Grik2 (glutamate ionotropic receptor kainate type subunit 2) - Rat Genome Database

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Gene: Grik2 (glutamate ionotropic receptor kainate type subunit 2) Rattus norvegicus
Analyze
Symbol: Grik2
Name: glutamate ionotropic receptor kainate type subunit 2
RGD ID: 2733
Description: Enables several functions, including PDZ domain binding activity; enzyme binding activity; and glutamate-gated receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Located in several cellular components, including dendrite cytoplasm; perikaryon; and terminal bouton. Part of ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive intellectual developmental disorder 6. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluK2; gluR-6; GluR6; glutamate receptor 6; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82053,717,564 - 54,415,283 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2053,716,090 - 54,415,202 (-)EnsemblGRCr8
mRatBN7.22052,135,325 - 52,833,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2053,835,165 - 54,527,304 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02053,484,886 - 54,177,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02054,176,501 - 54,864,656 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02053,791,428 - 54,517,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2053,789,760 - 54,517,709 (-)Ensemblrn6Rnor6.0
Rnor_5.02055,397,877 - 56,122,315 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42053,231,473 - 53,713,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2047,307,163 - 47,987,148 (+)NCBICelera
RGSC_v3.12053,258,695 - 53,741,826 (-)NCBI
Cytogenetic Map20q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
celecoxib  (ISO)
chlorpyrifos  (EXP)
citalopram  (ISO)
clozapine  (EXP)
cocaine  (EXP)
DDE  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
fluoxetine  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
linuron  (EXP)
lithium atom  (EXP,ISO)
lithium hydride  (EXP,ISO)
maneb  (ISO)
methylphenidate  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
phenethyl caffeate  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Chaudhry C, etal., Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12329-34. doi: 10.1073/pnas.0904175106. Epub 2009 Jul 15.
2. Domain organization and function in GluK2 subtype kainate receptors. Das U, etal., Proc Natl Acad Sci U S A. 2010 May 4;107(18):8463-8. doi: 10.1073/pnas.1000838107. Epub 2010 Apr 19.
3. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Egebjerg J, etal., Nature 1991 Jun 27;351(6329):745-8.
4. Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors. Fisher MT and Fisher JL, Neuroscience. 2014 Oct 10;278:70-80. doi: 10.1016/j.neuroscience.2014.08.009. Epub 2014 Aug 17.
5. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Garcia EP, etal., Neuron. 1998 Oct;21(4):727-39.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression. Guo W, etal., Eur J Pharmacol 2002 Oct 11;452(3):309-18.
9. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
10. Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. Jiang HX, etal., J Neurosci Res. 2007 Oct;85(13):2960-70.
11. Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidus. Jin XT, etal., Eur J Neurosci. 2006 Jan;23(2):374-86.
12. Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Konopacki FA, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19772-7. doi: 10.1073/pnas.1111575108. Epub 2011 Nov 16.
13. The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Kumar J, etal., Nat Struct Mol Biol. 2009 Jun;16(6):631-8. doi: 10.1038/nsmb.1613. Epub 2009 May 24.
14. Structure and assembly mechanism for heteromeric kainate receptors. Kumar J, etal., Neuron. 2011 Jul 28;71(2):319-31. doi: 10.1016/j.neuron.2011.05.038.
15. Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Köhler M, etal., Neuron. 1993 Mar;10(3):491-500. doi: 10.1016/0896-6273(93)90336-p.
16. High-affinity kainate and domoate receptors in rat brain. Lomeli H, etal., FEBS Lett 1992 Jul 28;307(2):139-43.
17. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
18. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
19. Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. MacDonald ME, etal., Neurology 1999 Oct 12;53(6):1330-2.
20. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Martin S, etal., Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
21. Structural mechanism of glutamate receptor activation and desensitization. Meyerson JR, etal., Nature. 2014 Oct 16;514(7522):328-34. doi: 10.1038/nature13603. Epub 2014 Aug 3.
22. Structural basis of kainate subtype glutamate receptor desensitization. Meyerson JR, etal., Nature. 2016 Sep 22;537(7621):567-571. doi: 10.1038/nature19352. Epub 2016 Aug 31.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
27. GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. Paternain AV, etal., J Neurosci. 2000 Jan 1;20(1):196-205.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Reiner A, etal., Cell Rep. 2012 Mar 29;1(3):234-40. doi: 10.1016/j.celrep.2012.01.003.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Transmembrane topology of the glutamate receptor subunit GluR6. Roche KW, etal., J Biol Chem. 1994 Apr 22;269(16):11679-82.
34. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
35. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. Savinainen A, etal., J Biol Chem. 2001 Apr 6;276(14):11382-6. Epub 2001 Jan 10.
36. Structural and compositional diversity in the kainate receptor family. Selvakumar P, etal., Cell Rep. 2021 Oct 26;37(4):109891. doi: 10.1016/j.celrep.2021.109891.
37. Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. Stolz JR, etal., Am J Hum Genet. 2021 Nov 4;108(11):2206. doi: 10.1016/j.ajhg.2021.09.018.
38. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
39. Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors. Unno M, etal., J Mol Biol. 2011 Oct 28;413(3):667-83. doi: 10.1016/j.jmb.2011.08.043. Epub 2011 Aug 26.
40. Conformational restriction blocks glutamate receptor desensitization. Weston MC, etal., Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. Epub 2006 Nov 19.
41. SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation. Zhu QJ, etal., FEBS Lett. 2012 May 7;586(9):1259-64. doi: 10.1016/j.febslet.2012.03.048. Epub 2012 Mar 31.
Additional References at PubMed
PMID:1310861   PMID:9141074   PMID:9490692   PMID:9580260   PMID:9880586   PMID:10479699   PMID:10704492   PMID:11069933   PMID:11144357   PMID:11182092   PMID:11744724   PMID:11985817  
PMID:12151522   PMID:12223554   PMID:12947409   PMID:12954862   PMID:14724198   PMID:15014126   PMID:15458844   PMID:15483117   PMID:15509753   PMID:15513934   PMID:15537878   PMID:15539395  
PMID:15632090   PMID:15673679   PMID:15677325   PMID:15796762   PMID:15928066   PMID:16219388   PMID:16267825   PMID:16354929   PMID:16439423   PMID:17005866   PMID:17174564   PMID:17428973  
PMID:17620617   PMID:18172894   PMID:18307989   PMID:18562501   PMID:18680160   PMID:19180187   PMID:19449206   PMID:19561126   PMID:19784088   PMID:20848775   PMID:21148565   PMID:21557511  
PMID:21734292   PMID:22114280   PMID:22345355   PMID:22445759   PMID:22522402   PMID:22813734   PMID:23400781   PMID:23530186   PMID:23720540   PMID:23861400   PMID:23949220   PMID:23955023  
PMID:23975096   PMID:24895134   PMID:25201974   PMID:25316086   PMID:26282342   PMID:28100490   PMID:28180184   PMID:28636947   PMID:29193067   PMID:30421168   PMID:30559217   PMID:31628192  
PMID:33537798   PMID:33724189   PMID:37544581  


Genomics

Comparative Map Data
Grik2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82053,717,564 - 54,415,283 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2053,716,090 - 54,415,202 (-)EnsemblGRCr8
mRatBN7.22052,135,325 - 52,833,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2053,835,165 - 54,527,304 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02053,484,886 - 54,177,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02054,176,501 - 54,864,656 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02053,791,428 - 54,517,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2053,789,760 - 54,517,709 (-)Ensemblrn6Rnor6.0
Rnor_5.02055,397,877 - 56,122,315 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42053,231,473 - 53,713,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2047,307,163 - 47,987,148 (+)NCBICelera
RGSC_v3.12053,258,695 - 53,741,826 (-)NCBI
Cytogenetic Map20q13NCBI
GRIK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386101,393,708 - 102,070,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6100,962,701 - 102,081,622 (+)Ensemblhg38GRCh38
GRCh376101,841,584 - 102,517,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366101,953,675 - 102,623,474 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346101,953,674 - 102,623,474NCBI
Celera6102,490,982 - 103,163,448 (+)NCBICelera
Cytogenetic Map6q16.3NCBI
HuRef699,289,230 - 99,962,155 (+)NCBIHuRef
CHM1_16102,108,429 - 102,780,216 (+)NCBICHM1_1
T2T-CHM13v2.06102,567,441 - 103,245,122 (+)NCBIT2T-CHM13v2.0
Grik2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391048,969,776 - 49,666,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1048,970,929 - 49,664,862 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381049,093,680 - 49,790,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1049,094,833 - 49,788,766 (-)Ensemblmm10GRCm38
MGSCv371048,819,269 - 49,508,560 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361048,789,404 - 49,471,824 (-)NCBIMGSCv36mm8
Celera1049,961,395 - 50,650,295 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1024.87NCBI
Grik2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541127,103,470 - 27,801,177 (+)Ensembl
ChiLan1.0NW_00495541127,096,214 - 27,759,503 (+)NCBIChiLan1.0ChiLan1.0
GRIK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25120,926,005 - 122,109,168 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16118,808,051 - 119,995,774 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0698,720,430 - 99,903,582 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16103,106,776 - 103,784,640 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6103,334,707 - 103,783,092 (+)EnsemblpanPan2panpan1.1
GRIK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11258,932,754 - 59,991,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1259,355,017 - 59,990,408 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1258,685,896 - 59,760,448 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01259,766,364 - 60,827,294 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1260,189,211 - 60,826,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11259,112,703 - 60,183,136 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01258,954,426 - 60,016,937 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01259,195,178 - 60,257,015 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grik2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494694,301,120 - 94,944,470 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366512,762,380 - 3,401,808 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366512,756,559 - 3,401,806 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl168,057,538 - 68,679,256 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1168,052,086 - 68,680,448 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2177,317,681 - 77,555,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11371,855,960 - 72,545,376 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1371,855,794 - 72,325,857 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604044,140,787 - 44,845,039 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248102,733,118 - 3,401,909 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248102,731,573 - 3,407,186 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grik2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11847,719,014 - 48,377,165 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grik2
4732 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000037559
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
D20Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82054,213,280 - 54,213,530 (+)Marker Load Pipeline
mRatBN7.22052,631,053 - 52,631,303 (+)MAPPERmRatBN7.2
Rnor_6.02054,294,088 - 54,294,337NCBIRnor6.0
Rnor_5.02055,896,923 - 55,897,172UniSTSRnor5.0
RGSC_v3.42053,738,804 - 53,739,053UniSTSRGSC3.4
RGSC_v3.42053,738,803 - 53,739,053RGDRGSC3.4
Celera2047,501,945 - 47,502,194UniSTS
RGSC_v3.12053,767,501 - 53,767,750RGD
RH 3.4 Map20562.35RGD
RH 3.4 Map20562.35UniSTS
Cytogenetic Map20q13UniSTS
BF394244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,771,477 - 52,771,687 (+)MAPPERmRatBN7.2
Rnor_6.02054,457,376 - 54,457,585NCBIRnor6.0
Rnor_5.02056,059,981 - 56,060,190UniSTSRnor5.0
RGSC_v3.42053,886,466 - 53,886,675UniSTSRGSC3.4
Celera2047,368,495 - 47,368,704UniSTS
