Grm5 (glutamate metabotropic receptor 5) - Rat Genome Database

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Gene: Grm5 (glutamate metabotropic receptor 5) Rattus norvegicus
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Symbol: Grm5
Name: glutamate metabotropic receptor 5
RGD ID: 2746
Description: Enables several functions, including A2A adenosine receptor binding activity; protein tyrosine kinase activator activity; and protein tyrosine kinase binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and regulation of signal transduction. Located in several cellular components, including astrocyte projection; dendrite; and nuclear inner membrane. Is active in glutamatergic synapse and postsynaptic membrane. Used to study alcohol dependence; alcohol use disorder; amphetamine abuse; cocaine dependence; and heroin dependence. Biomarker of alcohol use disorder and alcoholic neuropathy. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine dependence; and nicotine dependence. Orthologous to human GRM5 (glutamate metabotropic receptor 5); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; mGlur5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grm5em1Sage
Genetic Models: SD-Grm5em1Sage
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,722,711 - 151,297,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,733,678 - 151,296,649 (+)EnsemblGRCr8
mRatBN7.21141,310,069 - 141,884,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1149,310,130 - 149,851,201 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,480,747 - 157,027,623 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,354,664 - 149,901,543 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,207,846 - 151,785,038 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,517,676 - 158,096,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41143,857,225 - 144,477,419 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1139,643,467 - 140,193,665 (+)NCBICelera
RGSC_v3.11143,935,630 - 144,555,825 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acamprosate  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allethrin  (EXP)
ammonia  (EXP)
amphetamine  (EXP)
Ampicillin Sodium Mixture With Sulbactam Sodium  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cannabidiol  (EXP)
chaetocin  (EXP)
chlorpyrifos  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dieldrin  (ISO)
dopamine  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
heroin  (EXP)
L-glutamic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
nicotine  (ISO)
oxidopamine  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pyrethrins  (EXP)
Quisqualic acid  (EXP,ISO)
reserpine  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)
veratridine  (EXP)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  (IEA)
associative learning  (IMP)
cellular response to amyloid-beta  (IEA,ISO)
chemical synaptic transmission  (IMP)
cognition  (IEA,ISO)
conditioned place preference  (IDA)
desensitization of G protein-coupled receptor signaling pathway  (IDA)
G protein-coupled glutamate receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
G protein-coupled receptor signaling pathway  (IEA)
learning  (ISO)
learning or memory  (IEA,ISO)
locomotory behavior  (ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of dendritic spine morphogenesis  (IMP)
negative regulation of excitatory postsynaptic potential  (IDA)
operant conditioning  (IDA)
phosphatidylinositol-mediated signaling  (TAS)
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway  (IDA,IEA,ISO,TAS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (TAS)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cellular response to hypoxia  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dopamine secretion  (IMP)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of long-term neuronal synaptic plasticity  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of sensory perception of pain  (IMP)
protein localization to nuclear inner membrane  (IMP)
protein phosphorylation  (IDA)
regulation of DNA-templated transcription  (IDA)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of long-term synaptic depression  (IMP)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
regulation of postsynaptic membrane potential  (IEA)
regulation of synaptic transmission, glutamatergic  (IBA)
response to amphetamine  (IEP)
response to antibiotic  (IEP)
response to corticosterone  (IEP)
response to ethanol  (IEP)
response to morphine  (IEP)
sensory perception of hot stimulus  (IDA)
signal transduction  (IEA)
synapse organization  (IEA,ISO)
temperature homeostasis  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Abe T, etal., J Biol Chem. 1992 Jul 5;267(19):13361-8.
2. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
3. Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography. Akkus F, etal., Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):737-42. doi: 10.1073/pnas.1210984110. Epub 2012 Dec 17.
4. Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. Akkus F, etal., Transl Psychiatry. 2018 Jan 10;8(1):17. doi: 10.1038/s41398-017-0066-6.
5. Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats. Alasmari F, etal., Biomolecules. 2020 Jul 10;10(7):1030. doi: 10.3390/biom10071030.
