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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3multiple interactionsEXP 2303194RGDAcetylcholine affects binding [Epibatidine binds to Chrna3 protein] 
Chrna3multiple interactionsEXP 6480464CTD[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]PMID:12130716 PMID:15885267 PMID:7808438
Chrna3multiple interactionsISOCHRNA3 (Homo sapiens)6480464CTD4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]PMID:11711029 PMID:15885267 PMID:16931985 PMID:34628512 PMID:9454827
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