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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:4055
Term: cytisine
Definition: An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.
Chemical ID: MESH:C004712
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3multiple interactionsEXP 2303195RGDcytisine affects binding [Epibatidine binds to Chrna3 protein] 
Chrna3multiple interactionsEXP 6480464CTDcytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:11600638
Chrna3multiple interactionsISOCHRNA3 (Homo sapiens)6480464CTDcytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]PMID:9454827
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