Tek (TEK receptor tyrosine kinase) - Rat Genome Database

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Gene: Tek (TEK receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Tek
Name: TEK receptor tyrosine kinase
RGD ID: 620980
Description: Enables growth factor binding activity. Involved in several processes, including endochondral ossification; positive regulation of angiogenesis; and response to estrogen. Predicted to be located in several cellular components, including actin cytoskeleton; basolateral plasma membrane; and microvillus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase); PARTICIPATES IN angiopoietin signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH (S)-naringenin; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiopoietin-1 receptor; endothelial-specific receptor tyrosine kinase; TEK tyrosine kinase, endothelial; Tie-2; Tie2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85114,722,815 - 114,849,535 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5114,723,006 - 114,849,991 (+)EnsemblGRCr8
mRatBN7.25109,607,077 - 109,733,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5112,185,658 - 112,306,395 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05113,911,456 - 114,031,907 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05113,973,696 - 114,094,435 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)Ensemblrn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5108,234,353 - 108,354,536 (+)NCBICelera
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Cytogenetic Map5q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
baicalin  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
capsaicin  (EXP,ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crizotinib  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enalapril  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gefitinib  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
indoles  (EXP)
indometacin  (ISO)
Lasiocarpine  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
mancozeb  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
Morroniside  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nicotinic acid  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
ponatinib  (ISO)
progesterone  (ISO)
propranolol  (ISO)
resveratrol  (ISO)
Rhein  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
sumatriptan  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IEA,ISO)
branching morphogenesis of an epithelial tube  (IEA)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA,ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate adhesion  (IEA)
cellular response to mechanical stimulus  (ISO)
circulatory system development  (IEA)
endochondral ossification  (IEP)
endothelial cell proliferation  (IBA,ISO)
glomerulus vasculature development  (IMP)
heart development  (IEA,ISO)
heart trabecula formation  (ISO)
hemopoiesis  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of angiogenesis  (IBA,IMP,ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of endothelial cell migration  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of signal transduction  (IEA)
regulation of angiogenesis  (IEA,ISO)
regulation of cell migration  (IEA,ISO)
regulation of endothelial cell apoptotic process  (IEA)
regulation of endothelial cell proliferation  (IEA)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of intracellular signal transduction  (IEA)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
response to cAMP  (IEP)
response to estrogen  (IDA)
response to hypoxia  (IDA)
response to peptide hormone  (IEP)
response to retinoic acid  (IEA,ISO)
sprouting angiogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
Tie signaling pathway  (ISO,TAS)
vasculogenesis  (ISO,TAS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Abdulmalek K, etal., Am J Physiol Lung Cell Mol Physiol 2001 Sep;281(3):L582-90.
2. Measurement of the soluble angiopoietin receptor tie-2 in patients with coronary artery disease: development and application of an immunoassay. Chung NA, etal., Eur J Clin Invest. 2003 Jul;33(7):529-35.
3. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. DeBusk LM, etal., Arthritis Rheum. 2003 Sep;48(9):2461-71.
4. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. Dedkov EI, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1686-93. Epub 2006 May 19.
5. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Dewachter L, etal., Am J Respir Crit Care Med. 2006 Nov 1;174(9):1025-33. Epub 2006 Aug 17.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Hughes DP, etal., Circ Res. 2003 Apr 4;92(6):630-6. Epub 2003 Feb 27.
8. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Jones N, etal., J Biol Chem. 1999 Oct 22;274(43):30896-905.
9. A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Jones N, etal., Mol Cell Biol. 2003 Apr;23(8):2658-68.
10. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16.
11. Expression of vascular antigens by bone cells during bone regeneration in a membranous bone distraction system. Lewinson D, etal., Histochem Cell Biol. 2001 Nov;116(5):381-8. Epub 2001 Oct 18.
12. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Li WZ, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):523-7.
13. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. Lin P, etal., J Clin Invest. 1997 Oct 15;100(8):2072-8.
14. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. Madsen K, etal., J Am Soc Nephrol. 2010 Mar;21(3):448-59. doi: 10.1681/ASN.2009010045. Epub 2010 Jan 7.
15. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Changes of mRNA expression of vascular endothelial growth factor, angiopoietins and their receptors during the periovulatory period in eCG/hCG-treated immature female rats. Miyabayashi K, etal., J Exp Zoolog A Comp Exp Biol. 2005 Jul 1;303(7):590-7.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Peoch M, etal., Anticancer Res 2002 Jul-Aug;22(4):2147-51.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Puri MC and Bernstein A, Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12753-8. Epub 2003 Oct 6.
23. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3',5'-monophosphate. Ramsden JD, etal., J Clin Endocrinol Metab. 2001 Jun;86(6):2709-16.
24. The role of angiopoietins during angiogenesis in gliomas. Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Comprehensive gene review and curation RGD comprehensive gene curation
29. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
30. tie2, a putative protein tyrosine kinase from a new class of cell surface receptor. Runting AS, etal., Growth Factors. 1993;9(2):99-105.
31. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94.
32. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Sullivan CC, etal., Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12331-6. Epub 2003 Sep 25.
33. Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Tachibana K, etal., Mol Cell Biol. 2005 Jun;25(11):4693-702.
34. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Vikkula M, etal., Cell. 1996 Dec 27;87(7):1181-90.
35. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10.
36. A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Voskas D, etal., Am J Pathol. 2005 Mar;166(3):843-55.
37. DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth. Wang X, etal., Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H613-8. Epub 2002 Oct 31.
38. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
39. Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells. Willam C, etal., Circ Res 2000 Sep 1;87(5):370-7.
40. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. Witzenbichler B, etal., J Biol Chem. 1998 Jul 17;273(29):18514-21.
41. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
42. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Zacharek A, etal., Neurosci Lett. 2006 Aug 14;404(1-2):28-32. Epub 2006 Jun 9.
43. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. Zhang ZG, etal., J Cereb Blood Flow Metab 2002 Apr;22(4):379-92.
Additional References at PubMed
PMID:7596437   PMID:7958865   PMID:8980223   PMID:9683559   PMID:9846489   PMID:11375937   PMID:11513602   PMID:11822892   PMID:12816861   PMID:14665640   PMID:14966366   PMID:15260986  
PMID:15284220   PMID:15548727   PMID:15845622   PMID:15985432   PMID:18073453   PMID:18285514   PMID:18425119   PMID:18425120   PMID:18439490   PMID:18586890   PMID:18751736   PMID:18929864  
PMID:18947490   PMID:19223473   PMID:19409199   PMID:19424712   PMID:19615361   PMID:19689429   PMID:19712575   PMID:19786610   PMID:20060382   PMID:20969813   PMID:21701128   PMID:22577112  
PMID:22869617   PMID:23049737   PMID:25446117   PMID:26666854   PMID:26887441   PMID:27439004   PMID:30527680   PMID:38619512  


Genomics

Comparative Map Data
Tek
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85114,722,815 - 114,849,535 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5114,723,006 - 114,849,991 (+)EnsemblGRCr8
mRatBN7.25109,607,077 - 109,733,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5112,185,658 - 112,306,395 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05113,911,456 - 114,031,907 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05113,973,696 - 114,094,435 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)Ensemblrn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5108,234,353 - 108,354,536 (+)NCBICelera
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Cytogenetic Map5q33NCBI
TEK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38927,109,225 - 27,230,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl927,109,030 - 27,232,092 (+)Ensemblhg38GRCh38
GRCh37927,109,223 - 27,230,172 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36927,099,286 - 27,220,172 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34927,099,440 - 27,220,164NCBI
Celera927,037,320 - 27,158,328 (+)NCBICelera
Cytogenetic Map9p21.2NCBI
HuRef927,061,676 - 27,182,725 (+)NCBIHuRef
CHM1_1927,108,925 - 27,229,954 (+)NCBICHM1_1
T2T-CHM13v2.0927,119,797 - 27,240,735 (+)NCBIT2T-CHM13v2.0
Tek
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,627,322 - 94,763,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,627,526 - 94,763,213 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38494,739,086 - 94,874,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl494,739,289 - 94,874,976 (+)Ensemblmm10GRCm38
MGSCv37494,405,991 - 94,541,630 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36494,231,318 - 94,366,957 (+)NCBIMGSCv36mm8
Celera493,148,719 - 93,271,150 (+)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Tek
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554727,633,721 - 7,748,386 (-)Ensembl
ChiLan1.0NW_0049554727,633,790 - 7,748,130 (-)NCBIChiLan1.0ChiLan1.0
TEK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,313,642 - 97,436,178 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1997,319,581 - 97,442,141 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0926,955,339 - 27,077,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1927,561,421 - 27,683,572 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl927,561,421 - 27,683,572 (+)EnsemblpanPan2panpan1.1
TEK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11145,278,375 - 45,377,300 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1145,278,891 - 45,409,093 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1143,955,919 - 44,054,831 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01146,225,355 - 46,324,241 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1146,225,693 - 46,324,239 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11144,881,654 - 44,980,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01144,771,574 - 44,870,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01145,518,478 - 45,616,970 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tek
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947160,136,641 - 160,248,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366112,420,172 - 2,531,722 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366112,420,176 - 2,531,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1195,937,432 - 196,051,980 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11195,938,177 - 196,052,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,224,152 - 218,293,514 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TEK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1252,819,258 - 52,941,798 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Tek
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tek
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1157,802,275 - 57,871,572 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tek
911 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:92
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000032248
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1298077Bp157Blood pressure QTL 157arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5114474223121056531Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Uwm29  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85114,834,857 - 114,835,120 (+)Marker Load Pipeline
mRatBN7.25109,719,127 - 109,719,390 (+)MAPPERmRatBN7.2
Rnor_6.05113,838,123 - 113,838,385NCBIRnor6.0
Rnor_5.05117,784,669 - 117,784,931UniSTSRnor5.0
RGSC_v3.45115,181,496 - 115,181,758UniSTSRGSC3.4
Celera5108,339,861 - 108,340,123UniSTS
Cytogenetic Map5q33UniSTS
D5Lev12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,721,675 - 109,721,780 (+)MAPPERmRatBN7.2
Rnor_6.05113,840,671 - 113,840,775NCBIRnor6.0
Rnor_5.05117,787,217 - 117,787,321UniSTSRnor5.0
RGSC_v3.45115,184,044 - 115,184,148UniSTSRGSC3.4
Celera5108,342,409 - 108,342,513UniSTS
Cytogenetic Map5q33UniSTS
RH137123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,733,610 - 109,733,790 (+)MAPPERmRatBN7.2
Rnor_6.05113,852,606 - 113,852,785NCBIRnor6.0
Rnor_5.05117,799,152 - 117,799,331UniSTSRnor5.0
RGSC_v3.45115,195,979 - 115,196,158UniSTSRGSC3.4
Celera5108,354,343 - 108,354,522UniSTS
RH 3.4 Map5779.4UniSTS
Cytogenetic Map5q33UniSTS
RH138516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,732,963 - 109,733,181 (+)MAPPERmRatBN7.2
Rnor_6.05113,851,959 - 113,852,176NCBIRnor6.0
Rnor_5.05117,798,505 - 117,798,722UniSTSRnor5.0
RGSC_v3.45115,195,332 - 115,195,549UniSTSRGSC3.4
Celera5108,353,696 - 108,353,913UniSTS
RH 3.4 Map5782.8UniSTS
Cytogenetic Map5q33UniSTS
RH138553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,666,343 - 109,666,463 (+)MAPPERmRatBN7.2
Rnor_6.05113,784,732 - 113,784,851NCBIRnor6.0
Rnor_5.05117,731,278 - 117,731,397UniSTSRnor5.0
RGSC_v3.45115,108,168 - 115,108,287UniSTSRGSC3.4
Celera5108,293,629 - 108,293,748UniSTS
RH 3.4 Map5781.8UniSTS
Cytogenetic Map5q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 87 59 6 351 187 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032248   ⟹   ENSRNOP00000036086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5114,723,027 - 114,849,534 (+)Ensembl
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)Ensembl
