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Gene: P2rx3 (purinergic receptor P2X 3) Rattus norvegicus

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Symbol:

P2rx3

Name:

purinergic receptor P2X 3

RGD ID:

620253

Description:

Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; cellular response to ATP; and neuronal action potential. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATP receptor; P2X purinoceptor 3; P2X3; purinergic receptor P2X ligand-gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	90,487,506 - 90,531,315 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	90,487,506 - 90,531,794 (-)	Ensembl				GRCr8
mRatBN7.2	3	70,080,850 - 70,124,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	70,080,851 - 70,125,178 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	73,462,764 - 73,506,383 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	82,061,439 - 82,105,058 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	79,819,891 - 79,863,521 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	72,403,992 - 72,447,801 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	72,403,993 - 72,447,801 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	78,914,029 - 78,958,459 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	68,228,045 - 68,270,751 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	69,431,850 - 69,475,670 (-)	NCBI		Celera
RGSC_v3.1	3	68,124,416 - 68,167,123 (-)	NCBI
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hyperalgesia (ISO)

Nervous System Trauma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4-Hydroxybenzophenone (ISO)

6-propyl-2-thiouracil (EXP)

Aflatoxin B2 alpha (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

ATP (EXP)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

calcium atom (ISO)

calcium(0) (ISO)

chlorpyrifos (ISO)

choline (ISO)

clotrimazole (EXP)

Cuprizon (EXP)

cyclophosphamide (EXP)

deguelin (ISO)

ethylparaben (ISO)

eugenol (EXP)

fenvalerate (EXP)

folic acid (ISO)

gardenoside (EXP)

gentamycin (EXP)

hydralazine (ISO)

L-methionine (ISO)

methapyrilene (ISO)

methimazole (EXP)

mifepristone (EXP)

N(4)-hydroxycytidine (ISO)

okadaic acid (ISO)

ozone (EXP)

paracetamol (ISO)

picoxystrobin (ISO)

potassium dichromate (ISO)

pregabalin (EXP)

progesterone (EXP)

pyrimidifen (ISO)

quercitrin (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

silver atom (ISO)

silver(0) (ISO)

streptozocin (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

suramin (EXP)

testosterone (EXP)

thioacetamide (EXP)

trichloroethene (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to formalin induced pain (IMP)

behavioral response to pain (ISO)

calcium ion transmembrane transport (IBA,IDA,ISO)

cell surface receptor signaling pathway (IEA)

cellular response to ATP (IDA,ISO)

chemical synaptic transmission (ISO)

excitatory postsynaptic potential (IEA)

modulation of chemical synaptic transmission (ISO)

monoatomic cation transmembrane transport (IEA)

monoatomic cation transport (ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA,ISO)

nervous system process (IEA)

neuromuscular synaptic transmission (ISO)

neuronal action potential (IDA)

peristalsis (ISO)

protein homotrimerization (ISO,ISS)

purinergic nucleotide receptor signaling pathway (IEA)

regulation of membrane potential (IEA)

regulation of synaptic plasticity (ISO)

response to ATP (IEA,ISO)

response to carbohydrate (ISO)

response to cold (ISO)

response to heat (ISO)

response to hypoxia (ISO)

response to mechanical stimulus (ISO)

response to temperature stimulus (ISO)

sensory perception of taste (ISO)

transmembrane transport (ISO,ISS)

urinary bladder smooth muscle contraction (ISO)

Cellular Component

axon (ISO)

dendritic spine (IDA)

hippocampal mossy fiber to CA3 synapse (ISO)

membrane (IEA)

neuron projection (ISO)

neuronal cell body (IDA)

plasma membrane (IBA,IEA,IMP,ISO,ISS)

postsynapse (IEA)

presynaptic membrane (IDA,IEP)

receptor complex (ISO)

Schaffer collateral - CA1 synapse (ISO)

terminal bouton (IDA)

Molecular Function

ATP binding (IDA,IEA,ISO)

channel activity (IEA)

extracellularly ATP-gated monoatomic cation channel activity (IBA,IDA,IEA,ISO)

identical protein binding (IEA,IPI)

metal ion binding (IEA)

monoatomic ion channel activity (IEA)

nucleotide binding (IEA)

protein binding (IPI)

purinergic nucleotide receptor activity (IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes.	Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43.
2.	A P2X purinoceptor expressed by a subset of sensory neurons.	Chen CC, etal., Nature 1995 Oct 5;377(6548):428-31.
3.	Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits.	Diaz-Hernandez M, etal., Neurosci Lett. 2001 Apr 6;301(3):159-62.
4.	Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells.	Evans RJ, etal., J Physiol. 1996 Dec 1;497 ( Pt 2)(Pt 2):413-22. doi: 10.1113/jphysiol.1996.sp021777.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Presence of diverse functional P2X receptors in rat cerebellar synaptic terminals.	Hervas C, etal., Biochem Pharmacol. 2005 Sep 1;70(5):770-85.
8.	P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors.	Krimon S, etal., Pharmacol Biochem Behav. 2013 Nov;112:49-55. doi: 10.1016/j.pbb.2013.09.017. Epub 2013 Oct 9.
9.	Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.	Lewis C, etal., Nature 1995 Oct 5;377(6548):432-5.
10.	Coexpression of P2X(3) and P2X(2) receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons.	Liu M, etal., J Pharmacol Exp Ther. 2001 Mar;296(3):1043-50.
11.	Ultrastructural localization of P2X3 receptors in rat sensory neurons.	Llewellyn-Smith IJ and Burnstock G, Neuroreport. 1998 Aug 3;9(11):2545-50.
12.	Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons.	Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	GOA pipeline	RGD automated data pipeline
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.	Rodrigues RJ, etal., Neuropharmacology. 2016 Jun;105:241-257. doi: 10.1016/j.neuropharm.2016.01.022. Epub 2016 Jan 19.
19.	The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation.	Sokolova E, etal., Neurosci Lett. 2003 Mar 6;338(3):181-4.
20.	P2X3 receptor localizes into lipid rafts in neuronal cells.	Vacca F, etal., J Neurosci Res. 2004 Jun 1;76(5):653-61.

Additional References at PubMed

PMID:11069181	PMID:11069182	PMID:11466438	PMID:12477932	PMID:12813150	PMID:14672995	PMID:15081800	PMID:15258768	PMID:15292517	PMID:15736235	PMID:15927378	PMID:15947072
PMID:15961431	PMID:15973739	PMID:16000618	PMID:16322458	PMID:16566843	PMID:16616417	PMID:16753051	PMID:17074061	PMID:17287582	PMID:17462717	PMID:17481957	PMID:17512257
PMID:17521813	PMID:17917716	PMID:18026985	PMID:18067147	PMID:18276198	PMID:18309781	PMID:18551569	PMID:18565509	PMID:18715715	PMID:18722504	PMID:19064335	PMID:19223122
PMID:19266560	PMID:19283865	PMID:19383439	PMID:19625689	PMID:19628002	PMID:20118742	PMID:20121714	PMID:20406659	PMID:20705122	PMID:20860800	PMID:20868656	PMID:21051571
PMID:21195750	PMID:21303687	PMID:21642505	PMID:21669492	PMID:21678417	PMID:21810163	PMID:21851615	PMID:21883226	PMID:21907716	PMID:21958474	PMID:22044944	PMID:22157653
PMID:22286789	PMID:22314033	PMID:22422599	PMID:22528605	PMID:22616675	PMID:22790888	PMID:23186588	PMID:23201260	PMID:23249537	PMID:23382219	PMID:23520364	PMID:23771671
PMID:24154957	PMID:24378336	PMID:24387161	PMID:24755854	PMID:24798490	PMID:25367719	PMID:25592684	PMID:25634810	PMID:25680470	PMID:26130762	PMID:26475709	PMID:26686228
PMID:26836462	PMID:27385722	PMID:27595323	PMID:27626375	PMID:27802438	PMID:28979194	PMID:29219199	PMID:29550358	PMID:29560791	PMID:29608947	PMID:29636447	PMID:29932348
PMID:30196147	PMID:31074048	PMID:31115830	PMID:31269659	PMID:31950033	PMID:32145326	PMID:33902429	PMID:34622458	PMID:36397224	PMID:36633528	PMID:37656312

Genomics

Comparative Map Data

P2rx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	90,487,506 - 90,531,315 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	90,487,506 - 90,531,794 (-)	Ensembl				GRCr8
mRatBN7.2	3	70,080,850 - 70,124,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	70,080,851 - 70,125,178 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	73,462,764 - 73,506,383 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	82,061,439 - 82,105,058 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	79,819,891 - 79,863,521 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	72,403,992 - 72,447,801 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	72,403,993 - 72,447,801 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	78,914,029 - 78,958,459 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	68,228,045 - 68,270,751 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	69,431,850 - 69,475,670 (-)	NCBI		Celera
RGSC_v3.1	3	68,124,416 - 68,167,123 (-)	NCBI
Cytogenetic Map	3	q24	NCBI

P2RX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	57,335,950 - 57,372,396 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	57,338,352 - 57,372,404 (+)	Ensembl			hg38	GRCh38
GRCh37	11	57,105,826 - 57,139,869 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	56,862,525 - 56,894,125 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	56,862,524 - 56,894,125	NCBI
Celera	11	54,464,979 - 54,477,411 (+)	NCBI		Celera
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	53,454,728 - 53,486,434 (+)	NCBI		HuRef
CHM1_1	11	56,971,953 - 57,003,678 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	57,285,441 - 57,321,889 (+)	NCBI		T2T-CHM13v2.0

P2rx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	84,826,893 - 84,867,446 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	84,828,927 - 84,867,806 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	84,996,549 - 85,037,108 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	84,998,583 - 85,037,462 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	84,836,709 - 84,875,991 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	84,797,391 - 84,836,673 (-)	NCBI		MGSCv36	mm8
Celera	2	86,595,241 - 86,634,592 (-)	NCBI		Celera
Cytogenetic Map	2	D	NCBI
cM Map	2	49.45	NCBI

P2rx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955511	2,389,717 - 2,411,008 (+)	Ensembl
ChiLan1.0	NW_004955511	2,389,717 - 2,410,968 (+)	NCBI	ChiLan1.0	ChiLan1.0

P2RX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	58,492,901 - 58,531,132 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	59,509,857 - 59,548,082 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	52,579,190 - 52,614,329 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	160,070,860 - 160,104,550 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	160,070,875 - 160,106,120 (+)	Ensembl			panPan2	panpan1.1

P2RX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	38,773,930 - 38,801,217 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	38,772,529 - 38,802,057 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	38,319,548 - 38,346,782 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	39,455,279 - 39,482,558 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	39,453,201 - 39,482,831 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	39,035,826 - 39,065,122 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	38,609,330 - 38,638,605 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	39,242,142 - 39,269,413 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

P2rx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	15,002,140 - 15,032,591 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	5,115,492 - 5,146,634 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	5,116,276 - 5,146,378 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

P2RX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	13,584,925 - 13,617,785 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	13,584,913 - 13,619,652 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	13,347,685 - 13,381,122 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

