Oprm1 (opioid receptor, mu 1) - Rat Genome Database

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Gene: Oprm1 (opioid receptor, mu 1) Rattus norvegicus
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Symbol: Oprm1
Name: opioid receptor, mu 1
RGD ID: 3234
Description: Enables several functions, including G-protein beta-subunit binding activity; morphine receptor activity; and voltage-gated calcium channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway; estrous cycle; and regulation of signal transduction. Located in several cellular components, including dendrite; focal adhesion; and perikaryon. Is active in postsynaptic membrane; presynaptic membrane; and spine apparatus. Used to study obesity. Biomarker of brain ischemia; extrahepatic cholestasis; human immunodeficiency virus infectious disease; obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to human OPRM1 (opioid receptor mu 1); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (3,4-dihydroxyphenyl)acetic acid; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: M-OR-1; MOR-1; MORA; mu opioid receptor; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; mu-type opioid receptor; MUOR1; opioid receptor B; Oprm; Oprrm1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Oprm1_v3 ; Oprm1_v1 ; Oprm1_v2 ; Oprm1_v4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,565,371 - 45,818,722 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,565,371 - 45,638,756 (+)EnsemblGRCr8
mRatBN7.2143,160,057 - 43,413,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,160,057 - 43,413,409 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx143,700,986 - 43,954,675 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0149,688,216 - 49,941,908 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0143,776,469 - 44,030,156 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)Ensemblrn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera138,804,246 - 39,057,359 (+)NCBICelera
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
RH 3.4 Map1468.6RGD
Cytogenetic Map1q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloroethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3',5'-cyclic AMP  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7-Benzylidenenaltrexone  (ISO)
7-Hydroxymitragynine  (ISO)
acetylmethadol  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alvimopan  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
beta-Funaltrexamine  (EXP,ISO)
bisphenol A  (EXP)
buprenorphine  (EXP,ISO)
butan-1-ol  (EXP)
butorphanol  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carfentanil  (ISO)
carrageenan  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cocaine  (EXP,ISO)
codeine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
dextrorphan  (EXP)
diisopropyl fluorophosphate  (ISO)
dizocilpine maleate  (ISO)
DPDPE  (EXP)
dynorphin A  (EXP,ISO)
Endomorphin-1  (ISO)
Endomorphin-2  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etonitazene  (EXP,ISO)
fentanyl  (EXP,ISO)
fluoxetine  (EXP,ISO)
furan  (EXP)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
GTP  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
homovanillic acid  (EXP)
hydrocodone  (EXP)
hydromorphone  (EXP,ISO)
isotonitazene  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Leu-enkephalin  (ISO)
Levallorphan  (EXP)
Levorphanol  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylnaltrexone  (ISO)
Mitragynine  (ISO)
Morphiceptin  (EXP)
morphine  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
Nalmefene  (ISO)
naloxone  (EXP,ISO)
naltrexone  (EXP,ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
oxycodone  (EXP)
Oxymorphone  (EXP,ISO)
paraquat  (ISO)
paynantheine  (ISO)
PCB138  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP)
picrotoxin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
serotonin  (EXP)
sodium arsenite  (ISO)
speciogynine  (ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
tapentadol  (EXP,ISO)
thioglycolic acid  (EXP)
tianeptine  (ISO)
titanium dioxide  (ISO)
tramadol  (EXP)
trichostatin A  (ISO)
U69593  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (IEP)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  (IDA)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA,ISO,ISS)
adenylate cyclase-inhibiting opioid receptor signaling pathway  (IDA)
behavioral response to ethanol  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
cellular response to morphine  (IEA)
eating behavior  (IEA,IMP)
estrous cycle  (IEP)
excitatory postsynaptic potential  (IDA)
G protein-coupled opioid receptor signaling pathway  (IBA,IEA,ISO)
G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
immune response  (TAS)
locomotory behavior  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA)
negative regulation of cytosolic calcium ion concentration  (ISO,ISS)
negative regulation of luteinizing hormone secretion  (IMP)
negative regulation of nitric oxide biosynthetic process  (ISO,ISS)
negative regulation of Wnt protein secretion  (IEA,ISO,ISS)
neuropeptide signaling pathway  (IBA,IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of appetite  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gluconeogenesis  (IMP)
positive regulation of neurogenesis  (ISO,ISS)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cellular response to stress  (IEA,ISO)
regulation of NMDA receptor activity  (IMP)
response to cocaine  (IEP)
response to ethanol  (IDA,IEP)
response to food  (IEP)
response to growth factor  (IEP)
response to lipopolysaccharide  (IEP)
sensory perception of pain  (IBA,ISO,ISS)
signal transduction  (IEA)
social behavior  (IMP)
sperm ejaculation  (IDA)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
heroin pharmacokinetics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain. Ahmadi S, etal., Neuroscience. 2015 Jan 22;284:78-86. doi: 10.1016/j.neuroscience.2014.08.063. Epub 2014 Oct 5.
2. Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study. Al-Eitan LN, etal., BMC Psychiatry. 2021 Jan 5;21(1):5. doi: 10.1186/s12888-020-03006-z.
3. Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent. Al-Eitan LN, etal., Pharmgenomics Pers Med. 2012;5:99-111. doi: 10.2147/PGPM.S33351. Epub 2012 Sep 7.
4. Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial. Anton RF, etal., Alcohol Clin Exp Res. 2020 Oct;44(10):2084-2096. doi: 10.1111/acer.14431. Epub 2020 Sep 19.
5. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Anton RF, etal., Arch Gen Psychiatry. 2008 Feb;65(2):135-44. doi: 10.1001/archpsyc.65.2.135.
6. Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone. Bach P, etal., Addict Biol. 2020 Jan;25(1):e12717. doi: 10.1111/adb.12717. Epub 2019 Feb 12.
7. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
8. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
9. Mu opioid receptor gene variants: lack of association with alcohol dependence. Bergen AW, etal., Mol Psychiatry. 1997 Oct-Nov;2(6):490-4. doi: 10.1038/sj.mp.4000331.
10. Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats. Brown TG, etal., J Neurosci Res. 2022 Jan;100(1):35-47. doi: 10.1002/jnr.24640. Epub 2020 Jun 7.
11. Characterization and distribution of a cloned rat mu-opioid receptor. Bunzow JR, etal., J Neurochem 1995 Jan;64(1):14-24.
12. A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating. Chaijale NN, etal., Brain Res. 2008 Nov 13;1240:111-8. Epub 2008 Sep 4.
13. The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Chakrabarti S, etal., Mol Pharmacol. 1997 Jul;52(1):105-13.
14. Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Chakrabarti S, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20115-9. doi: 10.1073/pnas.1009923107. Epub 2010 Nov 1.
15. Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model. Chang SL, etal., J Virol. 2007 Aug;81(16):8406-11. Epub 2007 Jun 6.
16. Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization. Chen W and Marvizon JC, Neuroscience. 2009 Jun 16;161(1):157-72. Epub 2009 Mar 17.
17. Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Chen Y, etal., Mol Pharmacol. 1993 Jul;44(1):8-12.
18. [Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald] Cheng B, etal., Zhonghua Shao Shang Za Zhi. 2007 Feb;23(1):36-9.
19. Role of toll-like receptor 4 antagonist Lipopolysaccharide-Rhodobacter sphaeroides on acute stress-induced voluntary ethanol preference and drinking behaviour: In vivo Swiss Albino mouse model. Chuang HG, etal., Eur Neuropsychopharmacol. 2021 Apr;45:59-72. doi: 10.1016/j.euroneuro.2019.12.121. Epub 2020 Feb 1.
20. mu-1 opioid receptor stimulation decreases body temperature in conscious, unrestrained neonatal rats. Colman AS and Miller JH, Exp Biol Med (Maywood) 2002 Jun;227(6):377-81.
21. A polymorphism in the OPRM1 3'-untranslated region is associated with methadone efficacy in treating opioid dependence. Crist RC, etal., Pharmacogenomics J. 2018 Jan;18(1):173-179. doi: 10.1038/tpj.2016.89. Epub 2016 Dec 13.
22. A genetic association study of the mu opioid receptor and severe opioid dependence. Crowley JJ, etal., Psychiatr Genet. 2003 Sep;13(3):169-73. doi: 10.1097/00041444-200309000-00006.
23. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
24. Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine. Drake CT, etal., Exp Neurol. 2005 Dec;196(2):365-72. Epub 2005 Sep 27.
25. Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder. Ebrahimi G, etal., Am J Drug Alcohol Abuse. 2018;44(2):193-199. doi: 10.1080/00952990.2016.1275659. Epub 2017 Jan 25.
26. Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5alpha-dihydrotestosterone-induced rat polycystic ovary syndrome model. Feng Y, etal., Exp Physiol. 2012 May;97(5):651-62. doi: 10.1113/expphysiol.2011.063131. Epub 2012 Feb 15.
27. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
28. Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Formisano L, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4170-5. Epub 2007 Feb 28.
29. Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Francès F, etal., Bosn J Basic Med Sci. 2015 Apr 25;15(2):31-6. doi: 10.17305/bjbms.2015.243.
30. Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Franke P, etal., Am J Med Genet. 2001 Jan 8;105(1):114-9.
31. Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Fukuda K, etal., FEBS Lett 1993 Aug 2;327(3):311-4.
32. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X, etal., OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
33. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
34.  Role of µ-Opioid Receptor Polymorphism in Patients of Rheumatoid Arthritis and their Correlation with Severity of Disease. Gauri L, etal., J Assoc Physicians India. 2019 Apr;67(4):22-25.
35. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Gelernter J, etal., Alcohol Clin Exp Res. 2007 Apr;31(4):555-63. doi: 10.1111/j.1530-0277.2007.00339.x.
36. Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse. Gendy MNS, etal., Can J Addict. 2019 Dec;10(4):30-34. doi: 10.1097/cxa.0000000000000069.
37. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
38. Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Hadjimarkou MM, etal., Synapse. 2009 Jul;63(7):585-97.
39. μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury. Hakim JD, etal., Behav Brain Res. 2020 Mar 2;381:112416. doi: 10.1016/j.bbr.2019.112416. Epub 2019 Dec 10.
40. Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. Hardin J, etal., Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3399-406. doi: 10.1158/1055-9965.EPI-09-0960.
41. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
42. Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Hurley RW, etal., Neuroscience. 2003;118(3):789-96.
43. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Ide S, etal., Pharmacogenomics J. 2006 May-Jun;6(3):179-88. doi: 10.1038/sj.tpj.6500355.
44. NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Israel Y, etal., Peptides. 2005 Jul;26(7):1167-75. Epub 2005 Feb 26.
45. Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum. Jabourian M, etal., Eur J Neurosci. 2007 Mar;25(5):1546-56.
46. Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. Jin J, etal., BMC Neurosci. 2010 Mar 9;11:33. doi: 10.1186/1471-2202-11-33.
47. Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms. Jones JD, etal., Am J Addict. 2016 Jan;25(1):41-8. doi: 10.1111/ajad.12316. Epub 2015 Dec 21.
48. kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
49. A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin. Kapur S, etal., J Integr Neurosci. 2007 Dec;6(4):511-22. doi: 10.1142/s0219635207001635.
50. OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
51. Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. Kertes DA, etal., Alcohol Clin Exp Res. 2011 Mar;35(3):496-505. doi: 10.1111/j.1530-0277.2010.01366.x. Epub 2010 Dec 8.
52. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. Kim SG, Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):680-5.
53. The contribution of MOR-1 exons 1-4 to morphine and heroin analgesia and dependence. Klein G, etal., Neurosci Lett. 2009 Jul 3;457(3):115-9. doi: 10.1016/j.neulet.2009.04.012. Epub 2009 Apr 9.
54. ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. Koch T, etal., J Biol Chem. 2003 Mar 14;278(11):9979-85. Epub 2003 Jan 7.
55. A single nucleotide polymorphism in OPRM1(rs483481) and risk for heroin use disorder. Koijam AS, etal., J Addict Dis. 2020 Apr-Jun;38(2):214-222. doi: 10.1080/10550887.2020.1740070. Epub 2020 Mar 19.
56. Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons. Koyama S and Akaike N, Neurosci Res. 2008 Jan;60(1):22-8. Epub 2007 Sep 14.
57. Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. Kraus J, etal., J Biol Chem 2001 Nov 23;276(47):43901-8.
58. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
59. Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
60. Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
61. Side chain modifications change the binding and agonist properties of endomorphin 2. Lengyel I, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):153-61.
62. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
63. The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment. Levran O, etal., Pharmacogenomics. 2017 Oct;18(15):1387-1391. doi: 10.2217/pgs-2017-0092. Epub 2017 Oct 4.
64. Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling. Liang YJ, etal., Mol Pharmacol. 2007 Jan;71(1):123-31. Epub 2006 Sep 27.
65. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Luo X, etal., Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):97-108. doi: 10.1002/ajmg.b.20034.
66. Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation. McQuiston AR Neuroscience. 2008 Jan 2;151(1):209-21. Epub 2007 Oct 11.
67. Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex. Mena JD, etal., J Neurosci. 2011 Mar 2;31(9):3249-60. doi: 10.1523/JNEUROSCI.2050-10.2011.
68. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
69. Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics. Miyahara K, etal., J Psychiatr Res. 2023 Oct;166:10-16. doi: 10.1016/j.jpsychires.2023.08.007. Epub 2023 Aug 28.
70. Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area. Moreno E, etal., J Neurosci. 2017 Feb 1;37(5):1176-1186. doi: 10.1523/JNEUROSCI.2442-16.2016. Epub 2016 Dec 22.
71. Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain. Mousa SA, etal., Brain. 2007 Feb;130(Pt 2):502-13. Epub 2006 Dec 2.
72. OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. Muriel J, etal., Ann N Y Acad Sci. 2018 Aug;1425(1):82-93. doi: 10.1111/nyas.13735. Epub 2018 May 20.
73. Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat. Narita M, et al., Neuroscience. 2007 Feb 9;144(3):777-82. Epub 2006 Dec 6.
74. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
75. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Nishizawa D, etal., Neuropsychobiology. 2006;53(3):137-41. doi: 10.1159/000093099. Epub 2006 May 4.
76. OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV. Nugent NR, etal., AIDS Behav. 2012 Nov;16(8):2171-80. doi: 10.1007/s10461-011-0095-8.
77. Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. Pasternak DA, etal., J Neurochem. 2004 Nov;91(4):881-90.
78. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
79. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
80. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Pucci M, etal., Front Genet. 2019 Jun 14;10:523. doi: 10.3389/fgene.2019.00523. eCollection 2019.
81. FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor. Qiu Y, etal., Mol Pharmacol. 2014 Jan;85(1):37-49. doi: 10.1124/mol.113.087825. Epub 2013 Oct 10.
82. Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. Ray LA, Alcohol Clin Exp Res. 2011 Jan;35(1):166-74. doi: 10.1111/j.1530-0277.2010.01333.x. Epub 2010 Oct 6.
83. Ultrastructural evidence for co-localization of corticotropin-releasing factor receptor and mu-opioid receptor in the rat nucleus locus coeruleus. Reyes BA, etal., Neurosci Lett. 2007 Feb 21;413(3):216-21. Epub 2006 Dec 15.
84. GOA pipeline RGD automated data pipeline
85. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
86. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
87. Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. Rozenfeld R and Devi LA, FASEB J. 2007 Aug;21(10):2455-65. Epub 2007 Mar 23.
88. Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current. Schroeder JE, etal., Neuron. 1991 Jan;6(1):13-20.
89. Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders. Sener EF, etal., J Mol Neurosci. 2019 Jan;67(1):89-96. doi: 10.1007/s12031-018-1213-0. Epub 2018 Dec 5.
90. Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents. Stumm R, etal., Eur J Neurosci. 2005 Sep;22(5):1032-44.
91. -mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. Surratt CK, etal., J Biol Chem. 1994 Aug 12;269(32):20548-53.
92. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
93. Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Teodorov E, etal., Neuroscience. 2006 Sep 1;141(3):1225-31. Epub 2006 Jun 6.
94. The role of neuronal nitric oxide synthase in cocaine place preference and mu opioid receptor expression in the nucleus accumbens. Thériault RK, etal., Psychopharmacology (Berl). 2018 Sep;235(9):2675-2685. doi: 10.1007/s00213-018-4961-1. Epub 2018 Jul 10.
95. Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment. Tolami HF, etal., J Mol Neurosci. 2020 Apr;70(4):504-513. doi: 10.1007/s12031-019-01443-4. Epub 2019 Dec 18.
96. Evidence for MOR on cell membrane, sarcoplasmatic reticulum and mitochondria in left ventricular myocardium in rats. Treskatsch S, etal., Heart Vessels. 2016 Aug;31(8):1380-8. doi: 10.1007/s00380-015-0784-8. Epub 2015 Dec 19.
97. Mu opioid receptors and analgesia at the site of a peripheral nerve injury. Truong W, etal., Ann Neurol 2003 Mar;53(3):366-75.
98. Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein. Tsai RY, etal., Neuroscience. 2009 Dec 1;164(2):435-43. Epub 2009 Aug 12.
99. Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats. Tsuchida H, etal., Endocrinology. 2021 Oct 1;162(10):bqab140. doi: 10.1210/endocr/bqab140.
100. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
101. Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. Wachman EM, etal., JAMA. 2013 May 1;309(17):1821-7. doi: 10.1001/jama.2013.3411.
102. Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. Wang H and Pickel VM, J Neurosci. 2001 May 1;21(9):3242-50.
103. Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. Wang H, etal., J Mol Neurosci. 2017 May;62(1):17-27. doi: 10.1007/s12031-017-0905-1. Epub 2017 Mar 24.
104. Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. Wang HL, etal., J Neurochem. 2005 Mar;92(6):1285-94.
105. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
106. Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. Wang HY and Burns LH, PLoS One. 2009;4(1):e4282. doi: 10.1371/journal.pone.0004282. Epub 2009 Jan 27.
107. mu opiate receptor: cDNA cloning and expression. Wang JB, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10230-4.
108. Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. Wu DF, etal., J Biol Chem. 2007 Jul 27;282(30):22239-47. Epub 2007 Jun 4.
109. Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population. Xu J, etal., Biochem Genet. 2018 Oct;56(5):451-458. doi: 10.1007/s10528-018-9852-y. Epub 2018 Mar 21.
110. Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. Yamamoto T, etal., J Pharmacol Exp Ther. 2006 Jul;318(1):206-13. Epub 2006 Mar 24.
111. Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder. Yu J, etal., Neurosci Lett. 2023 Sep 25;814:137468. doi: 10.1016/j.neulet.2023.137468. Epub 2023 Sep 1.
112. Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Yu Y, etal., Peptides. 2006 Nov;27(11):2770-7. Epub 2006 Aug 9.
113. Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. Zhang D, etal., Biol Psychiatry. 2007 Jun 1;61(11):1244-51. doi: 10.1016/j.biopsych.2006.07.012. Epub 2006 Dec 8.
114. The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist. Zhang J, etal., Eur J Pharmacol. 2006 Sep 18;545(2-3):147-52. doi: 10.1016/j.ejphar.2006.06.069. Epub 2006 Jul 5.
115. Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal. Zhang L, etal., EMBO Mol Med. 2017 Nov;9(11):1521-1536. doi: 10.15252/emmm.201607324.
116. Effects of mu opioid receptors in paraventricular nucleus on ejaculation through mediating sympathetic nerve system activity. Zhang QJ, etal., Neuropharmacology. 2019 Nov 1;158:107709. doi: 10.1016/j.neuropharm.2019.107709. Epub 2019 Jul 13.
117. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of mu-Opioid Receptors in Primary Sensory Neurons. Zhang Y, etal., J Biol Chem. 2016 Apr 15;291(16):8475-85. doi: 10.1074/jbc.M115.711812. Epub 2016 Feb 25.
118. Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats. Zhao C, etal., Genes Brain Behav. 2020 Sep;19(7):e12662. doi: 10.1111/gbb.12662. Epub 2020 May 18.
119. Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study. Zhou H, etal., JAMA Psychiatry. 2020 Oct 1;77(10):1072-1080. doi: 10.1001/jamapsychiatry.2020.1206.
120. Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. Zhou Y, etal., J Endocrinol. 2006 Oct;191(1):137-45.
Additional References at PubMed
PMID:7532594   PMID:7733926   PMID:8189219   PMID:8240812   PMID:8738226   PMID:9037090   PMID:9689128   PMID:9915326   PMID:10835636   PMID:11304756   PMID:11994125   PMID:12000113  
PMID:12574430   PMID:12732339   PMID:12855366   PMID:12867258   PMID:12899684   PMID:12906839   PMID:14532289   PMID:14689476   PMID:14960335   PMID:15101090   PMID:15236578   PMID:15306235  
PMID:15308614   PMID:15322094   PMID:15327807   PMID:15467355   PMID:15659552   PMID:15857395   PMID:15950784   PMID:15967419   PMID:16139823   PMID:16140499   PMID:16159882   PMID:16200625  
PMID:16242731   PMID:16306173   PMID:16519691   PMID:16564113   PMID:16564625   PMID:16682964   PMID:16684876   PMID:16738492   PMID:17152089   PMID:17184926   PMID:17347322   PMID:17419755  
PMID:17436287   PMID:17492626   PMID:17532787   PMID:17919468   PMID:17980152   PMID:18032464   PMID:18216773   PMID:18248905   PMID:18269915   PMID:18343590   PMID:18364037   PMID:18381590  
PMID:18550291   PMID:18550774   PMID:18602454   PMID:18615498   PMID:18778083   PMID:19200236   PMID:19244586   PMID:19279569   PMID:19324084   PMID:19419664   PMID:19505458   PMID:19545549  
PMID:19596019   PMID:19666113   PMID:19822132   PMID:19861419   PMID:19889856   PMID:20525224   PMID:20562021   PMID:20574683   PMID:20592872   PMID:20615975   PMID:20626460   PMID:20653037  
PMID:20977770   PMID:21056047   PMID:21238509   PMID:21255438   PMID:21543633   PMID:21602922   PMID:21631922   PMID:21827637   PMID:22210742   PMID:22521830   PMID:22703995   PMID:22732447  
PMID:22796630   PMID:22865422   PMID:23106126   PMID:23270855   PMID:23299095   PMID:23598399   PMID:23671582   PMID:23760268   PMID:23801566   PMID:23843537   PMID:24063433   PMID:24120859  
PMID:24718557   PMID:24976397   PMID:25051156   PMID:25146548   PMID:25315826   PMID:25446676   PMID:25481857   PMID:26044640   PMID:26119705   PMID:26700246   PMID:27089914   PMID:27246300  
PMID:27508965   PMID:27743985   PMID:29237725   PMID:29257262   PMID:29473323   PMID:29563057   PMID:29589831   PMID:31030416   PMID:31697924   PMID:31926909   PMID:33108956   PMID:33400082  
PMID:33482313   PMID:33673008   PMID:33919998   PMID:35674691   PMID:35833821   PMID:36867667   PMID:37482304   PMID:38140734  


Genomics

Comparative Map Data
Oprm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,565,371 - 45,818,722 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,565,371 - 45,638,756 (+)EnsemblGRCr8
mRatBN7.2143,160,057 - 43,413,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,160,057 - 43,413,409 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx143,700,986 - 43,954,675 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0149,688,216 - 49,941,908 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0143,776,469 - 44,030,156 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)Ensemblrn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera138,804,246 - 39,057,359 (+)NCBICelera
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
RH 3.4 Map1468.6RGD
Cytogenetic Map1q11NCBI
OPRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,010,496 - 154,246,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,010,496 - 154,246,867 (+)Ensemblhg38GRCh38
GRCh376154,331,631 - 154,568,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,402,136 - 154,609,693 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346154,452,556 - 154,660,114NCBI
Celera6155,066,098 - 155,302,376 (+)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6151,895,214 - 152,131,143 (+)NCBIHuRef
CHM1_16154,595,701 - 154,831,638 (+)NCBICHM1_1
T2T-CHM13v2.06155,212,511 - 155,448,859 (+)NCBIT2T-CHM13v2.0
Oprm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39106,708,593 - 6,988,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl106,708,506 - 6,988,198 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38106,758,593 - 7,038,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl106,758,506 - 7,038,198 (+)Ensemblmm10GRCm38
MGSCv37103,308,332 - 3,557,940 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36103,309,340 - 3,557,732 (-)NCBIMGSCv36mm8
Celera106,736,075 - 7,000,690 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
Oprm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,757,569 - 7,923,817 (-)Ensembl
ChiLan1.0NW_0049554397,870,563 - 7,923,817 (-)NCBIChiLan1.0ChiLan1.0
OPRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,001,918 - 174,144,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16171,893,526 - 172,035,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06151,827,323 - 151,937,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,517,666 - 156,627,758 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6156,517,661 - 157,088,251 (+)EnsemblpanPan2panpan1.1
OPRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,972,915 - 44,037,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0144,157,040 - 44,221,809 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oprm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,253,997 - 139,325,813 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,506,207 - 6,548,946 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,506,207 - 6,567,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,528,672 - 12,702,443 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1112,634,125 - 12,702,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,770,415 - 14,819,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1pNCBI
OPRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,568,295 - 81,650,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,568,732 - 81,625,088 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604053,917,647 - 54,030,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,196,186 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Oprm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12196,129,277 - 196,205,035 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Oprm1
1379 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:682
Count of miRNA genes:283
Interacting mature miRNAs:367
Transcripts:ENSRNOT00000024682, ENSRNOT00000045144, ENSRNOT00000051837
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
D1Rat136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,284,731 - 43,284,926 (+)MAPPERmRatBN7.2
Rnor_6.0143,579,208 - 43,579,402NCBIRnor6.0
Rnor_5.0144,907,605 - 44,907,799UniSTSRnor5.0
RGSC_v3.4137,647,211 - 37,647,405UniSTSRGSC3.4
RGSC_v3.4137,646,940 - 37,647,484RGDRGSC3.4
Celera138,929,086 - 38,929,280UniSTS
RGSC_v3.1137,649,885 - 37,650,429RGD
RH 3.4 Map1469.71RGD
RH 3.4 Map1469.71UniSTS
SHRSP x BN Map120.49RGD
SHRSP x BN Map120.49UniSTS
Cytogenetic Map1p11UniSTS
D1Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,191,871 - 43,192,009 (+)MAPPERmRatBN7.2
Rnor_6.0143,486,630 - 43,486,767NCBIRnor6.0
Rnor_5.0144,815,471 - 44,815,608UniSTSRnor5.0
RGSC_v3.4137,546,625 - 37,546,763RGDRGSC3.4
RGSC_v3.4137,546,626 - 37,546,763UniSTSRGSC3.4
Celera138,836,062 - 38,836,199UniSTS
RGSC_v3.1137,549,570 - 37,549,708RGD
Cytogenetic Map1p11UniSTS
D10Chm38  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera138,913,039 - 38,913,196UniSTS
Celera1071,858,074 - 71,858,221UniSTS
Cytogenetic Map1p11UniSTS
RH94843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,232,582 - 43,232,708 (+)MAPPERmRatBN7.2
Rnor_6.0143,527,582 - 43,527,707NCBIRnor6.0
Rnor_5.0144,856,236 - 44,856,361UniSTSRnor5.0
RGSC_v3.4137,587,885 - 37,588,010UniSTSRGSC3.4
Celera138,876,692 - 38,876,817UniSTS
