OPRM1 (opioid receptor mu 1) - Rat Genome Database

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Gene: OPRM1 (opioid receptor mu 1) Canis lupus familiaris
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Symbol: OPRM1
Name: opioid receptor mu 1
RGD ID: 12314261
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); G-protein beta-subunit binding (ortholog); morphine receptor activity (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH AIDS Dementia Complex (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN dendrite (ortholog); dendrite cytoplasm (ortholog); dendrite membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mu-type opioid receptor; mu-type opioid receptor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,972,915 - 44,037,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,157,040 - 44,221,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
behavioral response to ethanol  (IEA)
eating behavior  (ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
G protein-coupled opioid receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
locomotory behavior  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of cAMP-mediated signaling  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of Wnt protein secretion  (IEA)
neuropeptide signaling pathway  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of appetite  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cellular response to stress  (IEA)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to growth factor  (ISO)
response to lipopolysaccharide  (ISO)
sensory perception of pain  (IEA)
signal transduction  (IEA)
social behavior  (ISO)
sperm ejaculation  (ISO)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
heroin pharmacokinetics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:19754583   PMID:20017823   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OPRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,972,915 - 44,037,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,157,040 - 44,221,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBIUU_Cfam_GSD_1.0
OPRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,010,496 - 154,246,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,010,496 - 154,246,867 (+)EnsemblGRCh38hg38GRCh38
GRCh376154,331,631 - 154,568,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,402,136 - 154,609,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 346154,452,556 - 154,660,114NCBI
Celera6155,066,098 - 155,302,376 (+)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6151,895,214 - 152,131,143 (+)NCBIHuRef
CHM1_16154,595,701 - 154,831,638 (+)NCBICHM1_1
T2T-CHM13v2.06155,212,511 - 155,448,859 (+)NCBIT2T-CHM13v2.0
Oprm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39106,708,593 - 6,988,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl106,708,506 - 6,988,198 (+)EnsemblGRCm39 Ensembl
GRCm38106,758,593 - 7,038,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl106,758,506 - 7,038,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37103,308,332 - 3,557,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,309,340 - 3,557,732 (-)NCBIMGSCv36mm8
Celera106,736,075 - 7,000,690 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
Oprm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,565,371 - 45,818,722 (+)NCBIGRCr8
mRatBN7.2143,160,057 - 43,413,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,160,057 - 43,413,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx143,700,986 - 43,954,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0149,688,216 - 49,941,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0143,776,469 - 44,030,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
Celera138,804,246 - 39,057,359 (+)NCBICelera
RH 3.4 Map1468.6RGD
Cytogenetic Map1q11NCBI
Oprm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,757,569 - 7,923,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554397,870,563 - 7,923,817 (-)NCBIChiLan1.0ChiLan1.0
OPRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,001,918 - 174,144,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16171,893,526 - 172,035,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06151,827,323 - 151,937,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,517,666 - 156,627,758 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6156,517,661 - 157,088,251 (+)Ensemblpanpan1.1panPan2
Oprm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,253,997 - 139,325,813 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,506,207 - 6,548,946 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,506,207 - 6,567,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,528,672 - 12,702,443 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,634,125 - 12,702,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,770,415 - 14,819,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1pNCBI
OPRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,568,295 - 81,650,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,568,732 - 81,625,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604053,917,647 - 54,030,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,196,186 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OPRM1
676 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00000070867   ⟹   ENSCAFP00000057666
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl143,972,219 - 44,037,477 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075755   ⟹   ENSCAFP00000047797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl143,972,219 - 44,021,545 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081298   ⟹   ENSCAFP00000048013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000252   ⟹   ENSCAFP00845000181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000257   ⟹   ENSCAFP00845000185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl144,156,501 - 44,224,047 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000261   ⟹   ENSCAFP00845000189
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl144,156,501 - 44,205,695 (+)Ensembl
RefSeq Acc Id: NM_001314122   ⟹   NP_001301051
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1143,972,915 - 44,037,477 (+)NCBI
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBI
ROS_Cfam_1.0144,157,080 - 44,221,809 (+)NCBI
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBI
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBI
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038653508   ⟹   XP_038509436
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0144,157,040 - 44,206,446 (+)NCBI
RefSeq Acc Id: NP_001301051   ⟸   NM_001314122
- UniProtKB: A0A0F6TMT6 (UniProtKB/TrEMBL),   A0A8C0T198 (UniProtKB/TrEMBL),   A0A8C0MUA3 (UniProtKB/TrEMBL),   A0A8I3MEW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000057666   ⟸   ENSCAFT00000070867
RefSeq Acc Id: ENSCAFP00000047797   ⟸   ENSCAFT00000075755
RefSeq Acc Id: ENSCAFP00000048013   ⟸   ENSCAFT00000081298
RefSeq Acc Id: XP_038509436   ⟸   XM_038653508
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MUA3 (UniProtKB/TrEMBL),   A0A8I3MEW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000189   ⟸   ENSCAFT00845000261
RefSeq Acc Id: ENSCAFP00845000181   ⟸   ENSCAFT00845000252
RefSeq Acc Id: ENSCAFP00845000185   ⟸   ENSCAFT00845000257

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000040985 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009060 UniProtKB/TrEMBL
  ENSCAFG00040017488 UniProtKB/TrEMBL
  ENSCAFG00845000160 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000070867.2 UniProtKB/TrEMBL
  ENSCAFT00000075755.2 UniProtKB/TrEMBL
  ENSCAFT00000081298.2 UniProtKB/TrEMBL
  ENSCAFT00030016947.1 UniProtKB/TrEMBL
  ENSCAFT00030016983.1 UniProtKB/TrEMBL
  ENSCAFT00030017026.1 UniProtKB/TrEMBL
  ENSCAFT00040032468.1 UniProtKB/TrEMBL
  ENSCAFT00040032493.1 UniProtKB/TrEMBL
  ENSCAFT00040032534.1 UniProtKB/TrEMBL
  ENSCAFT00845000252.1 UniProtKB/TrEMBL
  ENSCAFT00845000257 ENTREZGENE
  ENSCAFT00845000257.1 UniProtKB/TrEMBL
  ENSCAFT00845000261.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Mu_opioid_rcpt UniProtKB/TrEMBL
  Opioid_rcpt UniProtKB/TrEMBL
KEGG Report cfa:484041 UniProtKB/TrEMBL
NCBI Gene OPRM1 ENTREZGENE
PANTHER MU-TYPE OPIOID RECEPTOR UniProtKB/TrEMBL
  NEUROPEPTIDES RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MUOPIOIDR UniProtKB/TrEMBL
  OPIOIDR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0F6TMT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MUA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T042_CANLF UniProtKB/TrEMBL
  A0A8C0T198 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MA93_CANLF UniProtKB/TrEMBL
  A0A8I3MEW5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:110521 ENTREZGENE