6. The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice. Brown RM, etal., Drug Alcohol Depend. 2012 Jun 1;123(1-3):264-8. doi: 10.1016/j.drugalcdep.2011.11.002. Epub 2011 Nov 29.
7. Regulation of neurotransmitter release by metabotropic glutamate receptors. Cartmell J and Schoepp DD, J Neurochem. 2000 Sep;75(3):889-907.
8. Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats. Chan MH, etal., Pharmacol Biochem Behav. 2012 Dec;103(2):418-24. doi: 10.1016/j.pbb.2012.09.019. Epub 2012 Sep 29.
9. Inhibitory effect of spinal mGlu(5) receptor antisense oligonucleotide on the up-regulated expression of spinal G protein associated with chronic morphine treatment. Chen M, etal., Eur J Pharmacol. 2014 Jan 15;723:253-8. doi: 10.1016/j.ejphar.2013.11.024. Epub 2013 Dec 1.
10. mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration. Cleva RM, etal., Behav Neurosci. 2011 Feb;125(1):10-9. doi: 10.1037/a0022339.
11. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
12. Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence. Domenici MR, etal., Eur J Neurosci 2003 May;17(10):2047-55.
13. Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease. Doria JG, etal., Br J Pharmacol. 2013 Jun;169(4):909-21. doi: 10.1111/bph.12164.
14. The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease. Doria JG, etal., Neurobiol Dis. 2015 Jan;73:163-73. doi: 10.1016/j.nbd.2014.08.021. Epub 2014 Aug 24.
15. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Ferre S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11940-5.
16. Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory. Gass JT and Olive MF, Biol Psychiatry. 2009 Apr 15;65(8):717-20. doi: 10.1016/j.biopsych.2008.11.001. Epub 2008 Dec 19.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. Gryder DS and Rogawski MA, J Neurosci 2003 Aug 6;23(18):7069-74.
21. Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus. Iyo AH, etal., Neuroscience. 2010 Sep 15;169(4):1567-74. doi: 10.1016/j.neuroscience.2010.06.023. Epub 2010 Jun 23.
22. NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Izumi Y and Zorumski CF, Neuropsychopharmacology. 2012 Feb;37(3):609-17. doi: 10.1038/npp.2011.243. Epub 2011 Oct 12.
23. Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Kammermeier PJ and Worley PF, Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6055-60. doi: 10.1073/pnas.0608991104. Epub 2007 Mar 26.
24. Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. Kotecha SA, etal., J Biol Chem 2003 Jul 25;278(30):27742-9.
25. Pretreatment with group I metabotropic glutamate receptors antagonists attenuates lethality induced by acute cocaine overdose and expression of sensitization to hyperlocomotor effect of cocaine in mice. Kotlinska J and Bochenski M, Neurotox Res. 2011 Jan;19(1):23-30. doi: 10.1007/s12640-009-9136-8. Epub 2009 Nov 21.
26. mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. LaCrosse AL, etal., CNS Neurol Disord Drug Targets. 2015;14(4):476-85. doi: 10.2174/1871527314666150429112849.
27. Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Lavialle M, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12915-9. doi: 10.1073/pnas.1100957108. Epub 2011 Jul 13.
28. Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats. Lou ZZ, etal., Acta Pharmacol Sin. 2014 Dec;35(12):1485-92. doi: 10.1038/aps.2014.93. Epub 2014 Nov 17.
29. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Lujan R, etal., Eur J Neurosci. 1996 Jul;8(7):1488-500.
30. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. Luján R, etal., J Chem Neuroanat. 1997 Oct;13(4):219-41.
31. Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons. Mao L and Wang JQ, J Neurochem. 2003 May;85(4):1006-17. doi: 10.1046/j.1471-4159.2003.01750.x.
32. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Mao L, etal., J Neurosci. 2005 Mar 9;25(10):2741-52.
33. Rescue of striatal long-term depression by chronic mGlu5 receptor negative allosteric modulation in distinct dystonia models. Martella G, etal., Neuropharmacology. 2021 Jul 1;192:108608. doi: 10.1016/j.neuropharm.2021.108608. Epub 2021 May 13.
34. Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation. Matosin N, etal., Acta Neuropathol. 2015 Jul;130(1):119-29. doi: 10.1007/s00401-015-1411-6. Epub 2015 Mar 17.
35. Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. Matosin N, etal., Schizophr Res. 2015 Aug;166(1-3):212-8. doi: 10.1016/j.schres.2015.05.001. Epub 2015 Jun 2.id: 97053792 Error occurred: The following PMID is not available: 97053792
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. Milella MS, etal., Neuroimage. 2014 Sep;98:195-202. doi: 10.1016/j.neuroimage.2014.04.061. Epub 2014 May 2.
38. Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey. Mitrano DA and Smith Y, J Comp Neurol. 2007 Feb 1;500(4):788-806. doi: 10.1002/cne.21214.
39. Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens. Mitrano DA, etal., J Comp Neurol. 2010 Apr 15;518(8):1315-29. doi: 10.1002/cne.22277.
40. Involvement of mGluR5 in the ethanol-induced neuropathic pain-like state in the rat. Miyoshi K, etal., Neurosci Lett. 2006 Dec 20;410(2):105-9. doi: 10.1016/j.neulet.2006.08.083. Epub 2006 Nov 1.
41. N-Acetylcysteine reverses cocaine-induced metaplasticity. Moussawi K, etal., Nat Neurosci. 2009 Feb;12(2):182-9. doi: 10.1038/nn.2250. Epub 2009 Jan 11.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. Neugebauer V, etal., J Neurosci 2003 Jan 1;23(1):52-63.
44. A role for mGluR5 receptors in intravenous methamphetamine self-administration. Osborne MP and Olive MF, Ann N Y Acad Sci. 2008 Oct;1139:206-11. doi: 10.1196/annals.1432.034.
45. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Park JM, etal., Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. Poisik OV, etal., J Neurosci 2003 Jan 1;23(1):122-30.
48. Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB. Płoska A, etal., Brain Res. 2021 Oct 1;1768:147577. doi: 10.1016/j.brainres.2021.147577. Epub 2021 Jul 1.
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Ribeiro FM, etal., Hum Mol Genet. 2014 Apr 15;23(8):2030-42. doi: 10.1093/hmg/ddt598. Epub 2013 Nov 26.
52. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
53. The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease. Schiefer J, etal., Brain Res. 2004 Sep 3;1019(1-2):246-54.
54. Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization. Sergin I, etal., J Biol Chem. 2017 Mar 3;292(9):3637-3655. doi: 10.1074/jbc.M116.757724. Epub 2017 Jan 17.
55. Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Servitja JM, etal., Neuropharmacology 2003 Feb;44(2):171-80.
56. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15.
57. mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Sinclair CM, etal., Pharmacol Biochem Behav. 2012 May;101(3):329-35. doi: 10.1016/j.pbb.2012.01.014. Epub 2012 Jan 24.
58. The infralimbic cortex and mGlu5 mediate the effects of chronic intermittent ethanol exposure on fear learning and memory. Smiley CE, etal., Psychopharmacology (Berl). 2020 Nov;237(11):3417-3433. doi: 10.1007/s00213-020-05622-9. Epub 2020 Aug 7.
59. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Sorensen SD, etal., Mol Pharmacol. 2002 Jun;61(6):1303-12.
60. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. Sugi T, etal., EMBO J. 2007 Apr 18;26(8):2192-205. Epub 2007 Mar 29.
61. The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain. Tronci V and Balfour DJ, Behav Brain Res. 2011 Jun 1;219(2):354-7. doi: 10.1016/j.bbr.2010.12.024. Epub 2011 Jan 7.
62. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein. Um JW, etal., Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036.
63. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. Voulalas PJ, etal., J Neurosci. 2005 Apr 13;25(15):3763-73. doi: 10.1523/JNEUROSCI.4574-04.2005.
64. Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Wang H, etal., Science. 2009 Dec 11;326(5959):1554-7. doi: 10.1126/science.1178496.
65. Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model. Wang Y, etal., Neurotoxicology. 2021 May;84:14-29. doi: 10.1016/j.neuro.2021.02.003. Epub 2021 Feb 8.
66. Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury. Weisshaar CL, etal., J Neurotrauma. 2010 Dec;27(12):2261-71. doi: 10.1089/neu.2010.1460.
67. Effect of amphetamine on the expression of the metabotropic glutamate receptor 5 mRNA in developing rat brain. Yu MF, etal., J Mol Neurosci. 2000 Dec;15(3):177-88. doi: 10.1385/JMN:15:3:177.
68. mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen-activated protein kinase signaling pathway. Zhao L, etal., J Neurosci Res. 2012 Feb;90(2):447-60. doi: 10.1002/jnr.22751. Epub 2011 Oct 27.
Additional References at PubMed
PMID:7688218   PMID:7908515   PMID:9069287   PMID:9185557   PMID:9647694   PMID:9648851   PMID:9808458   PMID:9808459   PMID:10433269   PMID:10469171   PMID:10798399   PMID:11431513  
PMID:11595334   PMID:11850456   PMID:11943148   PMID:11973471   PMID:11986378   PMID:12077217   PMID:12176012   PMID:12529370   PMID:12562994   PMID:12646135   PMID:12660307   PMID:12727324  
PMID:12736269   PMID:12764131   PMID:12967992   PMID:14527949   PMID:14614082   PMID:14691258   PMID:14709549   PMID:15010207   PMID:15126034   PMID:15483135   PMID:15574735   PMID:15659214  
PMID:15661743   PMID:15777867   PMID:15882947   PMID:15893585   PMID:15894802   PMID:16024054   PMID:16153770   PMID:16280580   PMID:16289868   PMID:16302229   PMID:16436598   PMID:16836654  
PMID:16905160   PMID:17113328   PMID:17311919   PMID:17359492   PMID:17380680   PMID:17512115   PMID:17517168   PMID:17548216   PMID:17680995   PMID:17881561   PMID:17937975   PMID:17998101  
PMID:17998106   PMID:18065158   PMID:18185116   PMID:18242586   PMID:18469540   PMID:18554818   PMID:18621097   PMID:18715999   PMID:18716215   PMID:18816644   PMID:19116182   PMID:19118598  
PMID:19169252   PMID:19359367   PMID:19364772   PMID:19439188   PMID:19616571   PMID:19628026   PMID:19666081   PMID:19670629   PMID:19672584   PMID:19694902   PMID:19840937   PMID:19860857  
PMID:19864572   PMID:19894497   PMID:19903331   PMID:19961906   PMID:20043967   PMID:20056114   PMID:20058604   PMID:20177824   PMID:20180987   PMID:20181581   PMID:20193665   PMID:20519363  
PMID:20525770   PMID:20644995   PMID:20667449   PMID:20705895   PMID:20720114   PMID:20819696   PMID:20854878   PMID:20864408   PMID:21150906   PMID:21218453   PMID:21300123   PMID:21384157  
PMID:21486279   PMID:21731033   PMID:21795692   PMID:21880942   PMID:22015768   PMID:22147256   PMID:22172929   PMID:22179607   PMID:22193724   PMID:22238580   PMID:22245498   PMID:22310150  
PMID:22472649   PMID:22521775   PMID:22578356   PMID:22586220   PMID:22617006   PMID:22652057   PMID:23022504   PMID:23137441   PMID:23227193   PMID:23376485   PMID:23444015   PMID:23616528  
PMID:23978512   PMID:24032403   PMID:24050755   PMID:24373900   PMID:24395787   PMID:24510777   PMID:24663806   PMID:24670218   PMID:24910241   PMID:24941251   PMID:25113912   PMID:25160592  
PMID:25161282   PMID:25185819   PMID:25421413   PMID:25449406   PMID:25451626   PMID:25497704   PMID:25627107   PMID:25739080   PMID:25810529   PMID:25885040   PMID:25894678   PMID:26033576  
PMID:26071959   PMID:26095359   PMID:26318863   PMID:26365953   PMID:26389591   PMID:26454081   PMID:26538661   PMID:26777117   PMID:26791214   PMID:26837579   PMID:26902516   PMID:26946431  
PMID:27014856   PMID:27055771   PMID:27211252   PMID:27357735   PMID:27531836   PMID:27542344   PMID:27618534   PMID:27721389   PMID:27744406   PMID:27822496   PMID:27871824   PMID:28019025  
PMID:28433499   PMID:28455267   PMID:28533177   PMID:28851991   PMID:29074619   PMID:29191654   PMID:29266405   PMID:29337350   PMID:30010864   PMID:30291225   PMID:30413218   PMID:30444177  
PMID:30599269   PMID:30675062   PMID:30758331   PMID:31008528   PMID:31119680   PMID:31161451   PMID:31202839   PMID:31369778   PMID:31404590   PMID:31597090   PMID:31600563   PMID:31710636  
PMID:31830486   PMID:31891692   PMID:32039920   PMID:32087111   PMID:32145272   PMID:32454125   PMID:32976802   PMID:33352285   PMID:33444640   PMID:34137089   PMID:34197893   PMID:34547325  
PMID:34908130   PMID:35396501   PMID:36383609   PMID:36725696   PMID:37487948   PMID:39107945  


Genomics

Comparative Map Data
Grm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,722,711 - 151,297,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,733,678 - 151,296,649 (+)EnsemblGRCr8
mRatBN7.21141,310,069 - 141,884,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1149,310,130 - 149,851,201 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,480,747 - 157,027,623 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,354,664 - 149,901,543 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,207,846 - 151,785,038 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,517,676 - 158,096,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41143,857,225 - 144,477,419 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1139,643,467 - 140,193,665 (+)NCBICelera
RGSC_v3.11143,935,630 - 144,555,825 (+)NCBI
Cytogenetic Map1q32NCBI
GRM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381188,504,642 - 89,065,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1188,504,576 - 89,065,982 (-)Ensemblhg38GRCh38
GRCh371188,237,810 - 88,799,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,880,626 - 88,420,838 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341187,880,625 - 88,420,838NCBI
Celera1185,835,181 - 86,394,276 (+)NCBICelera
Cytogenetic Map11q14.2-q14.3NCBI
HuRef1184,476,702 - 85,036,122 (-)NCBIHuRef
CHM1_11188,120,759 - 88,679,818 (-)NCBICHM1_1
T2T-CHM13v2.01188,423,789 - 88,985,122 (-)NCBIT2T-CHM13v2.0
Grm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,233,212 - 87,784,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,233,376 - 87,784,115 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38787,583,981 - 88,135,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,584,168 - 88,134,907 (+)Ensemblmm10GRCm38
MGSCv37794,732,678 - 95,283,573 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36787,459,538 - 88,009,526 (+)NCBIMGSCv36mm8
Celera784,945,210 - 85,487,922 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
Grm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554144,424,245 - 4,919,399 (+)NCBIChiLan1.0ChiLan1.0
GRM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2989,380,890 - 89,943,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,422,432 - 90,987,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,514,978 - 84,077,650 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,103,730 - 87,658,987 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,107,788 - 87,868,953 (-)EnsemblpanPan2panpan1.1
GRM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,980,186 - 11,496,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,996,075 - 11,493,290 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2110,835,710 - 11,353,650 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02111,158,622 - 11,676,400 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2111,158,657 - 11,673,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,948,659 - 11,467,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02111,025,934 - 11,536,817 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02111,072,936 - 11,589,092 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,278,623 - 74,719,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736623,013 - 1,064,054 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936736623,118 - 1,060,273 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl921,917,735 - 22,436,063 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1921,914,422 - 22,438,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2924,418,550 - 24,660,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1179,636,636 - 80,206,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604345,522,256 - 46,088,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248451,079,564 - 1,627,880 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248451,064,866 - 1,631,722 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grm5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12113,137,118 - 113,670,109 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grm5
4572 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:34
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000022060, ENSRNOT00000050639
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Hmgc13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,875,982 - 141,876,303 (+)MAPPERmRatBN7.2
Rnor_6.01151,778,407 - 151,778,727NCBIRnor6.0
Rnor_5.01158,090,440 - 158,090,760UniSTSRnor5.0
RGSC_v3.41144,472,434 - 144,472,754UniSTSRGSC3.4
Cytogenetic Map1q32UniSTS
BF399922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,715,625 - 141,715,844 (+)MAPPERmRatBN7.2
Rnor_6.01151,611,818 - 151,612,036NCBIRnor6.0
Rnor_5.01157,923,033 - 157,923,251UniSTSRnor5.0
RGSC_v3.41144,367,210 - 144,367,428UniSTSRGSC3.4
Celera1140,030,162 - 140,030,380UniSTS
RH 3.4 Map11113.3UniSTS
Cytogenetic Map1q32UniSTS
AI850523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,882,118 - 141,882,273 (+)MAPPERmRatBN7.2
Rnor_6.01151,784,541 - 151,784,695NCBIRnor6.0
Rnor_5.01158,096,574 - 158,096,728UniSTSRnor5.0
RGSC_v3.41144,236,158 - 144,236,312UniSTSRGSC3.4
RGSC_v3.41144,478,568 - 144,478,722UniSTSRGSC3.4
Celera1140,194,815 - 140,194,969UniSTS
Cytogenetic Map1q32UniSTS
SGC30871  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,880,697 - 141,880,798 (+)MAPPERmRatBN7.2
Rnor_6.01151,783,120 - 151,783,220NCBIRnor6.0
Rnor_5.01158,095,153 - 158,095,253UniSTSRnor5.0
RGSC_v3.41144,477,147 - 144,477,247UniSTSRGSC3.4
Celera1140,193,393 - 140,193,493UniSTS
Cytogenetic Map1q32UniSTS
RH144288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,881,141 - 141,881,300 (+)MAPPERmRatBN7.2
Rnor_6.01151,783,564 - 151,783,722NCBIRnor6.0
Rnor_5.01158,095,597 - 158,095,755UniSTSRnor5.0
RGSC_v3.41144,477,591 - 144,477,749UniSTSRGSC3.4
Celera1140,193,837 - 140,193,995UniSTS
RH 3.4 Map11115.1UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to Grm5
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    


Genetic Models
This gene Grm5 is modified in the following models/strains:
SD-Grm5em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 6 11 139 45 50 24 26 24 6 108 56 6 122 16 44 26 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH007692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU559292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG021097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022060   ⟹   ENSRNOP00000022059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,733,678 - 151,294,424 (+)Ensembl
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)Ensembl
Rnor_6.0 Ensembl1151,439,409 - 151,783,256 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050639   ⟹   ENSRNOP00000040016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,733,678 - 151,293,559 (+)Ensembl
mRatBN7.2 Ensembl1141,312,368 - 141,880,970 (+)Ensembl
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157575   ⟹   ENSRNOP00000106840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,955,475 - 151,296,649 (+)Ensembl
RefSeq Acc Id: NM_017012   ⟹   NP_058708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,733,753 - 151,293,559 (+)NCBI
mRatBN7.21141,321,129 - 141,880,970 (+)NCBI
Rnor_6.01151,218,929 - 151,783,392 (+)NCBI
Rnor_5.01157,517,676 - 158,096,869 (+)NCBI
RGSC_v3.41143,857,225 - 144,477,419 (+)RGD
Celera1139,643,467 - 140,193,665 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229659   ⟹   XP_006229721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,722,711 - 151,297,585 (+)NCBI
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Rnor_5.01157,517,676 - 158,096,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588778   ⟹   XP_017444267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,722,711 - 151,297,585 (+)NCBI
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588779   ⟹   XP_017444268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,725,051 - 151,297,585 (+)NCBI
mRatBN7.21141,312,404 - 141,884,980 (+)NCBI
