RGD Reference Report - Dexamethasone induced alterations in the levels of proteases involved in blood pressure homeostasis and blood coagulation in rats. - Rat Genome Database

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Dexamethasone induced alterations in the levels of proteases involved in blood pressure homeostasis and blood coagulation in rats.

Authors: Rajashree, S  Puvanakrishnan, R 
Citation: Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1999 Jul;197(1-2):203-8.
RGD ID: 1599630
Pubmed: PMID:10485340   (View Abstract at PubMed)

This study was designed to investigate the alterations in the levels of various proteases such as angiotensin converting enzyme (ACE), kallikrein, aminopeptidases, urokinase and plasmin in serum-heart and kidney and to find out whether the changes in the levels of these enzymes could explain the pathogeneses of hypertension induced by Dexamethasone (Dex). Dex was administered to Male Wistar rats (180-200 g body weight) at a dosage of 2.5 mg/kg/week subcutaneously on alternate days for 2 weeks. One more week was included in this investigation to oversee the recovery process. Mean Arterial Pressure (MAP) showed significant elevation during administration and after withdrawal of Dex. The levels of enzymes such as angiotensin converting enzyme, carboxypeptidase-N and leucine aminopeptidase were found to be elevated in serum as well as in tissues. The level of kallikrein was observed to decrease in serum and tissues and that of thrombin, plasmin and urokinase exhibited variations. Thus, treatment with Dex altered the levels of these proteases which might have a role in the pathogenesis of hypertension and in altered blood coagulation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to glucocorticoid  IDA 1599630 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space  IDA 1599630 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cpn1  (carboxypeptidase N subunit 1)

Objects referenced in this article
Gene Cp ceruloplasmin Rattus norvegicus

Additional Information