Cytogenetic Map1p11UniSTS
RH94842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,232,553 - 43,232,680 (+)MAPPERmRatBN7.2
Rnor_6.0143,527,553 - 43,527,679NCBIRnor6.0
Rnor_5.0144,856,207 - 44,856,333UniSTSRnor5.0
RGSC_v3.4137,587,856 - 37,587,982UniSTSRGSC3.4
Celera138,876,663 - 38,876,789UniSTS
Cytogenetic Map1p11UniSTS
U19380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,232,551 - 43,232,655 (+)MAPPERmRatBN7.2
Rnor_6.0143,527,551 - 43,527,654NCBIRnor6.0
Rnor_5.0144,856,205 - 44,856,308UniSTSRnor5.0
RGSC_v3.4137,587,854 - 37,587,957UniSTSRGSC3.4
Celera138,876,661 - 38,876,764UniSTS
Cytogenetic Map1p11UniSTS
RH142407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,233,131 - 43,233,301 (+)MAPPERmRatBN7.2
Rnor_6.0143,528,131 - 43,528,300NCBIRnor6.0
Rnor_5.0144,856,785 - 44,856,954UniSTSRnor5.0
RGSC_v3.4137,588,434 - 37,588,603UniSTSRGSC3.4
Celera138,877,241 - 38,877,410UniSTS
RH 3.4 Map1468.6UniSTS
Cytogenetic Map1p11UniSTS
BF390122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,237,966 - 43,238,131 (+)MAPPERmRatBN7.2
Rnor_6.0143,532,966 - 43,533,130NCBIRnor6.0
Rnor_5.0144,861,620 - 44,861,784UniSTSRnor5.0
RGSC_v3.4137,593,269 - 37,593,433UniSTSRGSC3.4
Celera138,882,750 - 38,882,914UniSTS
RH 3.4 Map1434.07UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 2 15 119 44 44 13 51 13 6 127 83 1 99 22 33 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001038597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY225402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ680043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU024650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU024651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU024652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ699463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024682   ⟹   ENSRNOP00000024682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,565,371 - 45,638,756 (+)Ensembl
mRatBN7.2 Ensembl143,180,674 - 43,413,409 (+)Ensembl
Rnor_6.0 Ensembl143,475,589 - 43,704,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,454,870 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051837   ⟹   ENSRNOP00000051290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,589 - 43,527,605 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,589 - 43,508,870 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,589 - 43,527,605 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079628   ⟹   ENSRNOP00000072626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,565,371 - 45,628,802 (+)Ensembl
mRatBN7.2 Ensembl143,180,295 - 43,213,868 (+)Ensembl
Rnor_6.0 Ensembl143,475,595 - 43,703,276 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,454,867 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083308   ⟹   ENSRNOP00000074079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,565,371 - 45,638,756 (+)Ensembl
mRatBN7.2 Ensembl143,160,057 - 43,233,438 (+)Ensembl
Rnor_6.0 Ensembl143,475,597 - 43,700,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,418 - 43,527,716 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,562 - 43,510,853 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,180,674 - 43,411,737 (+)Ensembl
Rnor_6.0 Ensembl143,454,803 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,586,152 - 45,620,976 (+)Ensembl
mRatBN7.2 Ensembl143,180,879 - 43,222,855 (+)Ensembl
Rnor_6.0 Ensembl143,503,264 - 43,527,549 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,454,803 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,562 - 43,518,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,180,674 - 43,222,149 (+)Ensembl
Rnor_6.0 Ensembl143,475,589 - 43,517,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,454,867 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,475,589 - 43,510,657 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092034   ⟹   ENSRNOP00000068988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,565,371 - 45,627,338 (+)Ensembl
mRatBN7.2 Ensembl143,180,848 - 43,411,737 (+)Ensembl
Rnor_6.0 Ensembl143,475,589 - 43,703,276 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,454,867 - 43,527,693 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,565,371 - 45,628,173 (+)Ensembl
mRatBN7.2 Ensembl143,160,057 - 43,215,420 (+)Ensembl
Rnor_6.0 Ensembl143,454,803 - 43,527,693 (+)Ensembl
RefSeq Acc Id: NM_001038597   ⟹   NP_001033686
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,619,189 (+)NCBI
mRatBN7.2143,180,674 - 43,213,868 (+)NCBI
Rnor_6.0143,475,420 - 43,508,870 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 38,857,976 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001038599   ⟹   NP_001033688
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,627,467 (+)NCBI
mRatBN7.2143,180,674 - 43,222,149 (+)NCBI
Rnor_6.0143,475,420 - 43,517,148 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 38,866,254 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001038600   ⟹   NP_001033689
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,818,722 (+)NCBI
mRatBN7.2143,180,674 - 43,413,409 (+)NCBI
Rnor_6.0143,475,420 - 43,704,948 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 39,057,359 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001038601   ⟹   NP_001033690
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,817,050 (+)NCBI
mRatBN7.2143,180,674 - 43,411,737 (+)NCBI
