - 135,764,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,698,887 - 135,764,180 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385135,670,040 - 135,735,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,670,033 - 135,735,326 (+)Ensemblmm10GRCm38
MGSCv375136,165,084 - 136,211,195 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365135,973,841 - 136,019,952 (+)NCBIMGSCv36mm8
Celera5132,696,393 - 132,742,504 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.34NCBI
Por
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,698,589 - 14,748,520 (+)Ensembl
ChiLan1.0NW_00495545614,698,589 - 14,748,520 (+)NCBIChiLan1.0ChiLan1.0
LOC100990437
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,968,924 - 94,040,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,233,562 - 142,304,506 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0768,035,021 - 68,105,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,364,311 - 82,437,530 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,364,418 - 82,437,530 (+)EnsemblpanPan2panpan1.1
POR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,247,780 - 7,316,282 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,263,574 - 7,316,297 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha68,984,488 - 9,012,689 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.067,068,561 - 7,137,106 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,074,449 - 7,192,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,077,907 - 7,106,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,041,376 - 7,069,585 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,204,608 - 7,232,825 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101965545
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,708,573 - 131,760,586 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,274,059 - 2,328,008 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,275,981 - 2,327,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,212,735 - 10,281,823 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1310,212,734 - 10,272,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
POR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,145,070 - 10,230,836 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,197,503 - 10,230,468 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660706,191,559 - 6,265,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101712555
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,733,427 - 14,791,065 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474014,739,458 - 14,790,736 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116885210
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11618,289,979 - 18,337,656 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Por
548 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000001961
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
11530002Bss119Bone structure and strength QTL 11916.394e-17lumbar vertebra area (VT:0010570)lumbar vertebra area (CMO:0001688)122651003826983303Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
PMC180925P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,956,036 - 20,956,789 (+)MAPPERmRatBN7.2
Rnor_6.01224,003,392 - 24,004,144NCBIRnor6.0
Rnor_5.01226,000,644 - 26,001,396UniSTSRnor5.0
RGSC_v3.41222,083,610 - 22,084,362UniSTSRGSC3.4
Celera1222,718,658 - 22,719,410UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001961   ⟹   ENSRNOP00000001961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,971,860 (-)Ensembl
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100114   ⟹   ENSRNOP00000081146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,587,674 - 26,606,324 (-)Ensembl
mRatBN7.2 Ensembl1220,951,058 - 20,962,132 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101964   ⟹   ENSRNOP00000078537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,587,674 - 26,635,809 (-)Ensembl
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)Ensembl
RefSeq Acc Id: NM_031576   ⟹   NP_113764
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,635,809 (-)NCBI
mRatBN7.21220,951,058 - 20,999,198 (-)NCBI
Rnor_6.01223,998,411 - 24,017,063 (-)NCBI
Rnor_5.01225,995,663 - 26,014,366 (-)NCBI
RGSC_v3.41222,078,629 - 22,097,301 (-)RGD
Celera1222,713,689 - 22,732,174 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271229   ⟹   XP_063127299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,655,612 (-)NCBI
RefSeq Acc Id: XM_063271230   ⟹   XP_063127300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,587,674 - 26,624,001 (-)NCBI
RefSeq Acc Id: NP_113764   ⟸   NM_031576
- UniProtKB: P00388 (UniProtKB/Swiss-Prot),   A6J0C1 (UniProtKB/TrEMBL),   A0A8L2Q089 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001961   ⟸   ENSRNOT00000001961
Ensembl Acc Id: ENSRNOP00000081146   ⟸   ENSRNOT00000100114
Ensembl Acc Id: ENSRNOP00000078537   ⟸   ENSRNOT00000101964
RefSeq Acc Id: XP_063127299   ⟸   XM_063271229
- Peptide Label: isoform X1
- UniProtKB: P00388 (UniProtKB/Swiss-Prot),   A0A8L2Q089 (UniProtKB/TrEMBL),   A6J0C1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127300   ⟸   XM_063271230
- Peptide Label: isoform X1
- UniProtKB: P00388 (UniProtKB/Swiss-Prot),   A0A8L2Q089 (UniProtKB/TrEMBL),   A6J0C1 (UniProtKB/TrEMBL)
Protein Domains
FAD-binding FR-type   Flavodoxin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00388-F1-model_v2 AlphaFold P00388 1-678 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68335 AgrOrtholog
BioCyc Gene G2FUF-19628 BioCyc
Ensembl Genes ENSRNOG00000001442 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000101964 ENTREZGENE
  ENSRNOT00000101964.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot
  3.40.50.80 UniProtKB/Swiss-Prot
  NADPH-cytochrome p450 Reductase, Chain A, domain 3 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Flavdoxin-like UniProtKB/Swiss-Prot
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot
  P450R UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:29441 UniProtKB/Swiss-Prot
NCBI Gene 29441 ENTREZGENE
PANTHER NADPH--CYTOCHROME P450 REDUCTASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE-RELATED UniProtKB/Swiss-Prot
Pfam FAD_binding_1 UniProtKB/Swiss-Prot
  Flavodoxin_1 UniProtKB/Swiss-Prot
  NAD_binding_1 UniProtKB/Swiss-Prot
PharmGKB POR RGD
PhenoGen Por PhenoGen
PIRSF P450R UniProtKB/Swiss-Prot
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot
  FPNCR UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001442 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot
  SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A8I5ZS87_RAT UniProtKB/TrEMBL
  A0A8L2Q089 ENTREZGENE
  A6J0C1 ENTREZGENE, UniProtKB/TrEMBL
  NCPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Por  cytochrome p450 oxidoreductase  Por  P450 (cytochrome) oxidoreductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Por  P450 (cytochrome) oxidoreductase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference