ACTN2 (actinin alpha 2) - Rat Genome Database

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Gene: ACTN2 (actinin alpha 2) Canis lupus familiaris
Analyze
Symbol: ACTN2
Name: actinin alpha 2
RGD ID: 12089370
Description: ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); calcium ion binding (inferred); INVOLVED IN actin cytoskeleton organization (inferred); actin filament uncapping (inferred); cardiac muscle cell development (inferred); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); cardiomyopathy (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic actin cytoskeleton (ortholog); postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-actinin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,348,529 - 3,415,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,366,635 - 3,434,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,348,529 - 3,415,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,366,635 - 3,434,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBIUU_Cfam_GSD_1.0
ACTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,686,499 - 236,764,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,664,141 - 236,764,631 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,849,799 - 236,927,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,916,422 - 234,993,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 341233,175,848 - 233,253,281NCBI
Celera1210,097,994 - 210,176,743 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,337,725 - 207,384,040 (+)NCBIHuRef
CHM1_11238,123,313 - 238,199,388 (+)NCBICHM1_1
T2T-CHM13v2.01236,087,386 - 236,175,684 (+)NCBIT2T-CHM13v2.0
Actn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)EnsemblGRCm39 Ensembl
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBIMGSCv36mm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
Actn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,835,055 - 62,902,331 (+)NCBIGRCr8
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,331,681 - 61,398,784 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,334,806 - 65,401,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,489,000 - 59,556,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Actn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,483,511 - 3,555,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,483,704 - 3,554,831 (-)NCBIChiLan1.0ChiLan1.0
ACTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,395,471 - 12,501,244 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,611,346 - 12,711,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,245,742 - 212,323,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,276,899 - 217,321,103 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,272,597 - 217,321,103 (+)Ensemblpanpan1.1panPan2
Actn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,023,215 - 40,083,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,186,642 - 16,248,400 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,186,844 - 16,248,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,666,623 - 54,742,778 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,670,727 - 54,742,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,645,069 - 58,717,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,827,900 - 73,904,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,827,874 - 73,905,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605575,920,990 - 76,003,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477513,916,883 - 13,989,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477513,917,215 - 13,989,093 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACTN2
490 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 6
Medium 6
Low 4 12 5 6 8 6
Below cutoff 1 10 6 1 6 6 4 6

Sequence


RefSeq Acc Id: ENSCAFT00000017321   ⟹   ENSCAFP00000016032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062795   ⟹   ENSCAFP00000049582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004555   ⟹   ENSCAFP00845003640
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl43,366,635 - 3,434,981 (-)Ensembl
RefSeq Acc Id: XM_038472810   ⟹   XP_038328738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBI
RefSeq Acc Id: XM_038533826   ⟹   XP_038389754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBI
RefSeq Acc Id: XM_038598147   ⟹   XP_038454075
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBI
RefSeq Acc Id: XM_038662448   ⟹   XP_038518376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBI
RefSeq Acc Id: XM_851023   ⟹   XP_856116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.143,348,529 - 3,415,275 (-)NCBI
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBI
Sequence:
RefSeq Acc Id: XP_856116   ⟸   XM_851023
- UniProtKB: A0A8C0MXP0 (UniProtKB/TrEMBL),   A0A8C0Q4P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016032   ⟸   ENSCAFT00000017321
RefSeq Acc Id: ENSCAFP00000049582   ⟸   ENSCAFT00000062795
RefSeq Acc Id: XP_038328738   ⟸   XM_038472810
RefSeq Acc Id: XP_038454075   ⟸   XM_038598147
RefSeq Acc Id: XP_038518376   ⟸   XM_038662448
- UniProtKB: A0A8C0MXP0 (UniProtKB/TrEMBL),   A0A8C0Q4P0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389754   ⟸   XM_038533826
- UniProtKB: A0A8C0MXP0 (UniProtKB/TrEMBL),   A0A8C0Q4P0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003640   ⟸   ENSCAFT00845004555
Protein Domains
Calponin-homology (CH)   EF-hand

Promoters
RGD ID:13682854
Promoter ID:EPDNEW_C923
Type:multiple initiation site
Name:ACTN2_1
Description:actinin alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.143,415,221 - 3,415,281EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010822 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009495 UniProtKB/TrEMBL
  ENSCAFG00040001160 UniProtKB/TrEMBL
  ENSCAFG00845002571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000062795.2 UniProtKB/TrEMBL
  ENSCAFT00030017602.1 UniProtKB/TrEMBL
  ENSCAFT00030017675.1 UniProtKB/TrEMBL
  ENSCAFT00040002165.1 UniProtKB/TrEMBL
  ENSCAFT00040002177.1 UniProtKB/TrEMBL
  ENSCAFT00845004555 ENTREZGENE
  ENSCAFT00845004555.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report cfa:479191 UniProtKB/TrEMBL
NCBI Gene ACTN2 ENTREZGENE
PANTHER ALPHA-ACTININ-2 UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A8C0MXP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PT34_CANLF UniProtKB/TrEMBL
  A0A8C0Q4P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RGI1_CANLF UniProtKB/TrEMBL
  A0A8I3N2K8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37549 ENTREZGENE