Rnor_6.0143,475,420 - 43,703,276 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 39,055,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304733   ⟹   NP_001291662
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304734   ⟹   NP_001291663
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304735   ⟹   NP_001291664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304736   ⟹   NP_001291665
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304737   ⟹   NP_001291666
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304738   ⟹   NP_001291667
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304740   ⟹   NP_001291669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,565,371 - 45,638,756 (+)NCBI
mRatBN7.2143,160,057 - 43,233,438 (+)NCBI
Rnor_6.0143,454,803 - 43,528,437 (+)NCBI
Celera138,804,246 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013071   ⟹   NP_037203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,638,756 (+)NCBI
mRatBN7.2143,180,674 - 43,233,438 (+)NCBI
Rnor_6.0143,475,420 - 43,528,437 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 38,877,547 (+)NCBI
Sequence:
RefSeq Acc Id: NR_027877
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,983 - 45,817,050 (+)NCBI
mRatBN7.2143,180,674 - 43,411,737 (+)NCBI
Rnor_6.0143,475,420 - 43,703,276 (+)NCBI
Rnor_5.0144,804,181 - 45,034,145 (+)NCBI
RGSC_v3.4137,535,416 - 37,779,392 (+)RGD
Celera138,824,852 - 39,055,687 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282030   ⟹   XP_063138100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,469 - 45,631,896 (+)NCBI
RefSeq Acc Id: XM_063282032   ⟹   XP_063138102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,585,185 - 45,618,951 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001033686 (Get FASTA)   NCBI Sequence Viewer  
  NP_001033688 (Get FASTA)   NCBI Sequence Viewer  
  NP_001033689 (Get FASTA)   NCBI Sequence Viewer  
  NP_001033690 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291662 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291663 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291664 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291665 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291666 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291667 (Get FASTA)   NCBI Sequence Viewer  
  NP_001291669 (Get FASTA)   NCBI Sequence Viewer  
  NP_037203 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138100 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138102 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16075 (Get FASTA)   NCBI Sequence Viewer  
  AAA41630 (Get FASTA)   NCBI Sequence Viewer  
  AAA41643 (Get FASTA)   NCBI Sequence Viewer  
  AAA70049 (Get FASTA)   NCBI Sequence Viewer  
  AAA79180 (Get FASTA)   NCBI Sequence Viewer  
  AAP44725 (Get FASTA)   NCBI Sequence Viewer  
  AAP44726 (Get FASTA)   NCBI Sequence Viewer  
  AAQ77384 (Get FASTA)   NCBI Sequence Viewer  
  AAQ77386 (Get FASTA)   NCBI Sequence Viewer  
  AAQ77387 (Get FASTA)   NCBI Sequence Viewer  
  AAQ77388 (Get FASTA)   NCBI Sequence Viewer  
  ABH03502 (Get FASTA)   NCBI Sequence Viewer  
  ABW84396 (Get FASTA)   NCBI Sequence Viewer  
  ABW84397 (Get FASTA)   NCBI Sequence Viewer  
  ABW84398 (Get FASTA)   NCBI Sequence Viewer  
  ACA49729 (Get FASTA)   NCBI Sequence Viewer  
  ACA49730 (Get FASTA)   NCBI Sequence Viewer  
  ACA49731 (Get FASTA)   NCBI Sequence Viewer  
  ACM90347 (Get FASTA)   NCBI Sequence Viewer  
  AET97616 (Get FASTA)   NCBI Sequence Viewer  
  BAA03852 (Get FASTA)   NCBI Sequence Viewer  
  EDL92831 (Get FASTA)   NCBI Sequence Viewer  
  EDL92832 (Get FASTA)   NCBI Sequence Viewer  
  EDL92833 (Get FASTA)   NCBI Sequence Viewer  
  EDL92834 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024682
  ENSRNOP00000074079
  ENSRNOP00000082784
  ENSRNOP00000085499
GenBank Protein P33535 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001033689   ⟸   NM_001038600
- Peptide Label: isoform 1C1
- UniProtKB: A0A8L2QEH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033690   ⟸   NM_001038601
- Peptide Label: isoform 1C2
- UniProtKB: A0A8I5ZZ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037203   ⟸   NM_013071
- Peptide Label: isoform 1
- UniProtKB: Q64064 (UniProtKB/Swiss-Prot),   Q62846 (UniProtKB/Swiss-Prot),   Q4VWX8 (UniProtKB/Swiss-Prot),   Q4VWX7 (UniProtKB/Swiss-Prot),   Q4VWM7 (UniProtKB/Swiss-Prot),   Q4VWM5 (UniProtKB/Swiss-Prot),   Q2TV21 (UniProtKB/Swiss-Prot),   Q2TV20 (UniProtKB/Swiss-Prot),   Q64120 (UniProtKB/Swiss-Prot),   P33535 (UniProtKB/Swiss-Prot),   A6KIP5 (UniProtKB/TrEMBL),   B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033688   ⟸   NM_001038599
- Peptide Label: isoform 1B2
- UniProtKB: B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033686   ⟸   NM_001038597
- Peptide Label: isoform IA
- UniProtKB: B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291666   ⟸   NM_001304737
- Peptide Label: isoform 1
- UniProtKB: Q64064 (UniProtKB/Swiss-Prot),   Q62846 (UniProtKB/Swiss-Prot),   Q4VWX8 (UniProtKB/Swiss-Prot),   Q4VWX7 (UniProtKB/Swiss-Prot),   Q4VWM7 (UniProtKB/Swiss-Prot),   Q4VWM5 (UniProtKB/Swiss-Prot),   Q2TV21 (UniProtKB/Swiss-Prot),   Q2TV20 (UniProtKB/Swiss-Prot),   Q64120 (UniProtKB/Swiss-Prot),   P33535 (UniProtKB/Swiss-Prot),   A6KIP5 (UniProtKB/TrEMBL),   B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291664   ⟸   NM_001304735
- Peptide Label: isoform 1
