RGD Reference Report - Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. - Rat Genome Database

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Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.

Authors: Gryder, DS  Rogawski, MA 
Citation: Gryder DS and Rogawski MA, J Neurosci 2003 Aug 6;23(18):7069-74.
RGD ID: 731146
Pubmed: PMID:12904467   (View Abstract at PubMed)
PMCID: PMC6740668   (View Article at PubMed Central)

Topiramate is a widely used antiepileptic agent whose mechanism of action is poorly understood. The drug has been reported to interact with various ion channel types, including AMPA/kainate receptors. In whole-cell voltage-clamp recordings from principal neurons of the rat basolateral amygdala, topiramate at low concentrations (IC50, approximately 0.5 microm) selectively inhibited pharmacologically isolated excitatory synaptic currents mediated by kainate receptors containing the GluR5 subunit. Topiramate also partially depressed predominantly AMPA-receptor-mediated EPSCs, but with lower efficacy. Topiramate did not alter the degree of facilitation in paired-pulse experiments, and it reduced the amplitude of miniature EPSCs without affecting their frequency, demonstrating that the block of synaptic responses occurs postsynaptically. Inhibition of GluR5 kainate receptors could represent a key mechanism underlying the anticonvulsant activity of topiramate. Moreover, these results support the concept that GluR5 kainate receptors represent a novel target for antiepileptic drug development.

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
topiramate affects bindingISOGrik1 (Rattus norvegicus)731146; 731146topiramate binds to Grik1 proteinRGD 
topiramate affects bindingEXP 731146topiramate binds to Grik1 proteinRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heterocyclic compound binding contributes_toIPItopiramate731146 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik1  (glutamate ionotropic receptor kainate type subunit 1)

Genes (Mus musculus)
Grik1  (glutamate receptor, ionotropic, kainate 1)

Genes (Homo sapiens)
GRIK1  (glutamate ionotropic receptor kainate type subunit 1)

Objects referenced in this article
Gene Grm5 glutamate metabotropic receptor 5 Rattus norvegicus

Additional Information