P2RX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	15,872,124 - 15,906,452 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	113,214,882 - 113,249,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

P2rx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624864	3,229,979 - 3,253,094 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624864	3,233,019 - 3,253,525 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

P2rx3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	62,367,309 - 62,407,428 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in P2rx3
344 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	218
Count of miRNA genes:	148
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000033427
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	73592611	110333156	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	53651826	98651826	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	48876619	93876619	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	48876619	93876619	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	35403199	97383526	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
631832	Sach1	Saccharin preference QTL 1	2.7	0.02	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	3	47904172	92904172	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	48657744	93657744	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	58925062	103925062	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	48657744	93657744	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	50766145	95766145	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	50766145	95766145	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	48657744	93657744	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	48657744	93657744	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	48657744	93657744	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

RH139270

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	70,080,953 - 70,081,198 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	72,404,096 - 72,404,340	NCBI	Rnor6.0
Rnor_5.0	3	78,914,133 - 78,914,377	UniSTS	Rnor5.0
RGSC_v3.4	3	68,228,149 - 68,228,393	UniSTS	RGSC3.4
Celera	3	69,431,954 - 69,432,198	UniSTS
Cytogenetic Map	3	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	63	160	91	90	59	83	59	6	340	178	10	139	79	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_073054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF084975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB715302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X90651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X91167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033427 ⟹ ENSRNOP00000031629

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	90,487,506 - 90,531,029 (-)	Ensembl
mRatBN7.2 Ensembl	3	70,080,851 - 70,125,178 (-)	Ensembl
Rnor_6.0 Ensembl	3	72,403,993 - 72,445,775 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077573 ⟹ ENSRNOP00000071698

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	90,487,506 - 90,529,309 (-)	Ensembl
mRatBN7.2 Ensembl	3	70,080,851 - 70,125,178 (-)	Ensembl
Rnor_6.0 Ensembl	3	72,403,993 - 72,445,775 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088815 ⟹ ENSRNOP00000072187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	72,405,837 - 72,447,801 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146485 ⟹ ENSRNOP00000099956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	90,489,351 - 90,531,315 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000158499 ⟹ ENSRNOP00000106307

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	90,487,506 - 90,531,794 (-)	Ensembl

RefSeq Acc Id:

NM_001270621 ⟹ NP_001257550

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	90,487,506 - 90,529,309 (-)	NCBI
mRatBN7.2	3	70,080,850 - 70,122,658 (-)	NCBI
Rnor_6.0	3	72,403,992 - 72,445,775 (-)	NCBI
Rnor_5.0	3	78,914,029 - 78,958,459 (-)	NCBI
Celera	3	69,431,850 - 69,473,642 (-)	NCBI

Sequence:

