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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3increases expressionEXP 6480464CTDTretinoin results in increased expression of CHRNA3 mRNAPMID:20488242
Chrna3increases expressionISOCHRNA3 (Homo sapiens)6480464CTDTretinoin results in increased expression of CHRNA3 mRNAPMID:21934132
Chrna3increases expressionISOChrna3 (Mus musculus)6480464CTDTretinoin results in increased expression of CHRNA3 mRNA; Tretinoin results in increased expression of CHRNA3 proteinPMID:17203487
Chrna3multiple interactionsISOChrna3 (Mus musculus)6480464CTDTretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]PMID:17203487
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