Cytogenetic Map20q13UniSTS
AU046653  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82054,412,860 - 54,412,996 (+)Marker Load Pipeline
mRatBN7.22052,830,638 - 52,830,774 (+)MAPPERmRatBN7.2
Rnor_6.02054,515,269 - 54,515,404NCBIRnor6.0
Rnor_5.02056,119,893 - 56,120,028UniSTSRnor5.0
RGSC_v3.42052,447,060 - 52,447,195UniSTSRGSC3.4
Celera2047,309,450 - 47,309,585UniSTS
Cytogenetic Map20q13UniSTS
RH134654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,133,991 - 52,134,174 (+)MAPPERmRatBN7.2
Rnor_6.02053,790,095 - 53,790,277NCBIRnor6.0
Rnor_5.02055,396,544 - 55,396,726UniSTSRnor5.0
RGSC_v3.42053,230,140 - 53,230,322UniSTSRGSC3.4
Celera2047,988,299 - 47,988,481UniSTS
RH 3.4 Map20557.94UniSTS
Cytogenetic Map20q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 64 149 65 62 33 28 33 6 254 123 9 128 81 92 29 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000037559   ⟹   ENSRNOP00000033070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2053,716,090 - 54,189,233 (-)Ensembl
mRatBN7.2 Ensembl2052,133,851 - 52,607,007 (-)Ensembl
Rnor_6.0 Ensembl2053,789,760 - 54,269,525 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076234   ⟹   ENSRNOP00000068172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2053,716,090 - 54,415,202 (-)Ensembl
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)Ensembl
Rnor_6.0 Ensembl2053,789,954 - 54,517,709 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,135,527 - 52,606,868 (-)Ensembl
Rnor_6.0 Ensembl2053,789,954 - 54,517,709 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097789   ⟹   ENSRNOP00000082305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2053,721,429 - 54,415,202 (-)Ensembl
mRatBN7.2 Ensembl2052,147,995 - 52,606,868 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112090   ⟹   ENSRNOP00000081018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2053,719,952 - 54,415,202 (-)Ensembl
mRatBN7.2 Ensembl2052,135,239 - 52,838,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118241   ⟹   ENSRNOP00000080218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,135,239 - 52,838,375 (-)Ensembl
RefSeq Acc Id: NM_019309   ⟹   NP_062182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82053,717,564 - 54,415,283 (-)NCBI
mRatBN7.22052,135,325 - 52,833,061 (-)NCBI
Rnor_6.02053,791,428 - 54,517,691 (-)NCBI
Rnor_5.02055,397,877 - 56,122,315 (-)NCBI
RGSC_v3.42053,231,473 - 53,713,131 (-)RGD
Celera2047,307,163 - 47,987,148 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA77647 (Get FASTA)   NCBI Sequence Viewer  
  CAA77778 (Get FASTA)   NCBI Sequence Viewer  
  EDL99658 (Get FASTA)   NCBI Sequence Viewer  
  EDL99659 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068172
  ENSRNOP00000068172.1
GenBank Protein P42260 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062182   ⟸   NM_019309
- Peptide Label: precursor
- UniProtKB: F1M855 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033070   ⟸   ENSRNOT00000037559
Ensembl Acc Id: ENSRNOP00000068172   ⟸   ENSRNOT00000076234
Ensembl Acc Id: ENSRNOP00000082305   ⟸   ENSRNOT00000097789
Ensembl Acc Id: ENSRNOP00000080218   ⟸   ENSRNOT00000118241
Ensembl Acc Id: ENSRNOP00000081018   ⟸   ENSRNOT00000112090
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42260-F1-model_v2 AlphaFold P42260 1-908 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2733 AgrOrtholog
BioCyc Gene G2FUF-3235 BioCyc
Ensembl Genes ENSRNOG00000000368 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076234 ENTREZGENE
  ENSRNOT00000076234.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:54257 UniProtKB/Swiss-Prot
NCBI Gene 54257 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Grik2 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000368 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A0A8I5ZS08_RAT UniProtKB/TrEMBL
  A0A8I5ZU84_RAT UniProtKB/TrEMBL
  F1M855 ENTREZGENE, UniProtKB/TrEMBL
  GRIK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik2  glutamate ionotropic receptor kainate type subunit 2  Grik2  glutamate receptor, ionotropic, kainate 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik2  glutamate receptor, ionotropic, kainate 2      Name updated 70584 APPROVED