show sequence

ATCAAGGGGAGAGACTAGGCACTGGGCTACAGTTGCCTGGCTTACAGGAACTGGCTCTTTTCCT
CAAGCCTCATTAAGCAGCCCACTCCAGTTCTTGATCTTTGTCTCCCAGTCCTGAAGTCCTTTCT
CTCCTTAGGCTGCATCCACAGCCCTTCTAAGTGGCTGTGAGCAGTTTCTCAGTATGAACTGTAT
ATCAGACTTCTTCACCTACGAGACTACCAAGTCGGTGGTTGTGAAGAGCTGGACCATTGGGATC
ATCAACCGAGCCGTCCAGCTGCTGATTATCTCCTACTTTGTGGGGTGGGTTTTCTTGCATGAGA
AGGCCTACCAAGTGAGGGACACCGCCATTGAGTCCTCAGTAGTTACAAAGGTGAAAGGCTTCGG
GCGCTATGCCAACAGAGTCATGGACGTGTCGGATTATGTGACCCCACCCCAGAATGAAGAGAAG
TACCGCTGTGTGTCTGACAGCCAGTGTGGGCCTGAACGCTTCCCAGGTGGGGGGATCCTCACCG
GCCGCTGCGTGAACTACAGCTCTGTTCTCCGGACCTGTGAGATCCAGGGCTGGTGCCCCACTGA
GGTGGACACCGTGGAGATGCCTATCATGATGGAGGCTGAGAACTTCACCATTTTCATCAAGAAC
AGCATCCGTTTCCCTCTCTTCAACTTTGAGAAGGGAAACCTCCTGCCTAACCTCACCGACAAGG
ACATAAAGAGGTGCCGCTTCCACCCTGAAAAGGCCCCATTTTGCCCCATCTTGAGGGTAGGGGA
TGTGGTTAAGTTTGCTGGACAGGATTTTGCCAAGCTGGCCCGCACGGGTGGCGTTCTGGGTATT
AAGATCGGCTGGGTGTGCGATCTAGACAAGGCCTGGGACCAGTGCATCCCTAAATATTCCTTCA
CTCGGCTGGATGGAGTTTCTGAGAAAAGCAGTGTTTCCCCTGGCTACAACTTCAGGTTTGCCAA
ATACTATAAGATGGAGAACGGCAGCGAGTACCGCACACTCCTGAAGGCTTTTGGCATCCGCTTT
GATGTGCTGGTATATGGGAACGCTGGCAAGTTCAACATCATCCCCACCATTATCAGCTCGGTGG
CGGCCTTCACTTCTGTGGGAGTGGGCACTGTTCTCTGTGACATCATCCTGCTCAATTTCCTCAA
AGGGGCTGATCACTACAAAGCCAGGAAGTTTGAGGAGGTGACTGAGACAACACTGAAGGGTACT
GCGTCAACCAACCCAGTGTTCGCCAGTGACCAGGCCACTGTGGAGAAGCAGTCTACAGACTCAG
GGGCCTATTCTATTGGTCACTAGGGCCTCTTCCCAGGGTTCCATGCTCACCCTTAGGCTGCAGA
ACCTGCAAACAGGCCACTCTATCTAAGCAGTCAGGGGTGGGAGGGGGAGAAGAAGGGCTGCTAT
TTCTGCTGTTCACCCCAAAGACTAGATCCAGATATCTAGGCCCTCACTGTTCAACAGATAGGCA
ATGCTTCCCACTAAGACTTGAATCTTGCCTTTACCCCTTGCATGCCTCCCACCTGCTTCCCTGG
ATCCCAGGACAGCAGCATCCACCCCTTTCCAAAGGATTGAGAAAATGGTAGCTAAGGTTACACC
CATAGGACCTACCACGTACCAAGCACTTCCACACATATTATCCCTTTTCACCCTTAAAATAATC
CTATAAGGTAGATTTCTTGGGTTGTTTGTTTGTTTTGTTATTAAGAGAAGCAAAGGCCCAGGGA
GACCGAGGCGTTTGCCCCAGGCCATGTAGCTAGGAAGTGAGATCTACACCCTGGCTAGCCCTTC
TGCCCACATCTGTAATGGAAGAATGAACTCTCTAGGCATCTACCCTTCTGTGTCAGTTGCCTTT
CCCTGCCTTCCCATGATGCCCAACAGTGAGCTTTTTCAGGAATGCAGCCCTACTTTAGGGGAGC
CCACGGAAATGCAGAAGGAAATAGCTGTGACTATCAGTGATTTTTCCTTGCCTCACCCCATATC
GCAAGCTCAAGCTGAGGAAGAGACCTTTATTCTCCAATGAGGTCCTCACACATCCACACATCTG
GGCCCTCACTCCGGAATCTAGACAGAAAACACACACATACATGACCGACAAGAGGCAATTTCTA
ACCCTAGCACCATGTCCCAGTACATCAGCTGTCTTAGTTTATAGCACTGTTGGGAAAGCCATGG
TTAGGGGCTGGGGATGTAGTTGGGTAGGTAGAGTGTTTGTCTAGTATGTTAGCCCTAAGACCAA
CCTGCAGCACTTCATAAACCAGGCACACTTGTAATCCCAGCACTCGGGAGGTAGGCATGGAGGA
TCAAAAGTTCGAGTTTATCCTTGCCAACGCAATAAGTGTGAACCTTGCCTGGAACCCATGAAAC
TGTTTCAAAATAGAAGTGGGGAGACCCAGTAAGACCCAATACCTTGTGAGCATTCAGCCAGGGC
AGCAAGGCCTGTTTTCACAGGATCCTAACAGGTGATCAGGTAGAAGCTAAAGGAGCCTCAGAAA
CCATCATGTCTAGGCCTCTTGCTTACTGATCATTAACCCTGAGGCCAAAAATGAAAAATTTCTT
GCCTTGTGCCATTGTGAGGGGCCAAGAGAGGACACAGGTGTCCTGTGCATTATAAGCTGAAGAC
AAGTTCACATTGTCTCCATAGCCCAGATGTCCCATCTCCTTTCTGAGTTTTTAAAGAAAACAAG
AGATGTTGAGGAAGCTCTAAATGTAGCGGACAAAACTCAAGGACAGATCAAGGTGTAGGAAAGA
AGCAGGTTGAGAGGCTCTTTTGGTTTGGTTTGTTTATTTGGTTGGTTGGTTGGTTGGTTGGTTG
GTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTTTGATGAAAAGACTTTCCTGTGCATTCCTGGCT
GGCCTCAATTTACAGATCTCCTCTCTCAACTCAACTTTTCCCCAGTATTTGGATCTGCAGGCAA
GCGCCATTATACAGCTGGGGGCATCTCTTTTAAAAGAATATATGATTAAGTATCAGAAAAGTTC
ATGCAAATCAGTGGGCCTGAGGTATACATTTAATTAATATCAGGGCCAATCTGCCTCTTAAACA
TGGGCTTGATGCTGAGAGCTTAGAAGAGATGAGCATTCATGTGGACAGAGGGCTGGCCCCTCAC
CGGACGGTGCAAAGAGATGTGGGAGAGGGAGAGTCTAGGAGGACCACAGGAGTGCTCACACAGA
CCCAACCTCAATGATGCCCACCCCAGGGGGAGAAGGGGTAAGAGTCCTCCCACTAGCTTCATCA
ATCCTTTCTTCCCTCTGCTTGCCCACAGCCCCATCATAATGTGTGATGGGGTACTGTCTCCCTA
ACACCAGTGTCAATTCCTGGGTAGTATCCAGAGACCTGGCCAGGCTTCATCTCTCCAATAGAGA
CATCAGCAAAGGAAAGAGCACAGCCTCCAAGAAGGAAGCTTATAGCCCCTCATTGGGCCAAGGC
TGAGTTCACCAAGATGCTCCCTAGAAGAAGATGGAGACACTGTGTCCTAAGAGGATCTCATACC
CCAGACTAGAATAATTCTTCCCCACATGCCTGGACCTCTTCTGGGCCTTCAGTAAGTGTGTAAA
CTCCATGCTGTACTCTCCTTGTCTGAACCAAGTCCACTTCGATGTGCTAGATGTCAGCTAATCA
TAGAAATTACAACGACCAGCTTGTATCTGAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_031075 ⟹ NP_112337

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	90,487,506 - 90,529,309 (-)	NCBI
mRatBN7.2	3	70,080,850 - 70,122,658 (-)	NCBI
Rnor_6.0	3	72,403,992 - 72,445,775 (-)	NCBI
Rnor_5.0	3	78,914,029 - 78,958,459 (-)	NCBI
RGSC_v3.4	3	68,228,045 - 68,270,751 (-)	RGD
Celera	3	69,431,850 - 69,473,642 (-)	NCBI

Sequence:

show sequence

ATCAAGGGGAGAGACTAGGCACTGGGCTACAGTTGCCTGGCTTACAGGAACTGGCTCTTTTCCT
CAAGCCTCATTAAGCAGCCCACTCCAGTTCTTGATCTTTGTCTCCCAGTCCTGAAGTCCTTTCT
CTCCTTAGGCTGCATCCACAGCCCTTCTAAGTGGCTGTGAGCAGTTTCTCAGTATGAACTGTAT
ATCAGACTTCTTCACCTACGAGACTACCAAGTCGGTGGTTGTGAAGAGCTGGACCATTGGGATC
ATCAACCGAGCCGTCCAGCTGCTGATTATCTCCTACTTTGTGGGGTGGGTTTTCTTGCATGAGA
AGGCCTACCAAGTGAGGGACACCGCCATTGAGTCCTCAGTAGTTACAAAGGTGAAAGGCTTCGG
GCGCTATGCCAACAGAGTCATGGACGTGTCGGATTATGTGACCCCACCCCAGGGCACCTCTGTC
TTTGTCATCATCACCAAAATGATCGTTACTGAAAATCAAATGCAAGGATTCTGTCCAGAGAATG
AAGAGAAGTACCGCTGTGTGTCTGACAGCCAGTGTGGGCCTGAACGCTTCCCAGGTGGGGGGAT
CCTCACCGGCCGCTGCGTGAACTACAGCTCTGTTCTCCGGACCTGTGAGATCCAGGGCTGGTGC
CCCACTGAGGTGGACACCGTGGAGATGCCTATCATGATGGAGGCTGAGAACTTCACCATTTTCA
TCAAGAACAGCATCCGTTTCCCTCTCTTCAACTTTGAGAAGGGAAACCTCCTGCCTAACCTCAC
CGACAAGGACATAAAGAGGTGCCGCTTCCACCCTGAAAAGGCCCCATTTTGCCCCATCTTGAGG
GTAGGGGATGTGGTTAAGTTTGCTGGACAGGATTTTGCCAAGCTGGCCCGCACGGGTGGCGTTC
TGGGTATTAAGATCGGCTGGGTGTGCGATCTAGACAAGGCCTGGGACCAGTGCATCCCTAAATA
TTCCTTCACTCGGCTGGATGGAGTTTCTGAGAAAAGCAGTGTTTCCCCTGGCTACAACTTCAGG
TTTGCCAAATACTATAAGATGGAGAACGGCAGCGAGTACCGCACACTCCTGAAGGCTTTTGGCA
TCCGCTTTGATGTGCTGGTATATGGGAACGCTGGCAAGTTCAACATCATCCCCACCATTATCAG
CTCGGTGGCGGCCTTCACTTCTGTGGGAGTGGGCACTGTTCTCTGTGACATCATCCTGCTCAAT
TTCCTCAAAGGGGCTGATCACTACAAAGCCAGGAAGTTTGAGGAGGTGACTGAGACAACACTGA
AGGGTACTGCGTCAACCAACCCAGTGTTCGCCAGTGACCAGGCCACTGTGGAGAAGCAGTCTAC
AGACTCAGGGGCCTATTCTATTGGTCACTAGGGCCTCTTCCCAGGGTTCCATGCTCACCCTTAG
GCTGCAGAACCTGCAAACAGGCCACTCTATCTAAGCAGTCAGGGGTGGGAGGGGGAGAAGAAGG
GCTGCTATTTCTGCTGTTCACCCCAAAGACTAGATCCAGATATCTAGGCCCTCACTGTTCAACA
GATAGGCAATGCTTCCCACTAAGACTTGAATCTTGCCTTTACCCCTTGCATGCCTCCCACCTGC
TTCCCTGGATCCCAGGACAGCAGCATCCACCCCTTTCCAAAGGATTGAGAAAATGGTAGCTAAG
GTTACACCCATAGGACCTACCACGTACCAAGCACTTCCACACATATTATCCCTTTTCACCCTTA