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114153   ⟹   ENSRNOP00000083602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5114,762,973 - 114,849,991 (+)Ensembl
mRatBN7.2 Ensembl5109,647,237 - 109,733,804 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114201   ⟹   ENSRNOP00000083432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5114,723,006 - 114,849,991 (+)Ensembl
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136387   ⟹   ENSRNOP00000099554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5114,723,285 - 114,849,991 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160351   ⟹   ENSRNOP00000104871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5114,723,006 - 114,849,991 (+)Ensembl
RefSeq Acc Id: NM_001105737   ⟹   NP_001099207
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85114,722,815 - 114,849,534 (+)NCBI
mRatBN7.25109,607,077 - 109,733,804 (+)NCBI
Rnor_6.05113,725,717 - 113,852,799 (+)NCBI
Rnor_5.05117,672,484 - 117,799,345 (+)NCBI
RGSC_v3.45115,047,195 - 115,196,172 (+)RGD
Celera5108,234,353 - 108,354,536 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110892   ⟹   XP_038966820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85114,774,546 - 114,849,535 (+)NCBI
mRatBN7.25109,658,813 - 109,733,805 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97760 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036086
  ENSRNOP00000036086.4
  ENSRNOP00000083432.1
  ENSRNOP00000083602.1
  ENSRNOP00000099554.1
  ENSRNOP00000104871.1
RefSeq Acc Id: NP_001099207   ⟸   NM_001105737
- UniProtKB: D3ZCD0 (UniProtKB/TrEMBL),   A6JRG8 (UniProtKB/TrEMBL),   A0A8I5ZW61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036086   ⟸   ENSRNOT00000032248
RefSeq Acc Id: XP_038966820   ⟸   XM_039110892
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000083602   ⟸   ENSRNOT00000114153
Ensembl Acc Id: ENSRNOP00000083432   ⟸   ENSRNOT00000114201
Ensembl Acc Id: ENSRNOP00000104871   ⟸   ENSRNOT00000160351
Ensembl Acc Id: ENSRNOP00000099554   ⟸   ENSRNOT00000136387
Protein Domains
EGF-like   Fibronectin type-III   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCD0-F1-model_v2 AlphaFold D3ZCD0 1-1120 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693842
Promoter ID:EPDNEW_R4366
Type:initiation region
Name:Tek_1
Description:TEK receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05113,725,905 - 113,725,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620980 AgrOrtholog
BioCyc Gene G2FUF-40701 BioCyc
Ensembl Genes ENSRNOG00000008587 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032248 ENTREZGENE
  ENSRNOT00000032248.5 UniProtKB/TrEMBL
  ENSRNOT00000114153.2 UniProtKB/TrEMBL
  ENSRNOT00000114201.2 UniProtKB/TrEMBL
  ENSRNOT00000136387.1 UniProtKB/TrEMBL
  ENSRNOT00000160351.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro EGF_3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  LE_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kin_Tie2_Ig-like_dom-1_N UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:89804 UniProtKB/TrEMBL
NCBI Gene 89804 ENTREZGENE
PANTHER ANGIOPOIETIN-1 RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_Tie2_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Tek PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008587 RatGTEx
SMART EGF UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5ZW61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G914_RAT UniProtKB/TrEMBL
  A0ABK0L6J5_RAT UniProtKB/TrEMBL
  A0ABK0LGY4_RAT UniProtKB/TrEMBL
  A6JRG8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCD0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Tek  TEK receptor tyrosine kinase  Tek  TEK tyrosine kinase, endothelial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tek  TEK tyrosine kinase, endothelial  Tek  endothelial-specific receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tek  endothelial-specific receptor tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tek  endothelial-specific receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by endothelial cells 628494
gene_function receptor for Angiopoietin (Ang)-1 and Ang-2 628494
gene_physical_interaction binding of Ang-1 causes autophosphorylation and activation, but Ang-2 binding antagonizes this effect 628494
gene_process mediates the maturation of blood vessels during embryonic development 628494
gene_process plays a role in angiogenesis and stabilization of vascular integrity 628494
gene_regulation induced by hypoxia and inflammatory cytokines 724763
gene_regulation hypoxia reduces mRNA, protein, and phosphorylation levels in the lung, liver, cerebellum, and heart but not in the kidney and diaphragm 628494
gene_regulation inhibitory effect of hypoxia on the gene expression acts through the reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 628494