RGD Reference Report - Ironing out Ferroportin. - Rat Genome Database

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Ironing out Ferroportin.

Authors: Drakesmith, Hal  Nemeth, Elizabeta  Ganz, Tomas 
Citation: Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
RGD ID: 11534369
Pubmed: PMID:26437604   (View Abstract at PubMed)
PMCID: PMC4635047   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cmet.2015.09.006   (Journal Full-text)

Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through the iron exporter ferroportin. The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin, and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis. Fundamental questions about the structure and biology of ferroportin remain to be answered.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Cp  (ceruloplasmin)
Hamp  (hepcidin antimicrobial peptide)
Heph  (hephaestin)
Slc40a1  (solute carrier family 40 member 1)

Genes (Mus musculus)
Cp  (ceruloplasmin)
Hamp  (hepcidin antimicrobial peptide)
Heph  (hephaestin)
Slc40a1  (solute carrier family 40 (iron-regulated transporter), member 1)

Genes (Homo sapiens)
CP  (ceruloplasmin)
HAMP  (hepcidin antimicrobial peptide)
HEPH  (hephaestin)
SLC40A1  (solute carrier family 40 member 1)


Additional Information