ACTN2 (actinin alpha 2) - Rat Genome Database

Name: ACTN2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ACTN2 (actinin alpha 2) Chlorocebus sabaeus

Analyze

Symbol:

ACTN2

Name:

actinin alpha 2

RGD ID:

18743054

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); calcium ion binding (inferred); INVOLVED IN actin cytoskeleton organization (inferred); actin filament uncapping (inferred); cardiac muscle cell development (inferred); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); cardiomyopathy (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic actin cytoskeleton (ortholog); postsynaptic density membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alpha-actinin-2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACTN2 (actinin alpha 2)	NCBI	Ortholog
Mus musculus (house mouse):	Actn2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Actn2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Actn2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACTN2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACTN2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Actn2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACTN2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Actn2 (actinin alpha 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	73,827,900 - 73,904,516 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	73,827,874 - 73,905,146 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	75,920,990 - 76,003,746 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy (ISO)

cardiomyopathy (ISO)

catecholaminergic polymorphic ventricular tachycardia (ISO)

catecholaminergic polymorphic ventricular tachycardia 1 (ISO)

congenital myopathy 8 (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1A (ISO)

dilated cardiomyopathy 1AA (ISO)

dilated cardiomyopathy 1B (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

Distal Myopathy 6 (ISO)

familial hypertrophic cardiomyopathy (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

intrinsic cardiomyopathy (ISO)

Left Ventricular Noncompaction 1 (ISO)

long QT syndrome (ISO)

parathyroid carcinoma (ISO)

Syncope (ISO)

tetralogy of Fallot (ISO)

Ventricular Fibrillation (ISO)

Wilson disease (ISO)

Wolff-Parkinson-White syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA)

actin filament uncapping (IEA)

cardiac muscle cell development (IEA)

focal adhesion assembly (IEA)

microspike assembly (IEA)

muscle cell development (IEA)

negative regulation of potassium ion transport (IEA)

negative regulation of protein localization to cell surface (IEA)

phospholipase C-activating angiotensin-activated signaling pathway (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of endocytic recycling (IEA)

positive regulation of potassium ion transport (IEA)

protein localization to plasma membrane (IEA)

regulation of membrane potential (IEA)

sarcomere organization (IEA)

Cellular Component

actin cytoskeleton (IEA)

cell junction (IEA)

cell projection (IEA)

cortical actin cytoskeleton (IEA)

cytoplasm (IEA)

filopodium (IEA)

focal adhesion (IEA)

glutamatergic synapse (ISO)

plasma membrane (IEA)

postsynaptic actin cytoskeleton (ISO)

postsynaptic density membrane (ISO)

postsynaptic density, intracellular component (ISO)

sarcomere (IEA)

Z disc (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

calcium ion binding (IEA)

cytoskeletal protein binding (IEA)

FATZ binding (IEA)

identical protein binding (IEA)

LIM domain binding (IEA)

metal ion binding (IEA)

nuclear receptor coactivator activity (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA)

titin binding (IEA)

titin Z domain binding (IEA)

transmembrane transporter binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACTN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	73,827,900 - 73,904,516 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	73,827,874 - 73,905,146 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	75,920,990 - 76,003,746 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ACTN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	236,686,499 - 236,764,631 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	236,664,141 - 236,764,631 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	236,849,799 - 236,927,931 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	234,916,422 - 234,993,863 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	233,175,848 - 233,253,281	NCBI
Celera	1	210,097,994 - 210,176,743 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI
HuRef	1	207,337,725 - 207,384,040 (+)	NCBI		HuRef
CHM1_1	1	238,123,313 - 238,199,388 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	236,087,386 - 236,175,684 (+)	NCBI		T2T-CHM13v2.0

Actn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	12,284,312 - 12,355,613 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	12,284,312 - 12,355,641 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	12,269,426 - 12,340,732 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	12,269,426 - 12,340,760 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	12,361,693 - 12,432,999 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	12,323,759 - 12,395,065 (-)	NCBI		MGSCv36	mm8
Celera	13	12,189,170 - 12,257,137 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	4.54	NCBI

Actn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	62,835,055 - 62,902,331 (+)	NCBI		GRCr8
mRatBN7.2	17	58,143,334 - 58,210,622 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	58,142,625 - 58,210,622 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	61,331,681 - 61,398,784 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	65,334,806 - 65,401,909 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	59,489,000 - 59,556,099 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	66,304,530 - 66,397,647 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	66,304,501 - 66,397,653 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	68,050,946 - 68,143,522 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	68,705,160 - 68,773,261 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	68,681,756 - 68,784,094 (+)	NCBI
Celera	17	62,323,048 - 62,390,681 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

Actn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	3,483,511 - 3,555,190 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	3,483,704 - 3,554,831 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACTN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	12,395,471 - 12,501,244 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	12,611,346 - 12,711,988 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	212,245,742 - 212,323,387 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	217,276,899 - 217,321,103 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	217,272,597 - 217,321,103 (+)	Ensembl	panpan1.1		panPan2

ACTN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	3,348,529 - 3,415,275 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	3,348,449 - 3,415,273 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	3,395,551 - 3,461,987 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	3,368,361 - 3,435,149 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	3,366,635 - 3,434,981 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	3,368,494 - 3,434,944 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	3,498,915 - 3,565,693 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	3,719,762 - 3,786,237 (-)	NCBI		UU_Cfam_GSD_1.0

Actn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	40,023,215 - 40,083,168 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	16,186,642 - 16,248,400 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	16,186,844 - 16,248,394 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACTN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	54,666,623 - 54,742,778 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	54,670,727 - 54,742,717 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	58,645,069 - 58,717,200 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Actn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	13,916,883 - 13,989,153 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	13,917,215 - 13,989,093 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium			22
Low	22	13	24
Below cutoff	14	4	14

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007989885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007989887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007989888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037986059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000007804 ⟹ ENSCSAP00000005967

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	25	73,827,874 - 73,905,146 (+)	Ensembl

RefSeq Acc Id:

XM_007989885 ⟹ XP_007988076

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	73,827,900 - 73,903,765 (+)	NCBI
Vero_WHO_p1.0	NW_023666055	75,921,036 - 76,003,746 (+)	NCBI

Sequence:

show sequence

GCGGCGCGACTATTAAGCCGCGCGGCAGCTGCTCGCAGCCGGAGCTGGTGCTTCGCCCGAGACC
CAGCGCCCAGGCGTGCAGCCCCGAGAGGAGTCGCGCGAAGGTCACCCCGCGCCCGCCACCCGCC
ACCTCCGTGGGTCCATTTGCTCGTCAGCCCGTGCATCCGAGCTCCTCGCGCCCCGCCGCAGCCC
CGGCCAACCGAGCGCCATGAACCAGATAGAGCCCGGCGTGCAGTACAACTACGTGTACGACGAG
GATGAGTACATGATCCAGGAGGAGGAGTGGGACCGCGACCTGCTCCTGGACCCGGCCTGGGAGA
AGCAGCAGAGGAAGACCTTCACTGCCTGGTGTAACTCCCACTTAAGGAAAGCCGGCACCCAAAT
TGAGAACATCGAAGAAGACTTCAGGAATGGCCTTAAGCTCATGCTGCTTTTGGAAGTCATCTCA
GGGGAAAGGCTGCCCAAACCTGACCGAGGAAAAATGCGGTTCCACAAAATTGCTAACGTCAACA
AAGCTTTGGATTACATAGCCAGCAAAGGGGTGAAACTGGTGTCCATCGGGGCTGAAGAAATTGT
TGATGGCAACGTGAAAATGACCCTGGGCATGATCTGGACCATCATCCTTCGCTTTGCTATTCAG
GATATTTCGGTTGAAGAAACATCTGCCAAAGAAGGTCTGCTGCTTTGGTGTCAGAGGAAAACCG
CTCCTTATAGAAATGTAAACATTCAGAACTTCCATACTAGCTGGAAAGATGGCCTTGGACTCTG
TGCCCTCATCCACCGACACCGGCCTGACCTCATTGACTACTCAAAGCTTAACAAGGATGACCCC
ATAGGAAATATTAACCTGGCCATGGAAATCGCTGAGAAGCACCTGGATATTCCTAAAATGCTGG
ATGCTGAAGACATCGTGAACACCCCTAAACCCGATGAAAGAGCCATCATGACGTACGTCTCTTG
CTTCTACCACGCTTTTGCGGGCGCGGAGCAGGCTGAGACAGCGGCTAACAGGATATGTAAGGTT
CTTGCTGTGAATCAAGAGAATGAGAGGCTGATGGAAGAATATGAGAGGCTAGCGAGTGAGCTTT
TGGAATGGATTCGTCGCACGATCCCCTGGCTAGAGAACCGGACTCCTGAGAAGACGATGCAGGC
CATGCAGAAGAAGCTGGAGGACTTCCGGGATTACCGCCGGAAGCACAAACCACCCAAGGTGCAG
GAGAAATGCCAGCTGGAGATCAATTTCAACACATTGCAGACCAAGCTGCGGATCAGCAACCGGC
CTGCCTTCATGCCCTCTGAGGGCAAGATGGTGTCGGATATTGCTGGTGCCTGGCAGAGGCTGGA
GCAGGCTGAGAAGGGTTACGAGGAGTGGTTGCTCAATGAGATTCGGAGACTGGAGCGCTTGGAA
CACCTGGCTGAGAAGTTCAGGCAAAAGGCCTCAACCCACGAGACTTGGGCTTATGGCAAAGAGC
AGATCTTGCTGCAGAAGGATTACGAGTCGGCATCGCTGACAGAGGTGCGGGCTCTGCTGCGGAA
GCACGAGGCGTTCGAGAGCGACCTGGCAGCGCACCAGGACCGCGTGGAGCAGATCGCAGCCATC
GCGCAGGAGCTCAATGAACTGGACTATCACGACGCTGTCAATGTCAACGATCGGTGCCAGAAAA
TTTGTGACCAGTGGGACCGACTGGGAACACTTACTCAGAAGAGGAGGGAAGCCCTGGAGAGAAT
GGAGAAATTGCTAGAAACCATTGATCAGCTTCACCTGGAGTTTGCCAAGAGGGCTGCTCCTTTC
AACAATTGGATGGAGGGCGCTATGGAGGATCTGCAAGATATGTTCATTGTCCACAGCATTGAGG
AGATCCAGAGTTTGATCACTGCGCATGAGCAGTTCAAGGCCACGCTGCCCGAGGCGGACGGAGA
GCGGCAGTCCATCATGGCCATCCAGAATGAGGTGGAGAAGGTGATTCAGAGCTACAGTATCAGA
ATCAGCTCGAGCAACCCGTACAGCACTGTCACCATGGATGAGCTCCGGACCAAGTGGGACAAGG
TGAAGCAGCTCGTGCCCATCCGCGATCAGTCCCTGCAGGAGGAGCTGGCTCGCCAGCATGCTAA
CGAGCGTCTGAGGCGCCAGTTTGCTGCGCAAGCCAATGCCATCGGGCCCTGGATCCAGAACAAG
ATGGAGGAGATTGCCCGGAGCTCCATCCAGATCACAGGAGCCCTGGAGGACCAGATGAATCAGC
TGAAGCAGTACGAGCACAACATCATCAACTACAAGAACAACATCGACAAGCTGGAGGGAGACCA
TCAGCTCATCCAGGAGGCCCTTGTCTTTGACAACAAGCACACGAACTACACGATGGAGCACATT
CGTGTTGGATGGGAGCTGCTGCTGACAACCATCGCCAGAACCATCAATGAGGTGGAGACTCAGA
TCCTGACAAGAGATGCGAAGGGCATCACCCAGGAGCAGATGAATGAGTTCAGAGCCTCCTTCAA
CCACTTTGACAGGAGGAAGAATGGCCTGATGGATCATGAGGATTTCAGAGCCTGCCTGATTTCC
ATGGGTTATGACCTGGGTGAAGCCGAATTTGCCCGCATCATGACCCTGGTAGATCCCAATGGGC
AAGGTACTGTCACCTTCCAATCCTTCATCGACTTCATGACTAGAGAGACGGCCGACACGGATAC
CGCCGAGCAGGTCATCGCCTCCTTCCGGATCCTGGCTTCTGATAAGCCATACATCCTGGCGGAG
GAGCTGCGTCGGGAGCTGCCCCCGGATCAGGCCCAGTACTGCATCAAGAGGATGCCCGCCTACT
CGGGCCCAGGCAGTGTGCCTGGCGCCCTGGATTACACCGCGTTCTCCTCCGCACTCTATGGAGA
GAGCGATCTGTGACGCTGAGGTTCTGTAATCACTGATCCCATCAGAACGCAATAAAAGCAGAAG
TCACAGTTGGTTTCCTGGAAACTTTGACAGGTTCTATTAAGTTGGGAGAGAGAGGGGGGAAAAA
AAGCCTTTTGTAGTTCAGTAATTGCCAGCAATATAACACGGCTAAAATGAAGTTTCTACAGTAT
ATGACATAGTGCGCTTCATAAATAGGTTTATTTCTGAGTTTTTAGCTAAATGTAATGAAATATC
AGGTTGATTTCTTTGATTAAACGGAACAAATTACTTGAGTATTAGGAAATTAGGAGGATCTAGG
GACAGAAGGAAAGTGAAAAATGTGAAAATACAAAATATCCAAGATTTAAGACTGGGGGGGGGGG
AAATCCACAAATTGGTAAATAAAGGTTTGCTATTTGTAAAAAATTTCATTTCTCTCTAATATGC
CTATGTGATTGCCCCTAGGGGAGTATATTTGGGATTCTAATGTTTTATTTTCATGCTTATCCAA
AGATTACTATTGTGTCTTCAAATGAATTTAATTAATTGTGAGATGGAACTGCCAGGGATTAAAA
AGACTATCAAAAAGA

