Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3affects bindingEXP 2303194RGDEpibatidine binds to Chrna3 protein 
Chrna3affects bindingEXP 2303195RGDEpibatidine binds to Chrna3 protein 
Chrna3affects bindingEXP 6480464CTD[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine; epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]PMID:15615518 PMID:9687574
Chrna3multiple interactionsEXP 6480464CTDepibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:15615518
Chrna3affects bindingISOCHRNA3 (Homo sapiens)6480464CTD[CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidinePMID:9454827
Chrna3affects bindingISOChrna3 (Mus musculus)6480464CTDepibatidine binds to CHRNA3 proteinPMID:17203487
Chrna3multiple interactionsISOCHRNA3 (Homo sapiens)6480464CTD2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]; epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:21942635 PMID:22060139
Chrna3multiple interactionsISOChrna3 (Mus musculus)6480464CTDTretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]PMID:17203487
Go Back to source page   Continue to Ontology report