RGD Reference Report - Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. - Rat Genome Database

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Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury.

Authors: Jiang, HX  Guan, QH  Pei, DS  Zhang, GY 
Citation: Jiang HX, etal., J Neurosci Res. 2007 Oct;85(13):2960-70.
RGD ID: 2316528
Pubmed: PMID:17639597   (View Abstract at PubMed)
DOI: DOI:10.1002/jnr.21334   (Journal Full-text)

We investigated the possible relationships between KA2 subunit and GluR6 subunit, as well as the role of KA2 subunit in neuronal death induced by cerebral ischemia/reperfusion. Our results indicated that intracerebroventricular infusion of KA2 antisense oligodeoxynucleotides (AS) not only knocked down the expressions of KA2 and GluR6, but also suppressed the assembly of the GluR6/KA2-PSD95-MLK3 signaling module, and inhibited JNK activation and phosphorylation of c-jun. In addition, infusion of KA2 AS increased neuronal survival in CA1 region after 5 days of reperfusion. More interestingly, we found that the combination of KA2 and GluR6 AS exerted more significant effects than when pretreated with KA2 AS or GluR6 AS alone. Our results suggest that the KA2 subunit is involved in delayed neuronal death induced by cerebral ischemia, at the same time, it is noteworthy that the functional cooperation between KA2 and GluR6 subunits plays a critical role in the ischemic brain injury by PSD95-MLK3-MKK4/7-JNK3 signal pathway.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of neuron apoptotic process  IMP 2316528; 2316528 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIMap3k11 (Rattus norvegicus) and Dlg4 (Rattus norvegicus)2316528 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik2  (glutamate ionotropic receptor kainate type subunit 2)
Grik5  (glutamate ionotropic receptor kainate type subunit 5)

Genes (Mus musculus)
Grik2  (glutamate receptor, ionotropic, kainate 2 (beta 2))
Grik5  (glutamate receptor, ionotropic, kainate 5 (gamma 2))

Genes (Homo sapiens)
GRIK2  (glutamate ionotropic receptor kainate type subunit 2)
GRIK5  (glutamate ionotropic receptor kainate type subunit 5)


Additional Information