hide sequence

RefSeq Acc Id:

XM_007989887 ⟹ XP_007988078

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	73,827,900 - 73,903,765 (+)	NCBI
Vero_WHO_p1.0	NW_023666055	75,920,990 - 76,003,746 (+)	NCBI

Sequence:

show sequence

GCGGCGCGACTATTAAGCCGCGCGGCAGCTGCTCGCAGCCGGAGCTGGTGCTTCGCCCGAGACC
CAGCGCCCAGGCGTGCAGCCCCGAGAGGAGTCGCGCGAAGGTCACCCCGCGCCCGCCACCCGCC
ACCTCCGTGGGTCCATTTGCTCGTCAGCCCGTGCATCCGAGCTCCTCGCGCCCCGCCGCAGCCC
CGGCCAACCGAGCGCCATGAACCAGATAGAGCCCGGCGTGCAGTACAACTACGTGTACGACGAG
GATGAGTACATGATCCAGGAGGAGGAGTGGGACCGCGACCTGCTCCTGGACCCGGCCTGGGAGA
AGCAGCAGAGGAAGACCTTCACTGCCTGGTGTAACTCCCACTTAAGGAAAGCCGGCACCCAAAT
TGAGAACATCGAAGAAGACTTCAGGAATGGCCTTAAGCTCATGCTGCTTTTGGAAGTCATCTCA
GGGGAAAGGCTGCCCAAACCTGACCGAGGAAAAATGCGGTTCCACAAAATTGCTAACGTCAACA
AAGCTTTGGATTACATAGCCAGCAAAGGGGTGAAACTGGTGTCCATCGGGGCTGAAGAAATTGT
TGATGGCAACGTGAAAATGACCCTGGGCATGATCTGGACCATCATCCTTCGCTTTGCTATTCAG
GATATTTCGGTTGAAGAAACATCTGCCAAAGAAGGTCTGCTGCTTTGGTGTCAGAGGAAAACCG
CTCCTTATAGAAATGTAAACATTCAGAACTTCCATACTAGCTGGAAAGATGGCCTTGGACTCTG
TGCCCTCATCCACCGACACCGGCCTGACCTCATTGACTACTCAAAGCTTAACAAGGATGACCCC
ATAGGAAATATTAACCTGGCCATGGAAATCGCTGAGAAGCACCTGGATATTCCTAAAATGCTGG
ATGCTGAAGATTTAGTATACACTGCCAGACCTGATGAAAGAGCCATAATGACTTATGTTTCCTG
TTACTATCATGCTTTTGCTGGTGCACAGAAGGCTGAGACAGCGGCTAACAGGATATGTAAGGTT
CTTGCTGTGAATCAAGAGAATGAGAGGCTGATGGAAGAATATGAGAGGCTAGCGAGTGAGCTTT
TGGAATGGATTCGTCGCACGATCCCCTGGCTAGAGAACCGGACTCCTGAGAAGACGATGCAGGC
CATGCAGAAGAAGCTGGAGGACTTCCGGGATTACCGCCGGAAGCACAAACCACCCAAGGTGCAG
GAGAAATGCCAGCTGGAGATCAATTTCAACACATTGCAGACCAAGCTGCGGATCAGCAACCGGC
CTGCCTTCATGCCCTCTGAGGGCAAGATGGTGTCGGATATTGCTGGTGCCTGGCAGAGGCTGGA
GCAGGCTGAGAAGGGTTACGAGGAGTGGTTGCTCAATGAGATTCGGAGACTGGAGCGCTTGGAA
CACCTGGCTGAGAAGTTCAGGCAAAAGGCCTCAACCCACGAGACTTGGGCTTATGGCAAAGAGC
AGATCTTGCTGCAGAAGGATTACGAGTCGGCATCGCTGACAGAGGTGCGGGCTCTGCTGCGGAA
GCACGAGGCGTTCGAGAGCGACCTGGCAGCGCACCAGGACCGCGTGGAGCAGATCGCAGCCATC
