Actn2 (actinin alpha 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Actn2 (actinin alpha 2) Rattus norvegicus
Analyze
Symbol: Actn2
Name: actinin alpha 2
RGD ID: 1308097
Description: A structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in several processes, including focal adhesion assembly; regulation of potassium ion transport; and striated muscle cell development. Located in cortical actin cytoskeleton. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; congenital myopathy 8; and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-actinin-2; LOC291245
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,835,055 - 62,902,331 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1762,812,988 - 62,903,552 (+)EnsemblGRCr8
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1761,331,681 - 61,398,784 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,334,806 - 65,401,909 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,489,000 - 59,556,099 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)Ensemblrn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1762,323,048 - 62,390,681 (-)NCBICelera
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
CHIR 99021  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
glycidyl methacrylate  (ISO)
graphite  (ISO)
Heliotrine  (EXP)
heroin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maraviroc  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
spermine  (ISO)
sunitinib  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Familial effort polymorphic ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy map to chromosome 1q42-43. Bauce B, etal., Am J Cardiol. 2000 Mar 1;85(5):573-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons. Hodges JL, etal., PLoS One. 2014 Jul 9;9(7):e101770. doi: 10.1371/journal.pone.0101770. eCollection 2014.
5. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. Kim CK, etal., J Asthma. 2011 Dec;48(10):994-1000. doi: 10.3109/02770903.2011.623335. Epub 2011 Oct 24.
6. Alpha-actinin associates with polycystin-2 and regulates its channel activity. Li Q, etal., Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL. Schulz TW, etal., J Neurosci. 2004 Sep 29;24(39):8584-94.
14. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
15. Differential regional expression and ultrastructural localization of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain. Wyszynski M, etal., J Neurosci. 1998 Feb 15;18(4):1383-92.
Additional References at PubMed
PMID:8618961   PMID:8943213   PMID:9501083   PMID:10391924   PMID:10427098   PMID:10812072   PMID:11101506   PMID:11699871   PMID:11846417   PMID:12356918   PMID:15072553   PMID:15465019  
PMID:15665106   PMID:16120608   PMID:16407236   PMID:16585392   PMID:16807302   PMID:17110593   PMID:17360664   PMID:17944866   PMID:18761673   PMID:19040707   PMID:19815520   PMID:19932097  
PMID:19943616   PMID:20124353   PMID:20215401   PMID:20368620   PMID:21518265   PMID:22972877   PMID:23376485   PMID:23533145   PMID:24840128   PMID:25416956   PMID:25433700   PMID:25502805  
PMID:26143257   PMID:29206857   PMID:31515488   PMID:33098872   PMID:35352799   PMID:38990270  


Genomics

Comparative Map Data
Actn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,835,055 - 62,902,331 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1762,812,988 - 62,903,552 (+)EnsemblGRCr8
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1761,331,681 - 61,398,784 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,334,806 - 65,401,909 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,489,000 - 59,556,099 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)Ensemblrn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1762,323,048 - 62,390,681 (-)NCBICelera
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Cytogenetic Map17q12.1NCBI
ACTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,686,499 - 236,764,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,664,141 - 236,764,631 (+)Ensemblhg38GRCh38
GRCh371236,849,799 - 236,927,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,916,422 - 234,993,863 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341233,175,848 - 233,253,281NCBI
Celera1210,097,994 - 210,176,743 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,337,725 - 207,384,040 (+)NCBIHuRef
CHM1_11238,123,313 - 238,199,388 (+)NCBICHM1_1
T2T-CHM13v2.01236,087,386 - 236,175,684 (+)NCBIT2T-CHM13v2.0
Actn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)Ensemblmm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBIMGSCv36mm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
Actn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,483,511 - 3,555,190 (-)Ensembl
ChiLan1.0NW_0049554923,483,704 - 3,554,831 (-)NCBIChiLan1.0ChiLan1.0
ACTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,395,471 - 12,501,244 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,611,346 - 12,711,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,245,742 - 212,323,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,276,899 - 217,321,103 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,272,597 - 217,321,103 (+)EnsemblpanPan2panpan1.1
ACTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,348,529 - 3,415,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,366,635 - 3,434,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,023,215 - 40,083,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,186,642 - 16,248,400 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,186,844 - 16,248,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,666,623 - 54,742,778 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11454,670,727 - 54,742,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,645,069 - 58,717,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,827,900 - 73,904,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,827,874 - 73,905,146 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605575,920,990 - 76,003,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477513,916,883 - 13,989,153 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477513,917,215 - 13,989,093 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Actn2
632 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:28
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000024098
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)176109144668550213Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
D17Rat149  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81762,857,027 - 62,857,162 (+)Marker Load Pipeline
mRatBN7.21758,165,311 - 58,165,446 (-)MAPPERmRatBN7.2
Rnor_6.01766,349,744 - 66,349,878NCBIRnor6.0
Rnor_5.01768,095,697 - 68,095,831UniSTSRnor5.0
RGSC_v3.41768,727,524 - 68,727,658UniSTSRGSC3.4
RGSC_v3.41768,727,275 - 68,727,788RGDRGSC3.4
Celera1762,367,974 - 62,368,106UniSTS
RGSC_v3.11768,738,108 - 68,738,673RGD
RH 3.4 Map17608.2UniSTS
RH 3.4 Map17608.2RGD
SHRSP x BN Map1732.6999RGD
SHRSP x BN Map1732.6999UniSTS
Cytogenetic Map17q12.1UniSTS
AW531528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,179,874 - 58,180,060 (-)MAPPERmRatBN7.2
Rnor_6.01766,335,095 - 66,335,280NCBIRnor6.0
Rnor_5.01768,081,199 - 68,081,384UniSTSRnor5.0
RGSC_v3.41768,742,534 - 68,742,719UniSTSRGSC3.4
Celera1762,353,369 - 62,353,554UniSTS
RH 3.4 Map17600.5UniSTS
Cytogenetic Map17q12.1UniSTS
Actn2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,170,971 - 58,172,160 (-)MAPPERmRatBN7.2
Rnor_6.01766,343,009 - 66,344,197NCBIRnor6.0
Rnor_5.01768,089,352 - 68,090,540UniSTSRnor5.0
RGSC_v3.41768,733,003 - 68,734,191UniSTSRGSC3.4
Celera1762,361,269 - 62,362,457UniSTS
Cytogenetic Map17q12.1UniSTS
ha2028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X125,999,885 - 126,000,624 (+)MAPPERmRatBN7.2
mRatBN7.220235,421 - 236,610 (+)MAPPERmRatBN7.2
Rnor_6.020381,420 - 382,608NCBIRnor6.0
Rnor_6.0X133,645,066 - 133,645,804NCBIRnor6.0
Rnor_5.0X133,721,173 - 133,721,911UniSTSRnor5.0
Rnor_5.020367,136 - 368,324UniSTSRnor5.0
RGSC_v3.41768,765,642 - 68,767,052UniSTSRGSC3.4
Celera201,101,967 - 1,103,262UniSTS
CeleraX124,972,833 - 124,973,571UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 63 142 91 90 59 79 59 6 330 175 11 114 73 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000024098   ⟹   ENSRNOP00000024098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1762,834,145 - 62,902,327 (+)Ensembl
mRatBN7.2 Ensembl1758,143,334 - 58,210,622 (+)Ensembl
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101075   ⟹   ENSRNOP00000097425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1762,812,988 - 62,903,552 (+)Ensembl
mRatBN7.2 Ensembl1758,143,334 - 58,208,209 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101663   ⟹   ENSRNOP00000079744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1762,834,997 - 62,902,328 (+)Ensembl
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)Ensembl
RefSeq Acc Id: NM_001170325   ⟹   NP_001163796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,835,055 - 62,902,331 (+)NCBI
mRatBN7.21758,143,334 - 58,210,622 (+)NCBI
Rnor_6.01766,304,530 - 66,397,647 (-)NCBI
Rnor_5.01768,050,946 - 68,143,522 (-)NCBI
RGSC_v3.41768,705,160 - 68,773,261 (+)RGD
Celera1762,323,048 - 62,390,681 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001163796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06982 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024098.6
  ENSRNOP00000079744
  ENSRNOP00000079744.2
  ENSRNOP00000097425.2
RefSeq Acc Id: NP_001163796   ⟸   NM_001170325
- UniProtKB: D3ZCV0 (UniProtKB/TrEMBL),   A6KN31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024098   ⟸   ENSRNOT00000024098
Ensembl Acc Id: ENSRNOP00000079744   ⟸   ENSRNOT00000101663
Ensembl Acc Id: ENSRNOP00000097425   ⟸   ENSRNOT00000101075
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCV0-F1-model_v2 AlphaFold D3ZCV0 1-894 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700537
Promoter ID:EPDNEW_R11061
Type:single initiation site
Name:Actn2_1
Description:actinin alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01766,397,662 - 66,397,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308097 AgrOrtholog
BioCyc Gene G2FUF-8937 BioCyc
Ensembl Genes ENSRNOG00000017833 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024098.9 UniProtKB/TrEMBL
  ENSRNOT00000101075.2 UniProtKB/TrEMBL
  ENSRNOT00000101663 ENTREZGENE
  ENSRNOT00000101663.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report rno:291245 UniProtKB/TrEMBL
NCBI Gene 291245 ENTREZGENE
PANTHER SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Actn2 PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017833 RatGTEx
SMART EFh UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5ZN92_RAT UniProtKB/TrEMBL
  A0A8I6ARF4_RAT UniProtKB/TrEMBL
  A6KN31 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCV0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Actn2  actinin alpha 2   Actn2_predicted  actinin alpha 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Actn2_predicted  actinin alpha 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED