Cp (ceruloplasmin) - Rat Genome Database

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Gene: Cp (ceruloplasmin) Rattus norvegicus
Analyze
Symbol: Cp
Name: ceruloplasmin
RGD ID: 2387
Description: Enables copper ion binding activity. Involved in several processes, including female pregnancy; mammary gland development; and response to copper ion. Located in cell surface and extracellular space. Used to study brain edema. Biomarker of Wilson disease; brain ischemia; heart disease; and hyperthyroidism. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin); PARTICIPATES IN hypoxia inducible factor pathway; iron efflux pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bilitranslocase; CERP; ceruloplasmin (ferroxidase); cuproxidase ceruloplasmin; ferroxidase; ferroxidase ceruloplasmin; glutathione peroxidase ceruloplasmin; glutathione-dependent peroxiredoxin ceruloplasmin; RATCERP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cpem1Ang
Genetic Models: SD-Cpem1Ang+/- ; SD-Cpem1Ang-/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,368,336 - 104,427,119 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2104,368,456 - 104,427,087 (+)EnsemblGRCr8
mRatBN7.22102,439,433 - 102,498,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,439,624 - 102,498,075 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,952,949 - 109,011,420 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,074,093 - 107,132,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,037,140 - 102,095,422 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,744,249 - 104,803,034 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,744,461 - 104,799,853 (+)Ensemblrn6Rnor6.0
Rnor_5.02124,467,383 - 124,524,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42105,086,278 - 105,135,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,809,748 - 97,868,604 (+)NCBICelera
RGSC_v3.12105,031,239 - 105,080,329 (+)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP,ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
Bacoside a  (EXP)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorotoluron  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-penicillamine  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethylenediaminetetraacetic acid  (ISO)
felbamate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
formic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gabapentin  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
glafenine  (EXP)
glyburide  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
lidocaine  (EXP)
linalool  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
lupeol  (EXP)
malonaldehyde  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
natamycin  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (EXP)
nitrites  (EXP,ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
nystatin  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
pentanal  (ISO)
pentetic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenytoin  (EXP)
phosphane  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quinolinic acid  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium azide  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
undecane  (EXP)
uranium atom  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
withaferin A  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins. Battiston L, etal., Biochem Biophys Res Commun 1998 Jun 29;247(3):687-92.
2. Pro- and antioxidants in the central lymph in experimental chronic toxic hepatitis. Borodin JI, etal., Bull Exp Biol Med. 2008 Nov;146(5):566-8.
3. Differential impact of copper deficiency in rats on blood cuproproteins. Broderius MA and Prohaska JR, Nutr Res. 2009 Jul;29(7):494-502.
4. Increased Ceruloplasmin and Fibrinogen in Type 2 Diabetes Corresponds to Decreased Anti-oxidant Activity in a Preliminary Tertiary South Indian Hospital Study. Chacko SK and Cheluvappa R, Exp Clin Endocrinol Diabetes. 2009 Oct 15.
5. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
6. Copper concentrations in Egyptian infants with cholestasis: A single center study. El-Koofy N, etal., Arab J Gastroenterol. 2018 Mar;19(1):21-25. doi: 10.1016/j.ajg.2018.02.010. Epub 2018 Mar 6.
7. Primary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development. Fleming RE and Gitlin JD, J Biol Chem 1990 May 5;265(13):7701-7.
8. Structural and functional analysis of the 5'-flanking region of the rat ceruloplasmin gene. Fleming RE and Gitlin JD, J Biol Chem 1992 Jan 5;267(1):479-86.
9. Ceruloplasmin gene defect associated with epilepsy in EL mice. Garey CE, etal., Nat Genet 1994 Apr;6(4):426-31.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Efficacy of grape seed proanthocyanidins on cardioprotection during isoproterenol-induced myocardial injury in rats. Karthikeyan K, etal., J Cardiovasc Pharmacol. 2009 Feb;53(2):109-15.
13. Ceruloplasmin deficiency does not induce macrophagic iron overload: lessons from a new rat model of hereditary aceruloplasminemia. Kenawi M, etal., FASEB J. 2019 Dec;33(12):13492-13502. doi: 10.1096/fj.201901106R. Epub 2019 Sep 27.
14. Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats. Kim SW, etal., Proteomics. 2006 Oct;6(19):5291-302.
15. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
16. An inhibition of ceruloplasmin expression induced by cerebral ischemia in the cortex and hippocampus of rats. Li YW, etal., Neurosci Bull. 2008 Feb;24(1):13-20.
17. Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects. Mak CM, etal., Clin Chem. 2008 Aug;54(8):1356-62. doi: 10.1373/clinchem.2008.103432. Epub 2008 Jun 12.
18. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Meng Y, etal., Biochim Biophys Acta 2004 Nov 5;1690(3):208-19.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Hyperthyroidism is associated with increased aortic oxidative DNA damage in a rat model. Moulakakis KG, etal., In Vivo. 2007 Nov-Dec;21(6):1021-6.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain. Patel BN, etal., J Biol Chem 2000 Feb 11;275(6):4305-10.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Ceruloplasmin gene expression profile changes in the rat mammary gland during pregnancy, lactation and involution. Platonova NA, etal., J Trace Elem Med Biol. 2017 Sep;43:126-134. doi: 10.1016/j.jtemb.2016.12.013. Epub 2017 Jan 3.
27. Dexamethasone induced alterations in the levels of proteases involved in blood pressure homeostasis and blood coagulation in rats. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1999 Jul;197(1-2):203-8.
28. Evaluation of oxidative stress in Insulin Dependent Diabetes Mellitus (IDDM) patients. Ramakrishna V and Jailkhani R, Diagn Pathol. 2007 Jul 1;2:22.
29. Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats. Ratheesh M, etal., Inflammopharmacology. 2009 Apr;17(2):100-5.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis. Sun Q, etal., Nutrients. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet. Wiggins JE, etal., J Am Soc Nephrol. 2006 May;17(5):1382-7. Epub 2006 Apr 5.
36. Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25.
37. Up-regulation of brain ceruloplasmin in thrombin preconditioning. Yang S, etal., Acta Neurochir Suppl. 2006;96:203-6.
38. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Yoshida K, etal., Nat Genet. 1995 Mar;9(3):267-72.
39. Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid. Ziak M, etal., Biochem Biophys Res Commun 2002 Jul 19;295(3):597-602.
Additional References at PubMed
PMID:3818625   PMID:11880554   PMID:12555201   PMID:14707133   PMID:15172111   PMID:15634671   PMID:16436657   PMID:16502470   PMID:17316903   PMID:17383861   PMID:17897319   PMID:18708193  
PMID:19056867   PMID:19095659   PMID:19996109   PMID:20091025   PMID:20170749   PMID:20551380   PMID:21332026   PMID:21768302   PMID:22206666   PMID:22350470   PMID:22516433   PMID:23376485  
PMID:23533145   PMID:23872735   PMID:24006456   PMID:25656940   PMID:28450461   PMID:29078076   PMID:30315404   PMID:30955187  


Genomics

Comparative Map Data
Cp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,368,336 - 104,427,119 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2104,368,456 - 104,427,087 (+)EnsemblGRCr8
mRatBN7.22102,439,433 - 102,498,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,439,624 - 102,498,075 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,952,949 - 109,011,420 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,074,093 - 107,132,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,037,140 - 102,095,422 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,744,249 - 104,803,034 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,744,461 - 104,799,853 (+)Ensemblrn6Rnor6.0
Rnor_5.02124,467,383 - 124,524,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42105,086,278 - 105,135,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,809,748 - 97,868,604 (+)NCBICelera
RGSC_v3.12105,031,239 - 105,080,329 (+)NCBI
Cytogenetic Map2q24NCBI
CP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383149,162,414 - 149,221,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3149,162,410 - 149,221,998 (-)Ensemblhg38GRCh38
GRCh373148,880,201 - 148,939,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363150,373,220 - 150,422,519 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343150,374,073 - 150,422,277NCBI
Celera3147,300,808 - 147,350,343 (-)NCBICelera
Cytogenetic Map3q24-q25.1NCBI
HuRef3146,251,480 - 146,311,114 (-)NCBIHuRef
CHM1_13148,843,270 - 148,902,904 (-)NCBICHM1_1
T2T-CHM13v2.03151,913,150 - 151,972,585 (-)NCBIT2T-CHM13v2.0
Cp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,011,097 - 20,063,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,011,218 - 20,063,309 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38319,956,933 - 20,009,750 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,957,054 - 20,009,145 (+)Ensemblmm10GRCm38
MGSCv37319,857,054 - 19,907,609 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36320,149,330 - 20,184,741 (+)NCBIMGSCv36mm8
Celera319,946,245 - 19,996,873 (+)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.1NCBI
Cp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448473,179 - 523,100 (-)Ensembl
ChiLan1.0NW_004955448470,063 - 522,909 (-)NCBIChiLan1.0ChiLan1.0
CP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22147,051,806 - 147,111,317 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13147,056,837 - 147,116,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03146,180,527 - 146,239,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,768,362 - 153,817,591 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,764,830 - 153,817,544 (-)EnsemblpanPan2panpan1.1
CP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,969,297 - 44,033,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,969,435 - 44,030,369 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2343,833,488 - 43,897,430 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02344,595,848 - 44,659,908 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2344,595,850 - 44,657,211 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12344,184,564 - 44,247,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02344,232,408 - 44,296,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,486,640 - 44,550,551 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560283,263,259 - 83,302,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,431,144 - 6,481,858 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,431,156 - 6,473,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1389,396,708 - 89,463,476 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11389,396,713 - 89,463,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21397,390,612 - 97,455,765 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q32-q33NCBI
Cp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473026,462,550 - 26,511,078 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473026,458,554 - 26,510,796 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13134,123,631 - 134,182,678 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cp
504 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:116
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000016083
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
D2Wox54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,437,904 - 102,438,084 (+)MAPPERmRatBN7.2
Rnor_6.02104,742,726 - 104,742,905NCBIRnor6.0
Rnor_5.02124,465,845 - 124,466,024UniSTSRnor5.0
RGSC_v3.42105,084,543 - 105,084,722UniSTSRGSC3.4
Celera297,808,042 - 97,808,212UniSTS
Cytogenetic Map2q24UniSTS
D2Wox55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,438,708 - 102,438,945 (+)MAPPERmRatBN7.2
Rnor_6.02104,743,530 - 104,743,764NCBIRnor6.0
Rnor_5.02124,466,649 - 124,466,883UniSTSRnor5.0
RGSC_v3.42105,085,347 - 105,085,581UniSTSRGSC3.4
Celera297,808,837 - 97,809,069UniSTS
Cytogenetic Map2q24UniSTS
RH141500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,497,797 - 102,497,979 (+)MAPPERmRatBN7.2
Rnor_6.02104,802,647 - 104,802,828NCBIRnor6.0
Rnor_5.02124,523,753 - 124,523,934UniSTSRnor5.0
RGSC_v3.42105,148,654 - 105,148,835UniSTSRGSC3.4
Celera297,868,327 - 97,868,508UniSTS
RH 3.4 Map2620.9UniSTS
Cytogenetic Map2q24UniSTS
CP-000F  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,457,192 - 102,458,466 (+)MAPPERmRatBN7.2
Rnor_6.02104,762,011 - 104,763,284NCBIRnor6.0
Rnor_5.02124,485,130 - 124,486,403UniSTSRnor5.0
RGSC_v3.42105,103,828 - 105,105,101UniSTSRGSC3.4
Celera297,827,765 - 97,829,038UniSTS
Cytogenetic Map2q24UniSTS


Genetic Models
This gene Cp is modified in the following models/strains:
SD-Cpem1Ang+/-     SD-Cpem1Ang-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016083   ⟹   ENSRNOP00000016083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2104,368,456 - 104,413,352 (+)Ensembl
mRatBN7.2 Ensembl2102,439,624 - 102,484,311 (+)Ensembl
Rnor_6.0 Ensembl2104,744,461 - 104,789,146 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082627   ⟹   ENSRNOP00000075010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2104,368,673 - 104,427,087 (+)Ensembl
mRatBN7.2 Ensembl2102,439,624 - 102,495,001 (+)Ensembl
Rnor_6.0 Ensembl2104,744,476 - 104,799,853 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119964   ⟹   ENSRNOP00000089330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2104,368,673 - 104,427,081 (+)Ensembl