GCGCAGGAGCTCAATGAACTGGACTATCACGACGCTGTCAATGTCAACGATCGGTGCCAGAAAA
TTTGTGACCAGTGGGACCGACTGGGAACACTTACTCAGAAGAGGAGGGAAGCCCTGGAGAGAAT
GGAGAAATTGCTAGAAACCATTGATCAGCTTCACCTGGAGTTTGCCAAGAGGGCTGCTCCTTTC
AACAATTGGATGGAGGGCGCTATGGAGGATCTGCAAGATATGTTCATTGTCCACAGCATTGAGG
AGATCCAGAGTTTGATCACTGCGCATGAGCAGTTCAAGGCCACGCTGCCCGAGGCGGACGGAGA
GCGGCAGTCCATCATGGCCATCCAGAATGAGGTGGAGAAGGTGATTCAGAGCTACAGTATCAGA
ATCAGCTCGAGCAACCCGTACAGCACTGTCACCATGGATGAGCTCCGGACCAAGTGGGACAAGG
TGAAGCAGCTCGTGCCCATCCGCGATCAGTCCCTGCAGGAGGAGCTGGCTCGCCAGCATGCTAA
CGAGCGTCTGAGGCGCCAGTTTGCTGCGCAAGCCAATGCCATCGGGCCCTGGATCCAGAACAAG
ATGGAGGAGATTGCCCGGAGCTCCATCCAGATCACAGGAGCCCTGGAGGACCAGATGAATCAGC
TGAAGCAGTACGAGCACAACATCATCAACTACAAGAACAACATCGACAAGCTGGAGGGAGACCA
TCAGCTCATCCAGGAGGCCCTTGTCTTTGACAACAAGCACACGAACTACACGATGGAGCACATT
CGTGTTGGATGGGAGCTGCTGCTGACAACCATCGCCAGAACCATCAATGAGGTGGAGACTCAGA
TCCTGACAAGAGATGCGAAGGGCATCACCCAGGAGCAGATGAATGAGTTCAGAGCCTCCTTCAA
CCACTTTGACAGGAGGAAGAATGGCCTGATGGATCATGAGGATTTCAGAGCCTGCCTGATTTCC
ATGGGTTATGACCTGGGTGAAGCCGAATTTGCCCGCATCATGACCCTGGTAGATCCCAATGGGC
AAGGTACTGTCACCTTCCAATCCTTCATCGACTTCATGACTAGAGAGACGGCCGACACGGATAC
CGCCGAGCAGGTCATCGCCTCCTTCCGGATCCTGGCTTCTGATAAGCCATACATCCTGGCGGAG
GAGCTGCGTCGGGAGCTGCCCCCGGATCAGGCCCAGTACTGCATCAAGAGGATGCCCGCCTACT
CGGGCCCAGGCAGTGTGCCTGGCGCCCTGGATTACACCGCGTTCTCCTCCGCACTCTATGGAGA
GAGCGATCTGTGACGCTGAGGTTCTGTAATCACTGATCCCATCAGAACGCAATAAAAGCAGAAG
TCACAGTTGGTTTCCTGGAAACTTTGACAGGTTCTATTAAGTTGGGAGAGAGAGGGGGGAAAAA
AAGCCTTTTGTAGTTCAGTAATTGCCAGCAATATAACACGGCTAAAATGAAGTTTCTACAGTAT
ATGACATAGTGCGCTTCATAAATAGGTTTATTTCTGAGTTTTTAGCTAAATGTAATGAAATATC
AGGTTGATTTCTTTGATTAAACGGAACAAATTACTTGAGTATTAGGAAATTAGGAGGATCTAGG
GACAGAAGGAAAGTGAAAAATGTGAAAATACAAAATATCCAAGATTTAAGACTGGGGGGGGGGG
AAATCCACAAATTGGTAAATAAAGGTTTGCTATTTGTAAAAAATTTCATTTCTCTCTAATATGC
CTATGTGATTGCCCCTAGGGGAGTATATTTGGGATTCTAATGTTTTATTTTCATGCTTATCCAA
AGATTACTATTGTGTCTTCAAATGAATTTAATTAATTGTGAGATGGAACTGCCAGGGATTAAAA
AGACTATCAAAAAGA

hide sequence

RefSeq Acc Id:

XM_007989888 ⟹ XP_007988079

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	73,876,692 - 73,904,516 (+)	NCBI
Vero_WHO_p1.0	NW_023666055	75,969,736 - 76,003,746 (+)	NCBI

Sequence:

show sequence

ATGAGGAGGTCTTCAGTGCATTCAGGTGCAATGGCTGAGACAGCGGCTAACAGGATATGTAAGG
TTCTTGCTGTGAATCAAGAGAATGAGAGGCTGATGGAAGAATATGAGAGGCTAGCGAGTGAGCT
TTTGGAATGGATTCGTCGCACGATCCCCTGGCTAGAGAACCGGACTCCTGAGAAGACGATGCAG
GCCATGCAGAAGAAGCTGGAGGACTTCCGGGATTACCGCCGGAAGCACAAACCACCCAAGGTGC
AGGAGAAATGCCAGCTGGAGATCAATTTCAACACATTGCAGACCAAGCTGCGGATCAGCAACCG
GCCTGCCTTCATGCCCTCTGAGGGCAAGATGGTGTCGGATATTGCTGGTGCCTGGCAGAGGCTG
GAGCAGGCTGAGAAGGGTTACGAGGAGTGGTTGCTCAATGAGATTCGGAGACTGGAGCGCTTGG
AACACCTGGCTGAGAAGTTCAGGCAAAAGGCCTCAACCCACGAGACTTGGGCTTATGGCAAAGA
GCAGATCTTGCTGCAGAAGGATTACGAGTCGGCATCGCTGACAGAGGTGCGGGCTCTGCTGCGG
AAGCACGAGGCGTTCGAGAGCGACCTGGCAGCGCACCAGGACCGCGTGGAGCAGATCGCAGCCA
TCGCGCAGGAGCTCAATGAACTGGACTATCACGACGCTGTCAATGTCAACGATCGGTGCCAGAA
AATTTGTGACCAGTGGGACCGACTGGGAACACTTACTCAGAAGAGGAGGGAAGCCCTGGAGAGA
ATGGAGAAATTGCTAGAAACCATTGATCAGCTTCACCTGGAGTTTGCCAAGAGGGCTGCTCCTT
TCAACAATTGGATGGAGGGCGCTATGGAGGATCTGCAAGATATGTTCATTGTCCACAGCATTGA
GGAGATCCAGAGTTTGATCACTGCGCATGAGCAGTTCAAGGCCACGCTGCCCGAGGCGGACGGA
GAGCGGCAGTCCATCATGGCCATCCAGAATGAGGTGGAGAAGGTGATTCAGAGCTACAGTATCA
GAATCAGCTCGAGCAACCCGTACAGCACTGTCACCATGGATGAGCTCCGGACCAAGTGGGACAA
GGTGAAGCAGCTCGTGCCCATCCGCGATCAGTCCCTGCAGGAGGAGCTGGCTCGCCAGCATGCT
AACGAGCGTCTGAGGCGCCAGTTTGCTGCGCAAGCCAATGCCATCGGGCCCTGGATCCAGAACA
AGATGGAGGAGATTGCCCGGAGCTCCATCCAGATCACAGGAGCCCTGGAGGACCAGATGAATCA
GCTGAAGCAGTACGAGCACAACATCATCAACTACAAGAACAACATCGACAAGCTGGAGGGAGAC
CATCAGCTCATCCAGGAGGCCCTTGTCTTTGACAACAAGCACACGAACTACACGATGGAGCACA
TTCGTGTTGGATGGGAGCTGCTGCTGACAACCATCGCCAGAACCATCAATGAGGTGGAGACTCA
GATCCTGACAAGAGATGCGAAGGGCATCACCCAGGAGCAGATGAATGAGTTCAGAGCCTCCTTC
AACCACTTTGACAGGAGGAAGAATGGCCTGATGGATCATGAGGATTTCAGAGCCTGCCTGATTT
CCATGGGTTATGACCTGGGTGAAGCCGAATTTGCCCGCATCATGACCCTGGTAGATCCCAATGG
GCAAGGTACTGTCACCTTCCAATCCTTCATCGACTTCATGACTAGAGAGACGGCCGACACGGAT
ACCGCCGAGCAGGTCATCGCCTCCTTCCGGATCCTGGCTTCTGATAAGCCATACATCCTGGCGG
AGGAGCTGCGTCGGGAGCTGCCCCCGGATCAGGCCCAGTACTGCATCAAGAGGATGCCCGCCTA
CTCGGGCCCAGGCAGTGTGCCTGGCGCCCTGGATTACACCGCGTTCTCCTCCGCACTCTATGGA
GAGAGCGATCTGTGACGCTGAGGTTCTGTAATCACTGATCCCATCAGAACGCAATAAAAGCAGA
AGTCACAGTTGGTTTCCTGGAAACTTTGACAGGTTCTATTAAGTTGGGAGAGAGAGGGGGGAAA
AAAAGCCTTTTGTAGTTCAGTAATTGCCAGCAATATAACACGGCTAAAATGAAGTTTCTACAGT
ATATGACATAGTGCGCTTCATAAATAGGTTTATTTCTGAGTTTTTAGCTAAATGTAATGAAATA
TCAGGTTGATTTCTTTGATTAAACGGAACAAATTACTTGAGTATTAGGAAATTAGGAGGATCTA
GGGACAGAAGGAAAGTGAAAAATGTGAAAATACAAAATATCCAAGATTTAAGACTGGGGGGGGG
GGAAATCCACAAATTGGTAAATAAAGGTTTGCTATTTGTAAAAAATTTCATTTCTCTCTAATAT
GCCTATGTGATTGCCCCTAGGGGAGTATATTTGGGATTCTAATGTTTTATTTTCATGCTTATCC
AAAGATTACTATTGTGTCTTCAAATGAATTTAATTAATTGTGAGATGGAACTGCCAGGGATTAA
AAAGACTATCAAAAAGATCTTTTGGCACTTACCATTTTTAAAATAGAGTTTATGGTCATCTCTT
CATTGTTTAGGGCTGGATGGTCAACTCAGTTAGTGATTTTTGCTGCTTCTGTTATCCTCCAGAG
TAGAGACCTAAGGAAACATGGAAGTCAGTTTAATTGCCAGAGGGAAGGATGCAGTCACTAGGTT
AAATGAGGTTTTTAGGATTATTTATTGATTCCAGGTTCCCATGCTTTTTGTTGGAGCTTATTAG
TACAGGTTCTCAAGAGATGACCATATGAACGTGCTCTGTTTTTAAATAAGCAGGTTTCTGTAGT
AGTGATTCATCACAAGGCAAGTCAGAAACCAGCATCCTTCTAGCCCTCCAATCAGGACTTCATT
ATGCCTCTCGTTTTATGACCTTTTAAGGAGAAGCCAGAGTTATCGTAGGAAAGGACTGATTCTC
AGCAGCAGTGGAGGTGAGTTCTTTCTCTGCGGAAGCTTTACATATGTTTTGGGTAGTAGGAGTA
ACTAGATGTTTTAGCTACTGTGCAGTGTGTGTTCACCCCTGGGATTCGAGAGTATATCCTAACA
AGTCCCATGTCTGGTTCTGTGTCTGAAGGCCTGCTTCATGCCACAGGATGCTACATGCACTTCC
GCTCGCACATCTTGATCCACTGAATGTTCATTCTTCCTTTTTGCTCATACTGCTGTAGGCTATA
ATTCCCCCCTCTGTTTTTCCATCTTGTTGACAGCTTGTAGAGAATAAAGCAGGAATTATTTTTA