Rnor_6.01151,209,693 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588780   ⟹   XP_017444269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,724,924 - 151,297,585 (+)NCBI
mRatBN7.21141,312,404 - 141,884,980 (+)NCBI
Rnor_6.01151,209,693 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588781   ⟹   XP_017444270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,722,712 - 151,297,585 (+)NCBI
mRatBN7.21141,310,070 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096032   ⟹   XP_038951960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,722,711 - 151,297,585 (+)NCBI
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
RefSeq Acc Id: XM_063280720   ⟹   XP_063136790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,724,924 - 151,297,585 (+)NCBI
RefSeq Acc Id: XM_063280722   ⟹   XP_063136792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,722,712 - 151,297,585 (+)NCBI
RefSeq Acc Id: NP_058708   ⟸   NM_017012
- Peptide Label: precursor
- UniProtKB: A6I5Y9 (UniProtKB/TrEMBL),   A0A0H2UHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229721   ⟸   XM_006229659
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL),   A0A0H2UHN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444267   ⟸   XM_017588778
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017444270   ⟸   XM_017588781
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017444268   ⟸   XM_017588779
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL),   A0A0H2UHN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444269   ⟸   XM_017588780
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL),   A0A0H2UHN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022059   ⟸   ENSRNOT00000022060
Ensembl Acc Id: ENSRNOP00000040016   ⟸   ENSRNOT00000050639
RefSeq Acc Id: XP_038951960   ⟸   XM_039096032
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL),   A0A0H2UHN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136792   ⟸   XM_063280722
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063136790   ⟸   XM_063280720
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106840   ⟸   ENSRNOT00000157575
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31424-F1-model_v2 AlphaFold P31424 1-1203 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2746 AgrOrtholog
BIND 144395
BioCyc Gene G2FUF-58582 BioCyc
Ensembl Genes ENSRNOG00000016429 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022060 ENTREZGENE
  ENSRNOT00000022060.6 UniProtKB/Swiss-Prot
  ENSRNOT00000050639 ENTREZGENE
  ENSRNOT00000050639.3 UniProtKB/Swiss-Prot
  ENSRNOT00000157575 ENTREZGENE
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  GPCR_3 UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot
  GPCR_3_C UniProtKB/Swiss-Prot
  GPCR_3_CS UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt_5 UniProtKB/Swiss-Prot
  Metabotropic_Glu_rcpt_Homer-bd UniProtKB/Swiss-Prot
  mGluR UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24418 UniProtKB/Swiss-Prot
NCBI Gene 24418 ENTREZGENE
PANTHER METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_3 UniProtKB/Swiss-Prot
  ANF_receptor UniProtKB/Swiss-Prot
  GluR_Homer-bdg UniProtKB/Swiss-Prot
  NCD3G UniProtKB/Swiss-Prot
PhenoGen Grm5 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot
  MTABOTROPC5R UniProtKB/Swiss-Prot
  MTABOTROPICR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016429 RatGTEx
SMART GluR_Homer-bdg UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
UniProt A0A0H2UHN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UHW6 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y9 ENTREZGENE, UniProtKB/TrEMBL
  B2CZC8 ENTREZGENE, UniProtKB/TrEMBL
  GRM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm5  glutamate metabotropic receptor 5  Grm5  glutamate receptor, metabotropic 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grm5  glutamate receptor, metabotropic 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in the striatal GABAergic efferent neurons 625594
gene_process acts synergistically with the adenosine A2a-receptor (Adora2a) to increase c-fos expression in striatal sections, counteracting phencyclidine-induced motor activation 625594