Chrna3 (cholinergic receptor nicotinic alpha 3 subunit) - Rat Genome Database

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Gene: Chrna3 (cholinergic receptor nicotinic alpha 3 subunit) Rattus norvegicus
Analyze
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
RGD ID: 2345
Description: Enables acetylcholine binding activity; heterocyclic compound binding activity; and postsynaptic neurotransmitter receptor activity. Involved in several processes, including acetylcholine receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and response to carbon monoxide. Located in dendrite; neuronal cell body; and plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse; dopaminergic synapse; and postsynaptic specialization membrane. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; chronic obstructive pulmonary disease; cocaine dependence; lung cancer (multiple); and nicotine dependence. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-anabasine; (S)-nicotine; 1,1-dimethyl-4-phenylpiperazinium iodide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acetylcholine receptor alpha 3 (neuronal nicotine); acetylcholine receptor alpha3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Chrna3em1Mcwi ; Chrna3em9Mcwi
Genetic Models: LEW-Chrna3em9Mcwi ; LEW-Chrna3em1Mcwi
Candidate Gene For: Bp273
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,297,755 - 64,311,251 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl864,297,755 - 64,311,412 (-)EnsemblGRCr8
mRatBN7.2855,401,668 - 55,415,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx860,943,296 - 60,956,354 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,222,294 - 59,235,355 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,086,538 - 57,099,598 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)Ensemblrn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera854,888,972 - 54,929,562 (-)NCBICelera
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-anabasine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetylcholine  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atracurium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
carbachol  (EXP)
carbamazepine  (ISO)
carbaryl  (EXP)
celastrol  (ISO)
cisatracurium  (ISO)
cocaine  (EXP)
cytisine  (EXP,ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epibatidine  (EXP,ISO)
EPTC  (EXP)
ethanol  (ISO)
fenoxycarb  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (ISO)
glyphosate  (EXP)
Hexamethonium  (EXP)
imidacloprid  (ISO)
Licochalcone B  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (EXP)
methyllycaconitine  (EXP,ISO)
Mivacurium  (ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP)
nicotine  (EXP,ISO)
okadaic acid  (ISO)
pancuronium  (ISO)
panobinostat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rocuronium  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (EXP,ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tubocurarine  (EXP,ISO)
valproic acid  (ISO)
varenicline  (EXP)
vecuronium bromide  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. In vitro and in vivo effects of an alpha3 neuronal nicotinic acetylcholine receptor antisense oligonucleotide. Adams MR, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):67-79.
2. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. Amos CI, etal., J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205. doi: 10.1093/jnci/djq232. Epub 2010 Jun 16.
4. Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Balassiano K, etal., Cancer Lett. 2011 Dec 1;311(1):85-95. doi: 10.1016/j.canlet.2011.06.038. Epub 2011 Jul 14.
5. Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit. Boulter J, etal., Nature 1986 Jan 30-Feb 5;319(6052):368-74.
6. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Boulter J, etal., Proc Natl Acad Sci U S A 1987 Nov;84(21):7763-7.
7. New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Chikova A, etal., Life Sci. 2012 Nov 27;91(21-22):1103-8. doi: 10.1016/j.lfs.2011.12.023. Epub 2012 Jan 17.
8. The a7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane. Colón-Sáez JO and Yakel JL, J Physiol. 2011 Jul 1;589(Pt 13):3163-74. doi: 10.1113/jphysiol.2011.209494. Epub 2011 May 3.
9. Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush. Del Signore A, etal., J Neuropathol Exp Neurol. 2004 Feb;63(2):138-50.
10. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Di Angelantonio S, etal., Eur J Neurosci 2003 Jun;17(11):2313-22.
11. Developmental changes in the expression of nicotinic acetylcholine receptor alpha-subunits in the rat heart. Dvorakova M, etal., Cell Tissue Res. 2005 Feb;319(2):201-9. Epub 2004 Nov 10.
12. Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Falvella FS, etal., Clin Cancer Res. 2009 Mar 1;15(5):1837-42. doi: 10.1158/1078-0432.CCR-08-2107. Epub 2009 Feb 17.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors. Greenbaum L, etal., Hum Psychopharmacol. 2010 Nov;25(7-8):536-42. doi: 10.1002/hup.1149. Epub 2010 Oct 25.
16. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Haller G, etal., Hum Mol Genet. 2012 Feb 1;21(3):647-55. doi: 10.1093/hmg/ddr498. Epub 2011 Oct 31.
17. Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Haller G, etal., Hum Mol Genet. 2014 Feb 1;23(3):810-9. doi: 10.1093/hmg/ddt463. Epub 2013 Sep 20.
18. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
19. CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population. He P, etal., Int J Mol Sci. 2014 Mar 28;15(4):5446-57. doi: 10.3390/ijms15045446.
20. The nicotinic receptor in the rat pineal gland is an alpha3beta4 subtype. Hernandez SC, etal., Mol Pharmacol. 2004 Oct;66(4):978-87. doi: 10.1124/mol.104.002345. Epub 2004 Jul 9.
21. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
22. A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer. Jin G, etal., J Thorac Oncol. 2012 May;7(5):808-14. doi: 10.1097/JTO.0b013e31824c7d7c.
23. CHRNA3 genotype, nicotine dependence, lung function and disease in the general population. Kaur-Knudsen D, etal., Eur Respir J. 2012 Dec;40(6):1538-44. doi: 10.1183/09031936.00176811. Epub 2012 Mar 22.
24. CHRNA3 variant for lung cancer is associated with chronic obstructive pulmonary disease in Korea. Kim WJ, etal., Respiration. 2013;86(2):117-22. doi: 10.1159/000342976. Epub 2012 Nov 27.
25. CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers. Kupiainen H, etal., COPD. 2016 Aug;13(4):464-70. doi: 10.3109/15412555.2015.1049260. Epub 2016 Jan 11.
26. Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus. Lomazzo E, etal., J Neurochem. 2010 Nov;115(3):625-34. doi: 10.1111/j.1471-4159.2010.06967.x. Epub 2010 Sep 27.
27. The ultrastructural distribution of putative nicotinic receptors on cultured neurons from the rat superior cervical ganglion. Loring RH, etal., Neuroscience. 1988 Mar;24(3):1071-80.
28. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
29. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum. Mogg AJ, etal., J Pharmacol Exp Ther. 2002 Jul;302(1):197-204.
32. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy. Ochi S, etal., Neurosci Lett. 2014 May 21;569:33-7. doi: 10.1016/j.neulet.2014.03.054. Epub 2014 Apr 2.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography. Perry DC, etal., J Neurochem 2002 Aug;82(3):468-81.
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population. Pérez-Morales R, etal., Ann Hum Genet. 2018 Nov;82(6):415-424. doi: 10.1111/ahg.12264. Epub 2018 Jul 11.
39. Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: a case-control study. Ren JH, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):897-901. doi: 10.1007/s11596-013-1218-4. Epub 2013 Dec 13.
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems. Richmond-Rakerd LS, etal., Nicotine Tob Res. 2017 Apr 1;19(4):426-434. doi: 10.1093/ntr/ntw260.
44. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Saccone NL, etal., Cancer Res. 2009 Sep 1;69(17):6848-56. doi: 10.1158/0008-5472.CAN-09-0786. Epub 2009 Aug 25.
45. Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity--a mechanism relating to a damage at the level in post-transcription of the receptor genes. Shan KR, etal., Toxicology. 2004 Aug 5;200(2-3):169-77.
46. Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility. Shen B, etal., Mol Med Rep. 2012 Dec;6(6):1389-92. doi: 10.3892/mmr.2012.1101. Epub 2012 Sep 26.
47. Nicotine alters nicotinic receptor subunit levels differently in developing Mammalian sympathetic neurons. Srivatsan M, etal., Ann N Y Acad Sci. 2006 Aug;1074:505-13.
48. Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer. Sun Y, etal., Oncotarget. 2017 Dec 20;9(2):2435-2444. doi: 10.18632/oncotarget.23459. eCollection 2018 Jan 5.
49. Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. Tseng TS, etal., PLoS One. 2014 Sep 18;9(9):e107268. doi: 10.1371/journal.pone.0107268. eCollection 2014.
50. Time-dependent changes in rat brain cholinergic receptor expression after experimental brain injury. Verbois SL, etal., J Neurotrauma. 2002 Dec;19(12):1569-85.
51. Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives. Virginio C, etal., Neurosci Lett. 2005 Jun 24;381(3):299-304.
52. Nicotinic acetylcholine receptor subtypes in rat superior cervical ganglion neurons as studied by sequential application of two alpha-subunit-specific antibodies. Voitenko LP, etal., Neurosci Lett. 2001 Apr 27;303(1):37-40.
53. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. Wassenaar CA, etal., J Natl Cancer Inst. 2011 Sep 7;103(17):1342-6. doi: 10.1093/jnci/djr237. Epub 2011 Jul 11.
54. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Wu C, etal., Cancer Res. 2009 Jun 15;69(12):5065-72. doi: 10.1158/0008-5472.CAN-09-0081. Epub 2009 Jun 2.
55. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
56. Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. Yang L, etal., PLoS One. 2012;7(10):e46071. doi: 10.1371/journal.pone.0046071. Epub 2012 Oct 3.
Additional References at PubMed
PMID:8144606   PMID:8906617   PMID:10318955   PMID:10771006   PMID:11027228   PMID:11450844   PMID:11923417   PMID:12079404   PMID:14741388   PMID:15009132   PMID:15275829   PMID:15929983  
PMID:16162937   PMID:16904709   PMID:17192625   PMID:17434683   PMID:18227835   PMID:18249185   PMID:18615639   PMID:19228980   PMID:22064677   PMID:23846688   PMID:24398291   PMID:24825168  
PMID:25453771   PMID:26265139   PMID:33380469  


Genomics

Comparative Map Data
Chrna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,297,755 - 64,311,251 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl864,297,755 - 64,311,412 (-)EnsemblGRCr8
mRatBN7.2855,401,668 - 55,415,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx860,943,296 - 60,956,354 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,222,294 - 59,235,355 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,086,538 - 57,099,598 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)Ensemblrn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera854,888,972 - 54,929,562 (-)NCBICelera
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Cytogenetic Map8q24NCBI
CHRNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,593,052 - 78,620,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,593,052 - 78,621,295 (-)Ensemblhg38GRCh38
GRCh371578,885,394 - 78,913,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,674,706 - 76,700,377 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341576,674,706 - 76,700,377NCBI
Celera1555,821,707 - 55,849,902 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,642,483 - 55,671,504 (-)NCBIHuRef
CHM1_11579,003,962 - 79,032,196 (-)NCBICHM1_1
T2T-CHM13v2.01576,455,721 - 76,484,482 (-)NCBIT2T-CHM13v2.0
Chrna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)Ensemblmm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBIMGSCv36mm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
Chrna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450977,075 - 1,011,372 (-)Ensembl
ChiLan1.0NW_004955450979,630 - 1,011,316 (-)NCBIChiLan1.0ChiLan1.0
CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,807,750 - 67,835,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,973,644 - 72,000,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,523,553 - 57,550,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,486,416 - 76,513,899 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,487,710 - 76,512,044 (-)EnsemblpanPan2panpan1.1
CHRNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,330,287 - 38,343,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,328,814 - 38,346,246 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1338,289,178 - 38,306,359 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01338,802,608 - 38,819,775 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,802,250 - 38,833,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,493,778 - 38,510,924 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,603,187 - 38,616,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,078,181 - 39,095,376 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,579,566 - 118,599,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,427,495 - 36,457,758 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,427,598 - 36,447,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,899 - 47,384,303 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,324,501 - 2,357,723 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248942,324,480 - 2,357,389 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chrna3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1849,087,894 - 49,102,574 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chrna3
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:31
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000019307
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
D8Bord1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,415,430 - 55,415,660 (+)MAPPERmRatBN7.2
Rnor_6.0859,607,541 - 59,607,770NCBIRnor6.0
Rnor_5.0858,189,427 - 58,189,656UniSTSRnor5.0
RGSC_v3.4858,584,012 - 58,584,242RGDRGSC3.4
RGSC_v3.4858,584,013 - 58,584,242UniSTSRGSC3.4
Cytogenetic Map8q24UniSTS
D8Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,415,432 - 55,415,597 (+)MAPPERmRatBN7.2
Rnor_6.0859,607,543 - 59,607,707NCBIRnor6.0
Rnor_5.0858,189,429 - 58,189,593UniSTSRnor5.0
RGSC_v3.4858,584,015 - 58,584,179UniSTSRGSC3.4
Cytogenetic Map8q24UniSTS
BE108721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,401,691 - 55,401,902 (+)MAPPERmRatBN7.2
Rnor_6.0859,593,718 - 59,593,928NCBIRnor6.0
Rnor_5.0858,175,876 - 58,176,086UniSTSRnor5.0
RGSC_v3.4858,569,934 - 58,570,144UniSTSRGSC3.4
Celera854,888,683 - 54,888,893UniSTS
RH 3.4 Map8616.5UniSTS
Cytogenetic Map8q24UniSTS
Chrnb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,423,273 - 55,424,861 (+)MAPPERmRatBN7.2
Rnor_6.0859,615,383 - 59,616,969NCBIRnor6.0
Rnor_5.0858,197,269 - 58,198,855UniSTSRnor5.0
RGSC_v3.4858,591,855 - 58,593,441UniSTSRGSC3.4
Celera854,907,410 - 54,908,996UniSTS
RH 3.4 Map8614.4UniSTS
Cytogenetic Map8q24UniSTS
PMC312758P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,437,250 - 55,437,355 (+)MAPPERmRatBN7.2
Rnor_6.0859,629,357 - 59,629,461NCBIRnor6.0
Rnor_5.0858,211,243 - 58,211,347UniSTSRnor5.0
RGSC_v3.4858,605,829 - 58,605,933UniSTSRGSC3.4
Celera854,921,384 - 54,921,488UniSTS
Cytogenetic Map8q24UniSTS
Chrnb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8864,313,845 - 64,314,073 (+)Marker Load Pipeline
mRatBN7.2855,417,759 - 55,417,987 (+)MAPPERmRatBN7.2
Rnor_6.0859,609,870 - 59,610,097NCBIRnor6.0
Rnor_5.0858,191,756 - 58,191,983UniSTSRnor5.0
RGSC_v3.4858,586,342 - 58,586,569UniSTSRGSC3.4
Celera854,901,897 - 54,902,124UniSTS
RH 3.4 Map8614.4UniSTS
Cytogenetic Map8q24UniSTS


Genetic Models
This gene Chrna3 is modified in the following models/strains:
LEW-Chrna3em9Mcwi     LEW-Chrna3em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 21 127 46 41 15 23 15 5 111 61 109 25 48 26 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000019307   ⟹   ENSRNOP00000019307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl864,297,755 - 64,311,412 (-)Ensembl
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)Ensembl
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099747   ⟹   ENSRNOP00000085828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl864,297,755 - 64,309,655 (-)Ensembl
mRatBN7.2 Ensembl855,401,702 - 55,413,569 (-)Ensembl
RefSeq Acc Id: NM_052805   ⟹   NP_434692
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8864,297,755 - 64,311,251 (-)NCBI
mRatBN7.2855,401,668 - 55,415,165 (-)NCBI
Rnor_6.0859,594,007 - 59,607,122 (-)NCBI
Rnor_5.0858,176,165 - 58,189,008 (-)NCBI
RGSC_v3.4858,570,223 - 58,583,594 (-)RGD
Celera854,888,972 - 54,929,562 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_434692 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18001 (Get FASTA)   NCBI Sequence Viewer  
  AAA41673 (Get FASTA)   NCBI Sequence Viewer  
  AAS90350 (Get FASTA)   NCBI Sequence Viewer  
  CAA27170 (Get FASTA)   NCBI Sequence Viewer  
  EDL95561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019307
GenBank Protein P04757 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_434692   ⟸   NM_052805
- Peptide Label: precursor
- UniProtKB: P04757 (UniProtKB/Swiss-Prot),   Q6PW51 (UniProtKB/TrEMBL),   F1M7K6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019307   ⟸   ENSRNOT00000019307
Ensembl Acc Id: ENSRNOP00000085828   ⟸   ENSRNOT00000099747
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04757-F1-model_v2 AlphaFold P04757 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2345 AgrOrtholog
BioCyc Gene G2FUF-30384 BioCyc
Ensembl Genes ENSRNOG00000013829 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019307 ENTREZGENE
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
NCBI Gene 25101 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB CHRNA3 RGD
PhenoGen Chrna3 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013829 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A8I6GDE4_RAT UniProtKB/TrEMBL
  A0ABZ3NN66_RAT UniProtKB/TrEMBL
  A6J4N8_RAT UniProtKB/TrEMBL
  ACHA3_RAT UniProtKB/Swiss-Prot
  F1M7K6 ENTREZGENE
  P04757 ENTREZGENE
  Q6PW51 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrna3  cholinergic receptor nicotinic alpha 3 subunit  Chrna3  cholinergic receptor, nicotinic, alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Chrna3  cholinergic receptor, nicotinic, alpha 3  Chrna3  cholinergic receptor, nicotinic, alpha 3 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Chrna3  cholinergic receptor, nicotinic, alpha 3 (neuronal)  Chrna3  cholinergic receptor, nicotinic, alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chrna3  cholinergic receptor, nicotinic, alpha 3  Chrna3  cholinergic receptor, nicotinic, alpha polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-22 Chrna3  cholinergic receptor, nicotinic, alpha polypeptide 3  Chrna3  cholinergic receptor, nicotinic, alpha polypeptide 4  Name updated 68913 APPROVED
2001-07-23 Chrna3  cholinergic receptor, nicotinic, alpha polypeptide 4  Chrna3  Acetylcholine receptor alpha 3 (neuronal nicotine)  Name updated to reflect Human and Mouse nomenclature 67952 APPROVED