hide sequence

RefSeq Acc Id:

XM_037986059 ⟹ XP_037841987

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666055	75,967,570 - 76,003,158 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007988076	(Get FASTA)	NCBI Sequence Viewer
	XP_007988078	(Get FASTA)	NCBI Sequence Viewer
	XP_007988079	(Get FASTA)	NCBI Sequence Viewer
	XP_037841987	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005967
	ENSCSAP00000005967.1

RefSeq Acc Id:	XP_007988078 ⟸ XM_007989887
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_007988076 ⟸ XM_007989885
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RBH8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007988079 ⟸ XM_007989888
- Peptide Label:	isoform X4

RefSeq Acc Id:

ENSCSAP00000005967 ⟸ ENSCSAT00000007804

RefSeq Acc Id:	XP_037841987 ⟸ XM_037986059
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009716	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007804.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	1.20.58.60	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	Actinin_actin-bd_CS	UniProtKB/TrEMBL
	CH-domain	UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF-hand_Ca_insen	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Spectrin/alpha-actinin	UniProtKB/TrEMBL
	Spectrin_repeat	UniProtKB/TrEMBL
KEGG Report	csab:103230816	UniProtKB/TrEMBL
NCBI Gene	ACTN2	ENTREZGENE
PANTHER	ALPHA-ACTININ-2	UniProtKB/TrEMBL
	SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
	EFhand_Ca_insen	UniProtKB/TrEMBL
	PF00307	UniProtKB/TrEMBL
	Spectrin	UniProtKB/TrEMBL
PROSITE	ACTININ_1	UniProtKB/TrEMBL
	ACTININ_2	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	PS50021	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
	efhand_Ca_insen	UniProtKB/TrEMBL
	SM00033	UniProtKB/TrEMBL
	SPEC	UniProtKB/TrEMBL
Superfamily-SCOP	Spectrin repeat	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF47576	UniProtKB/TrEMBL
UniProt	A0A0D9RBH8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM