P2RX3 (purinergic receptor P2X 3) - Rat Genome Database

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Gene: P2RX3 (purinergic receptor P2X 3) Sus scrofa
Analyze
Symbol: P2RX3
Name: purinergic receptor P2X 3
RGD ID: 14146596
Description: ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN behavioral response to formalin induced pain (ortholog); behavioral response to pain (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hyperalgesia (ortholog); intellectual disability (ortholog); FOUND IN dendritic spine (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: P2X purinoceptor 3; P2X3R; purinergic receptor P2X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,584,925 - 13,617,785 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,584,913 - 13,619,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2213,347,685 - 13,381,122 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22041665   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P2RX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,584,925 - 13,617,785 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,584,913 - 13,619,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2213,347,685 - 13,381,122 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,335,950 - 57,372,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,338,352 - 57,372,396 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,105,826 - 57,139,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,862,525 - 56,894,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,862,524 - 56,894,125NCBI
Celera1154,464,979 - 54,477,411 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,454,728 - 53,486,434 (+)NCBIHuRef
CHM1_11156,971,953 - 57,003,678 (+)NCBICHM1_1
T2T-CHM13v2.01157,285,441 - 57,321,889 (+)NCBIT2T-CHM13v2.0
P2rx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,826,893 - 84,867,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,828,927 - 84,867,806 (-)EnsemblGRCm39 Ensembl
GRCm38284,996,549 - 85,037,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,998,583 - 85,037,462 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,836,709 - 84,875,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,797,391 - 84,836,673 (-)NCBIMGSCv36mm8
Celera286,595,241 - 86,634,592 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
P2rx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,487,506 - 90,531,315 (-)NCBIGRCr8
mRatBN7.2370,080,850 - 70,124,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,080,851 - 70,125,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,462,764 - 73,506,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0382,061,439 - 82,105,058 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,819,891 - 79,863,521 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,403,992 - 72,447,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,403,993 - 72,447,801 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,914,029 - 78,958,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,228,045 - 68,270,751 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1368,124,416 - 68,167,123 (-)NCBI
Celera369,431,850 - 69,475,670 (-)NCBICelera
Cytogenetic Map3q24NCBI
P2rx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,389,717 - 2,411,008 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555112,389,717 - 2,410,968 (+)NCBIChiLan1.0ChiLan1.0
P2RX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,492,901 - 58,531,132 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,509,857 - 59,548,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,579,190 - 52,614,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,070,860 - 160,104,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,070,875 - 160,106,120 (+)Ensemblpanpan1.1panPan2
P2RX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,773,930 - 38,801,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,772,529 - 38,802,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,319,548 - 38,346,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,455,279 - 39,482,558 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,453,201 - 39,482,831 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11839,035,826 - 39,065,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,609,330 - 38,638,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,242,142 - 39,269,413 (-)NCBIUU_Cfam_GSD_1.0
P2rx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494715,002,140 - 15,032,591 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,115,492 - 5,146,634 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365815,116,276 - 5,146,378 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,872,124 - 15,906,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038113,214,882 - 113,249,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,229,979 - 3,253,094 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248643,233,019 - 3,253,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2RX3
1347 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system reproductive system
High
Medium
Low 2 1
Below cutoff 8 2 1 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031039   ⟹   ENSSSCP00000019980
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl213,584,925 - 13,617,785 (-)Ensembl
RefSeq Acc Id: XM_003353865   ⟹   XP_003353913
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1213,584,913 - 13,619,652 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003353913   ⟸   XM_003353865
- UniProtKB: I3L7H5 (UniProtKB/TrEMBL),   A0A4X1VK46 (UniProtKB/TrEMBL),   A0A8D0NC53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019980   ⟸   ENSSSCT00000031039


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005010703 UniProtKB/TrEMBL
  ENSSSCG00015027082 UniProtKB/TrEMBL
  ENSSSCG00025047712 UniProtKB/TrEMBL
  ENSSSCG00030055515 UniProtKB/TrEMBL
  ENSSSCG00035049911 UniProtKB/TrEMBL
  ENSSSCG00040057878 UniProtKB/TrEMBL
  ENSSSCG00045021276 UniProtKB/TrEMBL
  ENSSSCG00050061941 UniProtKB/TrEMBL
  ENSSSCG00055005040 UniProtKB/TrEMBL
  ENSSSCG00060022719 UniProtKB/TrEMBL
  ENSSSCG00065045235 UniProtKB/TrEMBL
  ENSSSCG00070025914 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031039 ENTREZGENE
  ENSSSCT00000031039.4 UniProtKB/TrEMBL
  ENSSSCT00005016898.1 UniProtKB/TrEMBL
  ENSSSCT00015035963.1 UniProtKB/TrEMBL
  ENSSSCT00025064885.1 UniProtKB/TrEMBL
  ENSSSCT00030077355.1 UniProtKB/TrEMBL
  ENSSSCT00035066501.1 UniProtKB/TrEMBL
  ENSSSCT00040078489.1 UniProtKB/TrEMBL
  ENSSSCT00045036344.1 UniProtKB/TrEMBL
  ENSSSCT00050084378.1 UniProtKB/TrEMBL
  ENSSSCT00055009900.1 UniProtKB/TrEMBL
  ENSSSCT00060030835.1 UniProtKB/TrEMBL
  ENSSSCT00065061887.1 UniProtKB/TrEMBL
  ENSSSCT00070051839.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/TrEMBL
InterPro P2X3_purnocptor UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/TrEMBL
KEGG Report ssc:503656 UniProtKB/TrEMBL
NCBI Gene P2RX3 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/TrEMBL
  PTHR10125:SF8 UniProtKB/TrEMBL
Pfam P2X_receptor UniProtKB/TrEMBL
PIRSF P2X_purinoceptor UniProtKB/TrEMBL
PRINTS P2X3RECEPTOR UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/TrEMBL
UniProt A0A4X1VK46 ENTREZGENE
  A0A8D0NC53 ENTREZGENE, UniProtKB/TrEMBL
  I3L7H5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1VK46 UniProtKB/TrEMBL
VGNC ID VGNC:91120 ENTREZGENE