- UniProtKB: Q64064 (UniProtKB/Swiss-Prot),   Q62846 (UniProtKB/Swiss-Prot),   Q4VWX8 (UniProtKB/Swiss-Prot),   Q4VWX7 (UniProtKB/Swiss-Prot),   Q4VWM7 (UniProtKB/Swiss-Prot),   Q4VWM5 (UniProtKB/Swiss-Prot),   Q2TV21 (UniProtKB/Swiss-Prot),   Q2TV20 (UniProtKB/Swiss-Prot),   Q64120 (UniProtKB/Swiss-Prot),   P33535 (UniProtKB/Swiss-Prot),   A6KIP5 (UniProtKB/TrEMBL),   B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291662   ⟸   NM_001304733
- Peptide Label: isoform 1G1
- UniProtKB: B8K2Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291669   ⟸   NM_001304740
- Peptide Label: isoform 1
- UniProtKB: Q64064 (UniProtKB/Swiss-Prot),   Q62846 (UniProtKB/Swiss-Prot),   Q4VWX8 (UniProtKB/Swiss-Prot),   Q4VWX7 (UniProtKB/Swiss-Prot),   Q4VWM7 (UniProtKB/Swiss-Prot),   Q4VWM5 (UniProtKB/Swiss-Prot),   Q2TV21 (UniProtKB/Swiss-Prot),   Q2TV20 (UniProtKB/Swiss-Prot),   Q64120 (UniProtKB/Swiss-Prot),   P33535 (UniProtKB/Swiss-Prot),   A6KIP5 (UniProtKB/TrEMBL),   B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291667   ⟸   NM_001304738
- Peptide Label: isoform 1
- UniProtKB: Q64064 (UniProtKB/Swiss-Prot),   Q62846 (UniProtKB/Swiss-Prot),   Q4VWX8 (UniProtKB/Swiss-Prot),   Q4VWX7 (UniProtKB/Swiss-Prot),   Q4VWM7 (UniProtKB/Swiss-Prot),   Q4VWM5 (UniProtKB/Swiss-Prot),   Q2TV21 (UniProtKB/Swiss-Prot),   Q2TV20 (UniProtKB/Swiss-Prot),   Q64120 (UniProtKB/Swiss-Prot),   P33535 (UniProtKB/Swiss-Prot),   A6KIP5 (UniProtKB/TrEMBL),   B8Q1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291665   ⟸   NM_001304736
- Peptide Label: isoform 1H2
- UniProtKB: D2CKI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291663   ⟸   NM_001304734
- Peptide Label: isoform 1G2
- UniProtKB: D2CKI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068988   ⟸   ENSRNOT00000092034
Ensembl Acc Id: ENSRNOP00000072626   ⟸   ENSRNOT00000079628
Ensembl Acc Id: ENSRNOP00000051290   ⟸   ENSRNOT00000051837
Ensembl Acc Id: ENSRNOP00000024682   ⟸   ENSRNOT00000024682
Ensembl Acc Id: ENSRNOP00000074079   ⟸   ENSRNOT00000083308
RefSeq Acc Id: XP_063138102   ⟸   XM_063282032
- Peptide Label: isoform X2
- UniProtKB: G9BXT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138100   ⟸   XM_063282030
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3E3 (UniProtKB/TrEMBL),   A6KIP6 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33535-F1-model_v2 AlphaFold P33535 1-398 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689594
Promoter ID:EPDNEW_R119
Type:single initiation site
Name:Oprm1_1
Description:opioid receptor, mu 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,475,662 - 43,475,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3234 AgrOrtholog
BioCyc Gene G2FUF-61680 BioCyc
Ensembl Genes ENSRNOG00000018191 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024682 ENTREZGENE
  ENSRNOT00000083308 ENTREZGENE
  ENSRNOT00000088253 ENTREZGENE
  ENSRNOT00000092578 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Mu_opioid_rcpt UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25601 UniProtKB/Swiss-Prot
NCBI Gene 25601 ENTREZGENE
PANTHER MU-TYPE OPIOID RECEPTOR UniProtKB/Swiss-Prot
  NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB OPRM1 RGD
PhenoGen Oprm1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUOPIOIDR UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018191 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC232659
UniProt A0A8I5ZVK2_RAT UniProtKB/TrEMBL
  A0A8I5ZZ23 ENTREZGENE
  A0A8I6A3E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QEH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R051_RAT UniProtKB/TrEMBL
  A0A8L2R6Q6_RAT UniProtKB/TrEMBL
  A0A8L2R8W0_RAT UniProtKB/TrEMBL
  A6KIP3_RAT UniProtKB/TrEMBL
  A6KIP4_RAT UniProtKB/TrEMBL
  A6KIP5 ENTREZGENE, UniProtKB/TrEMBL
  A6KIP6 ENTREZGENE, UniProtKB/TrEMBL
  B8K2Q4 ENTREZGENE, UniProtKB/TrEMBL
  B8Q1M0 ENTREZGENE, UniProtKB/TrEMBL
  D2CKI4 ENTREZGENE, UniProtKB/TrEMBL
  D2CKI5 ENTREZGENE, UniProtKB/TrEMBL
  G8XRH3_RAT UniProtKB/TrEMBL
  G9BXT6 ENTREZGENE, UniProtKB/TrEMBL
  OPRM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2TV20 ENTREZGENE
  Q2TV21 ENTREZGENE
  Q4VWM5 ENTREZGENE
  Q4VWM7 ENTREZGENE
  Q4VWX7 ENTREZGENE
  Q4VWX8 ENTREZGENE
  Q62846 ENTREZGENE
  Q64064 ENTREZGENE
  Q64120 ENTREZGENE
UniProt Secondary Q2TV20 UniProtKB/Swiss-Prot
  Q2TV21 UniProtKB/Swiss-Prot
  Q4VWM5 UniProtKB/Swiss-Prot
  Q4VWM7 UniProtKB/Swiss-Prot
  Q4VWX7 UniProtKB/Swiss-Prot
  Q4VWX8 UniProtKB/Swiss-Prot
  Q62846 UniProtKB/Swiss-Prot
  Q64064 UniProtKB/Swiss-Prot
  Q64120 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Oprm1  opioid receptor, mu 1    Opioid receptor, mu 1  Name updated 625702 APPROVED
2002-06-10 Oprm1  Opioid receptor, mu 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in thalamus, medial habenula, hypothalamus and the caudate putamen 729179
gene_function receptor for beta-endorphin 70786
gene_process activates opioid receptors which in turn activates G-protein receptors and inhibits adenylyl cyclase 70522
gene_process plays a role in immunosuppression 70786
gene_product belongs to the G-protein coupled receptor family 70786
gene_regulation C terminal amino acid is necessary for high binding affinity; carboxamide group decreases the binding and biological activity 70522
gene_regulation mRNA level in primary neurons is increased by incubation with interleukin-4 (IL4) 70786
gene_transcript contains an IL4 response element at the -727 position in promoter region 70786