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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620253
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2rx3
Name: purinergic receptor P2X 3
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2rx3multiple interactionsISOP2RX3 (Homo sapiens)6480464CTDTrichloroethylene binds to and results in decreased activity of P2RX3 protein; Trichloroethylene inhibits the reaction [[alpha,beta-methyleneadenosine 5'-triphosphate binds to and results in increased activity of P2RX3 protein] which results in increased abundance of Calcium]PMID:12694404
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