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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2746
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grm5
Name: glutamate metabotropic receptor 5
Acc ID: CHEBI:4469
Term: (S)-amphetamine
Definition: A 1-phenylpropan-2-amine that has S configuration.
Chemical ID: MESH:D003913
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grm5decreases expressionEXP 6480464CTDDextroamphetamine results in decreased expression of GRM5 mRNAPMID:11303782
Grm5increases expressionEXP 6480464CTDDextroamphetamine results in increased expression of GRM5 mRNA; Dextroamphetamine results in increased expression of GRM5 proteinPMID:11303782 PMID:11665859
Grm5multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]; Cycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]; Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]; Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]PMID:11665859
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