Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | WLS (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
|
Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | WLS (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
|
|
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. | Bartscherer K, etal., Cell. 2006 May 5;125(3):523-33. |
2. | A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. | Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1. |
3. | Wntless in Wnt secretion: molecular, cellular and genetic aspects. | Das S, etal., Front Biol (Beijing). 2012 Dec 1;7(6):587-593. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. | Jin J, etal., BMC Neurosci. 2010 Mar 9;11:33. doi: 10.1186/1471-2202-11-33. |
6. | Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. | Reyes BA, etal., Exp Neurol. 2012 Jan;233(1):205-13. doi: 10.1016/j.expneurol.2011.09.037. Epub 2011 Oct 6. |
7. | GOA pipeline | RGD automated data pipeline |
8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
10. | Comprehensive gene review and curation | RGD comprehensive gene curation |
11. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
PMID:15326124 | PMID:15489334 | PMID:16678095 | PMID:17804805 | PMID:18160348 | PMID:19841259 | PMID:20614471 | PMID:20652957 | PMID:24768165 | PMID:26501177 |
Wls (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WLS (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wls (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wls (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WLS (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WLS (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wls (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WLS (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WLS (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wls (Heterocephalus glaber - naked mole-rat) |
|
.
Variants in Wls
522 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH140979 |
|
||||||||||||||||||||||||||||||||||||||||
RH127338 |
|
||||||||||||||||||||||||||||||||||||||||
RH131641 |
|
||||||||||||||||||||||||||||||||||||||||
RH131683 |
|
||||||||||||||||||||||||||||||||||||||||
RH135449 |
|
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 22 | 6 | 19 | 6 | 8 | 9 | 74 | 35 | 36 | 11 | 8 |
Low | 35 | 35 | 35 | 2 | 5 | ||||||||
Below cutoff |
RefSeq Transcripts | NM_001085353 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_199408 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039102736 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039102737 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AY569010 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC062391 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000002 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
MW396102 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000055245 ⟹ ENSRNOP00000052120 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000080305 ⟹ ENSRNOP00000073668 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | NM_001085353 ⟹ NP_001078822 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | NM_199408 ⟹ NP_955440 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_039102736 ⟹ XP_038958664 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | XM_039102737 ⟹ XP_038958665 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
Protein RefSeqs | NP_001078822 | (Get FASTA) | NCBI Sequence Viewer |
NP_955440 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038958664 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038958665 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH62391 | (Get FASTA) | NCBI Sequence Viewer |
AAS75313 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000052120 | ||
ENSRNOP00000052120.2 | |||
ENSRNOP00000073668.2 | |||
ENSRNOP00055041909 | |||
ENSRNOP00060001203 | |||
ENSRNOP00065002480 | |||
GenBank Protein | Q6P689 | (Get FASTA) | NCBI Sequence Viewer |
QST78132 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_955440 ⟸ NM_199408 |
- UniProtKB: | Q6P689 (UniProtKB/Swiss-Prot), A0A0G2K645 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001078822 ⟸ NM_001085353 |
- UniProtKB: | Q6P689 (UniProtKB/Swiss-Prot), A0A0G2K645 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000073668 ⟸ ENSRNOT00000080305 |
RefSeq Acc Id: | ENSRNOP00000052120 ⟸ ENSRNOT00000055245 |
RefSeq Acc Id: | XP_038958665 ⟸ XM_039102737 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6HWU8 (UniProtKB/TrEMBL), A0A0G2K645 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038958664 ⟸ XM_039102736 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A0G2K645 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q6P689-F1-model_v2 | AlphaFold | Q6P689 | 1-541 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13691845 | ||||||||
Promoter ID: | EPDNEW_R2369 | ||||||||
Type: | initiation region | ||||||||
Name: | Wls_1 | ||||||||
Description: | wntless Wnt ligand secretion mediator | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
Database | Acc Id | Source(s) |
AGR Gene | RGD:735139 | AgrOrtholog |
BioCyc Gene | G2FUF-50682 | BioCyc |
Ensembl Genes | ENSRNOG00000036816 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ENSRNOG00055029316 | UniProtKB/Swiss-Prot | |
ENSRNOG00060001368 | UniProtKB/Swiss-Prot | |
ENSRNOG00065002669 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000055245 | ENTREZGENE |
ENSRNOT00000055245.4 | UniProtKB/Swiss-Prot | |
ENSRNOT00000080305.2 | UniProtKB/TrEMBL | |
ENSRNOT00055050866 | UniProtKB/Swiss-Prot | |
ENSRNOT00060002003 | UniProtKB/Swiss-Prot | |
ENSRNOT00065003590 | UniProtKB/Swiss-Prot | |
IMAGE_CLONE | IMAGE:5621215 | IMAGE-MGC_LOAD |
InterPro | WLS-like_TM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Wntless | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:362065 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:72636 | IMAGE-MGC_LOAD |
NCBI Gene | 362065 | ENTREZGENE |
PANTHER | PROTEIN WNTLESS HOMOLOG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR13449 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | MIG-14_Wnt-bd | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Wls | PhenoGen |
RatGTEx | ENSRNOG00000036816 | RatGTEx |
ENSRNOG00055029316 | RatGTEx | |
ENSRNOG00060001368 | RatGTEx | |
ENSRNOG00065002669 | RatGTEx | |
UniProt | A0A0G2K645 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8A1UKH9_RAT | UniProtKB/TrEMBL | |
A6HWU8 | ENTREZGENE, UniProtKB/TrEMBL | |
Q6P689 | ENTREZGENE, UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2021-03-09 | Wls | Wnt ligand secretion mediator | LOC108350151 | uncharacterized LOC108350151 | Data merged from RGD:11514906 | 737654 | PROVISIONAL |
2018-12-04 | Wls | Wnt ligand secretion mediator | Wls | wntless Wnt ligand secretion mediator | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2016-08-02 | LOC108350151 | uncharacterized LOC108350151 | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2013-11-11 | Wls | wntless Wnt ligand secretion mediator | Wls | wntless homolog (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2011-08-02 | Wls | wntless homolog (Drosophila) | Gpr177 | G protein-coupled receptor 177 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-03-05 | Gpr177 | G protein-coupled receptor 177 | LOC362065 | CG6210-like | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-09-30 | LOC362065 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |