RGD Reference Report - Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits. - Rat Genome Database

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Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits.

Authors: Diaz-Hernandez, M  Gomez-Villafuertes, R  Hernando, F  Pintor, J  Miras-Portugal, MT 
Citation: Diaz-Hernandez M, etal., Neurosci Lett. 2001 Apr 6;301(3):159-62.
RGD ID: 1642676
Pubmed: PMID:11257422   (View Abstract at PubMed)

Adenosine 5'-triphosphate (ATP) stimulates a [Ca(2+)](i) increase via specific ionotropic receptors, termed P2X receptors, in rat midbrain presynaptic terminals. A microfluorimetric technique enabled study of the [Ca(2+)](i) increase in isolated single synaptic terminals, showing that 33.4+/-2.5% of them responded to ATP. Immunological studies carried out, after functional studies, with specific anti-P2X receptor subunit antibodies showed only positive labelling with anti-P2X(3) antibodies in 23.5+/-1.7% of the terminals. All positively P2X(3) labelled synaptic terminals responded to ATP. Nevertheless, not all of them responded to alpha,beta-meATP, these representing 6.7+/-1.5% of the total. In addition, 9.8+/-2.3% of the terminals responded to ATP but exhibit negative P2X(3)-labelling. These results demonstrate the existence of a heterogeneous population of ionotropic ATP receptors at the presynaptic level.

Objects referenced in this article
Gene P2rx3 purinergic receptor P2X 3 Rattus norvegicus

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