mRatBN7.2 Ensembl2102,439,624 - 102,498,075 (+)Ensembl
RefSeq Acc Id: NM_001270961   ⟹   NP_001257890
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,368,670 - 104,427,119 (+)NCBI
mRatBN7.22102,439,624 - 102,498,075 (+)NCBI
Rnor_6.02104,744,443 - 104,802,924 (+)NCBI
Rnor_5.02124,467,383 - 124,524,140 (+)NCBI
Celera297,809,748 - 97,868,604 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012532   ⟹   NP_036664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,368,670 - 104,413,355 (+)NCBI
mRatBN7.22102,439,624 - 102,484,311 (+)NCBI
Rnor_6.02104,744,443 - 104,789,160 (+)NCBI
Rnor_5.02124,467,383 - 124,524,140 (+)NCBI
RGSC_v3.42105,086,278 - 105,135,367 (+)RGD
Celera297,809,748 - 97,854,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281287   ⟹   XP_063137357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,368,336 - 104,426,319 (+)NCBI
RefSeq Acc Id: XR_590972
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,368,336 - 104,427,088 (+)NCBI
mRatBN7.22102,439,433 - 102,498,053 (+)NCBI
Rnor_6.02104,744,250 - 104,803,034 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036664   ⟸   NM_012532
- Peptide Label: isoform 1 precursor
- UniProtKB: Q64719 (UniProtKB/Swiss-Prot),   P13635 (UniProtKB/Swiss-Prot),   G3V7K3 (UniProtKB/TrEMBL),   A6IHC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257890   ⟸   NM_001270961
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A8I6A708 (UniProtKB/TrEMBL),   A6IHC3 (UniProtKB/TrEMBL),   Q9JL97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016083   ⟸   ENSRNOT00000016083
Ensembl Acc Id: ENSRNOP00000075010   ⟸   ENSRNOT00000082627
Ensembl Acc Id: ENSRNOP00000089330   ⟸   ENSRNOT00000119964
RefSeq Acc Id: XP_063137357   ⟸   XM_063281287
- Peptide Label: isoform X1
- UniProtKB: Q9JL97 (UniProtKB/TrEMBL),   A0A8I6A708 (UniProtKB/TrEMBL),   A6IHC3 (UniProtKB/TrEMBL)
Protein Domains
Plastocyanin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13635-F1-model_v2 AlphaFold P13635 1-1059 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691257
Promoter ID:EPDNEW_R1780
Type:multiple initiation site
Name:Cp_1
Description:ceruloplasmin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02104,744,446 - 104,744,506EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2387 AgrOrtholog
BioCyc Gene G2FUF-53608 BioCyc
Ensembl Genes ENSRNOG00000011913 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016083 ENTREZGENE
  ENSRNOT00000082627 ENTREZGENE
  ENSRNOT00000119964 ENTREZGENE
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot
InterPro Ceruloplasmin-like_CuRO_5 UniProtKB/Swiss-Prot
  Cu-oxidase UniProtKB/Swiss-Prot
  Cu-oxidase_2 UniProtKB/Swiss-Prot
  Cu-oxidase_3 UniProtKB/Swiss-Prot
  Cu-oxidase_fam UniProtKB/Swiss-Prot
  Cu_oxidase_CS UniProtKB/Swiss-Prot
  Cu_oxidase_Cu_BS UniProtKB/Swiss-Prot
  Cupredoxin UniProtKB/Swiss-Prot
  Factor_5/8-like UniProtKB/Swiss-Prot
NCBI Gene 24268 ENTREZGENE
PANTHER CERULOPLASMIN UniProtKB/Swiss-Prot
  MULTI-COPPER OXIDASE UniProtKB/Swiss-Prot
Pfam Cu-oxidase UniProtKB/Swiss-Prot
  Cu-oxidase_2 UniProtKB/Swiss-Prot
  Cu-oxidase_3 UniProtKB/Swiss-Prot
PharmGKB CP RGD
PhenoGen Cp PhenoGen
PIRSF Factors_V_VIII UniProtKB/Swiss-Prot
PROSITE MULTICOPPER_OXIDASE1 UniProtKB/Swiss-Prot
  MULTICOPPER_OXIDASE2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011913 RatGTEx
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot
TIGR TC229708
UniProt A0A0G2K9I6_RAT UniProtKB/TrEMBL
  A0A8I6A708 ENTREZGENE, UniProtKB/TrEMBL
  A6IHC3 ENTREZGENE, UniProtKB/TrEMBL
  A6IHC4 ENTREZGENE, UniProtKB/TrEMBL
  A6IHC5_RAT UniProtKB/TrEMBL
  CERU_RAT UniProtKB/Swiss-Prot
  G3V7K3 ENTREZGENE, UniProtKB/TrEMBL
  P13635 ENTREZGENE
  Q64719 ENTREZGENE
  Q9JL97 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q64719 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Cp  ceruloplasmin  Cp  ceruloplasmin (ferroxidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Cp  ceruloplasmin (ferroxidase)  Cp  ceruloplasmin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cp  ceruloplasmin    Ceruloplasmin (ferroxidase)  Name updated 625702 APPROVED
2002-06-10 Cp  Ceruloplasmin (ferroxidase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma 727562
gene_cellular_localization alternatively spliced glycosylphosphatidylinositol (GPI)-anchored form predominates in brain and is localized to the surface of astrocytes 727562
gene_disease mutation of the human homolog causes aceruloplasminemia, a disorder of iron metabolism 727562