AAATAATCCTATAAGGTAGATTTCTTGGGTTGTTTGTTTGTTTTGTTATTAAGAGAAGCAAAGG
CCCAGGGAGACCGAGGCGTTTGCCCCAGGCCATGTAGCTAGGAAGTGAGATCTACACCCTGGCT
AGCCCTTCTGCCCACATCTGTAATGGAAGAATGAACTCTCTAGGCATCTACCCTTCTGTGTCAG
TTGCCTTTCCCTGCCTTCCCATGATGCCCAACAGTGAGCTTTTTCAGGAATGCAGCCCTACTTT
AGGGGAGCCCACGGAAATGCAGAAGGAAATAGCTGTGACTATCAGTGATTTTTCCTTGCCTCAC
CCCATATCGCAAGCTCAAGCTGAGGAAGAGACCTTTATTCTCCAATGAGGTCCTCACACATCCA
CACATCTGGGCCCTCACTCCGGAATCTAGACAGAAAACACACACATACATGACCGACAAGAGGC
AATTTCTAACCCTAGCACCATGTCCCAGTACATCAGCTGTCTTAGTTTATAGCACTGTTGGGAA
AGCCATGGTTAGGGGCTGGGGATGTAGTTGGGTAGGTAGAGTGTTTGTCTAGTATGTTAGCCCT
AAGACCAACCTGCAGCACTTCATAAACCAGGCACACTTGTAATCCCAGCACTCGGGAGGTAGGC
ATGGAGGATCAAAAGTTCGAGTTTATCCTTGCCAACGCAATAAGTGTGAACCTTGCCTGGAACC
CATGAAACTGTTTCAAAATAGAAGTGGGGAGACCCAGTAAGACCCAATACCTTGTGAGCATTCA
GCCAGGGCAGCAAGGCCTGTTTTCACAGGATCCTAACAGGTGATCAGGTAGAAGCTAAAGGAGC
CTCAGAAACCATCATGTCTAGGCCTCTTGCTTACTGATCATTAACCCTGAGGCCAAAAATGAAA
AATTTCTTGCCTTGTGCCATTGTGAGGGGCCAAGAGAGGACACAGGTGTCCTGTGCATTATAAG
CTGAAGACAAGTTCACATTGTCTCCATAGCCCAGATGTCCCATCTCCTTTCTGAGTTTTTAAAG
AAAACAAGAGATGTTGAGGAAGCTCTAAATGTAGCGGACAAAACTCAAGGACAGATCAAGGTGT
AGGAAAGAAGCAGGTTGAGAGGCTCTTTTGGTTTGGTTTGTTTATTTGGTTGGTTGGTTGGTTG
GTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTTTGATGAAAAGACTTTCCTGTGCAT
TCCTGGCTGGCCTCAATTTACAGATCTCCTCTCTCAACTCAACTTTTCCCCAGTATTTGGATCT
GCAGGCAAGCGCCATTATACAGCTGGGGGCATCTCTTTTAAAAGAATATATGATTAAGTATCAG
AAAAGTTCATGCAAATCAGTGGGCCTGAGGTATACATTTAATTAATATCAGGGCCAATCTGCCT
CTTAAACATGGGCTTGATGCTGAGAGCTTAGAAGAGATGAGCATTCATGTGGACAGAGGGCTGG
CCCCTCACCGGACGGTGCAAAGAGATGTGGGAGAGGGAGAGTCTAGGAGGACCACAGGAGTGCT
CACACAGACCCAACCTCAATGATGCCCACCCCAGGGGGAGAAGGGGTAAGAGTCCTCCCACTAG
CTTCATCAATCCTTTCTTCCCTCTGCTTGCCCACAGCCCCATCATAATGTGTGATGGGGTACTG
TCTCCCTAACACCAGTGTCAATTCCTGGGTAGTATCCAGAGACCTGGCCAGGCTTCATCTCTCC
AATAGAGACATCAGCAAAGGAAAGAGCACAGCCTCCAAGAAGGAAGCTTATAGCCCCTCATTGG
GCCAAGGCTGAGTTCACCAAGATGCTCCCTAGAAGAAGATGGAGACACTGTGTCCTAAGAGGAT
CTCATACCCCAGACTAGAATAATTCTTCCCCACATGCCTGGACCTCTTCTGGGCCTTCAGTAAG
TGTGTAAACTCCATGCTGTACTCTCCTTGTCTGAACCAAGTCCACTTCGATGTGCTAGATGTCA
GCTAATCATAGAAATTACAACGACCAGCTTGTATCTGAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NR_073054

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	90,487,506 - 90,531,315 (-)	NCBI
mRatBN7.2	3	70,080,850 - 70,124,664 (-)	NCBI
Rnor_6.0	3	72,403,992 - 72,447,801 (-)	NCBI
Rnor_5.0	3	78,914,029 - 78,958,459 (-)	NCBI
Celera	3	69,431,850 - 69,475,670 (-)	NCBI

Sequence:

show sequence

TACGTTTCTCCCCCTTCTTTTAAAATGGATTCGCCCACTGCCCGCGAATTTGAACGCGGATCGA
TCCATCCCAATCGTCCCGCGGGGGAGCAGGGCCCATGCACACCCGGAGCCCGGGAATCGCGACC
ACCCACCTCTTCGAACTGCAGCCTCGCGACGACACAGCTGCATCCACAGCCCTTCTAAGTGGCT
GTGAGCAGTTTCTCAGTATGAACTGTATATCAGACTTCTTCACCTACGAGACTACCAAGTCGGT
GGTTGTGAAGAGCTGGACCATTGGGATCATCAACCGAGCCGTCCAGCTGCTGATTATCTCCTAC
TTTGTGGGGTGGGTTTTCTTGCATGAGAAGGCCTACCAAGTGAGGGACACCGCCATTGAGTCCT
CAGTAGTTACAAAGGTGAAAGGCTTCGGGCGCTATGCCAACAGAGTCATGGACGTGTCGGATTA
TGTGACCCCACCCCAGGGCACCTCTGTCTTTGTCATCATCACCAAAATGATCGTTACTGAAAAT
CAAATGCAAGGATTCTGTCCAGAGAATGAAGAGAAGTACCGCTGTGTGTCTGACAGCCAGTGTG
GGCCTGAACGCTTCCCAGGGATCCTCACCGGCCGCTGCGTGAACTACAGCTCTGTTCTCCGGAC
CTGTGAGATCCAGGGCTGGTGCCCCACTGAGGTGGACACCGTGGAGATGCCTATCATGATGGAG
GCTGAGAACTTCACCATTTTCATCAAGAACAGCATCCGTTTCCCTCTCTTCAACTTTGAGAAGG
GAAACCTCCTGCCTAACCTCACCGACAAGGACATAAAGAGGTGCCGCTTCCACCCTGAAAAGGC
CCCATTTTGCCCCATCTTGAGGGTAGGGGATGTGGTTAAGTTTGCTGGACAGGATTTTGCCAAG
CTGGCCCGCACGGGTGGCGTTCTGGGTATTAAGATCGGCTGGGTGTGCGATCTAGACAAGGCCT
GGGACCAGTGCATCCCTAAATATTCCTTCACTCGGCTGGATGGAGTTTCTGAGAAAAGCAGTGT
TTCCCCTGGCTACAACTTCAGGTTTGCCAAATACTATAAGATGGAGAACGGCAGCGAGTACCGC
ACACTCCTGAAGGCTTTTGGCATCCGCTTTGATGTGCTGGTATATGGGAACGCTGGCAAGTTCA
ACATCATCCCCACCATTATCAGCTCGGTGGCGGCCTTCACTTCTGTGGGAGTGGGCACTGTTCT
CTGTGACATCATCCTGCTCAATTTCCTCAAAGGGGCTGATCACTACAAAGCCAGGAAGTTTGAG
GAGGTGACTGAGACAACACTGAAGGGTACTGCGTCAACCAACCCAGTGTTCGCCAGTGACCAGG
CCACTGTGGAGAAGCAGTCTACAGACTCAGGGGCCTATTCTATTGGTCACTAGGGCCTCTTCCC
AGGGTTCCATGCTCACCCTTAGGCTGCAGAACCTGCAAACAGGCCACTCTATCTAAGCAGTCAG
GGGTGGGAGGGGGAGAAGAAGGGCTGCTATTTCTGCTGTTCACCCCAAAGACTAGATCCAGATA
TCTAGGCCCTCACTGTTCAACAGATAGGCAATGCTTCCCACTAAGACTTGAATCTTGCCTTTAC
CCCTTGCATGCCTCCCACCTGCTTCCCTGGATCCCAGGACAGCAGCATCCACCCCTTTCCAAAG
GATTGAGAAAATGGTAGCTAAGGTTACACCCATAGGACCTACCACGTACCAAGCACTTCCACAC
ATATTATCCCTTTTCACCCTTAAAATAATCCTATAAGGTAGATTTCTTGGGTTGTTTGTTTGTT
TTGTTATTAAGAGAAGCAAAGGCCCAGGGAGACCGAGGCGTTTGCCCCAGGCCATGTAGCTAGG
AAGTGAGATCTACACCCTGGCTAGCCCTTCTGCCCACATCTGTAATGGAAGAATGAACTCTCTA
GGCATCTACCCTTCTGTGTCAGTTGCCTTTCCCTGCCTTCCCATGATGCCCAACAGTGAGCTTT
TTCAGGAATGCAGCCCTACTTTAGGGGAGCCCACGGAAATGCAGAAGGAAATAGCTGTGACTAT
CAGTGATTTTTCCTTGCCTCACCCCATATCGCAAGCTCAAGCTGAGGAAGAGACCTTTATTCTC
CAATGAGGTCCTCACACATCCACACATCTGGGCCCTCACTCCGGAATCTAGACAGAAAACACAC
ACATACATGACCGACAAGAGGCAATTTCTAACCCTAGCACCATGTCCCAGTACATCAGCTGTCT
TAGTTTATAGCACTGTTGGGAAAGCCATGGTTAGGGGCTGGGGATGTAGTTGGGTAGGTAGAGT
GTTTGTCTAGTATGTTAGCCCTAAGACCAACCTGCAGCACTTCATAAACCAGGCACACTTGTAA
TCCCAGCACTCGGGAGGTAGGCATGGAGGATCAAAAGTTCGAGTTTATCCTTGCCAACGCAATA
AGTGTGAACCTTGCCTGGAACCCATGAAACTGTTTCAAAATAGAAGTGGGGAGACCCAGTAAGA
CCCAATACCTTGTGAGCATTCAGCCAGGGCAGCAAGGCCTGTTTTCACAGGATCCTAACAGGTG
ATCAGGTAGAAGCTAAAGGAGCCTCAGAAACCATCATGTCTAGGCCTCTTGCTTACTGATCATT
AACCCTGAGGCCAAAAATGAAAAATTTCTTGCCTTGTGCCATTGTGAGGGGCCAAGAGAGGACA
CAGGTGTCCTGTGCATTATAAGCTGAAGACAAGTTCACATTGTCTCCATAGCCCAGATGTCCCA
TCTCCTTTCTGAGTTTTTAAAGAAAACAAGAGATGTTGAGGAAGCTCTAAATGTAGCGGACAAA
ACTCAAGGACAGATCAAGGTGTAGGAAAGAAGCAGGTTGAGAGGCTCTTTTGGTTTGGTTTGTT
TATTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTTTG
ATGAAAAGACTTTCCTGTGCATTCCTGGCTGGCCTCAATTTACAGATCTCCTCTCTCAACTCAA
CTTTTCCCCAGTATTTGGATCTGCAGGCAAGCGCCATTATACAGCTGGGGGCATCTCTTTTAAA
AGAATATATGATTAAGTATCAGAAAAGTTCATGCAAATCAGTGGGCCTGAGGTATACATTTAAT
TAATATCAGGGCCAATCTGCCTCTTAAACATGGGCTTGATGCTGAGAGCTTAGAAGAGATGAGC
ATTCATGTGGACAGAGGGCTGGCCCCTCACCGGACGGTGCAAAGAGATGTGGGAGAGGGAGAGT
CTAGGAGGACCACAGGAGTGCTCACACAGACCCAACCTCAATGATGCCCACCCCAGGGGGAGAA
GGGGTAAGAGTCCTCCCACTAGCTTCATCAATCCTTTCTTCCCTCTGCTTGCCCACAGCCCCAT
CATAATGTGTGATGGGGTACTGTCTCCCTAACACCAGTGTCAATTCCTGGGTAGTATCCAGAGA
CCTGGCCAGGCTTCATCTCTCCAATAGAGACATCAGCAAAGGAAAGAGCACAGCCTCCAAGAAG
GAAGCTTATAGCCCCTCATTGGGCCAAGGCTGAGTTCACCAAGATGCTCCCTAGAAGAAGATGG
AGACACTGTGTCCTAAGAGGATCTCATACCCCAGACTAGAATAATTCTTCCCCACATGCCTGGA
CCTCTTCTGGGCCTTCAGTAAGTGTGTAAACTCCATGCTGTACTCTCCTTGTCTGAACCAAGTC
CACTTCGATGTGCTAGATGTCAGCTAATCATAGAAATTACAACGACCAGCTTGTATCTGAAAAA
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039105918 ⟹ XP_038961846

