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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3234
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor, mu 1
Acc ID: CHEBI:7465
Term: naltrexone
Definition: An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.
Chemical ID: MESH:D009271
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1affects bindingEXP 6480464CTDNaltrexone binds to OPRM1 proteinPMID:7562497
Oprm1affects response to substanceISOOPRM1 (Homo sapiens)6480464CTDOPRM1 affects the susceptibility to NaltrexonePMID:18250251
Oprm1multiple interactionsISOOprm1 (Mus musculus)6480464CTD[Cannabidiol co-treated with Naltrexone] results in decreased expression of OPRM1 mRNAPMID:29859012
Oprm1multiple interactionsISOOPRM1 (Homo sapiens)6480464CTD[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMPPMID:11413242
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