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	90,487,506 - 90,530,956 (-)	NCBI
mRatBN7.2	3	70,080,850 - 70,124,339 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001257550	(Get FASTA)	NCBI Sequence Viewer
	NP_112337	(Get FASTA)	NCBI Sequence Viewer
	XP_038961846	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD47381	(Get FASTA)	NCBI Sequence Viewer
	AAH81783	(Get FASTA)	NCBI Sequence Viewer
	CAA62223	(Get FASTA)	NCBI Sequence Viewer
	CAA62594	(Get FASTA)	NCBI Sequence Viewer
	EDL79328	(Get FASTA)	NCBI Sequence Viewer
	EDL79329	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031629
	ENSRNOP00000071698
	ENSRNOP00000106307
GenBank Protein	P49654	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112337 ⟸ NM_031075
- Peptide Label:	isoform 1
- UniProtKB:	P49654 (UniProtKB/Swiss-Prot), A6HMS8 (UniProtKB/TrEMBL), Q66HM4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKV KGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDSQCGPERFP GGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLL PNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQC IPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIP TIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVE KQSTDSGAYSIGH hide sequence

RefSeq Acc Id:	NP_001257550 ⟸ NM_001270621
- Peptide Label:	isoform 2
- UniProtKB:	Q9R1K3 (UniProtKB/TrEMBL), A0A0G2K147 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKV KGFGRYANRVMDVSDYVTPPQNEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVLRTCEIQGW CPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPIL RVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNF RFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILL NFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH hide sequence

Ensembl Acc Id:

ENSRNOP00000031629 ⟸ ENSRNOT00000033427

Ensembl Acc Id:

ENSRNOP00000071698 ⟸ ENSRNOT00000077573

Ensembl Acc Id:

ENSRNOP00000072187 ⟸ ENSRNOT00000088815

RefSeq Acc Id:	XP_038961846 ⟸ XM_039105918
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2QGY3 (UniProtKB/TrEMBL), Q66HM4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000099956 ⟸ ENSRNOT00000146485

Ensembl Acc Id:

ENSRNOP00000106307 ⟸ ENSRNOT00000158499

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P49654-F1-model_v2	AlphaFold	P49654	1-397	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620253	AgrOrtholog
BioCyc Gene	G2FUF-49140	BioCyc
Ensembl Genes	ENSRNOG00000008552	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000033427	ENTREZGENE
	ENSRNOT00000077573	ENTREZGENE
	ENSRNOT00000158499	ENTREZGENE
Gene3D-CATH	2.60.490.10	UniProtKB/Swiss-Prot
	atp-gated p2x4 ion channel	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7134300	IMAGE-MGC_LOAD
InterPro	P2X3_purnocptor	UniProtKB/Swiss-Prot
	P2X_extracellular_dom_sf	UniProtKB/Swiss-Prot
	P2X_purnocptor	UniProtKB/Swiss-Prot
	P2X_RECEPTOR_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:81739	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93384	IMAGE-MGC_LOAD
NCBI Gene	81739	ENTREZGENE
PANTHER	P2X PURINOCEPTOR	UniProtKB/Swiss-Prot
	PTHR10125:SF8	UniProtKB/Swiss-Prot
Pfam	P2X_receptor	UniProtKB/Swiss-Prot
PhenoGen	P2rx3	PhenoGen
PIRSF	P2X_purinoceptor	UniProtKB/Swiss-Prot
PRINTS	P2X3RECEPTOR	UniProtKB/Swiss-Prot
	P2XRECEPTOR	UniProtKB/Swiss-Prot
PROSITE	P2X_RECEPTOR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008552	RatGTEx
UniProt	A0A0G2K147	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QGY3	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0KYL7_RAT	UniProtKB/TrEMBL
	A0ABK0LKQ4_RAT	UniProtKB/TrEMBL
	A6HMS8	ENTREZGENE, UniProtKB/TrEMBL
	P2RX3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q66HM4	ENTREZGENE, UniProtKB/TrEMBL
	Q9R1K3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	P2rx3	purinergic receptor P2X 3	P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3		purinergic receptor P2X ligand-gated ion channel, 3	Name updated	1299863	APPROVED
2002-08-07	P2rx3	purinergic receptor P2X ligand-gated ion channel, 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	forms heteromer with P2X2 to create the ATP-activated currents seen in sensory neurons	728995

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)